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THE NEED
Coronary heart disease is the single leading cause of death in America today. High
cholesterol levels contribute to the development of heart disease.
Supplement Facts
Serving Size 2 Softgels
Servings Per Container 60 COMPETITIVE SOLUTIONS
Amount
Per Serving
% Daily Some brands offer just phytosterols. Others may supply only omega-3 fatty acids.
Value
and warnings. †Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. A
daily dose of Phytomega (4 softgels) supplies 1,000 mg of EPA and DHA.
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THE SIX MAJOR Cholesterol is a waxy substance found throughout your body. It helps form cell
CONTROLLABLE RISK FACTORS membranes, hormones, and vitamin D. Some cholesterol is made inside your body,
FOR HEART DISEASE and some comes from foods in your diet like meats, whole-milk dairy products, egg
1. High blood cholesterol yolks, poultry, and fish. Since your liver makes all the cholesterol you need, too much
2. High blood pressure dietary cholesterol and saturated fat can make blood cholesterol levels rise too high,
3. Smoking specifically low-density lipoprotein (LDL) cholesterol. This “bad” cholesterol can
4. Diabetes damage the inside of the arteries that carry blood to the heart (and other parts of the
5. Physical inactivity and obesity body); and it can build up in those arteries and gradually reduce or even completely
6. Stress block blood flow. High-density lipoprotein (HDL) cholesterol, on the other hand, helps
remove excess LDL cholesterol from the blood—helping prevent plaque buildup. That’s
In addition, three uncontrollable risk why HDL is known as “good” cholesterol.
factors are: being male, having a family
history of heart disease, and being over the Phytosterols: Mimicking Cholesterol to Naturally Lower
age of 45. Cholesterol Levels
Each daily dose of Phytomega contains 2,000 mg of phytosterol esters. These plant-based
ingredients are found in vegetable oil, seeds, nuts, and coniferous trees. They’re essential for
stabilizing cell membranes in plants. A similar role is shared by cholesterol in animals. Since
the 1950s, phytosterols have been known to exhibit cholesterol-lowering properties by
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inhibiting cholesterol absorption in the small intestine.
Scientists believe phytosterols work to reduce cholesterol because they have similar
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chemical properties to cholesterol and they compete for absorption sites in the body. As
a result, phytosterols interfere with cholesterol absorption in the intestine—essentially
blocking some of the cholesterol from being absorbed by your body. The unabsorbed
cholesterol harmlessly leaves the body as waste.
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THREE MORE PHYTOSTEROL Also in 2003, a trial was conducted to evaluate both the efficacy and the safety of
STUDY RESULTS long-term phytosterol consumption. For a year, 185 healthy volunteers (with ages that
s )N A TRIAL CONSUMPTION OF n ranged from 34 to 64 years old) consumed 20 grams of margarine spread enriched with
grams of plant sterols reduced total 1.6 grams of plant sterols and a control spread. Subjects continued their habitual diets
serum cholesterol by up to 6.4%. and lifestyles. At the end of the year, consumption of the phytosterol-enriched spread
LDL cholesterol was lowered by had consistently lowered total cholesterol by 4% and LDL cholesterol by 6%. There were
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up to 10.1%. no long-term adverse effects reported.
s )N RESEARCHERS INVESTIGATED
the cholesterol-lowering effects of Phytosterols and Other Heart-Healthy Ingredients Can Effectively
phytosterol-enriched margarine as Lower Cholesterol
part of a low-fat diet. The results? Total Perhaps the most compelling study to date on phytosterols was reported in the
cholesterol was reduced anywhere Journal of the American Medical Association. In 2003, researchers found that a diet rich in
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from 7.3%–9.2% with the phytosterol- phytosterols and fiber can reduce cholesterol levels by nearly 30%.
enriched margarines. LDL cholesterol From the 1950s to today, the blood-cholesterol lowering effect of phytosterols has
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dropped by 10.4%–12.7%. been investigated in a large number of clinical trials on over 1,800 people, with up to
s !LSO IN A STUDY SHOWED THAT MEN 25 grams per day and durations of up to three years. No significant adverse effects have
with elevated cholesterol levels who been observed in the decades of medically supervised clinical efficacy testing and the
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consumed plant sterols showed a 7.9% general clinical use of plant sterols.
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decrease in LDL cholesterol.
Enhancing Phytosterol Solubility with Omega-3 Fatty Acids
Phytosterols naturally lower cholesterol levels which can make them a valuable
OMEGA-3 FATTY ACIDS CAN ally in the fight against cardiovascular disease. But phytosterol solubility in the
BENEFIT MORE THAN JUST body traditionally proved to be a problem because they need to be taken with fat
YOUR HEART* to be effective. In the 1990s, however, it was discovered that phytosterols could be
Various studies show that omega-3 fatty incorporated efficiently into high-fat foods like spreads and dressings. Margarines, for
acids can help support: instance, are composed of 34% to 80% fat and they can carry plant sterol esters. Once
s (EALTHY JOINTS consumed, these fatty acids help release the phytosterols for use by the body.
s .ERVOUS SYSTEM FUNCTION Melaleuca’s scientists, however, chose not to use a saturated fat to form the
s %YESIGHT fatty matrix needed for Phytomega’s phytosterols. Instead, they opted for a “good”
s .ORMAL BRAIN DEVELOPMENT polyunsaturated fat that has proven itself to be a natural asset to heart health—omega-3
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in children fatty acids. Fish oil containing omega-3 fatty acids is an effective carrier for plant sterols
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s -ENTAL HEALTH and it also complements a heart-healthy lifestyle which is low in saturated fat.
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s )MMUNE SYSTEM FUNCTION
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s (EALTHY LUNGS Omega-3 Fatty Acids: Studies Suggest Cardiovascular Benefits
Each daily dose of Phytomega contains 1,000 mg of fish oil from non-predatory fish,
which includes 330 mg of eicosapentaenoic acid (EPA) and 220 mg of docosahexaenoic
acid (DHA). These two omega-3 fatty acids received worldwide attention in the 1970s
LOWER CHOLESTEROL— when Danish scientists compared the coronary mortality statistics in Greenland
AT A MUCH LOWER PRICE!
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Eskimos and in Danish people living in Greenland. The scientists found few deaths
from coronary artery disease in the Eskimos—but many deaths in the Danes. After an
PHYTO- Omega- Cost extensive analysis of the diet of both groups, it was discovered that the “arctic diet” of
PRODUCTS STEROLS 3 Fatty (30-day
(mg) Acids (mg) supply) the Eskimos—consisting of cold-water fish like whale, seal, and salmon—was high
Phytomega 2000 1000 $22.99†
in EPA and DHA. The Danes, however, ate a diet high in saturated fat and cholesterol
from meat and dairy products and suffered more coronary problems.
Coromega™ 11
Omega-3 0 650 $39.95‡ A 2001 study verified the results of the earlier Danish studies. Researchers
Packets examined the diets of 426 Nunavik Inuit of Quebec aged 18 to 74. The Inuits’ blood
Twinlab® plasma samples were analyzed for fatty acid composition. Despite some westernization,
Cholesterol 900 0 $26.99‡ the Inuits still partly consume the diet of their ancestors, which is rich in fish and
Success
Enzymatic marine animals. Mortality from coronary artery disease in the Inuit is 50% less than
Therapy 300 0 $27.99§ that in the Quebec province as a whole.
Cholestoril
Plus™ In the Nurses’ Health Study, fish consumption was found to be associated with
a lower risk of coronary heart disease (CHD) and a lower rate of all-cause mortality
during 16 years of follow-up. Researchers concluded: “Findings are consistent with
† Preferred Customer price. Based on daily serving. ‡Price from Drugstore.com, July
2008. § Price from VitaminShoppe.com, July 2008. Actual prices may vary. Product the hypothesis that omega-3 fatty acids are the active agent primarily responsible for
names are trademarks or registered trademarks of their respective companies.
the apparent protective effect of fish. This prospective study supports the association
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7. DJA Jenkins, CWC Kendell, A Marchie, DA Faulkner, et Alpha lipoic acid is a fatty acid found naturally inside every cell in the body. It’s needed
al., “Effects of a Dietary Portfolio of Cholesterol-Lowering
Foods vs Lovastatin on Serum Lipids and C-Reactive by the body to produce the energy for our body’s normal functions. It is believed
Protein,” Journal of the American Medical Association, Vol.. 290, that alpha lipoic acid has the ability to recycle antioxidants such as vitamin C and
2003, No. 4, p. 502–510.
glutathione after they have been used up, thus earning it the title of “super” antioxidant.
8. DJ Sanders, HJ Minter, D Howes, and PA Hepburn,
“The Safety Evaluation of Phytosterol-Esters Part 6: “The
Comparative Absorption and Tissue Distribution of Phytomega Combines Four Natural Cardio-Protective Ingredients in
Phytosterols in the Rat,” Food and Chemical Toxicology, 2000.
One Dietary Supplement
9. TT Nguyen, LC Dale, K von Bergmann, and IT Croghan, Scores of human clinical and animal studies have shown that a daily intake of
“Cholesterol Lowering Effect of Stanol Ester in a US
Population of Mildly Hypercholesterolemic Men and phytosterols and omega-3 fatty acids have beneficial effects on serum cholesterol and
Women: A Randomized Controlled Trail,” Mayo Clinic LDL cholesterol levels—without causing unwanted effects. Phytomega, with 2,000
Proceedings, Vol. 74, 1999, No. 12, p. 1198–1206.
mg of phytosterols and 1,000 mg of omega-3 fatty acids, can be a safe and effective
10. E Dewailly, C Blancet, S Lemieux, et al. “n-3 Fatty Acids
and Cardiovascular Disease Risk Factors Among the Inuit
for adults who want to naturally lower blood cholesterol levels and promote healthy
of Nunavik,” American Journal of Clinical Nutrition, 2001; triglyceride levels. Plus, Phytomega includes CoQ10 and alpha lipoic acid for additional
74: p. 464–473.
heart health benefits. Phytomega, along with ProvexCV, a healthy diet, and regular
11. FB Hu, L Bronner, WC Willett, MJ Stampfer, KM exercise, helps you make a whole-hearted effort to support your cardiovascular health.*
Rexrode, CM Albert, D Hunter, JE Manson, “Fish and
Omega-3 Fatty Acid Intake and Risk of Coronary Heart
Disease in Women,” Journal of the American Medical
Association, Vol. 287, 2002, p. 1815–1821.
12. MA Hallikainen, ES Sarkkinen, H Gylling, and MI
Uusitupa, “Comparison of the Effects of Plant Sterol
Ester and Plant Sterol Ester-enriched Margarines
in Lowering Serum Cholesterol Concentrations in
Hypercholesterolemic Subjects Fed a Low-Fat Diet,”
European Journal of Clinical Nutrition, Vol. 54, 2000, p.
715–725.
13. PJH Jones, M Raeini-Sarjaz, FY Ntanios, CA Feng, and
W Parsons, “Modulation of Plasma Lipid Levels and
Cholesterol Kinetics by Phytosterol Versus Phytostanol
Esters,” Journal of Lipid Research, Vol. 41, 2000, p. 697–705.
14. HO Bang and J Dyerberg, “The Composition of Food
Consumed by Greenlandic Eskimos,” Acta Med Scand,
1973; 200:69–73.
15. American Journal of Clinical Nutrition, Vol.54, 1991,
p. 438–463.
16. Omega-3s improves Alzheimer’s patients quality of life,
International Journal of Neuroscience, Vol. 87, November
1996, p. 141–149.
17. Journal of Clinical Investigation, 1993, Vol. 92, p. 105–113.
18. American Journal of Clinical Nutrition, Vol. 65, April 1997,
p. 1011–1117.
19. KD Stark, EJ Park, VA Maines, BJ Holub, “Effect of Fish
Oil Concentrate on Serum Lipids in Postmenopausal
Women Receiving and Not Receiving Hormone
Replacement Therapy in a Placebo-Controlled, Double-
Blind Trial,” American Journal of Clinical Nutrition, Vol. 72,
2000, p. 389–394.
20. ML Burr, AM Fehily, JF Gilbert, et al. “Effects of Changes
in Fat, Fish, and Fibre Intakes on Death and Myocardial
Reinfarction: Diet and Reinfarction Trial (DART),” Lancet,
1989, Vol. 2, p. 757–761.
21. GISSI Prevenzione Investigators, “Dietary
Supplementation with n-3 Polyunsaturated Fatty Acids
and Vitamin E After Myocardial Infarction: Results of the
GISSI-Prevenzione Trial,” Lancet, Vol. 354, 1999,
p. 447–455.
22. ML Burr, AM Fehily, JF Gilbert, et al. “Effects of Changes
in Fat, Fish, and Fibre Intakes on Death and Myocardial
Reinfarction: Diet and Reinfarction Trail (DART), Lancet,
1989, ii: p. 757–761.
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