Paediatrica Indonesiana

VOLUME 54

September

NUMBER 5

Original Article

Anti-S. typhi Vi IgG levels in children with

and without typhoid vaccinations
Sriandayani, Tonny H. Rampengan, Hesti Lestari, Novie Rampengan

Abstract

Background 7\SKRLG IHYHU LV HQGHPLF WR ,QGRQHVLD ZLWK DQ DQQXDO

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EH DQ HIIHFWLYH PHWKRG WR SUHYHQW W\SKRLG IHYHU 2I VHYHUDO YDFFLQH W\SHV
the polysaccharide Vi vaccine is the most commonly used typhoid
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Objective 7R FRPSDUH WKH PHDQ VHUXP DQWLERG\ WLWHUV RI DQWL S. typhi
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XVLQJ LQGHSHQGHQW 7 WHVW DQG )LVKHUV WHVW 6HUXP DQWL S. typhi Vi
,J* OHYHOV ZHUH PHDVXUHG E\ enzyme-linked immunosorbent assay
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Results 6HYHQW\ VL[ VXEMHFWV ZHUH
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Conclusion 7KH PHDQ VHUXP DQWL S. typhi Vi IgG antibody level in
FKLOGUHQ ZKR KDG EHHQ YDFFLQDWHG PRUH WKDQ
\HDUV SULRU WR WKH VWXG\
LV KLJKHU WKDQ LQ FKLOGUHQ ZKR KDG QHYHU UHFHLYHG W\SKRLG YDFFLQDWLRQV
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VLJQLILFDQWO\ GLIIHUHQW EHWZHHQ WKH WZR JURXSV [Paediatr Indones.
2014;54:284-8.]
Keywords: anti-S. typhi Vi IgG, Vi
polysaccharide typhoid vaccine, typhoid fever,
children

284 Paediatr Indones, Vol. 54, No. 5, September

2014

yphoid fever is an acute, life-threatening

disorder commonly characterized by
fever, headache, malaise, anorexia, spleen
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problem due to its rapid spread, especially in dense
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\HDUV 7 Data collected from Department of Pediatrics,
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From the Department of Child Health, Sam Ratulangi University

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Reprint requests to
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Paediatr Indones, Vol. 54, No. 5, September 2014

284

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raised the necessity for an effective prevention

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Studies have reported that the cumulative
efficacy of the Vi polysaccharide vaccine lasts only
for
WR
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\HDUV
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regarding the protective response of the typhoid
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implicitly indicated that the quality of UHVSRQVH WR
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Methods
We conducted a descriptive, analytic, cross-sectional
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subjects Kartu Menuju Sehat (KMS) or other
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XQGHUZHQW VHUXP DQWLERG\ level examinations for anti-S.
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antibody levels and Chi-square test for the
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Results
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VXEMHFWV DUH VKRZQ LQ Table 1
,QGHSHQGHQW 7 WHVW UHVXOWV RQ PHDQ DQWL-S. typhi
9L DQWLERG\ OHYHOV EHWZHHQ WKH WZR JURXSV DUH VKRZQ in
Table 2, ZKLOH &KL VTXDUH WHVW UHVXOWV WR FRPSDUH WKH
SURSRUWLRQ RI FKLOGUHQ ZLWK SURWHFWLYH DQWL-S.

Table 1. 5WDLGEVU EJCTCEVGTKUVKEU

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P

Variables

0Q V[RJQKF XCEEKPCVKQP
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MI O2

Table 2. %QORCTKUQP QH CPVK S. typhi 8K +I) NGXGNU DGVYGGP VJG XCEEKPCVGF CPF
WPXCEEKPCVGF ITQWRU
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CPVK S. typhi Vi IgG NGXGN zI O.

/GCP
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VQ
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typhi 9L DQWLERG\ OHYHOV EHWZHHQ WKH WZR JURXSV DUH VKRZQ

LQ Table 3
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2
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In our study, the mean anti-S. typhi Vi IgG level of
the YDFFLQDWHG JURXS ZDV QRW LQ SURWHFWLYH UDQJH 6WXG\
conducted by Acosta et al
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the incidence of typhoid fever (diagnosed clinicaly and
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study found that in the second year after vaccination

Table 3. 2TQRQTVKQP QH EJKNFTGP YKVJ RTQVGEVKXG CPVK S. typhi 8K +I) NGXGNU

zI O.
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Discussion
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from the bacteria Salmonella typhi
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Although the underlying immunological mechanism of response to the Vi polysaccharide typhoid
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vaccine may vary depending on typhoid endemicity of
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inconclusive on the need for vaccination or revaccina-

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suggest a role of environmental antigen exposure
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compared to unvaccinated group, although this
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years
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stated
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antibody levels to S.typhi DW PRUH WLPH SRLQWV ,QWHUYDO
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levels measurement in vaccinated group also not
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protective levels of immunity against S. typhi $OVR
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References
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Pearman J, Collioud A, et al 9DFFLQHV DJDLQVW W\SKRLG IHYHU
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7UDQV 5
6RF 7URS 0HG +\J
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cases of typhoid fever imported to Split-Dalmatia County
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Analysis of data gaps pertaining to Salmonella enterica serotype
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SRO\VDFFKDULGH W\SKRLG fever vaccine to primary school
children in North Jakarta,
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