SPECIAL 1000th ISSUE Jeaders a ate a Hanks on the thrill Ng re BY | : U- AMAZING meee TRENDS a ame ela Regents 10 New ‘an nis Families and FAITHeessec sen seesees WV Non aca ora Re Taal ye ee NE gece i exp 2 ieee yy iN iG Tal would lead to tod S Sun er leae) ed if Your skin has collected 4 lifetime of Sun memories. If you've seen ie dermatologist about those rough, scaly sun-damaged spots on your head or face C4 ed Actiric KeratosiS (AK), you know there are probably more still developing: And that left untreated, AK could lead to serious skin problems. So why wait? Call or log on for your free Sun + Skin Information Kit. You'll learn more about AK, and 4 proven alternative to treat the AKs you see as well a5 the ones nearby» still developing underneath. After all, your skin has memories: Let's help keep them happy: 3M Pharmaceuticals from the 3M Health Care familytreating Learn all you can about (AK). eG Keratosis Ce) Call for cat free Sun & Skin Information Kit. 988-50-TREAT AK - -888-508- -7328) or visit WWW. treat-AK.comSPECIAL LOOOth ISSUE 7. el : | Jeaders Digest Face to Face with Tom Hanks sara oavioson On space, camping out, and laughing his way through life. AUGUST 2005 It's All About YOU 97 14 Amazing Trends That Will Change Your Life health > 98 Re-engineering Your Body ban rerser, exo ‘Technology is providing the tools for us to live longer, happier and health- ier than ever before. >108 Do-It-Yourself Doctoring .sa covvier coor These days, we're diagnosing, and treating, what ails us. Proceed with caution. media > 116 Me Me Media WARREN BERGER Whether it’s TV or radio, news or entertainment, the iRevolution gives power to the people. > 124 Deadly Games ROBERT F. HOWE Are kids so hooked on video violence that it becomes their reality? 2 money > 132 Making Your Job Work for You maria eartinomo With the coming labor shortage, you'll have more freedom, more flexibility, and maybe even a fatter paycheck. > 138 Pump! Swipe! Scan! DOUG COLLIGAN A week in the life of a serve-yourself superhero. living > 144 Meals That Heal NEENA SAMUEL Want more energy, or better sleep? Reach for a menu instead of medicine. > 150 Tanks for the Memories rerer scostic More and more vacationers are going to extremes. PHOTOGRAPHED BY GREG GORMAN COVER: (BACKGROUND) PICTUREQUEST: (HANKS) GREG GORMAN154 Utopia, USA MAX ALEXANDER There’s a new destination for a scitech > 162 Always On SETH STEVENSON Tune in, turn on, drop out? No way. 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You'll get informa- me of address and other tion on over 80 supplements inquiries can be made and their impact on hun- at rd.com/help. dreds of health problems. 6This Is What Happens When You Weigh Long-Lasting, Non-Drowsy Allegra 180 mg Against The Alternatives. Not one of these allergy medicines can give you long-lasting seasonal allergy relief without the risk of drowsiness. Allegra 180mg can. For people 12 and over. Side effects with Allegra 180mg a are low and may include headache, cold or backache. —_— Please see additional important information on next page. ALLEGRA. THE RELIEF GOES ON. RR Brands lsted are trademarks of thei respective companies IVEMTIS 6 2005 Averns Pharmaceuicals Ine. USAFEX 05.04.54 ‘Aventis Pharmaceuticals, a member of the sanof-aventis Group sanALLEGRA® {fexofenadine hydrocmlordey Capsules and Tablets INDICATIONS AND USAGE ‘Seasonal Allergic Rhinitis ALLEGRA is indicated fr the relief of symptoms associated with seasonal allerBc rhinitis in adults and cildren 6 years of age and older. Sym gtoms treated elfecively were sneezing, thinorihea, (chy nose/palateftivoa, Nelinatered eyes ALLEGRA 1s indicated fr treatment of uncomplicated skin manifestations of chronic ibopathic urticaria magus and clden 6 yeas of ae and older. sigifiantly reduces pruritus and the numberof wheal CONTRAINDICATIONS. ALLEGRA is contraindicated in patents with krown hypersensitity to anyof is ingtesients PRECAUTIONS ‘Diug interaction with Enthromycin and Ketoconazole fexofenadine hycioctoride hes een shown {0 exibit minimal (ca. 58) metabolism, However, co-adannisration of fxatenaline hydrachlorde with ketoconazole and enthronan ed to increased plasma levels of fexofenadine hydrochioride. Fevotenadine hydrachlonie had no effec-an the pharm ok ‘ico enthnostycin and kelxonazole tn twa separate studs, fevokenadi hydrochlorde 120 mg tice daiy wo times the recommended twice daily dose) vas coadministered with enthromycin 590 mg every 8 hours or keto conaxole 400 mg once day unde steady state conditions o normal, heathy wo Linters 24, each str No dfevences in advese eve 0 OT iN “were obsewed when patients were acimnstered fexofenadine hydride alan ot in combitation with eytiromycin ot ketoconazole. The indings of these suis are summarized ir the following abe Efecs on steady-state fexofenadine hydrochloride pharmacokinetics after7 days of coaiministration with fexofenadine hydrochloride 120 mg ‘every 12 hours two times the recommended twice daily dose) in normal volunteers (t=24) Concomitant Drug Gon IC gosoe {Peale (Eaten of semi concentration) exposuite) Enythromycin +828, 109%, {BOO mgever 8 hrs, Ketoconazole +1358 64% {800 me ance daly The changes in plasma faves were within te ange of plasms levels chine inadequate and wel contol cial al, Te mechanism of hee nteragtor a ben elated in vi, sty and ‘in vivo animal mode's, These studies indicate that ketoconazole or erythromyain Coatiminisration enhances fesufenadine gastrointestinal absoptin. fr ¥¥0 animal studies also suggest that n addition to increasing absorption, ketocona: dale decreases feotenadive hychloade griveinesiral secretion, whe erytluonyein np aka deere ny ein, Drug Interactions with Antacids Administration of 1200 fexatenadinelidrechlonde 2x €0 mgcapsule wil {15 minutes of an aluminum and magnesium containing antacid (Maalos') decreased fexofenadine AUC by £1% and, by 42% ALLEGRA should not be (aie cosy dee wit aur wl mages conta ing antacids, Carcinogenesis, Mutagenesis, Impairment of Fertility The carcinogenic potential ant reoraductve toxaty of fexofenadine hwdrachlo Fide were assesed using terfenadine studies with acequate fexofenadine hydchloride exposure (based on plasma area underthe-concentation vs ‘ime (AUC values}, No evidence ef carcinogenicity was observe in a. 8-mnooth study in mice andl in a2 monty study in rats at oral doses upto 150 mg, of terlenaine which ied to fewieradine exposures that were respectively ppronmatey 3 and 5 times the exposure from the masta recommended daily oral ose of fexofenadine hydrochloride in adults and chide. Ini ito acterial Reverse Mutation, CHO'HIGPRT Fonardl Mutation, and Rat Lymphocyte Chromosomal Aberration assays) ana vivo [Mouse Bon Marrow ieronceus ass) tests, fexofenadine hycrochlovide revealed re evidence of mutagenicity. In rat fertity studies, doserelated reductions an implants and increases {in postimplantation loses were observed aan oral dose of 150 mag of terferadine (which led to fexoenadine hyekochlorde exposures that were approciiatly 3 times the exposure of the maxirumn recommended daily oral, dose of fesoferadine nycrochloride in adult) Pregnancy Teratogenic Effects: Category C. There was no evidente of teratogenicity is ‘ais oF rabbis at oral doses of terlenadine un to 300 melkg fvhich led to Fexolenadine exposures that were approamatey 4 and 31 tines, espedively, the exposure from the maximum recommended day oral dose a fexolenad ne ro adequate and well contralled studies in pregnant women, Fexoenadine should be used during pregrancy only ifthe potential benefit Insts the potential rik tothe fetus. Nonteratogenic Effects. Dose related decreases in pup weight gain and suri were observed in rats exposed to an orl dase of 150 mg a terlen acne {approximately 3 times the maximum recommended daily cal dose of ‘exolenadine hydrachleice in adults ased on comparison of fexolenadine Fydiochonide AUG} Nursing Mothers ‘There ae no adequate and wellcontrole studies in women during atation ‘Because many drugsare excreted in human mil, caution shouldbe exercised when fecteradine ycciforide 1s adi nstered fo a rursing woman, Pediattic Use ‘The ecommended dose inpatients 6011 years of age is based om rest comparison ofthe pharmacokinetics f ALLEGRA nalts and pediatric patiens and on the safety profile of fexoenadine hyroclovie in bh at and ped aticpaventsat doses equal toot higher than the commended dees ‘he safety of ALLEGRA tablets ata dase of 30 mg twice day hasbeen demon strated 1438 pediatric patients to 11 year of agen two placebo-conrol ed 22.wek seasonal allergic rit tras, The safely of ALLEGRA forthe treatment Of eon kiopathic urticaria in patiens 6101 yeas of ae is based on rss siudy companion of the pharmacokinetics of ALLEGRA in ad and peda patients and on the safety profe of texafenadine in both adult and peiatnc tients at doses equal to or hiher than the recommended dose. The efectiveness of ALLEGRA forthe treatment of sezsonal allergic init in patients 6f0 11 years of age was demonstrated in one nal (n=) in which ALLEGRA tablets 30 mg ce daly igicaly reduced total symptom sores compared to placebo, slong with extrapolation of demonstrated elicacy in patents age 12 years and abore, ad the pharmacokinetic companions in cuits and chien, The evleciveness of ALLEGRA forte treatment of chronic ‘diopathicuricana in patients to 11 years ol ages based onan entrandlton ofthe demonstrated efficacy of ALLEGRA in adults with this condition and the od that the disease couse, pathophysiology andthe dug’ Subsatialysrain chile otha of aul pales “Thvee cial saet studies comparing 151mg ID (=85} and 30-mg 1D (1=330) cof an experimental ‘mulation of Faenadine to placebo (n=430 have been Conducted in nitric pains age 6 rns fa 5 years, In gene, fexatena dine hydrochloride was wel tolerated in these studies. No uneapeced adverse ens were seen gen the knawn safety profile of Fevolenadine and likely adverse reactions for tis patient population. See ADVERSE REACTIONS anc ‘CUNICAL PHARMACOLOGY) ‘The sity and efectivene’sf fexoferadine hydeoctlride in peda patients ude 6 year of axe ave no beet essed. Geriatric Use Clinical tutes f ALLEGRA tables and capsules dl nt include sufficient nun aes of subjects age 65 years and over to determine whether cis population esponc’s difeenly trom younger palents. Other reported clinical experience tuas not identified diferences in esponses ietween the geatric and younger ‘tients. Tisdrugis known tobe substantally excreted by the Kdney. and the tisk of oxic reactions to tis drug may be greater in patients witn-mpaired ‘enal funtion. Because eke patiens armor ikl to have decreased eral funcion, care shouldbe taken in dose selection, and may be useul to manitoe ‘enal function. (See CLINICAL PHARMACOLOGY) [ADVERSE REACTIONS Adults. In paceoo-cntoledsesonal legit clinical alsin patients 1 2yearsalage and older, which included 2461 patents recening fexoleradine Injdochlonde capsules at dasesof 20 mg to 240 mg twice daily, edverse evens were simian fexofenadine hydroclonde and placebo-treated ates. ll aeverse event's that were reported by greater than 1 of patients wo rece the recommended daily dose of fexofenadine hydrochlvide 460 mg capsules twice daily, an that were move common with featenadine aytrachionde than plcebo, are sted in Tale la placebocentol ed circa sy in the United State, which included ‘50 patients aged 12 yeas and alder recenng fexofenadine hvdrochlon de tablets at doses of 120 or 1a mg once dai, adverse events were similar in fexofenadine hydrochloride and placebo-treated patients Table 1 also lists averse experiences that were repated by greater than 2% of patents teated with exaenadinehyrechlande abet doses of 18) rmgonce daly an that were moe omaon wth eatenadne hyrctiare than placebo. The incidence of adverse events, including dromsiness, was not dosereated «red similar cos sbgroups define by age, gees, and aceTable 1 adverse experiences inpatients ages 12 years and older reported in lace>-controled seasonal allergic rhinitis clinical tris in the United States ‘Twice daily dosing wit fexofenadine capsules at rates of greater than 1% Adverse eyperce Fovofenadine © mg Pawel Tce Baily (0=679) Viral infetion (cold ty, 23 Nausea 16% Dysmenorthes 16 Drowsiness 1395 Dyspepsa 13% Faigue 13% ‘once daily dosing with fexofenadine hydrochloride tablets at rates of greater than 2% Adverse experience Fexofonadive 190.mg Placebo once daly (n=283) Headache Taek 79% Uber Resiratory Trae Infeebon 3.28, a Back Pain 2% 14% ‘The frequency and agate of laboratory abnormalities were smile in ferofenainehydrocotde and placebo ated patents Pediat. Table 2istsaderse experiences plents gee 60 11 years of age which were reported by greaterthan 2% of patients treated with fexofenadine hydrochloride tablets at a dose of 30 mg twice daily in placebo-controlled sesso allege iis studies nthe United Stats and Canad that ere more con mon wth fxcenadice hyaclonde han placebo. ‘Adverse experiences reported in placebo-controlled seasonal allergic rhinitis studies in pediatric patients ages 6 to 11 in the United States and Canada at rates of greater than 2% Advere perience Fewofenadine 30 mg ‘ice aly (0=209) Headuche 7% Accidental Injury 29% Coughing 38% Fever 246 Pain 24% otitis media 24% Upper Respiratory Tract Infection 4.3% ‘Three cnical safety sues in 815 children age! 6 mont to 5 yeas compar ing 15mg BID (n=85) and 30 rg BID =330) of an experimental lormulation of Fesofenadine to placebo (n=430) have been cunducted. In general, exfena dine hydrochloric we wel tolerated in these tudes. No unexpeced adverse events were seen giver the knw safety profile of fecclenacine and likely averse reactions for this patie populaion. See PRECAUTIONS Pediatric Use} Advene evens reported by patenis 12 yeas of age and older in placebo contol chronic iiopahic urticaria udies were similar to those reported in placebo-contoled seasonal allergic shins studies. in placebo-ant led ‘vic idpaic uta cna al, which nude 72 paints 12 years of age and older reciing fexofenadine hydrochloride tobe at doses af 2010 24 mg twice dl, adverse evexts were similar in fexofenadine hydrochiorde dang plovebosteaced pater. Table 3 lists adverse experiences io petents aged ‘yeas and older which were reported by aeater than 2% of patients treated with fexofenadine nection de 60 mg abet twice daily in canted einial studies in the United States and Canada ard that were more common with ‘evoieatine hyd chlor thanplaceb, Vesa a escnatine hyradho fice i the teatment of chronic idiopathic utr en pedi patients 10 71 yeatsof age isbased an thesafetyprotiteofesafenadine hydrochloride adults Aantadlescent panerts at does ea Toor higher than the recommended ose (ee Fedatne Ue), Table 3 ‘Adverse experiences reported inpatients 12 years and older in placebo conttolled chronic idiopathic urticaria studies inthe United States and ‘Canada at rates of greater han 2% Advere experience Fexoeradine 60 mg Placebo twice cally (a8, (0-186) Back Pain 20% 11% Sinus U6 Dizziness a Drowsiness a0 ALLEGRA® (fexofenadine hydrochloride) Capsules and Tablets Events that have been reported during controlled eiical trials invobing seasonal allergic tints and chronic idbopathic urticaria patients wth in ddences less than 1% and similar to placebo and heve been rarely reported ‘ducieg posimarkeiing surveillance iclide: insomnia, nervousness, 2nd sleep disurdess or pavonitia, In are cases, ash, urticaria pruritus and hypersensiin- ityreactons with manifestations suchas angioedema, chest tightness, dyspnea flushing and sysernic anaphylas Fave been reported ‘QVERDOSAGE Reports of exofenacline hydrochonie overdose have been infrequert and co tain limited information. However, dazines, drowsiness, and dry mouth have been reported Single doves of fexofenadine hysrechionde up to 860 mg (se ‘parma volunteers at this dove level), and doses up to 680 mg twice daly for ‘Tanith (three norma volunteers a tis dose level or 249 mag oree daly for 7 year 236 normal volunteers a thes dose level) were admin sete vathout the development of cinicaly silica adverse events 25 compared to placebo. ln the event af overdose, conser ¢andard measures to remove any una ‘sorbed ug, Sympiormatic and supportive eatment'srecommensted Hemocialiss did nat eflecively remove fetaferadine hydrachionie fromm blood (1.7% remaved) following terfenadine administration. Nodeaths ocurred at orl dasesofferofenadine hyerchlorde up 190M gig nice (10 umes the maxsrwume recommended daly cal dose in adalts ane 200, umes the maximum recomumended daly aldose in children based on my and upto $000 mg/kg in ats [230 times the maximum cecommended daily eal ‘dose in adulls 2nd 400 times the maximum recemmenced daly aal dose in Clren based on man, Altona, no cial signs o toxcay or os patho- gal findings wese observed. in dogs, ao evidence of toxty was observed at ‘ra doses up to 2000 ma (200 times hve maximum recommended daly orl dose in adults and 530 times the maximum recommenced daly orl dose in cde based on ma DOSAGE AND ADMINISTRATION ‘Adults and Children 12 Years and Older, The recommended dose of ‘ALLEGRA 6 mg sce daily, oF 180 mgorcedally A dase of 601mg once daly is recommended as te starting dose patients wath decreased eral function {see CLINICAL PHARIMACOLOGY) Children 6 to 11 Years. The recommendet dase ot ALLEGRA 30 mg twice ally. dose of 30 mg once eal is recommended asthe stating dose in pedi- ac patients with decreased renal funcion (ee CUNICAL PHARMACOLOGY, (Chronic idiopathic Urticaria Aull and Children 12 Years and Older. The econvinesded lose of ALLEGRA 1 ma twice daily dose ol 60 me ence daily ic recommended asthe stating ‘dese in patents wih clecreased renal urction (see CLINICAL PHARMACOLOGY Children 6 t0 11 Years. tee recommenced case of ALLEGRA i 301g twice ally. A dose of 30. mg once city is recommended asthe starting dase n ped atic patients with decreased renal function (ee CLINICAL PHARMACOLOGY, lease see product circular for fll pres bing ionmation, Reonly Rev. Mey 20038 Bret Surimary ‘Avenis Pharmaceuticals In Kansas ity, MO 4137 USA Us Patents 4.254, 129: 5.7% vow allesracom al-mayD3a-B-Anleader's Digest FOUNDERS DEWITT WALLAGE AND LILA ACHESON WALLACE Editor-in-Chief Jacqueline Leo Executive Editors Marcia Rockwood, Jacob Young. 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Clinical trial results from an international study involving over 5,000 postmenopausal women show that Femara greatly increased the chances of staying cancer free (that is, Femara reduced the risk of cancer returning by 38% compared to placebo). Femara is approved for the extended adjuvant treatment of early breast cancer in postmenopausal women who are within three months of completion of five years of tamoxifen therapy. The benefits of Femara in tthe clinical trial are based on 24 months of treatment. Further follow-up will be needed to determine long-term results, including side effects. 193: Lowered the risk of number of a ‘cancer coming back by 38% Sire enter pp g retumed | without _with Ferrara Femara In addition to increasing the chances of staying cancer free, Femara also significantly lowered the risk of breast cancer returning to another part of the body. For the thousands of women who've recently completed tamoxifen, Femara is more than hope, it’s help. Important Safety Information You should not take Femara if you are pregnant as it may cause fetal harm. You must be postmenopausal to take Femara. Commonly reported side effects are generally mild to moderate. Those seen more often with Femara versus placebo were hot flashes (50% vs 43%), joint pain (22% vs 18%) and muscle pain (7% vs 5%). Other side effects, which were comparable to placebo, include fatigue (34% vs 32%), swelling due to fluid retention (18% vs 16%), headache (20% vs 20%), increase in sweating (24% vs 22%) and increase in cholesterol (16% vs 16%). Longer follow-up is needed to determine the risk of fracture associated with long-term use of Femara. The percentage of patients on Femara versus placebo reporting a fracture was 5,9% vs 5.5%, The percentage of patients reporting osteoporosis was 6.9% vs 5.5%. Bisphosphonates, a class of drugs to help with bone strength, were given to 21.1% of Femara patients and 18.7% of placebo patients. Femara is a convenient, once-a-day prescription therapy. Ask your oncologist if Femara can increase your chances of staying cancer free. 4 For more information, call 1-866-346-1751 or visit www.us.femara.com Z 2 (letrozole tablets) Please see important product information on the next page. Novae omocasiak Caperaten CAEMIOSEFemara® (letrozole tablets) 2.5 mg Tablets x only ‘BRIEF SUMMARY: Please see pachage insur fr fl presribing infaratn, INDICATIONS AND USAGE: Femara (trae tates) iindcted forthe extended ‘xjuvatweatnent of ea breast carcar i postmenopausal women who ave rected 5 years of adnan tronten therapy (see Cia Stes inte Fl rescring itr raion} The lcvense camara in vended aunt esas of ety asst (Gover tse ona at of lsc re surements ested Soran (428 warts (se CLIVCALPHARAUCOL OGY, Cina tudes i he il presrtng linormaton|. Fur ata wile reqived ta determine anger autre Femara is ince for fete teatnent of postmen women wat hme receptor posi or hormone receptor union loca) afvanced ar meta teat (noes Fa islsaibsted fr terest of avnced breast ncaa past: ienapasl women with dstase progression faving an estragen tery ‘CONTRAINDICATION: eae is cntrainated in patents wth known hypersenstity ‘aFemaraaran df ts ecpets WARNINGS: Propeane:Ltrozale nay use fl hm when skeet regnnt omen Stuies raat ses equal oor geater tan 0.003 mag about 1/100 he (by main recommen a ase onan Base) atmaeteed ding te pevad a rganagenes, tae Sham that eae emetic and fetta 35 (ted by etrouirne marly. neressed esargtan erased postirgoainn aes, (ered numbers of ve feiss and Teal anara es ud absence and shriey feral apa, dian of weer edera and icamgle as ican of tora sul 2nd tetas. Leva was trogen nas. A OS afeg dose aba 1/10 he day maximum ecamme fed human dase on min? bs) caused ffl domed had a ‘eel ontam vera un, Letroales enbnyotoricat des equalta or greater than 0.02 mig and ec then administered oaths at 002 mfg (abot 1/100.000 and 110000 te daly immu ecanae fed human dasean a gin? tas, expecta) Fetal anaes induded ieangiteassiioatn of Se Sal, treba, and fre: an inde. ‘There arena suis in roqnatt women. Femac® isin fr pastnenapsal ore ¥ fate is eager fo asl rng peg). aie sho be apried (ite patria anardto he tus and ote is ktortssf te pregnancy. PRECAUTIONS: Since igue an dzsness have Deen served wt he use of Femara? al samaclence was ucamanly repaid, cutansabised when dingo using ochony Laboratory Tet: Ho dase-elted ete ot Femara onan henatcngo ar cin chem: ‘dy poate es eent. adatedecresrein Ymmace cows nce nical spitcance, were cbsere in same patents receiving Femara 25 9. Ts ‘kepesson ws tans Saat hal fase sted. Ts gation Fu de ‘ned tramtaytapen: long t the sty drag escent weds Che to Stren armas ator eae a ty treater or ne osm Increases in SGOT, SGPT and gamma GT 25 tines he upper iit aca (ULI) and fteatin=t 5 tes the LN ere mast en asacate wth mane datas fhelver taut 2 of tty ticpartsrecting Femara td anomalies in ver Cemistes ne asacated wth dncameted metastases these snares may have been eld t tay dug therapy In fhe magestol ast compara study aot i pater treated wan megestolacebte had abnormaies ner chests tet were tot assaf d wth dace ted vr mtastinsn the amaaguetnmnide ty bai ‘sof annogiethine reste pte Wo abnormal ier chemist ek soci wih hepa metastases. ‘Bono Efets: Primi rests (raion duration offoow-up was 20 mantis) tom ‘hetioe sist (Calcium 500g and Vinin D 400 IU pe day mandy: isphos fonates nt alowed) demonstrate tat at 2 erste mean cara ca mpared ahs: Sn np BND Fema pate ms 3% vO. for ace (P0088). he mean erento baseline BMD resi he lute sie at 2 years wes Femara 4% (heres and plaen 27% (P=0089) Cansfaton Soul eghen fo rrantarg BMD, Drag nections: incineration die wth cnet and wart inde that ‘ecaatmnstaton of Femara wi these drugs das aot rest elncaly fea (hag inractions. (See CLINICAL PHAKACOLOGY ite fullreserbig iran) (Caxias ot Fenara and tameen 201 ca ested nareducton af eozle plasma eels by 3% ot average. Theres wo cnical experince dae on these ot Femara in cambiatinn wit afer anicancer agents Hepat nsutieiney Subjects wih casi and severe meate dystinction wha wee ose with 25 ng of Fenara exgerienced apraxia twice the exons to tarde shea voles with nana ver uncon. (See DOSAGE AND ADMINISTRATION) Drug sboratary Testneraction: Ne adeeved {Carinagenoss, Mutagenesis Impaimeni ol Frill: A camvenfonl carcinogenesis sud in ioe af dase of 06 0 n/a (abot to 100 times fe day xm ‘eeamimnded haan dase a2 mgin? Sass) smntred by oral garage fr up t02 ors eveid 3 dose tsed ease i he mdence a eign avaran stromal tunars ‘heicidence of camtind Neat: elaraderoa atl carcnama showed a sn ficart ‘rein ema when fe nigh ose rau wes excued ue aw survival. a ep fle uty. plasma AUC arts i mice a 60 malay were 55 tines igher ian te ‘AUG eye eas cca patents a Be recomended dose The cacnageny sud ies at al doses af 01810 magia faut 440 tis the daly ma frum reaper human dose an agi bass) fr upto 2 years aa pred an Ineasein te modems Seng avaran staal umarsat 10 mghayay Oran Typerlasa was oserved in females a doses equal or greater an 0.1 mghaey 1110 mig. plasma AUCaan, levels ats were 80 tines higher tan he lee in Breast caver patents at therermended dose Letromle was not miagenc in in trots (Aes aE cobctral tess) but was hse tobe 3 pte catogen in nit soay (CHO KY and CL 61 Chines Nam ‘er ovary cas) Letrzoewas no claogene i wo (mizanuris st in 5), ‘Suidiest neste tect f trent an erty hae nt Been conducted: hose ‘ep dain sed saa racy inna sd stray of te raat tak intales and fae at doses 00,01 and 0.03 meg in ic, as and dag, respec ‘Sel (about ane 04 an 04 the day maxim un recommended human dose a 2rmghn= tus, especie) Progaany: Pregnany Category D (Sve WARWINGS) Nursing Matar: snot knw etwas exceed inhuman i. Because many Gugsare excreted i nuran nik auton sould be exercised when lore admin ‘eed tv nursing worn ee WARIS aad PRECAUTIONS) Poti Use: Te sey and etecenssin peda pens nave nt teen ecobiched, (Gevitrie Use Te selina of pts in al sti o fies ine ad sind trast test of tata breast cancer was 64-5 years. Abit 13 of he pants were 270 ears nthe fstine soy, pens 270 years of ape expesencod kage tie 2 {uma progression and higher espace rts tan patients 70. Far teeended a ‘ait setng.aretan 5100 postenapasal waren wee ered tthe cial st) Intl, 41% of patents were aged years adr a eoimen ie 12% wee 73 ler. Na overall iferercs i salar eficacy were observed beteen these oker furs ant yunger pens ad ane epared clcl eperence as ot ented Citerencs in esposes between fe ele and younger patient, but greater senstiay (fsa er nuns cnnet era oi ADVERSE REACTIONS: Fea ws gona wel fled arse astute in scl seca metastatic tretEnce ol a exende dst estat women who have recatied por tandard aan oxen Weatnent Gener, the served aterse reactions are mir mucerae in ae ‘tended Adjuvant aakwent ol Ear Breast Cancer in Postmenopausal Women Who Have Received 8 Years Adj wren Tamaxian Therapy: Th man dstion ‘odes juan testa rs 24 mate and the aan ura ota for ‘Slt was 28 mac for patents receiving tole and posh Tale dese etta adverse avers nturting ata trquancy fat leat 5% in any rea sit group cn teste lst aber evets pated re Grade 1 sn Grade 2 tase onthe Comsnan Tal Ceri Versan 20. nthe edeed adjuantseng the feared drg-rebed adverse vers tat wee sical dere tam glacetn were Dol fases, ahaa and mya Table’: Prcertae of Pains wit Adverse Evens ‘unber()o1Pafens Number(s) ef Palit vr Grate 1-4 Adve Event wid Grade 34 Adverse Event Tetra abo «Laker ate Ce ee ‘oy Ravare Evel 282 A) ATA (eas) AD E_—58D ST) Wear Diarées = 1575 (SS) 1280 TH) ZH 9) Psy v7 (az) 14 23,3) Genmal Diewdos 1154 (O10 24) D1) enon a2 (m6 0 G21) fay 7 faa) Elena HOS i (ks 448 (182) 4 9] Maule etal eerdere ma 2s G25) RM) armrage, 5 (Zo 5 18t) maa) ats 0S. wa (G7 me (4s) 9 Ia 2) Mega wiz m2 47) 8 98 2) eax an vs 6 12 aa) 8 073) Nereus System Dieroere 3 7 89 G1) BH ey vendo ste (aly) soa (ia7) far) Ozosese 3 (M2 342 993) 9 gaa) ‘Skin Disrdore Bo 4 Far aos) 8 a8) Swatnglnsed 619 42} 577 (@24) 1 et} askoitestinal Decors ms a3) 71 ae) D2 8) (cretion mo (m3) 4 (18) 92 ( emge HERE'S TO MEAT? =— F FS A oak’PHOTOGRAPHED BY JOHN MADERE MY PLANET MARY ROACH On the Road Again FAMILY Is A collection of people who share the same genes but cannot agree ona place to pull over for lunch. Ed and I, plus his parents and sister Doris and eight-year-old niece Al- isha, are on a road trip to Yosemite. Poppy wants Subway, Ed wants In-N-Out Burger, Mary wants Sonic. In the end, we compromise on Mc- Donalds, where Alisha will get an “Incredibles” action figure that will come in handy later for breaking the heater vent. We've rented a minivan that seats eight, yet somehow, there are not enough cupholders. How can this be? This is America: To every pas- senger, a cupholder, and to every cupholders, a watered-down soda big enough to baptize a harbor seal. “Alisha!” says Doris. “Take Mr. In- credible out of Poppy’s cupholder.” It’s a three-hour drive to Yosem- ite, but we’re taking a little Longer, as we're working in a tour of High- way 80’s public restrooms. As the saying goes, Not one bladder emp- ties, but another fills. I am reminded of that track and field event wherein one person runs for a while, and then hands off the restroom key to the next person, who runs until she’s done, and then another person runs. Unhappily, many of these rest- rooms belong to gas stations. Gas- station customers, perhaps inspired by the nozzles on the pumps out- ILLUSTRATED BY CARLA VENTRESCARD | AUGUST 2005 side, are prone to dribble and slosh. Though I almost prefer this to the high-tech humiliation of air travel, where the restrooms have faucets programmed to respond to precisely executed hand signals no one has taught you, and the toilets flush mere seconds after you sit down. It’s like It's a3 hour drive but it’s taking us longer, as we're working in a tour of Hwy. 80's restrooms. having your plate cleared before you've even salted your potatoes. We get back on the road. Poppy’s driving now. We've entered the road- trip doldrums, the point when all the cheesy tabloids have been read and the travel Etch A Sketch has grown boring, and anyone under age 12 is required to say “Are we there yet?” at ever-shortening intervals. Ed and his sister, two middle-aged adults, are playing with the highway bingo set. Alisha is making Mr. In- credible fight with Poppy’s earlobes. Doris covers the bingo square that says motel. “BINGO!” “No way,” says Ed. “A motel is only one story high and has a swimming pool full of algae. That was a hotel.” “Same diff.” says Doris. “MA! Doris is cheating!” Alisha kicks the back of Poppy’s seat. “Are we there yet?” If by “there” she means the end of our rope, then, 60 yes, we're pulling in right now. Just outside Manteca, we stop for coffee. Coffee is an important fea- ture of the relay-restroom training regimen. Without it, the chain could be broken, the gold medal lost. At a Starbucks checkout, Ed buys a CD of Joni Mitchell's favorite musical picks. The hope is it will have a calming effect. The first cut is by Duke Ellington. Alisha makes a face. “Is Uncle Ed trying to annoy us?” “Tt’s not my favorite El- lington number,” agrees Nana. The CD returns to its case, pending the day Joni Mitch- ell joins us on our annual vacation. Pulling back onto the highway, it starts to pour, which at least quells the debate over whether to have the windows open. Depending on whom you ask, the temperature inside the minivan is either “freezing” or “so hot I’m going to suffocate.” ‘Then something amazing happens. As we climb the Sierras, the rain turns to snow. The pines are flocked with white. We're struck dumb by the scene outside. For a solid 15 min- utes, everyone forgets about their bladder, their blood sugar, the tem- perature in the van. Alisha has never seen snow, so we pull over to make snow angels and catch falling flakes ‘on our tongues, Then Ed realizes we need tire chains, and we have to turn back and drive 30 miles to Oakhurst. “Good,” says Poppy. “There was avery nice restroom there.” &With Real Fruit Juice 100%. Vitamin C fo] A (1hDeat No More Technology helps a mother hear her children again BY MARGOT DOUGHERTY S MOLLY BROWN makes her way through the House Ear Institute (HEI) in Los Ange- les, she stops in front of a plastic replica of the research cen- ter’s namesake organ. The ersatz ear is rendered in a cross section that reveals all the inner workings— cochlea, auditory nerve, muscles, neurons—that allow most of us to make sense of speech, music, the shushing of cereal spilling into a bowl or the wail of a police siren. “See all that,” she says, pointing at the model. “I don’t have any of it.” She’s exaggerating, but not much. The 45-year-old mother of three is completely deaf as a result of neu- rofibromatosis type IT (NFTI), a rare genetic disease. It strikes about one in 40,000 Americans, producing tu- mors on the auditory, or hearing, PHOTOGRAPHED BY GARY BENSON FAMILY MATTERS Cea eta Pea Cea says Molly Lee nerves. The tumors almost always render those nerves useless. Once, the onset of NFII would have made Brown’s hearing loss an irreversible fact. But her presence at the House Ear Institute today marks another triumph in her battle against the disease. Brown is here for follow-up testing on the Pene- trating Auditory Brainstem Implant (PABI) she received in November 60ARD | AUGUST 2005 2003 at nearby St. Vincent Medical Center. As part of a federally subsi- dized clinical trial, doctors planted 22 microelectrodes in and on the surface of her brainstem. When cur- rent flows through the electrodes, it stimulates the neurons in her brain that perceive different pitches of One morning, she woke up at 5 and realized she hadn't heard Michael cry all night. sound. The result: Since the opera- tion, Brown has begun to compre- hend speech again, to understand her husband when her back is turned, to talk on the phone with her three children, even to recog- nize her favorite songs by John Den- ver and Stevie Wonder. Biologically deaf, she can hear thanks to elec- tronic intervention. “ have zero nerves to my brain for hearing,” she says in a chatty e-mail. “And yet hearI do. The clicking of this keyboard tells me so! You would be shocked at what I hear—the squeaking of a hinge, the bubbles in a glass of pop, the ticking of a clock. The list is endless—and I am eternally thankful.” Brontc MEN AND WoMEN—human- machine hybrids—used to be purely the stuff of science fiction. Not any- more. Today, electronic devices such 60B as Molly Brown’s PABI are at the heart of a fast-growing field with a wide range of practical applications. Known as neuroprosthetics, these devices activate nerves when nor- mal biological functions can’t. They help patients unable to use their hands regain rudimentary move- ment. For Parkinson's suf- ferers, they quell the disease’s tremors. Re- searchers at Cleveland’s Functional Electrical Stimulation Center at Case Western Reserve University are even work- ing on devices meant to help spinal-cord injury patients move their hands and stand and walk. Says Bob Shannon, HEI’s head of auditory implants and perception research: “We're sticking electrodes pretty much anywhere you can think of sticking them.” In Brown's case, the PABI proce- dure required two arrays of elee- trodes: 14 on the surface of her brainstem and 8 buried inside. For the doctors who performed it, Derald Brackmann and William Hitselberger, the trickiest part was shooting the electrodes into just the right spot, the cochlear nucleus, where sound is translated. “You're dealing with an area that is just 1/8 of an inch,” says Brackmann, “so it’s extremely difficult.” Five of the eight penetrating elec- trodes hit their marks (the three that missed did no harm), making Brown’s operation the most success-Work at Home Be a Medical Billing Specialist Earn up to $40,000 a year* No previous experience needed... learn at home. Prepare medical claims for doctors, hospitals, clinics. ‘This exciting money-making opportunity is wide open. So if you want to make a good living at home—without commuting, without selling...and working the hours you choose—call the toll-free number below or mail the coupon for free facts about what could be the greatest job opportunity of your life! There are plenty of high-pay office jobs, too! 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Bender seat ewe nDATS 800-388-8765 isoars ; YES! Rush me free facts on how I can train at home to work as a Medical Claims = : and Billing Specialist. : : Name Age * Address Apt. : City State _ Zip bs:Life is good again for Molly and daughter Jennifer. ful one to date. Her hearing isn’t perfect, but combined with her lip- reading ability, she’s made huge strides. ‘This morning, Brown and her daughter Melissa Langstraat meet audiologist Steve Otto at HEL Otto starts the testing by isolating each electrode and sending beeps of in- creasing intensity through the head- set Brown wears. She tells him when she can hear the beeps, when they’re too loud, and when they’re just right, Day-to-day, Brown can adjust the volume and quality of sounds she hears via a Walkman-size box at her waist. The gadget connects to a small magnetic disc fixed to her scalp that contacts the implant. Set to Program 1, the device tunes in to the surface electrodes. Program 2 contacts the embedded ones. Pro- gram 3 combines the two. “That,” she says, “is the one I like best.” 60C MOLLy MABERRY grew up a few miles from her present home in Lynden, Washington. Her family owned an 800- acre raspberry, blueberry and strawberry farm. Come sum- mer, she says, “My parents would allow me to pick the berries with my friends if I shut my mouth, which was very hard for me.” In high school she was voted Most Friendly and Homecoming, Princess as a junior. Allen Brown was the prince. The royal engagement progressed toa first date—and beyond. ‘At 19, they married. Molly juggled office work at the farm with starting a family—first Jennifer, now 25, then Melissa, 23, and Michael, 19. It was during those years that she remembers first hav- ing difficulty hearing, especially when talking on the phone. Allen began to notice that she often said “What?” when he spoke to her. Doctors first blamed a childhood sinus condition. But a CAT scan later revealed an acoustic neuroma—a Jemon-size tumor on her left audi- tory nerve. Brown was just 24. It took two surgeries totaling 30 hours to remove the tumor. Her left auditory nerve was destroyed in the process, leaving her deaf in that ear. Because she had trouble hearing with her right ear, she wore a hear- ing aid. NFII was never mentioned. Brown’s ordeal was just begin- ning. One morning in Novembersh taste and thinly sliced. N COUNT ON OSCAR Rear WEN eC) CeeRD | AUGUST 2005 1985, when Michael was three weeks old, she woke up at 5 and realized she hadn’t heard him cry all night. When she tried to tell Allen, though, she couldn’t hear herself speak. “Be- tween putting Michael to bed and waking up to feed him, my remain- ing hearing had gone.” By the time she arrived in Los Angeles, the tumor had become life-threatening. Doctors discovered another tu- mor, this one on her right auditory nerve. NFII was considered, and dis- missed. One bright spot: During this round of surgery, the auditory nerve was spared. Still, the last vestiges of Brown’s hearing were gone. “For someone who has grown up hearing, it is very lonely being deaf” she says. “I could be in a room with a thousand people and still feel all by myself. It is hard to imagine. Go home and stick cotton in your ears and put a hat over your head. Then go to a party and try to interact.” Brown, by nature a funny, outgo- ing, charismatic woman, plunged into depression. While she sought counseling, her family adjusted as best they could. They all learned sign language. Michael could sign for milk when he was just seven months old. At home, Brown wore a special wristband that alerted her to 60D the doorbell and to any sounds com- ing from her son's room. Because she still had an intact au- ditory nerve, Brown was eligible for acochlear implant—a device that functions via electrodes placed on the cochlea, or inner ear. The elec- trodes on this PABI precursor can stimulate nerve endings within the inner ear to carry signals to the cochlear nucleus in the brainstem. There, they are processed and translated. In 1987, she had the operation. “T loved my cochlear implant from the start,” she says. But in July 2003, NFII—still undiagnosed—re-emerged. Brown suffered periods of excruciating pain in her upper jaw. “It felt like a million volts of electricity passing into my face,” she says. A large tumor, it turned out, was pressing on her trigeminal nerve, which sup- plies sensation to the face. Finally, doctors at Seattle’s Virginia Mason Medical Center diagnosed NFII. Mapping the tumor’s size and lo- cation required an MRI scan. That meant removing the cochlear im- plant—Brown’s bridge to the hear- ing world. She was devastated. Her primary doctor, Douglas Backous, suggested she go to Los Angeles to have the tumor removed and a PABI implanted at the same time. Luckily, Brown took his advice. By the time she arrived in L.A., the tumor had become life-threatening. It was so large it was on the verge of disfiguring her brainstem.This body can follow the beat. Lead the race. Move chairs, sofas. Mountains, too. Given half a chance, your body will astonish you with its capabilities. Even bledder weakness just takes a little Poise? - cup mayonnaise mixture. Grill or broil pork chops, turning once and brushing frequently with remaining mayonnaise mixture, until pork chops are done. [4] Serve with reserved mayonnaise mixture. ——— “BRING OULTHE BEsT’5 ATUBRING OU starting eet Fridays on Thursday night. ts Reese aamsteet eats een eeic Ser eo ey Pat ay < PR Moet aes eee ya ct) Dr ed neg Eye cad Me ee ea ‘/2 cup; set aside. Grill or broil pork, brushing with 1/2 cup mixtures until done. Serve with reserved 1/2 cup. Ra eek eden Bring out the best”ideas advertisement Get Cookin’ Together The start of the school year is just around the corner. Here's a healthy after-school snack kids will love and you can feel good about serving. Plus, it's so easy they can make it themselves! Also try Sun-Maid Yogurt Raisins. 100% natural raisins covered with smooth and creamy yogurt coating. Available in Vanilla and Chocolate flavors. Raisin-Apple Tortilla Roll-Ups Makes 4 servings 6" flour or whole-wheat tortillas Ths. low-fat cream cheese tsp. honey cup Sun-Maid® Natural Raisins cup finely chopped or coarsely grated apple (about 1 medium apple) 1 tsp. cinnamon sugar (1 tsp. sugar with a pinch of cinnamon) A SNNA [1] Combine cream cheese and honey in a small bowl. [2] Stir in raisins and apples. [3] Divide raisin-apple mixture between 4 tortillas. [4] Sprinkle with cinnamon sugar. [5] Roll and place seam side down on a microwave-safe plate. [6] Heat each roll on half power for 1 minute or until warmed through. Savory variation: Add 2 tsp. curry powder to cream cheese mixture and omit cinnamon sugar. For more ways to enjoy America’s favorite dried fruit, visitww .sunmaid com ‘©2005 Surthael Growers of Cafonia Powered by the Sun."i Kil flavor KIKKOMAN TERIYAKI Kikk Up The Flavor with Kikkoman aki Sauces and Marinades at your next meal. Its full-bodied ilavor is perfectly balanced with a savory sweetness. Visit KikkUpTheFlavor.com for recipes. (©2005 Kikkoman International Inc. advertisement Kikk Up the Flavor of your kabobs A to Z Kabobs (makes 6 servings) ‘a cup Kikkoman Teriyaki Marinade & Sauce 1m cup dry white wine 1 Tb. vegetable oil “ay tsp. black pepper 1% tsp. dried oregano leaves, crumbled 1 clove garlic, pressed 3 medium zucchini (about 1 Ib.) Boiling water 2 lbs. boneless tender beef steaks (1" thick) 2 _ large cooking apples 6 10" metal or bamboo skewers* [1] Combine first six ingredients. [2] Cut zucchini in half lengthwise, then crosswise into 1-')" pieces. [3] Cover with boiling water; let stand 5 minutes, covered. [4] Drain and cool. [5] Cut beef into 1-")" pieces; place with zucchini in plastic bag and pour in teriyaki mixture. [6] Marinate 30 minutes; turning bag over occasionally. [7] Meanwhile, core apples and cut into 40" pieces. [8] Reserving marinade, remove beef and zucchini; thread alternately with apple on skewers, leaving space between pieces. [9] Place on grill 5" from hot coals. [10] Cook about 6 minutes on each side (for medium-rare), or to desired doneness, brushing occasionally with reserved marinade. *Soak bamboo skewers in water 30 minutes to prevent burning. @KIKKOMAN www.kikkoman-usa.comILLUSTRATED BY MARGARET RIEGEL MEDICAL UPDATE THE LATEST ADVANCES IN RESEARCH, TREATMENT AND TECHNOLOGY more fruits, veg- etables and fish— and less junk food. Ina l2-year study, researchers analyzed the diets of some 15,000 people and found that those who ate the most fruit, vegetables and fish were at lower risk of developing VTE. Eat in Vein ‘HE WAY you eat | could prevent a deadly blood clot. Risk factors for the condition, venous thromboembolism (VTE), include taking long flights, being in the hospital and stay- ing inactive for ex- tended periods of time. Drugs can help prevent the condi- Lead researcher Lyn Stef- tion, but experts at the University of fen points to the new food Minnesota and other institutions pyramid as a guide for vein- may have found another way: Eat healthy eating. inapol, 46% Quit Smoking for Good of people More than 70% of smokers have tried to quit and J failed. Now, companies are developing nicotine vac- said they had ines that could help smokers kick the habit for good. experienced When nicotine is absorbed into the bloodstream, it pain inthe travels to the brain, producing a high. The vaccine NicQb creates antibodies that bind to nicotine in the blood. Together, they're too large to reach the area of the brain stimulated by nicotine, With no pleasure de- rived from nicotine, cravings are reduced over time. In a study of the vaccine (which may be available in five years), 57% of those who achieved high levels of anti- previous two weeks. Where it hurts: Back . Knees Head . Legs . bodies stopped smoking for at least four months. Shoulders . Several other antismoking vaccines are in the works, Feet . and two drugs, rimonabant and varenicline, are also Hands promising. Both work by blocking brain receptors that Stomach.......4% give us the reward response. Experts say many smok- ers will still need counseling to break the habit. SOURCE: ABC News/USA Today’ Stanford University Medical Center 61RD | AUGUST 2005 Medication Nation We're dedicated to our statins, painkillers and antidepressants: 54% of people currently taking a drug AIN, DEPRESSION, heart disease, Prowcporis Whatever the condition, it seems, there’s a drug to fight it. And many of us rely on these medications: 48% of adults in family s households are taking prescription drugs— 82% for a long-term condition and 26% for a short-term condi- tion, according tothe | Reader’s Digest Family Index, a measure of the overall well-being of the American family, conducted with the Gallup Organization. = say if their medication were taken off the market, they'd try to get it elsewhere. Only 37% would stop using the drug. Men were especially willing to do what they could to get their pills (60% would try to get them elsewhere, compared to 50% of women). So to what lengths would we go? Some 78% would try to buy them online; another 17% say they'd travel to another country to get them, both risky moves at best. In 2000, 82% of women age 18 and up had undergone a Pap smear in the past three years, but just 45% age 50 and up had a colon cancer screening in the past five years. eee Urey Another Reason to Limit Trans Fats Dangerous trans fats found in shortening and many processed foods can wreak havoc on our hearts. But they may also increase the risk of gall- stones, say doctors at the University of Kentucky Medical Center and Har- vard Medical School. Ina 14-year study of 46,000 men, they found that those who ate about 4.5 62 grams of trans fats a day had a 23% higher risk of gallstones than those who ate 1.4 grams (most of us eat about 6 grams a day). Most gallstones are cho- lesterol balls that form in the gallbladder. They can be extremely painful and may lead to gallbladder cancer. Trans fats may in- crease the risk because they lower “good” HDL cholesterol in the body, says study author Chung: Jyi Tsai. Since there's no known “safe” level of trans fats, experts recommend limit- ing intake. Starting in Jan- uary, the amount of trans fats will be listed on food packages. Until then, read labels: The word hydro- genated in the ingredient list is a dead giveaway.25 TAP Pharmacouti ABITTER Fl ye 7 A DAMAGED TASTE IN THE Jd A ESOPHAGUS. A BURNING, PIERCING FIREBALL. Acid reflux disease can affect people differently. Some feel a burn rising from their stomach, some have difficulty sleeping, and others have a recurring sore throat or have trouble swallowing. Fortunately, there's Prevacid’ It can be taken in many forms — one that's a pill, one you can drink, and one that disintegrates in your mouth — to help treat heartburn and many other kinds of symptoms related to acid reflux disease in many kinds of people. Maybe it's time to see if it can help yours. So ask your doctor if there’s a Prevacid that's right for you. Put to your acid test. For a FREE trial certificate, call 1-888-3PREVACID or visit prevacid.com today. If you suffer from persistent heartburn two or more days a week, despite treatment and diet changes, it may be acid reflux disease (ARD). Heartburn is the most common symptom of ARD. Prevacid Capsules, Prevacid for Oral Suspension, and Prevacid® SoluTab” (lansoprazole) Orally Disintegrating Tablets are used to treat ARD. Individual results may vary. Prescription Prevacid has a low occurrence of side effects such as diarrhea, abdominal pain, and nausea. Symptom relief does not rule out serious stomach conditions. Please see adjacent brief summary of important information and talk to your doctor.Bi Surunay of Pub oman es, oe 3, a0. 13 71) (00S RS- Bn. i, 2d PREVACID® (lansoprazole) Dslayed-Release capsules PREVACID® (lansoprazok For Dalayed-Relese ‘ral Suspension PREVACID® SoluTab™ (lansoprazole) Delayed Release Orly Disitegating Tablets ‘lesan “usparson ate ‘Shor-Toum Heart (4 ete Otea ar Ao eno Po ik Han “lesa. PREC Damon tl eapy PREICanoitn ‘Won eller ang onary wanton or ‘io reece tome 8 acm spec oisonacs of Hse unin ens ane toes del msn bead #2 rt, Sorta Tate (10 8 wens) of ative Bn ite Ue Hein of SAD site as en Hepat yn co FSD ea, Cond she di miter toad ss ol ecton of SAD sui ste Ue Angin sty a dnt ete vo teu eee an WH Caml sie ‘extend beyond 12 weeks. Sjteesnagea Rei Danse GERD) Sta ent Sa ERO Sora Tet po eof sepa Fortes Gra hal uth VAIO 8 wee teeing beta ge an adil els ta oon mcm she eh ira hence of PAID ng cee oisnanes of aig of Erie Ecpaiis ane tos it ted U2 Fathlogia!Hyperasetoy Condos tin Zing so Satan * ‘panes PREVACID te aise in patns it trun Ieee ny camper oe mista Hen oxi is contindaed in palonts with « noun Ingram a panen tone aia nts ina un cans to clatrony, smn, ad ay ro aces imenraantadminstaion of caitorysin_ with spd, pimodde asianizol, of teine i onan Thew tat ban pst adaing por ot ‘hug laches vn elton aor ey vonyci ‘fe coachinstned th esapid, maid aia, fesnadoereuling in cares aihas (OT organ, ener tarda, vere rato, fan gates de poms) most ly cet nbon of Mattos of so drugs by enya and clara, Fats have ben pri Plage lero racing formation oa xin ‘nd catbonyein elore reser.) ‘uzun CLARTHADUYON SHOULD NOT ge USED Wi PRESHAT ‘WOVEN EYCEPT 1 CLINICAL ORGUNSTANGES HERE No AUTERNATIVE THERAPY Is) AEPROPRIATE. IF FREGIANGY OLCURS WHILE TAKING CLARTHROM I “TE PATENT SHOULD BE APPRISED CF THE BOTENTAL HAZARD TO THE FETUS, (SEE WARNINGS MI PRESCRINS MgoRuarioN FoR cLAaTHROMYCH fafomaniant casas heaped tae all anibatera agents, ineudinglarihvonyeln a mex a ney ranger sere om mi le Aheaen ing, Threlre ii impor to emnsider this slagnots in “pens who present wit tea Sulseq ent ie admiisaton ol antaderal age Treat vy anita agents aes he mma ota offhcaan an nay emit org of ost She Iinjeab that fxn posal by lst dies nay caus of ambit ols” ‘trie dao of psenfonambraus cals hs boon ceded heaps osu soul be il. Mi Cases of peaxomenbtanos cols usualy repond ty Cdscanirusion of he dg along In medals fo seer as, creation shoul be gon a aaa ith fies and deco, petan suppammtton, and te vik an aided ug cal) ects ast os di cas. ews and gran) hal ypersansvty (orp eens ha bon tpra n pats on Bentln any. Ths econ ae ore bo ain Fras ha hy cipnin pert andor 2 sore state muh alee, ve ee ddd gos of nds pani hperssbay aie mo hae epetead Some peters racers hen tad ha epilspn Bag tay th any penci,crel nur shoul b made conzming Droows. hyprsesiyreactons. opening feplspins, acer ages an algo acon seas, amon fe scons an he Spon ttany ntt, SEsjs AIPHTLAGNC REACTIONS _REOURE WED" EMERGENCY TREAT” EFEPARIE, OFVGE, MTRAVENOLS STEROIDS, AID AARWAVHISREN MLO TUBA, SHOULD ALSO ADMSTERED AS INDICATED Brecon Spl esorate haa witlansxpaladoesnot praca te pesos of gst: nage Umino atts PREVACID aaa s acs, aly iain fat and ol suspension, an alin 15m a 5g sa, ass be aad lil mein anialon rao cs ae fom pele ton, PRECIO sod een bore sa FREAD rt SHOUD HOT CRUSHED ce Pato: unin Phan 25 yy 18 ng Tablt an 8 my yer my Tal Aainnsraton Opts 4, PREVACID Daya Robe Capi, Flt ae os Cpt sod i srl wl, Atay for pets vo hae ay sealing Caples, PREVAID Clad Raves Cops cn be {Fd deh: cays “SH mat gas on cr leap of ite flea, ENSORE® png, cotap ces, yoo tame pais. «Sao mei PAEVACI Ceyac ease Copsls ray a bo spd ino a smal wane of eter apie ibs. ands oe or tale and nial sls: Chan casa Sp ta grr nto a mal yr of itera es, ross rot ce B= pany ayo te oa, the ls hold te amead tuo of moe yous ean he ans send are USE 1H OTHER OOS AND LIQUICS, Wks. WOT BEEN STUDIED. CLIMCALLY “AND 1S THEREFORE “WoT FESOUNMENCED. 2. PREVAGD Solutio Cayce aaa ae PREVA Sah snl ab shud a the it era a gal ih tat ur the pares cn Esai. The et py asin es han i, ‘teat. or chien or thar gas ho hae uly tau tabs, PREVI STAD fan bo ‘sti e PREVACID Sota Oat ying For aint via cl singe, PREVAID So can cise ales: + laa sg ten ol ying ad daw up analy nf wala omg an Synod dha Up arin 1 a Babi ek hw er he el is pata, ans te ons wih 5 ins al stgs ith pprimasy 2 (mort 20, in lf al. tak ey, and adn ay fea ints PREVACID SoTab - Naspistic ibs Adniistaion 2a anc Forint via nasopstic is, PREVI Stab ‘annie is laa 8 mg Ul je ad kaw up Ara ok abo pls 0 mg a Sige a a oray {80 ota + Shh elo for a ick depra “air Bt he dana tht ‘samc be na ihe smh within funn. «Este yaga ih appa 3m of ae, soko ‘ya isk rasa REND Daya ls Ol Sei FREVAGIO fr Oe ats Oral Suspend ba acral: pepo SW pega 3 dose, ergy th pao cons ni 3 zl coaning 2 taepeons of WATER. 0 HOT Ui or Lau 0800s. it wa kim {ay mall ean a kg, a ror a, i, retin ms ths padi shclé nl bein though nll anidtaton bes, Sp ineratons Lermoprzl fs mde trou he etochome Pe, stam. spacial vough the OYP3A an CYP2CTO isozmis. Sis fae shoan hat arp os nt have drial sgn nacre hohe as Tansblan by (Ge fcane Pu Ssh 35 Maran, ani, neta, ura phen Propane, ednc, daxpam, of cthonyan ih Fe sup Tesoampnonds vet (auch Various cyacrome Pa soaymes nlang YP CipaGy,cYP2cto, YP20e, and GYPHA,” When Tansopazd vas “aunt “concn th tipi (Het CY PBN 9 minor meas 12) In the ceranes of hexpyne was en, ease nal ants de een ett ecpyina Aaa, flan rly iabs lc xe. Hnasass nd! poten nay route eal ivan of te thsphyie dosage we lareprazl ts stator dopedo rare cincaly tice Hondo. Iasi of ty uj ter phamacolnics oftvarnn eaoner nr perenne ea acd {along sige ot rte ob mg doses ot cpa Hono the have bie eats ot nea! otal Hnmalis¢ no (HE) and tenn ten pats ‘osting prcon pup ins uly ez, ana arkn "cores Treas aed Ben nema ad nol bg awn ‘ath Pans ted ih lon pumpin ad arn coon nn BS mone Tt ince in IF ad vont tn, Tinsopramle his de Pan aon fo hae no clay slg iat ah aoa in’ gles ceswet su) arin iopccla 2B mg al rz 201m each nied aba cmon ith sua 1 gan, soon of he froin pump bos vas ayaa tr beni {as tadued bp 17 aid eh, oma hen Anita conan wih susie, Thao pron pup rho shoud en at fas 30 ies Prior ovale. cial trae, ance are Schistrt oncom wh PREVACID ay kas Gesu sc wt rte this fi. ita: fh nt i ion figs axscrton hrc, is ay psa tht ho zag ie ih te absorpion eds ae an pot “raat esa 9, tweomca arin ao, ron sao {anni Hg pan oy In vo 2-nenincagenisy stds. Spenue-Calay fats et ed wall th doses a5 {80 maha ato of sf xr ona bod sue mg) fas, ofa sg pats of tags ght (146 2) sure aa) gan he ecommenced human sof Sih mgd 222 nga. ansonane pce tese illd catenin Et) oly pla Tae ol rcs oh ale a faa a9 inca inca eal met oh ic ‘fhm noses nna asopan pds Stover caso esata call Seonas, The Ince these adenomas Gs tsi dss ts 10 moat 4 4 es ha trea navn dics to fod sare 3) ‘sous helo grand iene (ang 01) {nv is sano a Her mera esa 3a (amen? 120/26 Wane wh mp (12 bis Hhercnrmndl nan ds asd obo) sar a) ima yar toe sa Hi a Anant arcs she COM mice yao wid oy wih dss fo 0 B10 mohglay, 2 fa ms he nme van sa ed surhes aaa, Larsopazle prota a dsehsd incase one of ase EC cl typeiaia aso Prodieed "an ingeased hoses hat hinors Thipatcarasenoma. ls. caranoma). The timer ies nls ea wh 3 a0 rp Cao es te corned made bes onay surace sea) ae tale min wel wi 15010 63t mggiay (23 a 0 asthe ecoriraned huran ‘ots hast on Un tn ae epee gis at Sicrund odes iste ons fr ts stun at fru Larseparoe Wtmem poser) agama ote isi in tle mics aang 7 w GOD gk (10 Dio ened sn dot ad 8 oy ‘ala Larsopae wis ot oer ne Anes st the cecrig hopatecy uch! OAR Safes (103) ea, em vo ute ren el Nea be ‘fon cel evomesoma eran te 8a pesONe ‘rato muman ympmngeoommsoral erat anys Lineup a rd diem up e180 mpkay (0 ames {heaved hut dase Last ot buy sete} ‘was bur 1 Rae tata ey 268 produce Datiomarc of mae and inet ras, regancy:eatogea cs, Pugraney aang 8 ‘Teatlogy ses tae been peread in pega ats at faces unto 10 mata a0 mes ne ezoriended fran one bret on hoy tee re) a eran Taths atl oars up io 90 mgtisy [15 teres he tected Muar de baad ay sua a) and eed ence mse iy ort a ss ove senate. Te ae howe oe or waco tes inept vmen Pease aial apocetan Sk a tot aye poet ot huan reper, te Bro) au ese ing prepay ony cay toe Peary Cae Samra ‘Sex WAFWINGS (000) nt ul peserBieg itr oe travers venga woman Musing Meters Chasez smells at ext in the mi of fat [et roam wher nse 6 eHEa N uma nile Besse man drugs ae exit in furan sik tease te petra fabs aes reece fis ns fon aneonamae 2d because Oe obra for meget shown for anspor at aranpunciy sides, 2 dson shoud ba made wether fe earache tn on acco twimoarance of be dug toe not, Peano ue “The saley a fecivenss of PREVACID mane been cxhstonedin eae pens 17 year ofa ctor fen taainan ef Syupenabe GERD” and chee papas. ce PREVA nhs popalton is egret 2 sede tom aoe and wel -coned sd ot PREVACID nas wh ada ina, arma ‘ant phormaccéymamic sudes paroemee esac arts Tha sere meri role m patie pete © Sarto tat of aluhs Te wee he aes Feta nic ses ta ware ety ‘src ks Te see are eaters PREVACID Ingest year fae tae rol bon aah. ‘38 yer tae The peatve anety of PRLVBOID. Deyee-Reease Css is feo aes iB gee ares et ‘lp it ea af age OF We 6S pans wh GERD 5s {0} nk PREVAGD Yor wees ane (TE) oe 2 Wea, The most fewer epoted (2 o€ mare ats) tratnen alt cdr rts pants 11 yeas at ae (HH65} ie legato} an adie (8 Wie 7 yeaesot ae The suey PREVACID Drape Reese Cases as en seemed in ese HF adaetcnt aes, 0 he Facteur ptonts wih GERD (687) tok PAEAGID fe wks, 9% (BUT) for 10 wees, ane He (Bye sO Thee aque teptas (tsk 94} etna il aves evens ne pens we Rea 9), ‘oterand pa (34) naien (3) and cenness ‘Fenimortetadesnec, parte nine pada rent as acurig [0 cs facil Danes, was ported the ‘Susy by 3 kev gain wrth aoarote GERD, wt Hac ianass corcutonty wit tar ers uch 26 rie, jena, ant verti) Dar {O90 ore weve taba oA ansopazoe, Ue lng res n amas wete smi pose ae, The osdatos a of are suena ae ht Seen mals, Use i avs Paine ‘Bathe aes ery pales ae ini La ese a ‘yauoe age arcun, The odo aes faves evens ‘pont toe sbrormalnes ao da snl fo ose Sten pene pa Tor ery fate oso ani ‘amisiaton of esuorah ed ok be aber or paeabeindiaon ovine REACTIONS inca ie, om T0900 pats ave bee ate tn Iba Pe 2a i ttn ous Gea ai sutto of amet nner ton bus FREWACIO Opeanance Cagcues 0 PAR or Oey Rots Gr Sensor a sr Inger sopra weet hs eran Deets aterm as. “efor aeas ret are by est etn eve pele rs ok vg fricorreret exec Drees patensam oeenat 2 rae m PREG Dat pater a bo ‘ra at nn Ply way ‘tatant late verse Eves eof, Pisce Contolie Saes preci" Posee e268) eK) ony teva oem | Batya vie secon Fen a 12 ose Sys ‘Contain 1 a Dares a 23 cl __| 13 __{_i2_ sae peal hn 1% inci bt samen ou pla. The ides of tog Ares Sir baer pts vo ented pte and Dates wie bene lasipaol 9 mp and 30m. But Fer ie pars hy rte anecpale 89 mg (23%. 5, a2 dT spec) ‘he ros: commonly eparted posshy or pataly ented ie eet ie mane ey Th Ref eductan stugy of PREVACIO foe NSAID soda pune ewe. the seoeon xt Ds reed wih PREVALIO ws 9%, mango 22% ia pace fdieral afese exarincas eecurng in <1 of pas ov sugsis i donoaie tak are s20n? ble Fett to Posareing ft aoveee tacos oxen siete iowa matte shonen elated lee sac arcana eee ca a (ok fates cor ut ea pcg) alls nk pan ne nga an. pele yan Grose Sytem Eig, enyiama, tater, srebrevascla Acdlena/wrabal actin, hypuersitypomesion, nigaime, myocar aidot, palates. shock (Gfeaaory flue}, symcepe, ushers, vasedion, Dosis Systm = abeard sous, aria bz Cardasyasm chit, clts. ey mows, ope, ihsghagu tens, erlatnnesoyagel sents ‘opts de, ote al elon tater, Dis roduc yar lis," gests bisentens, gatortesind ronal. gasbomtstn feanerqueotesal neranrage gare. gum Fromage terse, Inretsed ioe, ceased ska, ee Mou ston, nase a V, usa ad rting and heal ona, ral GBsedec veil Parag, oma, owns. Pest, Tonmie aso, wceave’ xs, ere. sionals, Ensorae Sym dues motte, S00F Fpaioisor, namic and Lopate Sytem ~ sar, arin, yrakasop ay Make aid Muir! ‘Bese goa deren ypgsseniaupa era, pigs eter yea glo a stat ‘ras ats, tow dard, ont sone, ko feamis.fustubsieldal par, malge, nyastana poi fous Sst ora rams aise, Arsin ety pay, confusion cans ‘ep saltiness, soo, dere, emebora faba. alucnators,Pamiplega, Restiny agg, hypeknesa, hypeona, peste, insomnia, tide Glerrseainieaden, naestes, avons, puesnes, Sep asorey someday trea tant verge Reriatay Syste ~ aha, rai, egh Ie pe psa inet ee roplasa, plaryogts, wel dso, omaurona, Feapesigy on daotden oper resplatary Ietbmmatartecien mins, siete, tir Si an ‘appandsges «ans, ope, cola: nai, oy sn, fie pon, fa sone, aclgapur rsh ral Sewer wars. ash, sn crhoma, ao Seo Sean, amar agen Senses —ehaomal Sn, Blo wisn courts, dees, cy jes, ext Gece gai, atts neta, pacene, zaompteba, el ceca, ase os “ase peso. tia, "is be dee Uren Syste = ateoral ese, Brea ‘enargementtremst fan beat lndemoss, heenres, Gye, ymca, pecs, ia ‘ous, kidney gan, holes, metortega, meatus lvortr, piisalsort. pours tes soe, ata an usta quer ima ct leon, Uy fn un spe ais Pesinatnng ‘Organ ‘Sty Sorin: dino ade expeenoes amen potea src sora es bem mar Te ‘gon of tea cat testucad anaaatieip {rsa sro wr echt Fuca wx vee oot wt ra yogiin cf urow ats of tepey anol eae, he aS tony COSTAR ay Buoy a a Woot» aap he eaten, Ogee Sister» Ppt, prema, vontng. me and rata Sten ~ rants “rors Irena. bain, neve. eyo. (Wraneospr ar arin ranbesyopmms pa ‘Stn a ns sone aoeinoe reatons inauongefera mutatne,Sxeriensen soto te eae neni (same ba Sec = pion dace ogee Stary Contain Therap with Anes and Clrramysi In cil tal sig eortia tag ls PREVECC ts eosin etd duaayein, an PREVKSD us Sei. aeve8e rescons pata to Mase GUD Comtingiore vere sbseved Aue aston tht Me ‘rune ham er ied oes tat hale pets ‘por wih PREVACID. onc or aya “ge Tena. Preacoranoagmart nee The mot agirty esa s0sese ue er prions wh eve tie tetany for 14 date wae arr 7) Insaco a pr a Te Satsteny sgiieaaifeanens vy tm Megerey ot apostate te TD a 1-9 te thorny lepers. ha tusimew-eraointaterse overt ‘ere otceridar conan ngrer aks wipe ary Ah th ay ual apy eg ‘al Tara: VAIN ‘The moa Faery eared advee sven for pes sa Ime PREVACIO pus ec 14 foray ure Garton ce} ane Fundcte (74). No (reatnge- omega ater rons ary sbsored at Stary Ma ie ih CIAO Saosin id da tray hn wn PREVAID aloe or ras vation on aha econ en srclin cor dartromyer rts ln he page nse, ADVERSE REACTIONS ters {ator vaees “he folotig changes 6 aboraiary paamstes fr Stsaornl re repeals avers see ‘Soon ‘uncon fs, aon’ SOOT (AST) moras SGPT (ALT eased Ce ang, cae ‘Male pero rest louis, nceied STP Seselcmnsdabeoeal WED, aio 9ma AD rao Stan f8e binorens, easel, rostgem. Insraseieasad ents crwesiliest ee chester increased gino, ecreoed LOK Iorewsedidceasedainorma platens, ant see destin bss Une snares sah a alouninu Ghestura, ae Menatra nave aea noted. Acer ‘Soe abort abo roles ae potas, [Me lash conoid sis. oben SGOT (AST anc SGPT LT) wre sels O45 (097) abo pa ee O41 (TET) nsonrate pabenls hal nave fs ea hae ie peo a ‘age atthe rl Wasmer three te sopra alas repste [ares at ay te our os Incl Wa using exriaten tay wh PREVACID pls anavcan 26 deahoryen, 208 PREVACID. us Spoil po reeaad ara bere parr {tas drug rete wwe che For are atwraten on cnoatry value chang wit ams carte rer ote gacage ats. ‘ADVERSE REACTIONS soe, ‘ovERDOSAGE ia Sov up to S000 gg in ts aoa 10a ste veonmendiaran do bet on bay tenes) ad me dort 787 tse cade Iran fos ged oy God see ae) i ne pode At or ay ira sons. insane inch femoved tom the eiuaon ty humdi mane repre ace of oar, the ata consumed ed a of atsoprzot uo ate cio. Disrewes o TAP area ras BME US. ase earas Fe, 5965s Ray 04 (G19 2064 TAP Prumaeaubl Prat In, ex mot tis frm, fl preseting ‘orraton or sonte TA bc rte Tair 622 200, isnae 0108