+

Renal Pharmacology
Shan Nanji

Question
nWhich

receptor can be stimulated

to increase the release of Renin?
n __________________

Shan Nanji - NanjiMD@gmail.com

Osmotic Diuretics
nMannitol
MOA:
n Increases

n Clinical
n

Renal Tubular Fluid Osmolarity

Use:

Used to lower IOP and ICP

Shan Nanji - NanjiMD@gmail.com

Osmotic Diuretics
nMannitol
n Contraindicated:
n
n

Shan Nanji - NanjiMD@gmail.com

__________________
__________________

Loop Diuretics
nFurosemide/Ethycrynic Acid
n Ethycrynic Acid __________________

MOA:
__________________in the Thick Ascending limb
of the __________________
n Stimulates the release of __________________
n Action of __________________inhibited by
_________________
n

n Clinical
n

Use:

__________________

Shan Nanji - NanjiMD@gmail.com

Loop Diuretics
nFurosemide/Ethycrynic Acid
n Ethycrynic Acid Does NOT have sulfur
n S/E:

__________________
n __________________
n Dehydration
n Sulfa-drug Allergy
n Interstitial Nephritis
n Gout
n

Shan Nanji - NanjiMD@gmail.com

Carbonic Anhydrase Inhibitor

nAcetazolamide - ACIDazolamide
n MOA:
n

Inhibits Carbonic Anhydrase in Proximal Convoluted Tubule

n Causes Increased [Bicarb] in the Lumen

n Clinical
n
n

Use:

__________________
__________________

Shan Nanji - NanjiMD@gmail.com

Carbonic Anhydrase Inhibitor

nAcetazolamide - ACIDazolamide
n S/E:
n

__________________

n Sulfa-drug

Shan Nanji - NanjiMD@gmail.com

Allergy

Thiazide Diuretics
nHydrochlorothiazide
MOA:
n

Inhibits __________________Reabsorption in
Early Distal Convoluted Tubule

n Clinical

Use:

Hypertension
n CHF
n __________________
n __________________
n Decreases __________________of the Kidney
n Urine becomes __________________
n

Shan Nanji - NanjiMD@gmail.com

10

Thiazide Diuretics
nHydrOchlOrOthiazide
nS/E:
n HyperGlycemia

__________________
n HyperUricemia
n HyperCalcemia
n __________________
n HypOnatremia
n

Shan Nanji - NanjiMD@gmail.com

11

Potassium Sparing Diuretics

nSpironolactone

MOA:
n

_______________________________________ in the
Cortical Collecting Tubule

Clinical Use:
Hirsutism!
n __________________
n CHF
n

Shan Nanji - NanjiMD@gmail.com

12

Potassium Sparing Diuretics

nSpironolactone
S/E:
n

__________________ -> possible Arrythmias

n Gynecomastia
n Anti-Androgen

Shan Nanji - NanjiMD@gmail.com

Effects

13

Potassium Sparing Diuretics

nTriamterene/Amiloride
MOA:
n

__________________in the Cortical Collecting Tubule

Clinical Use:
__________________
n CHF
n K+ depletion
n

Shan Nanji - NanjiMD@gmail.com

14

Potassium Sparing Diuretics

nTriamterene/Amiloride
S/E:
n __________________

Shan Nanji - NanjiMD@gmail.com

15

ACE Inhibitors
nCaptopril,

Enalapril, and Lisinopril

MOA:
n

Inhibit Angiotensin Converting Enzyme

n Therefore decreases [Angiotensin II]
n Also __________________
n Decreased __________________ (NO
Constriction __________________)

Clinical Use:
Hypertension
n CHF
n

Renal Disease due to Diabetes

Shan Nanji - NanjiMD@gmail.com

16

ACE Inhibitors
nCaptopril,

Enalapril, and Lisinopril

S/E:
n

__________________

n Angioedema
n Teratogen
n Fetal

Renal Abnormalities
n HypOtension
n Hyperkalemia
n

__________________
n Decreased

Shan Nanji - NanjiMD@gmail.com

GFR

17

Angiotensin Receptor Blocker

nCandeSARTAN,
n

-sartans

Sweet as CANDYsartan because Least Side Effects

MOA:
n

Block Angiotensin II Receptor

n Actions similar to ACE inhibitors
n Do NOT __________________
n Clinical

Use:

Hypertension
n CHF
n Renal Disease due to Diabetes
n

Shan Nanji - NanjiMD@gmail.com

18

Angiotensin Receptor Blocker

nCandeSARTAN,
n

-sartans

Sweet as CANDYsartan because Least Side Effects

S/E:
n

Similar to ACE Inhibitors EXCEPT:

n ___________
n ______
n _Due to Not Increasing __________________

Shan Nanji - NanjiMD@gmail.com