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Methionine Cycle

Folate Cycle
Urea
Arginine

MAT

Neurotransmitter

THF

Tryptophan

Thymidine
synthesis

Tyrosine
BH4

dUMP

Methionine

DMG
BHMT
MS

ammonia

Microglial
Activation

Dopamine
MAO B

HIAA

COMT

Homocysteine
B6,
CBS
P5P
Cystathionine

HVA
Peroxynitrate
Super Oxide

Oxidative-Inflammatory Disease

Creatine
Creatinine
adenosine

Transsulfuration

Ammonia
Cysteine + KG
MAO B
Taurine

0 BH4

Neuronal
Damage

Serotonin
MAO A

Cobalamin
Cycle

NorEp
1 BH4

Citrulline + NO

SAHH
5 Methyl
THF

BH2
2 BH4

Urea

SAH

MTHFR
MSR

NOS

Methylation
Guanido Ac

TMG

Ornithine
DHPR

SAMe

DNA, RNA,
Protein,
Lipids

COMT

Sulfite
Moly

Glutathione
SUOX

Sulfate
VMA

Adapted from
Dr. Amy Yasko
2012 The Institute for Functional Medicine