: :

N NN NN N

: :

: :

HH
H
+

] ]

] ]

] ]

H
H

H
] ]

H HH

N NN

N N

] ]

HH

rr
rr

rr

rr
rr

rr
rr

] ]

H
OH

O
H
rr

H2O

Hrr

rr
rr

rr

HH

] ]

O
O
N

O
O
O

N
O

H
N

N
H2

HN
O

NH2

] ]

O
H
N
H

O
NH

O
NH

H
H2O

O
O

OH

H
H
H

I
I

HO
I

HO

Oaa+

O
H

H
O

OH

OH

OH
gg HNH3)2

O
H

OH

gg0

NH3

] ]

] ]

+
+

O
HO
OH

rr

O
O

OH

rr

OH

H
O
O
H

rr

H
OH

OH

O
HO

rr

OH

O
OH

O
H

rr

OH

OH
rl

rl
ee
rl

O
O
O

ee O

Hrl

ll- NH3

NH2

Hrl

NN N

] ] ] ] ] ] ] ]

a
H
] ]

] ]

a
] ] ] ] ] ] ] ]

H
a