PENDOPHARI, division defo (7 PENDOPHARM OPEN MINDS THINK ALIK February 9", 2015 Ms. Tyana Grundig Associate Producer CBC News Marketplace Dear Mrs. Grundig, ‘We thank you for your email of February Sth, 2015 and the opportunity to respond to CBC Marketplace regarding the upcoming expose of Natural Health Products (NHPs) and th registration process in Canada. As the regulatory approval pathways for healthcare product are complex in nature, Pendopharm is hereby providing a written response to your questions and respectfully declines the invitation for an on-air interview. Firstly and most importantly, Pendopharm is fully committed to providing healthcare products that are of high quality, efficacious and safe for all Canadians. We abide to the highest level of ethics for the industry and adhere to the rigorous standards of evidence as required by Canadian law and as interpreted in Health Canada policies and guidelines. Helixia Cough Prospan is a NHP that is derived from the extract of the dried ivy leaf. In Canada, Helixia Cough Prospan is considered as a NHP with non-traditional, non-compendial claims that require at least 2 pieces of scientific evidence (e.g. clinical trials). ‘The evidence required by Health Canada to support this type of NHP is more rigorous than a NHP making a traditional use claim. Pendopharm provided above and beyond the Health Canada requirements including data from 3 clinical studies which led to an approval in 2011. ‘As further evidence of its safety and effectiveness, Prospan Cough Syrup (as it is known internationally) has been available on the market for over 2 decades and used by millions of consumers, The product was first launched in Germany in 1991 and is distributed in over 85 countries worldwide. Aga ., Pendopharm thanks you for the opportunity to respond to your inquiry. Sincerely, ( Didier pévonond, MD Senior Director, Medical Affairs latmascience ine, 6111, avenue Royalmount Ave Tai (514) 340.5045. TelecopieuriFax: 1 866 926-7664 Service aia cienele/Cusiomer Service. 1 865 826-7589 Infarmation médicale et scienfique/Medieal nd Scent infomation Servioes' 1 988 550-6060 seauiSute 100, Montréal, Québec, HAP 214, CANADA