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Immune Pharmacology
Shan Nanji

Immuno Pharmacology
nCyclosporine
n Binds to __________________
n Inhibits __________________which prevents production
of I __________________and its receptor.

Shan Nanji - NanjiMD@gmail.com

Immuno Pharmacology
nTacrolimus TacrolimBBus
n

Aka FK506

Inhibits __________________

S/E:
Nephrotoxicity
n __________________
n __________________
n Hyperglycemia
n __________________
n

Shan Nanji - NanjiMD@gmail.com

Immuno Pharmacology
nSirolimus SEEroLIMus
Aka Rapamycin
n __________________
n Limits __________________ proliferation
n

S/E
__________________
n Thrombocytopenia
n Leukopenia
n

Shan Nanji - NanjiMD@gmail.com

Immuno Pharmacology
nDaclizumab DA-Klizumab
Antibody against __________________
n Clinical Use:
n DA-Kidney Transplants
n

Shan Nanji - NanjiMD@gmail.com

Immuno Pharmacology
nAzathioprine
n

Antimetabolite precursor __________________ that interferes

with metabolism and synthesis of nucleic acids.

n Clinical
n
n

Use:

Kidney Transplantation
__________________

S/E:
n
n

Shan Nanji - NanjiMD@gmail.com

__________________, active metabolite Mercaptopurine

is metabolized by Xanthine Oxidase
Toxic effects increased on __________________.

Immuno Pharmacology
nMuromonab Morononab
Monocolonal AB that binds to __________________ on the
surface of T-Cells - __________________
n __________________
n Clinical Use:
n Immunosuppression after Kidney Transplantation
n

S/E:
n
n

Shan Nanji - NanjiMD@gmail.com

Cytokine Release Syndrome

Hypersensitivty

Immuno Pharmacology
nTrastuzumab/Herceptin
TRUSTuzumab
Target: erb-B2
n Clinical Use:
n Her-2 overexpressing Breast Cancer
n DONT TRUST HER
n

Shan Nanji - NanjiMD@gmail.com

Immuno Pharmacology
nRituximab
Target: CD20
n Clinical Use:
n __________________
n

Shan Nanji - NanjiMD@gmail.com

10

Immuno Pharmacology
nInfliximab INFL-iximab
Target: __________________
n Clinical Use:
n Crohns Disease
n Rheumatoid Arthritis
n Psoriatic Arthritis
n Ankylosing Spondylitis
n

Shan Nanji - NanjiMD@gmail.com

11

Immuno Pharmacology
nAdalimumab
Target: TNF-Alpha
n Clinical Use:
n Crohns Disease
n Rheumatoid Arthritis
n Psoriatic Arthritis
n

Shan Nanji - NanjiMD@gmail.com

12

Immuno Pharmacology
nEtanercept
Target: __________________
n Clinical Use:
n Crohns Disease
n Rheumatoid Arthritis
n Psoriatic Arthritis
n

Shan Nanji - NanjiMD@gmail.com

13

Immuno Pharmacology
nDigoxin

Immune Fab

Target: Digoxin
n Clinical Use:
n Digoxin poisoning
n

Shan Nanji - NanjiMD@gmail.com

14

Immuno Pharmacology
nAbciximab
Target: __________________
n Clinical Use:
n

Prevents Cardiac Ischemia in:

n Unstable Angina
n Percutaneous Coronary Intervention Patients
n Current Myocardial Infarction Patients

Shan Nanji - NanjiMD@gmail.com

15

Immuno Pharmacology
nOmalizumab
n Target

__________________

n Clinical

Use:

n Treatment

Shan Nanji - NanjiMD@gmail.com

option for __________________

16

Immuno Pharmacology
nMycophenolate
n Target

__________________Prevents Production of the

Nucleoside Guanine
n Leads to rapid arrest of B/T cell proliferation
n Clinical

Use:
n Transplants
n

Shan Nanji - NanjiMD@gmail.com

__________________

17

Immuno Pharmacology
nThalidomide (AKA Contergan)
n Target:

__________________

n Clinical

Use:
n Immunosupression:
n

__________________

n Organ Transplants
n Anti-Angiogenic

Shan Nanji - NanjiMD@gmail.com

18

Immuno Pharmacology
nThalidomide (AKA Contergan)
nS/E:
n

__________________ (fetal development problems)

Underdeveloped/malformed limbs and bones
n Encephalocele
n Hydrocephalus
n Leads to Vomiting and Migraines
n Bicornate Uterus
n Heart and Kidney Malformations
n Urethral Abnormalities
n Short Stature
n

Shan Nanji - NanjiMD@gmail.com

19

Immuno Pharmacology
nAldesleukin
n Interleukin-2
n Clinical

Recombinant Cytokine

Use:
n Renal Cell Carcinoma
n Metastatic Melanoma

Shan Nanji - NanjiMD@gmail.com

20

Immuno Pharmacology
nErythropoietin
n Epoetin
n Clinical

Recombinant Cytokine

Use:
n Anemias
n In Renal Failure Especially Due to
EPO not being produced

Shan Nanji - NanjiMD@gmail.com

21

Immuno Pharmacology
nFilgrastim FilGRA STIM
n ________________________________
n IL-___
n Clinical

Use:
n _____________________

Shan Nanji - NanjiMD@gmail.com

22

Immuno Pharmacology
nSargramostim SarGRA MoSTIM
n _____________________
n IL-3
n Clinical Use:
n _____________________

Shan Nanji - NanjiMD@gmail.com

23

Immuno Pharmacology
n-Interferon
n Recombinant

n Clinical

Cytokine

Use:

n _____________________
n Kaposis

Sarcoma
n _____________________
n Malignant Melanoma

Shan Nanji - NanjiMD@gmail.com

24

Immuno Pharmacology
n-Interferon
n Recombinant

n Clinical

Cytokine

Use:

n _____________________

Shan Nanji - NanjiMD@gmail.com

25

Immuno Pharmacology
n-Interferon
n Recombinant

n Clinical

Cytokine

Use:

n _____________________
n

Shan Nanji - NanjiMD@gmail.com

Aids Phagocytes

26

Immuno Pharmacology
nOprelvekin
n _____________________

n Clinical

Recombinant Cytokine

Use:
n Thrombocytopenia

Shan Nanji - NanjiMD@gmail.com

27

Immuno Pharmacology
nThrombopoietin
n Recombinant

n Clinical

Cytokine

Use:
n Thrombocytopenia

Shan Nanji - NanjiMD@gmail.com