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ANTIHYPERTENSIVE

AGENTS
Michael L. Villavert
MD 17th Batch

Factors

Age
Race
Genetics
Education
Environment
Stress
(psychological)
- LIFESTYLE
-

Damage in:

Hypertension
-

Renal failure
Coronary disease
Cardiac failure
Stroke

- Kidney
- Heart
- Brain

Etiology
Primary

/ Essential Hypertension
Secondary Hypertension
Renal

artery constriction

COA
Pheochromocytoma
Cushings
Primary

disease

aldosteronism

BP Regulation

BP = CO X PVR

BP Regulation

Baroreflexes
ANS

According to the principal regulatory


site or mechanism on which they act
Diuretics
Depleting

the body of sodium and reducing blood

volume
Sympathoplegic
Reducing
Inhibits

agents

peripheral vascular resistance

cardiac function

Increasing

venous pooling in capacitance vessels

According to the principal regulatory


site or mechanism on which they act
Direct

vasodilators

Relaxing vascular smooth muscle; thus dilating resistance


vessels

Agents that block production or action of angiotensin

Reduce peripheral vascular resistance and (potentially)


blood volume