Definisi

Medical science applied to interactions

between marketed medications and the
population
Comes from Greek:
pharmacon (poison)
epi (concerning)
demos (people)
logos (study)

DEFINISI
FARMAKOEPIDEMIOLOGI
Farmako dan Epidemiologi
Farmakologi: studi mengenai efek tentang obat
Farmakologi klinik: studi tentang efek obat pada
manusia farmakokinetik dan farmakodinamik
Epidemiologi: studi mengenai distribusi dan
penyebab penyakit pada populasi tertentu

DEFINISI
FARMAKOEPIDEMIOLOGI
Jadi, farmakoepidemiologi merupakan:
Ilmu terapan yang menjembatani antara
farmakologi klinik dan epidemiologi
Penerapan metode epidemiologi pada ilmu
farmakologi klinik

Pharmacoepidemiology
In epidemiology, primary focus is the
relationship between exposure to a risk
factor and disease outcome.
In pharmacoepidemiology, the exposure is
the drug and the outcome is an adverse
drug reaction.
Hence in many ways,
pharmacoepidemiology is a subset of
epidemiology and uses epidemiological
methods

The study of the use

and effects of
medications in large
numbers of people

Strom

The application of
epidemiologic knowledge,
methods, and reasoning to
the study of the effects
(beneficial and adverse) and
use of drugs in human
populations.
Porta and Hartzema

The study of drugs

as determinants of
health and disease in
the general
unselected
population.
Spitzer

Clinical pharmacology

Pharmacoepidemiology

Epidemiology
Strom

Pharmacology

Therapeutics

Pharmacoepidemiology

Epidemiology

Statistics
Spitzer

Clinical epid
em

iology

Epidemiology

Health services
research

Outcomes
research

Economics

Health
economics

PharmacoEpidemiology

Conceptualization by Harry Guess

AREAS
Pharmacoepidemiology has four major
areas:
Benefit: obtained from efficacy and
effectiveness
Safety: obtained by pharmacovigilance
Use: obtained by drug utilization review
Value: obtained by pharmacoeconomics