West Visayas State University

COLLEGE OF NURSING
La Paz, Iloilo City

DRUG STUDY
Name of Patient:
Age:
Name of Drug
Generic:
methylergonovi
ne

Ward/Bed Number:
Dosage,
Route,
Frequency
and Timing
Dosage:

Route:

Brand:
methergine

Frequency:

Timing:

Classification

Attending Physician:
Impression/Diagnosis:

Mechanisms of
Action
Stimulates alphaadrenergic,
serotonin
receptors,
producing arterial
vasoconstriction.
Causes
vasospasm of
coronary
arteries. Directly
stimulates uterine
muscle.
Therapeutic
Effect: Increases
strength,
frequency of
uterine
contractions,
decreases uterine
bleeding.Rapidly
absorbed from GI
tract after IM
administration.
Distributed

Indication

Adverse
Reactions

Prevention/treat
ment of
postpartum,
postabortion
hemorrhage due
to atony,
involution (not
for induction,
augmentation
of labor).

Severe
hypertensive
episodes may
result
in CVA, serious
arrhythmias,
seizures.
Hypertensive
effects are more
frequent
with pt
susceptibility,
rapid IV
administration,
concurrent use of
regional
anesthesia,
vasoconstrictors.
Peripheral
ischemia
may lead to
gangrene.

Contraindication
s

Side Effects

Special
Precautions

Nursing Responsibilities

Contraindicated Determine baseline serum

during
calcium level, B/P, pulse.
pregnancy. Small Assess for any evidence of
amounts
bleeding before
distributed
administration.
in breast milk.
Monitor uterine tone,
bleeding, B/P, pulse
Assess extremities for
color, warmth,
movement,pain. Report
chest pain promptly.
Provide support with
ambulation if dizziness
occurs
Avoid smoking because of
added vasoconstriction.
Report increased
cramping,
bleeding, foul-smelling
lochia.
Report pale, cold
hands/feet (possibility of
diminished circulation)

Functional:
Oxytoxic agent,
uterine
stimulant.
Chemical:
Ergot alkaloid
rapidly to
plasma,
extracellular fluid,
tissues.
Metabolized
in liver,
undergoes firstpass
effect. Primarily
excreted in urine.
Students Name:
Clinical Instructor:

Hypertension,
pregnancy,
toxemia,
concurrent use
with
CYP3A4
inhibitors (e.g.,
protease
inhibitors).
Cautions:
Renal/hepatic
impairment,
cardiovascular
disease,
occlusive
peripheral
vascular
disease, sepsis,
second
stage of labor.

Frequent:
Nausea, uterine
cramping,
vomiting.
Occasional:
Abdominal pain,
diarrhea,
dizziness,
diaphoresis,
tinnitus,
bradycardia,
chest pain. Rare:
Allergic
reaction (rash,
pruritus),
dyspnea; severe
or sudden
hypertension.