DE(50)= 1.

0359
Log (E/Emax-E)
E/Emax -E
-1.9192539379 0.01204332
-1.0444337093 0.09027475
-0.2940780169 0.50806816
0.2216634605 1.66595575
0.6767330402 4.75043128
0.9679252855 9.28806584
1.5501837024 35.4963504

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
0.01
0.09
0.5
2
5
10
25
60

DE(50)= 16.7235
Log (E/Emax-E)
E/Emax -E
-1.8353382027 0.01461039
-0.9958599785 0.10095783
-0.7026283429 0.19832235
-0.1798946881 0.66085368
0.2274167039 1.68817204
0.5046599132 3.1963911
1.3690347505 23.3902439

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
4
8
10
15
20
25
45
100

DE(50)= 1935.14
Log (E/Emax-E)
E/Emax -E
-1.7621045965
0.017294
-1.4033914754 0.03950104
-0.8168097533 0.15247205
0.0820643941 1.20799293
0.5974602311 3.95785821
0.9484825512 8.88142292
1.2538077668 17.9393939

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
1000
1300
1500
2000
2300
2600
3000
6419

DE(50)= 0.17575
Log (E/Emax-E)
E/Emax -E
-2.1842545148 0.00654253

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
0.07

-1.0308865612
-0.2457360689
-0.0187644402
0.3299563255
0.7622478448
1.5982476442

0.09313511
0.56788962
0.95771339
2.1377471
5.78426052
39.6504065

Rocorium
DE(50)=
Log (E/Emax-E)
E/Emax -E
-0.7367867068 0.18332145
-0.4209462719 0.37936191
-0.2357170958 0.58114286
-0.0252245253 0.94357293
0.2686958391 1.85650379
0.7399918146 5.49530516
1.1021921532 12.6529605

Succinil colina
DE(50)=
Log (E/Emax-E)

E/Emax -E

0.1
0.15
0.17
0.2
0.25
0.4
0.9

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
0.15
0.3
0.45
0.75
1.25
2.5
3.75
5

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)

-0.861586724
-0.8466890882
-0.4611548254
0.0445271458
0.2812859375
0.8625937702
1.6045330447

0.13753501
0.14233474
0.34581607
1.10796782
1.91111111
7.2877551
40.2284264

Hesperidina
DE(50)=
Log (E/Emax-E)
E/Emax -E
-1.050071539
-0.5454572478
-0.2803375281
0.0024617418
0.2678744252
0.5738076598
0.9940845334

Diacepam
DE[50]=1,995877
Log (E/Emax-E)
-1.193294902
-1.067399415
-0.975489873
-0.418844499
-0.222462254
0.243293452
0.493069718

E/Emax -E
0.06407743
0.0855625
0.10580596
0.38120229
0.59915301
1.75102946
3.11221591

0.1
0.15
0.3
0.75
1.25
2.5
3.75
5

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
1.5
3
5.5
12
25
50
90
142

Datos de la Curva Dosis-Respuesta de

Dosis (mg/kg)
0.5
0.9
1
1.5
1.8
2.3
2.8
5

Buspirona

e la Curva Dosis-Respuesta de Buspirona

Log Dosis
% Efecto
-2
1.19
-1.0458
8.28
-0.301
33.69
0.301
62.49
0.699
82.61
1
90.28
1.3979
97.26
1.7782
100
Difenhidramina

e la Curva Dosis-Respuesta de Difenhidramina

Log Dosis
% Efecto
0.6021
1.44
0.9031
9.17
1
16.55
1.1761
39.79
1.301
62.8
1.3979
76.17
1.6532
95.9
2
100

Etanol

e la Curva Dosis-Respuesta de Etanol

Log Dosis
% Efecto
3
1.7
3.1139
3.8
3.1761
13.23
3.301
54.71
3.3617
79.83
3.415
89.88
3.4771
94.72
3.8075
100

Rocuronium

e la Curva Dosis-Respuesta de Rocuronium

Log Dosis
% Efecto
-1.1549
0.65

-1
-0.8239
-0.7696
-0.699
-0.6021
-0.3979
-0.0458

8.52
36.22
48.92
68.13
85.26
97.54
100

e la Curva Dosis-Respuesta de Rolipram

Log Dosis
% Efecto
-0.8239
12.86
-0.5229
22.83
-0.3468
30.51
-0.1249
40.3
0.0969
53.95
0.3979
70.23
0.574
76.93
0.699
83.01

e la Curva Dosis-Respuesta de Succinilcolina

Log Dosis
% Efecto

-1
-0.8239
-0.5229
-0.1249
0.0969
0.3979
0.574
0.699

9.82
10.12
20.87
42.69
53.32
71.42
79.25
81.22

e la Curva Dosis-Respuesta de Hesperidina

Log Dosis
% Efecto
0.1761
9.4
0.4771
16.67
0.7404
29.84
1.0792
38.74
1.3979
47.82
1.699
60.58
1.9542
73.35
2.1523
74.36

de la Curva Dosis-Respuesta de Diacepam

Log Dosis
% Efecto
-0.301
5.23
-0.0458
6.85
0
8.31
0.1761
23.97
0.2553
32.54
0.3617
55.28
0.4472
65.73
0.699
86.85

Buspirona
120
f(x) = 30.5929734451x100
+ 52.4795342096
R = 0.9538347553
80
60

% Efecto

40
20
-2.5

-2

-1.5

-1

-0.5

0.5

1.5

Log Dsis

Difenhidramina
120
f(x) = 84.9113597638x - 56.2662046318
R = 0.9144146352

100
80

% Efecto

60
40
20
0
0.5

0.7

0.9

1.1

1.3

1.5

1.7

1.9

2.1

Log Dsis

Etanol
120
100

f(x) = 151.092449212x - 448.6364105166

R = 0.7908812323

80

% Efecto

60
40
20
0
2.9

3.05

3.2

3.35

3.5

3.65

3.8

Log Dsis

Rucoronium
f(x) = 102.5584411306x + 126.0767536023
R = 0.852226879

120
100
80

% Efecto

60
40
20

Rucoronium
120

f(x) = 102.5584411306x + 126.0767536023

R = 0.852226879

100
80
60

% Efecto

40
20
-1.4

-1.2

-1

-0.8

-0.6

-0.4

-0.2

Log Dsis

Etanol
100

f(x) = 277.7731843747x - 862.6972148799

R = 0.9735401198

80
60

% Efecto

40
20
0
3.05

3.1

3.15

3.2

3.25

3.3

3.35

3.4

3.45

3.5

Log Dsis

Rolipram
90
80

R = 0.9941283541

70
60
50
40
30
20
10

-1

-0.8

-0.6

-0.4

-0.2

0.2

Succinilcolina
90
R = 0.9863816889

80
70
60
50

0.4

0.6

0.8

Succinilcolina
90
80

R = 0.9863816889

70
60
50
40
30
20
10

-1.2

-1

-0.8

-0.6

-0.4

-0.2

0.2

0.4

0.6

0.8

Hesperidina
80
70

R = 0.9917187287

60
50
40
30
20
10
0

0.5

1.5

2.5

Diacepam
3.5
3
2.5

f(x) = - 0.0447941143x + 3.4952125242

R = 0.896237358

2
% Efecto

1.5
1
0.5
0
10

20

30

40

50
Log dosis

60

70

80

Buspirona
120
f(x) = 1.2466365997x + 43.4868856094
R = 0.4198763404

100

96

80
60

% Efecto

40
20
1

1.5

10

20

30

40

50

60

70

Dsis

Difenhidramina
120

f(x) = 0.9859852792x + 22.2501677033

R = 0.6370544617

100
80
60

% Efecto

40
20

1.7

1.9

2.1

20

40

60

80

100

120

Dsis

Etanol
120

66

f(x) = 0.018355951x + 8.5708277666

R = 0.5489385826

100
80

% Efecto

60
40
20
0

3.65

536023

3.8

1000

2000

3000

4000

5000

Dsis

Rocuronium
120

120

100

100

80

80

60

% Efecto

60

40

40

20

20

f(x) = 105.4274824081x + 26.1353049257

R = 0.5455505353

6000

7000

Rocuronium

536023

120

120

100

100

80

80

60

.4

-0.2

% Efecto

f(x) = 105.4274824081x + 26.1353049257

R = 0.5455505353

60

40

40

20

20

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

Dsis

Rocuronium
120
100

f(x) = 156.215963222x + 169.1911703551

R = 0.9451511222

80
60

% Efecto

40
20

.45

-1.1

3.5

-1

-0.9

-0.8

-0.7

-0.6

-0.5

-0.4

0
-0.3

Log Dsis

Rolipram
90
80
70
60
50
40
30
20
10
0
0.6

R = 0.8681274253

0.8

Succinilcolina
90
80
70
60
50

R = 0.8681274253

Succinilcolina
90
80
70
60
50
40
30
20
10
0

0.6

R = 0.8681274253

0.8

Hesperidina
160
140
120
100
80
60
40
20
0

R = 0.7647139499

10

20

30

40

50

70

80

f(x) = 20.0079267752x + 10.8399246512

R = 0.896237358

60
50

3.4952125242

sis

70

Diacepam

60

2.5

40
% Efecto

30
20
10

60

70

80

90

0
0

0.5

1.5
Dosis

2.5

50

Buspirona

Log (E/Emax-E)

60

2
1.5
f(x) = 0.9986798236x - 0.01534718
1
R = 0.9958807473
0.5
0
-2
-1.5
-1
-0.5 -0.50
0.5

-2.5

1.5

-1
-1.5
-2
-2.5

70

Log Dsis

Difenhidramina

Axis Title

100

120

2
1.5
1
0.5
0
0.4
-0.5
-1
-1.5
-2

f(x) = 3.0434953911x - 3.7231751028

R = 0.9985321511
0.6

0.8

1.2

1.4

1.6

1.8

Log Dsis

Etanol
1.5
1

f(x) = 6.8068422118x - 22.3716342631

R = 0.9872917096

0.5

Log (E/Emax-E)

0
2.9
-0.5

3.1

3.2

3.3

3.4

3.5

3.6

-1
-1.5
6000

7000

-2

Log Dsis

Rocuronium

f(x) = 4.8796378921x + 3.6845928118

R = 0.9871195573

Log (E/Emax-E)

-1.2

-1.1

-1

-0.9

-0.8

-0.7

-0.6

-0.5

2
1.5
1
0.5
0
-0.4 -0.5
-0.3
-1
-1.5

Rocuronium

f(x) = 4.8796378921x + 3.6845928118

R = 0.9871195573

Log (E/Emax-E)

0.8

0.9

-1.2

-1.1

-1

-0.9

-0.8

-0.7

-0.6

-0.5

2
1.5
1
0.5
0
-0.4 -0.5
-0.3
-1
-1.5
-2
-2.5

Log Dsis

120
100
80
60
40
20
-0.4

0
-0.3

Chart Title
1.5
1

R = 0.9829156087

0.5
-1

-0.8

-0.6

-0.4

-0.2

0.2

0.4

-0.5
-1
5

Column S

Linear (Column S)

Chart Title
1.5

R = 0.9829156087

1
0.5

0.6

0.8

Chart Title
1.5
1

R = 0.9829156087

0.5
-1

-0.8

-0.6

-0.4

-0.2

0.2

0.4

0.6

0.8

-0.5
5

-1

Column S

Linear (Column S)

Hesperidina
1.5
1
R = 0.9861951896

0.5
0

0.5

1.5

2.5

-0.5
70

-1

80

-1.5

cepam

Diacepam

12
10

x + 10.8399246512

8
Log (E/Emax-E
6
4

1.5
Dosis

2.5

3.5

2
0
10

20

f(x) =
R = 0

30

40

Log Dosis
50

60

1.5

.4

1.6

1.8

6342631

3.4

-0.5

3.5

3.6

2
1.5
1
0.5
0
-0.4 -0.5
-0.3
-1
-1.5

.6

-0.5

2
1.5
1
0.5
0
-0.4 -0.5
-0.3
-1
-1.5
-2
-2.5

0.8

.6

0.8

2.5

Diacepam

40

Log Dosis
50

60

70

80

90