25/9/2015

Ctimvctrn?|cschysinhMicroworld&Macromind

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Tholuntrong'Sinhhcphnt/SHPTtbo'btubikingkong774,30Thngmi2012.

kingkong774Thnhvinmi
Sbivit:2
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imthnhtch:1
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TisaoB1ARgycoctim,trongkhiB2ARgyginctrnmchmu?????Mcdcchungltrnh
tnhiucAMP=>cAMPPK.

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Ctimvctrn?|cschysinhMicroworld&Macromind

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Bivitkhc:
DNAvRNA
SmallquestionaboutourDNA
HintngAccommodationlg?Slinquancanvi...
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ngdngcasinhhcphnttrongyhc
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Phnmmthitkonmi
Proteinkinase&Phosphorylasekhcnhauthno?
kingkong774,30Thngmi2012
#1

NguynPhcLongAdministrator
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cthch:1,248
imthnhtch:616
Giitnh:Nam

utinbnKingkong774cnhiurngcAMPlphnttruyntinth2,nlmnhimvhothaphntsaun,
nghalchngvaitrtrunggian,sauccltrnhtnhiumithcsbanu(mtltrnhtnhiuylun
baogmmtsb'kit'nhtnh),bnthncAMPkhngquytnhltrnhnosdinrahaymtpngnhtnh
sphixyrakhicshindincan.
trlicuhinytacnnmrmhcvcchgycoccactrnvctimkhcnhaunhthno.
1.Ctrn(cbitlctrnphqun):Dltrnhtnhiugckchhot,nhtnhphicshothaMLCK
(myosinlightchainkinase)gnmtgcphosphatevoMLCthmicscoctrnxyra,vbncnbitthm
rngbnthncAMPlmtphntcchMLCK[giithchtisaoththbeta2gyginctrn(phqun)].
MtluthmlshothacoctrnthngquashothasimyosinbiCa2+/calmodulinldobnthntbo
nykhngcphntTroponin.
HyxemthmvCaldesmonvCalponinna!

2.Ctim:Tngt,dltrnhtnhiugckchhot,nhtnhsgiatngnngCa2+gnvoTroponinCl
tinquytqutrnhcocxyra.
ucnlulthnhphncoccactimgingvicbmxng(cvn).
Tisaolicskhcnhaunhvy?
Ccbnhyluticutrcmhcphntca2loimnysr(cpimmuchttrn).
.
Luthmviccbnlcchgitnphnttngtcviththtrnmtcutrctbonovnirngnc
chcnngA,B,Clsailm.Vd,nugiendothelinlphntgycomchmnhnht,bnsthiuxtkhnng
gyginmchcngcmnhngncankhiththhindintimtvtrkhc.(Gi,tboctrnmch
muvtbonimmchmu,endothelinc2ththchiurchcnngv1ththcnangnghin
cu).
Tngt,vicgitnththrisuyrancchcnngglmtsailmlnkhc.
Cchkhcphc:Nmrcutrcmhctivtrxtlncchvnhnhcathth.
Thn.
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Ctimvctrn?|cschysinhMicroworld&Macromind

Trangch:
http://nguyenphuoclong.com
ThngtintrnRG:
http://www.researchgate.net/profile/Nguyen_Phuoc_Long
DinncschYsinhcnhiuEbookYSinhhcdnhchothnhvin.Ccbncththamkhotiy.Nuchalthnhvin,bnhyngkti
y.Ngoiraccbncngcthyucuschtiy.
NguynPhcLong,30Thngmi2012
#2
kingkong774,ntluan1991andlargoltvlikethis.

NguynPhcLongAdministrator
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Bsungstnacubnhi:C2ththBeta1vBeta2adrenergicuhotngthngquacAMP(GsPCR),tuy
nhinmtsloiththbeta2scchthayvhothacAMP,mtsloililinkthotngviGqthayvGs.
imkhcnaca2ththnylththBeta2rtkmpng,haycthniltrongmtsiukinnht
nh,ntrviNoradrenaline.
Trangch:
http://nguyenphuoclong.com
ThngtintrnRG:
http://www.researchgate.net/profile/Nguyen_Phuoc_Long
DinncschYsinhcnhiuEbookYSinhhcdnhchothnhvin.Ccbncththamkhotiy.Nuchalthnhvin,bnhyngkti
y.Ngoiraccbncngcthyucuschtiy.
NguynPhcLong,30Thngmi2012
#3

NguynThinLunAdministrator
Sbivit:368
cthch:399
imthnhtch:616
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SaukhibnxemcutrlicabnLongtrn,mnhnghbnkingkong774tsuylunvcthmtiliurt
raccutrlichomnh.Mnhchxinphptholunthmmtsdatrnhnhmbnpostlntrongcuhi:
1)Drngnuchngtaisuvothththbeta1vbeta2ARscnhngimkhcbitnhtnh,nhngtrong
trnghpny,clbncngngvimnhrngchngtachxtvigcnhnnginl:c2ththkhic
hothaudntishnhthnhcAMP.Nhvyvncbnyslphasau,miloitbosc
nhngthgctrngcAMP"hotha".
2)Nhnitrn,tboctrn,cAMPcnhhngnhotngcaMLCK.Theosuynghngin,cAMP
chnhthnhstiptchnhthnhcAMPproteinkinase,ml1proteinkinasethnsphosphorylhamt
phntnokhc.ivictrn,phntcphosphorylhaslMLCK.QutrnhnycgilcAMP
dependentphosphorylationofMLCK.BnchrngMLCKkhicphosphorylhathhottnhcansgim,hay
nimtcchcthhnlscnnhiuphchpCa++calmodulinhncc1phntMLCKhotng.Nh
vyttnhinsdnnginc,chodcAMPclmtngnngCa++trongtboctrnhaykhng.
3)ThcsthcAMPclmgimnngCa++trongtboctrn.Cth,trongtboctrncmthintng
gil"Ca++spark"(bntratinnh).Mnhningin,Ca++trongtboctrncdtrcclini
cht,trnc1knhCa++gilRYR(gingnhRYRtrnctim,vkhcviIP3Rnhbn),knhnysc
nhnglcmvphngvobotngrtnhanhmtlngionCa++,hintngnygil"Ca++spark".VcAMP
slmtngtnsmknhRYRny.VynngCa++nibostng.Nhngbnxemlihnhtrnlctrn
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ngitanhnmnhrngcmtknhK+.ylknhK+phthucCa++.DokhicCa++spark,Ca++nibo
tngnnhothaknhK+ny,K+iratbovlmtboctrntrnn"quphncc"hyperpolarization.Khi
ccknhCa++phthucinth(LTCC)sngli,vlmgimlngCa++votbo.Dotboctrns
gin.
4)Nhvymnhmunnitmgnli,nhbnLongnitrn,vnykhngphichththbeta1hay
beta2,mvnlcutrcmhccatngloitboc.Vynnnubnmunnmchcvnnythhyc
thtkliphnmhccatngloitboc.
5)Crtnhiutiliuvitvvnny.Mnhxingiithiu2quyncllphhpbnxydngnntng.
1lquynMhccathyNguynTrDngvthyPhanChinThng(gm2tp).Thnhtlvylschting
Vit,thhailvhnhnhminhhartp,bnnnmuaschgcthamkholudi.Phnccloitboc
trongquynnyvitkhk.
2lvvnbnanghi,bncthxemquynBerneandLevyPhysiology,phnsinhlctrongquynnyvit
rtk,chnhnhminhhap,vcngkhngquchuynsu,mnhnghlsbngiipthcmc.
6)Mongbnsphnhilinhnggchathanghockhngng.
7)Bitrlivnthiumtshnhnhminhhavccngunthngtinmbotnhchnhxc.Nhnggibunngquri,mnhthmvosauvy^^.
DnTHVINHCLIUDSYSbtuctrinkhai!yslthvinhcliuYSinhlnnhtttrcnnay
NguynThinLun,31Thngmi2012
#4

hunter25,kingkong774,NguynPhcLongand1otherpersonlikethis.

NguynPhcLongAdministrator
Sbivit:2,130
cthch:1,248
imthnhtch:616
Giitnh:Nam

Bnntluanithmkhsuvnhctikhinim'Ca2+spark',ththRyR,vaitrcaknhK+vhintngqu
phncc.NhngvnnyscngchiurhnkhibnkingkongtmhiuthmvCa2+vicckhinimnh
'phnbkhnggianvthigiancaCa2+',linhgiaCa2+vitithvlinicht,sikhngcngnhng
vncaCa2+viccionhatr2khc(mtcimcngkhhay,dnhtimtsloiproteinvcthnincn
phctphnmiquanhgiaCa2+vK+na),...
lmtsmrngtmhiuvqutrnhcocmtcchchititvy.Nuccbnmuntholunthmth
chngtacngtmhiunh!!!
Tuynhinmnhlultrongtrnghpnyngitadngkhinim'musclecontraction'v'musclerelaxation'nh
mtcpchkhngdngt'muscledilation',nhvydngtco/nghctrnghpnyclchnhxchn
co/gincnhcchgitheothiquen.Xtcchcngvy.
Nuccbntmracchgyginthcschkhngphilchlmgimyutgyco(vdnhtrongccltrnh
caNOSchnghn)thhychomnhbitnh!
ThamkhothmslinhgiaCa2+vtithtiy.
ThamkhothmvNitricoxidetiy.
Trangch:
http://nguyenphuoclong.com
ThngtintrnRG:
http://www.researchgate.net/profile/Nguyen_Phuoc_Long
DinncschYsinhcnhiuEbookYSinhhcdnhchothnhvin.Ccbncththamkhotiy.Nuchalthnhvin,bnhyngkti
y.Ngoiraccbncngcthyucuschtiy.
NguynPhcLong,31Thngmi2012
#5

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ntluan1991thchbiny.

NguynThinLunAdministrator
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cthch:399
imthnhtch:616
Giitnh:Nam

CmnbnLongnhcnhvviclmdngthutng"ginc"trongtrnghpny.Chngtaphichhn
natrongvicdngccthutngchuynngnh,nukhngsmclitrongvicdngtnhmnhtrn .
Nhntin,bncthcthmvcutrcvsinhlco/ginmchmutiy.
DnTHVINHCLIUDSYSbtuctrinkhai!yslthvinhcliuYSinhlnnhtttrcnnay
NguynThinLun,1Thngmimt2012
#6
NguynPhcLongthchbiny.

kingkong774Thnhvinmi
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cthch:0
imthnhtch:1
Giitnh:Nam

Trctinkhihicunythmnhthcmcltronghnh1,ththBta1timckchhotdntihnhthnh
cAMP=>kchhotcAMPPK=>hothoknhLTCC(knhcanxiphthucinth)=>gytngCa2+nibo=>kch
hotRYR=>bmCa2+dtr=>cngtngCa2+nibo.VnhvyBta2ctrncnggytngCa2+nibo
=>tngCamodulin+Ca2+....nhngnh2cunycaccbnmnhhiu.Thanks!!!!
"bnthncAMPlmtphntcchMLCK"
"DokhicCa++spark,Ca++nibotngnnhothaknhK+ny,K+iratbovlmtboctrntrnn
"quphncc"hyperpolarization.KhiccknhCa++phthucinth(LTCC)sngli,vlmgimlng
Ca++votbo.Dotboctrnsgin"
kingkong774,2Thngmimt2012
#7

(Bnphingnhphocngktrlibivit.)

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