CONFIDENTIAL REPORT [EVALUATION OF THE EFFICACY OF A HAIR GROWTIE ACCELERATION TREATMENT: {5 HAIR GROWTH KINETICS MEASUREMENT. 1 SELF-EVALUATION QUESTIONNAIRES Sampoo : 304170 In viv et on subjects Sub Sams: me pace ws Ak ade ae ees SPINCONTROL. EC MNMLECAMSOLECRA VON) otc Shampoo 306179 — Condor 918 Confer DocentCONTENTS TRIAL CONDITIONS... ‘Shey power Sco ts Scene ii 868) Bi ey Ai = 2 bj, 2 ‘St Papi 2 “apres dhe uh Sng Dat 3. METHODOLOGY, a 3 3 3 a Stl Se cose eepenceseeetcece say, En i aia i i satth Pes nei 2 321 Pred Appear” Pail 3a Nendo 431 Gonahlnas meni sett Seen a raumaton fet 421 Gabler te pola ha fain, ws Sate ii 4. ETHICAL AND LEGAL CONSIDERATIONS 0 4 tut Pena 2 ‘ning ee. a Deca i 8 0 3 ‘Ace f esac 0 % Sree rn = a ‘ea of Ase tL a ‘ane cmon oo diy ied, B RESULTS, i‘ fin it a su Conpince wit be poten 2 $21 Gites nce a S22 Inert et nt 2 Serene mate ae i ANNEX 1: GLOBAL RESULTS ~ GROWTH KINETICS MEASUREMENTS [ANNEX 2: INTERPRETED RESULTS ~ OROWTI KINETICS MEASUREMENTS. [ANNEX 5: RESULTS SELF-EVALUATION [ANNEX 4 COPY OP THE PROTOCOLE (sch Vrion) [ANNEX 5 CERTIFICATIONS AND ATTESTATIONS Space t2e C-MX-BCMSHL-EC-RA ON)1. TRIAL CONDITIONS 1A. Site of Experimentation ‘SPINCONTROL 238 rue Gireaudau ~ F-37000 TOURS ~ FRANCE “Tl: +33 (0)2.47 37 62 79 Fax: #33 (0)2.4737 58.28 ‘email: sginconsol@ssincook 12, Study Sponsor 2c BP GIT F-59061 ROUBAIX Cedex 01 - FRANCE. ‘Study Monitor SCCATRYSSE BRC BP oI F-59061 ROUBAIX Cedex 01 ~ FRANCE ‘Tel: +53 (0)3 202627 28 Fax #33 (0)3 2026.27 48 1A, Investigator P.BEAU, PhD Manager SPINCONTROL, 1S, Scientific Manager & Study Director JCPITTET, PhD ‘SPINCONTROL. Tel: +33 (0)2 4737 1286 email: it@spicontol 16, Technician SJACOB SPINCONTROL 1.7. Quality Assurance Manager CPERRIER SPINCONTROL ‘Tek: +33 (92.47 3709.49 Spinco EC MROL-BCSHL-EC-RAAVON) Produc Shampoo 30 170—Condoer S918 Cone Dome2. STUDY SUMMARY 24. Objectives ‘The objective of this teal was to assess the efficacy of a hair growth accelerator treatment. This treatment was composed ofa treatment shampoo and a conditioner identified under the reference number listed below: ‘Shampoo Ref: 304 170 Conditioner Ref: 509180 ‘This assessment was performed using: "= Selfevaluation questionnaires answered by the test subjects; ‘© An analysis ofthe hair grown rate ‘The assessment was undertaken over atta period of 28 days of treatment application. 22. Study Population ‘The test was cared out on 60 healthy subjects. The individuals recruited for this study were all women ‘These subjects had to strictly meet the inclusion/exclusion criteria listed in paragraph 3.11. ‘The 60 subjects were divided into two distinct group: ‘Group 1:30 subject who eppied no har weatment tal (Coml Group) ‘Group 2:30 subjects who eppied the two products daily (Treated group) ‘Their average age and ait type (lly and dry) were equslly represented within the 2 groups 23, Trial period, kineties, and schedule ‘The trials began on April 17 and 18, 2001, and were concluded on May 15 and 16, 2001 Study kinetis: 0 ‘Tr days | 17 18 Apri, 2001, 15 & 16 May, 2001 Hair bleaching Hair sampling ~ Self-evaluation questionnaire 24, Study Design + This study was an “open” study. Iwas a comparative study, i the effects ofthe treatment observed on Group? (Greate) were compared to the natural variations observed on Control Group | ‘The subjects didnot serve as their own contol reference. Spaces EC-ROLECMSOLEC RAYON ‘Prod: Shampoo 04170 Coditoner 0180 “Conntal Dacomert3. METHODOLOGIE, 3.4. Subjects Selection SPINCONTROL’s test panel was made up of subjects who had answered a computer ‘questionnaire prior to selection about their medical history, allergies, skin care and cosmetics habits, as well as various administrative details. The enrolments were undertaken by a licenced beautician ‘The procedure used to recruit, select, and include the subjects, who fieely gave their filly- informed consent to participate in this study, was drawn up to ensure clear and precise information enabling the later to appreciate the object and consequence of their consent. ‘This procedure inclades in particle: =A preliminary interview bel to explain the study objective and protocol, the study Setedule and, a the case may be, the forms of compensation, a5 well a any posible cosmetics benefits tobe expected, the constrains and potent rik linked othe tay, + Thereading ofa data sheet hat sipalates the essential features ofthe study o enable the subjects to fely decide wheter fo psticpate or not based on the proposed conditions, ‘nd theo sign dhs fom giving their expres, informed conser; ‘This consent makes it possible include the subject for coverage by the civil ability insurance policies taken out independently by the stay Sponsor and Investigator as soon 1 the subjects has been definitively admit to participate nthe study by its coordinator, ‘The subjects recruited for the study were selected under the responsibility of the study investigator and coordinator based on the inclusionexclusion and proscripion/estrction Criteria listed in this protocol ‘There were 60 subjects recruited fr this study ‘The results presented cover the totality ofthe subjects on hand forthe final assessment day (728 days). 3.1.1. The inclusion, exclusion and restrictions criteria defined in the protocol are listed below General Healthy subjects; ‘Available forth entire duration of the study; Motivated to freely participate in the study; ‘Not simultaneously engaged in any other testing with or without a direct therapeutic fect ‘+ Having no remaining effcts from a prior cosmetic, demmetological or medical study atthe ‘beginning ofthe study involving the scalp or hair; ‘+ Not having modified their cosmetic habits skin-care products, cleansers, et.) ina least the past 15 days; + Able to justify having a permanent address; ‘Able to understand the French language: i. French-speaking subjects capable of reading ‘and understanding the study documents and able to follow the explanations given; ‘+ Having the benefit of social security medical coverage Specific tothe study + Female; © Caucasian; Spaces 2e EC MKOLRCMSHL-EC:RA) Proc: Shmpu 9470 Condiner 509180 "Cotati DaceBetween 18 and 40 years of ege; With cily or dry hair (30 ofeach inthe two 2 groups); With mid-length har ofa dark shade (chestnut, brown to black); ‘With healthy skin (free of psoriasis, eczema, erythema, edema, seas, or cancerous legions) and particularly onthe scalp; "Neither pregnant nor nursing a baby fora last the past 3 months; ‘© Not having changed ther contraception methods in the past tree months and agreing 10 continue ther present method forthe duration ofthe study, ‘© Having a regular cycle or taking an orl contraceptive; ‘© Taking no hormonal treatments linked toa health condition (thyroid problems, ete); ‘+ Having no skin hypersensitivity or allergy to cosmetics, and particularly to hair Bleaching product; ‘Not suffering from stop skin; ‘+ Not having undertaken any type of weight-loss diet fr at last the past tree months and ‘ot planning to do so during the study; ‘+ Accepting not to undertaken any UV sessions in an institut for the entire duration ofthe study; ‘Accepting not to dry their hair witha hair dryer; ‘© Accepting not to colour or bleach ther air forthe duration ofthe study 3.1.2, Non-inclusion criteria ‘Lacking any inclusion criteria listed above; ‘© Having filed to heod the provision of article L 209-17 ofthe modified law dated 20/12/88 pertaining to: © The prohibition of taking part simultancously in several biomedical studies without direct individual benefit, (© The period of “non inclusion” during which an individual may not take part in any other biomedical study without direct individual benefit ‘+ Being deprived of liberty due toa legal or administrative decision, suffering from ilness and in need of emergency care (article 209-5); ‘+ Being a minor or of age but under legal guardianship or institutional cae, ‘study can be undertaken ina different manne article 1209-6) ‘+ Failing to acquiesce by refusing to sign the express, informed consent form, insofar as the 3.13 Proseriptions and Restrictions ‘+ Application of any other cosmetic product tha ints, bleaches, or teats hair is proscribed ‘+ Use of another shampoo beside the one provided for the group applying the treatment is proscribed. (The subjets in the control group ean use their usual produet, without "vitching to another, forthe duration ofthe study); ‘©The subjects selected must under no circumstances have their hair eut during the entire study. 32. Product Presentation ‘The products under study were provided by the study sponser. The products (shampeo and conditioner were packaged in 250ml bate). ‘The sponsor was responsible for manufacturing, packaging, identifying, and monitoring the purity, composition, innocuousness and other characteristics of the products being tested, "The sponsor agreed to furnish a certificate confirming the absence of any toxicity in the products being tested, Reda Spon a8 = C FC-MXDL-BE-MSOL-DE-RAVON)‘Shampoo Ref: 304 170 Conditioner Ref: 509180 For the purpose of this study, the sponsor provided ‘©The number of products necessary for the subjects participating inthe study, ‘© Enough product for the additional subjects taking part in study. ‘+ One product per reference and one per batch forthe Spincontol company's sample collestion. ‘The products were stored away from the light and at ambient temperature. 32, Product Application ~ Frequency ~ Methods For the treated group (group 2) ‘The products were applied daily, moming or evening. Applicaton was undertaken bythe subjesis. ‘The treatment consisted in a preliminary hair washing using the shampoo provided. A three- to-four minute penetration period was then heeded prior to rinsing. “The conditioner was applied evenly over the entre scalp on wet har following rinsing, being especially careful to apply the product right down tothe hair root. The rinsing was undertaken at least five minutes after product application to guarantee its action. All of these recommendations were stiplated inthe data sheet provided the subjects (See the protocol in !nnex) atthe start of the study, as well as imperted orally during the first assessment on TO, For the control group (group 1) ‘The subjects recruited for group 1 used their usual shampoo and at thei usual intervals Without, however, being allowed to switch brandstypes for the entre duration of the sta. ‘They were not permited to apply any haircare product. 322. Tolerance ‘The incidents that occurred during the course ofthe study wer listed by the study coordinator inthe study binder. The nature, sever, date of appearance, duration, date of termination, assessment, and possible treatments undertaken were listed in detail in the observation ‘notebook, along with the causes ofthe incidents observed All serious undesirable effects were reported to the study monitor within 48 hours and confirmed in writing within three days. 33. Choice oftriat ‘+ This was an “open study in which the investigaor and the subjects were all aware of| the nature ofthe products being tested ‘+ This was a comparative study in which the results obtained by the treated group (group 2) were compared tothe results obtained by the contol group (group 1). 1+ The subjects did not serve as ther own contro Space BIC ECMNDLECMSOL-EC-RAVOH)34, Randomisation ‘There was no randomisation carried out. The subjects selected were divided into group 1 (contol) and group 2 (treated) in such & way so as to ensure that the two groups were ‘homogeneous, both in terms of age of hair type (oilydry). 35. Assessment methods 35.1. Growth kinetics measurement ‘The objective was to quantity the hair growth kinetics for both the treated and for the control ‘group respectively, and then to compar them. ‘To do so, the technique consisted in measuring the length ofa sample of 10 hats after 28 ays of treatment During the initial period prior to treatment: stand of hat, made up of about thity airs located on the top of the scalp, was selected and a length ofthis hair measuring two to three cm was bleached starting atthe root, As this bleaching operation did not penetrate the hair follicle, the hair was not physiologically disturbed and its capacity for growth was therefore ‘unaffected. ‘After applying the bleaching product for 20 minutes, it was then thoroughly rinse. After 28 days of treatment: a least 10 hairs from this strand were pulled out for sampling, purposes. The distance between the root and the limit of the bleached length was then ‘measured on these 10 sample hairs 352. Self-Evaluation Questionnaires ‘A self evaluation was also undertaken by the group that hed applied the treatment In ‘agreement withthe sponsor, the questionnaire was organised inthe following manner: Questionnaire composition: 2) Spomtancous responses: What did you think ofthe hair revtalising and growth ‘accelerating treatment? Positive polnts / Negative points, 2) Cosmetic appreciation ofthe products and assessment of treatment efficay: Possible responses to affirmations (questions from 1 10 10) ‘© Entirely agree Agree Donotentrely agree Donotagree at all Question 1: The shampoo’s texture i pleasant. Question 2: The conditioner’ texture is pleasant. Question 3: The scent ofthe products is pleasant. (Question 4: My hair's appearance has improved, (Question 5: My ai is shinier. (Question 6: My iris healthier. Spncnna 2c ECAMNLBCSOL-DC-RAAVON) Protacts Shampos 36 179— Coane 0980, "Conds DocentQuestion 7: My haie quality has improved. (Question 8: [noted tht my hair grew faster. Question 9: I thought the treatment was effective. Question 10: Lam satisfied with the treatment. Question 11: The fundamental nature of my har sealp has not changed (oily har, appearance of dandruff, tc.) F“Do not entirely agree” or "Do not agree at al” explain why. 1 would be prepared to continue the treatment. (yesno) would be prepared to purchase these products. (yes) Global score attributed to the treatment (shampoo and conditioner) (n/10) ‘These documents were drawn up and processed using Scan’Bac sofware (3SI company), The forms were read with the help ofa Fujitsu M3096GX scanner and the same program. The data ‘vas then analysed and presented using Microsoft Excel. 36, Examination schedule ‘The effects ofthe treatment were assessed over a 28-day period. The measurment procedures. were as follows: (On To, the first day prior to product application: + Locating ofthe hair strand tobe studied; ‘Bleaching a2 to 3em length of the hair strand, starting atthe rot + Distribution ofthe products othe treatment group (group2) and usage recommendations. On day T28: Rapid questioning about their tolerance tothe products; Filling out ofthe self-evaluation questiounaize by te subjewts (goup 2), Locating ofthe bleached hair strand; Polling outa minimum of 10 bars; Measurement of the length of the samples; ‘Termination ofthe stud. Comment: The questionnaire was filled in by the subject prior to taking the hair samples 50 that the latter would not influence their judgement about the treatment. Measurement Dates: - T0 Apri 17 and 18, 2001 day T28: May 15 and 16, 2001, Spaces 82 ECAMNOLBCMSOL-ECRAAVON) Prod: Shamu 0470 Conner 0180 ‘Comore Docent37. Presentation of results “Two typeof presentation were made: = lobal: corresponding to the average values forthe entire tet panel and expressed inthe form of tables. = per subject: summary given a table ofthe all the values measured during the 3.71. Global results for the panel as whole ‘This presentation enables a rapid and overall visualisation ofthe evolution in the parameters under study. “These global results are presented forthe subjects as a whole on the Final day of measuring at day 728. ‘The global results show the air growth kinetics ofthe treated group and the control group as well as the differential between them, ‘This differential is also expressed in tems of percentage in relation tothe untreated control group (group 1) 3.72. Individual results For each subject, the overall gross length messurement, the average value of the 10 samples, ‘and the dispersion (standard deviation) are presented 3173. Statistics Instrumental techniques ‘The significance of the results was assessed using the Student's Hest for non-pared groups (cubject to application conditions being verified). The test was aplied to the “gross” values ‘of measured hai lengths “The acceptability threshold was set at 5% Seffevaluation Frequency- charts were drawn up to present the results ofthe qualitative questions by taking a census of the number of volunteers and by tallying the frequerey of the various possible responses (expressed as a percentage). The responses oblained for each question were then recorded in tabular form (individuals and frequencies), The statistical difference in the frequencies (%) was evaluated using a chi-square test As forthe responses that corresponded to agreement or disagreement, the 4 different responses were grouped into two categories a8 show below: AGREE > Agree entirely [edge 0 DONOT AGREE Do mot Agree entirely * Disagree Space BBE FOMNOL4. ETHICAL AND LEGAL CONSIDERATIONS 4.1, Study Personne! ‘The investigator guaranteed that all the individuals taking part inthe tral had the required ualifieations and skills to adequately perform the diverse measurements. 42. Archiving of the data ual archiving was undertaken using two diffetent media: paper documents and electronic data files. The paper files are archived in a locked cabinet, close to an extinguisher. The electronic dat-a stored on DAT cassettes and kept fora 10-yeas period. ‘The investigator retained a copy ofthe protocol signed by the study sponsor and by himself as well as te orginal “observation records” (and all documents used to draw them up), the pricipation consents, and documents of any sort elated tothe project fo a 10-yeats period. Al documents are accessible for inspection by the study sponsor on his request. Al elements fare retained for a 10-years period as of the delivery date of the final report and they are available for inspection after reasonable notification by either a representative authorised by the study sponsor or by study supervision authorities. The investigator wil inform the study sponsor when the data isto destroyed following the 10-years period. 43, Insurance ‘The investigator and the study sponsor both took out an insurance policy covering their civil lisilty with regard to the subjects. ‘The study Sponsor tok out an insurance policy covering potential lability resulting from the test project with the AXA company, poicy n° 132.131.28.04, ‘The study Investigator took out an insurance policy covering his civil ibility withthe AXA ‘company, policy n° 79.191.004, 44. Declaration to the CNIL In accordance with the law covering “Information technology and freedom” dated January 6%, 1978 the database needed to undertake all the studies earied out by Spinconeol had been declared tothe CNIL. 4S. Anonymity of the subjects ‘The subjects were identified for the study sponsor by an alphanumeric code with five characters and by a number. A confidential computerised list, with the names and addresses of the volunteers, is kept at Spincontrel headquarters. Spncnteoh BIC OMNBL RC ABI EC RA (8) Fretucer Shampoo 304179 Con Conia Doasat46. Consent to participate inthe study ‘An information sheet was given to each subject providing full details about + the study objectives, methods, and duration; + the expected benefits, constants and potential risks of the test (particularly incase of study discontinuation), the non-inclusion period, the amount of the compensation, the right of access to ata files, and their subsequent destruction. 47. Confidentiality All information, data and results of the study are confidential All persons having avvess 10 such data were informed that they are confidential. ‘Medical information conceming the subjects oblained by the investigator during the recruitment and admission was handled confidentially in compliance with article 226-13 and the following of the Penal Code, as well a5 with the medizal profession's code of ethics (decree n° 95-1000, December, 1995). entifiable information ofa private nature was not imparted to the study sponsor. “The investigator and all persons conducting the testing are bound by’ profesional secrecy. ‘concerning the nature of the products studied, the trials, the volunteers, and the final results” {excerpt fom Antile R 5120 of Decree a? 90-872 dated September 1990, under modified law 1 88-1138 dated December 20, 1988, regarding the protection of human biomedical research subjects: Huret law), 48. Quality Assurance ‘The study was subjected to quality assurance procedures in compliance with regulatory recommendations. The protocol and data were verified slong with the specific procedures, ‘The final report was reviewed to ensure that it accurately describes the methods and procedures, and that the resulis accurately reflected the raw data. Verifications of the data ‘generated in this study were performed in accondance with "Procédure des Procédures” (procedure accomplishment) n® PRE-ASQL ‘The final report was issued following a Qulity Assurance evaluation of the completed drat report. This report includes all study deals, along with to following additions ‘The signature ofthe Investigator and the Study Director authenticating the repor. © A statement certifying thatthe report has been subjected to a Quality Assurance [Evaluation signed by the quality assurance manager. Spncntoh BC ECMINOL-BEMSU-ECRAAVOIY rac Shampoo 30 170— Conor 09180 ‘Content Dome49. Annex documents not directly related tothe study ‘The documents included in annex 5 correspond to an carler study carted out by the BIODEV Iaboraory (F-87000 Limoges) which has not direct link to the Spincontrol company. The Spincentol company leaves the entire responsibilty for its contents to this study's Investigator. 5. RESULTS 5.1. Compliance with the protocol ‘The protocol was heeded asa whole. The subjects applied the product in a regular fashion. All the har bleaching procedures carried out on TO and the hair samgles obtained 28 days later took place under the conditions anticipated in the protocol and without any technical problens, Homogeneity ofthe groups ‘Where the homogeneity of the two groups is concemed, their age was statistically idetical both inthe “treated” and the “control” group, with a respective aveuage of 26.2 and 26.4 years of age Reprecenativeness in terms of either “oily” of “dry” hair was vetwally equivalent in both soups (fig. 1). Pelerance group veraus 3926-01 No ‘Numbe’ of subject with oly hat -roates 6 [Number of subjects with ry hat treated 4 [Number of ubjects with oly hat Reference 5 ‘Numbe of subjects wih ry ha = Reference 7 Fiares Homoeny of he nated and the “otal” grape th raps theatre ofthe hired average age of he abe Number of subjects ‘At the conclusion of the study, the mumiber of subjects inthe “reted” and inthe “contol” ‘group was, respectively, 29 and 32. Inthe “Wweated” group, the subject identified as SOUVA was excluded from the trial for non-compliance with the protocol because she became pregnant during the study. 582. Hair growth kinetics measurement results 4521, Global results (annex 1) ‘The hsir-growth length measurements were carried iut on samples having a minimum of 10 ‘ais fo each subjects, as shown in figure 2 Spncncatnc ECMROLECMSOL-ECRAVOH) Prod Shampue 3470 Codione 0180 ‘Conn Dove0 s ‘Tie govt as 10 15 Groth ira 2 pe 20 ‘Bleaching 070 2s: 30 Fe: eon eg meen angle of 1 fae ‘These measurements made it possible to show that hie growth kinetics in the control group amounted to 14.7-4.6 mm, [At the same time, the har growth in the treated group appeared to be somewhat stperior by (05 mm at it amounted to 152 +18 mm. The difference between the two groups is not statistically verified (p()>0.05), ‘The hair growth kinetics in the subgroups “dry bar treated” and “oily har treated” compared to that of their equivalent in the contol group does not show any statistically significant difference (p()>005), ‘The subject MARC9 shows the greatest effect observed inthe “treated” group, athieving & growth of 18.1 mm in 28 days of treatment. Compared tothe average value obiaied by the ‘control group (14.7 mm), this subject presented a hair growth rate that is 23% higher. This ‘maximum effect cbserved is only indicative and is not intended to be representative ofthe ‘efficacy observed forthe panel as a whole. 52.2, Interpreted results (Annex 2) Beyond the gross results obtained for the panel as a whole, and as is shown in fgure 3, it appears that the growth kinetics are superior in the group of subjects who applied the ‘weatment in relation tountrsted group. Space BBE ECMNOL-ECMSO-ECRAWVOIS‘Pere 3 Comparaion oh ba oh ins ote cn he eater ad Teor” Brum ‘Si senor free ‘This observation enables showing that 18 subjects in the “treated” group, or 62.1 %, showed 8 hair growth rate (16.3 mm) superior by 7.1% following the 28 days compared to that ‘observed on average inthe “control” group subjects (14.7 mim). Ths difference appears to be Statistically significant after 28 days of treatment (o()=0.0007: significant at 590), 53. Self-evaluation results (Annex 3) ‘The product evaluation questionnaire (shampoo and conditioner) submited to the volunteers who bad applied the product during the 28-days period shows a genuine appreciation for the products as much for their cosmetic characteristics as for their effectivenes. Cosmetic characteristics ‘The responses conceming the cosmetic characteristics as a whole are ia the majority and significantly postive. The satisfaction felt by the subjects with regard to the hedonistic factors ‘Were broken down as fllows Yes Significant at 5147 ‘The shampoo texture is pleasant 6% Yer ‘The conditioner texture is pleasant: o% Ye ‘The shampoo seent is pleasent n% Yer ‘The conditioner scent is pleasant: 16% Yes Treatment efficacy ‘The global efficacy ofthe treatment as a whole (shampoo ~ conditione) was recognised by the majority ofthe subjects and in a significant fashion as shown below: Yes Significant at 47 Hiair appearance improved: 66% Yer Hair shinier O% Yer Hair healthier: 83% Yer SpincntobinC ECMXOLECMSOL-EC-RAVOI) Prdects Shampoo 30 170—Condoner 05180 “Sonntal DecentHair quality improved: 66% Yes Hair grows faster 16% Yes Hair growth acceleration effectiveness: 79% Yes Global satisfaction ‘The vast majority ofthe subjects who used the products are prepared to continue the treatment ‘and purchase it The average score attributed tothe treatment 8 7.5/10, Yes Significant at 5%? Will you continue the treatment? 93% Yes Will you purchase the treatment 66% Yes ‘Spontancous comments (positive and negative points conceraing the products) Globally and in non-exhaustive way the positive and negative points made by the subjects Positive Points ‘The conditioners peasant scent (13%) ‘The shampoo's quality (7%) ‘The teatment's efficacy (6%) ‘The hair's improved appearance (19%) ‘These spontaneous comments as a whole confirm the globe appreciation of the treatment Aeserbed inthe questionnaire and presented above tthe same time, afew negative pints were made spontaneously Negative points ‘The shampoo's scent isnot appreciated (5%) ‘The shampoo is oo liquid (5%) ‘The conditioner makes the har oly, it doesn't untangle hair enough... (13%) 54. Conclusion ‘The treatment, tested for a 28ay period by 29 subjects and compared toa control group of 32 subjects who did not apply the products, made it possible to show significantly accelerated hair grovth kines of 7.1% for 03% of te subjects. ‘The maximum effect observed on the group of treated subjects amounted t 18.1 mm in 28 days, equivalent 1 a growth rate 23% shove the average value abtained by the contol group (this is indicative information that is not representative ofthe efficacy obse-ved en the panel asa whole) At the same time, 79% of the subjects questioned recognised that thei had grown at an sceeeratd rate afer 28 days of treatment significant: p(t) <0.05), while 93% of them would be prepared to continve using it (significant: p()<0.05) Splncnre2c PoMNeLnearsersenasvon Proc: Shape 30470 Condtine 509180 ott DsomeatANNEX 1: GLOBAL RESULTS GROWTH KINETICS MEASUREMENTS, ne ECANILECMSIL-ECRAAVOEC-MXDL-DC-MSb Spacnee2C ECMXOL-RCMSOL-EC-RAVON) Prod: Shape 0470 Cntr S180 “Conta DocentEC-MNOI-RC-MSOI Length measurements carried out the halr samples after 28 days of treatment Statistics = Referers grup versus West BO2EOT No. ‘Number of ubects with oy hall - ested 6 Number of ubects with dry hal ~ vested “ [Number af ubects with aly hall ~Rserence 8 [Number of subsets wih dry hail = Reference a “Treats group versus reference group ‘5156-02 NO. OlynarTrentea rou versus Relerence group A BDE01 NO. ‘ry na: Treawa group voreus Reference group 672E-02 NO. Spice 8 ECMSOLECMSOL-EC RAVANNEX 2: INTERPRETED RESULTS GROWTH KINETICS MEASUREMENTSEC-MNOL-BCMSOL De ROUSSE DES CHEVEUN SUPERIFURE ALA VALEUR DE REFERENCE SSRathr ti a ete eae 14a wie Stone Spinconteb 6 ECANOL-BCMSOL-EC-RAVO) roduc: Shape 304170 Condon 09180 "Conunl DecwestANNEX 3: RESULTS SELF - EVALUATION Spinich BIE ECAMKOLBCMSOL-PC-RA.VOI) Proc: Shampoo 30170 Cndoner 59180 "Conn Doceony LOSHDOIONH ‘ewesSi aOR en EVALUATION OF THE EFFICACY OF A HAIR GROWTH ACCELERATION TREATMENT BY: | MAIR GROWTH KINETICS MEASUREMENT {'SELF-EVALUATION QUESTIONNAIRES + Nunberofsubjecs: Group 1 30 bjs who applied no sc remen at al (Contl gop) ‘Group: 30subjets who applied he wo products dly (Tree rp) Kine: T0728 jours rina ete for erent: Ts average ag nd hi tp olan dy) were ually represetd within he 2 reps, Baton IB a 0 ens of a + Messremeat Dates TO: Apa 7 and 18, 2001 fay 1S 416, 2001 | Shampoo Ref: 304170 ‘aodner Ref $09 180 ‘Applicaton equeny: Dally 2 Choice ofl "Gp" *Conpuatvesudy: Tree group compared to refence group Tie subject dl at sre ar coal way ee 7 Mio hates + eee mo gue tbr eS BS eT on pop ey The treatment, eed fr a 28-day pvod Hy 29 sujet and cmpae oa cont! group of 32 sje who it at opply the oduct, mde i pone show sgiicany accelerated bar growth Knees of 117% for “The maximum effec oberved onthe proupof treated subjects amounted 8. ma ia 28 ay, equalet a2 owt ate 125% above the average ale obtained by the cool group (his is inate information thas Et repcientive of he fac observed othe pel ta ole) Altheste tine, 79% cf te subjects questioned ognized ht ic hai ad prow aa aceeae te er28 day tenet sgncanp)-).03), wile 98% of tem woul be propre econ wing (sgntcan p=. Spinco