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Fatty Acid Catabolism

Chapter 17

Tissue Fuel Stores for Average 70-kg Human


Fuel

p. 710

Weight
(g)

Energy Content
(kJ/g)

Total Energy
(kJ)

Triacylgycerols

~15,000

37

555,000

Protein

~6,000

17

100,000

Glycogen

~400

17

6,800

Glucose

~20

17

340

17.8

Mobilization and transfer of FA from adipose tissue

ATGL = adipose triglyceride lipase


HSL = hormone-sensitive lipase
MGL = monoacylglycerol lipase

17.13

Oxidation of Fatty Acids


Outline of oxidation process:
1, 2. Activation by formation of
CoA derivative
3. Transport into mitochondria via
carnitine carrier system
4. Oxidation by series of rxns in
which fatty acyl chain shortened
by 2C at a time = -oxidation.
Occurs exclusively in mito.

17.16

1. Activation

17.17

2. Transport into mitochondria

Inhibited by
Malonyl-CoA

17.18

3. Oxidation reactions

17.19

17.19
17.20

17.19

thiolase

Palmitoyl-CoA + 7Co-SH + 7FAD + 7NAD+


8 acetyl-CoA + 7FADH2 + 7NADH + 7H+

Reaction
Activation of palmitate to palmitoylCoA
Oxidation of 8 acetyl-CoA

-2
8 X 10 = 80

Oxidation of 7 FADH2

7 X 1.5 = 10.5

Oxidation of 7 NADH

7 X 2.5 = 17.5

Net: Palmitate CO2 + H2O

17.1

ATP Yield

106

p. 729

Oxidation of odd-chain FA
thiolase

17.22

Regulation of fatty acid oxidation is tightly coordinated with regulation


of fatty acid synthesis
ACC
(acetyl-CoA carboxylase)

17.36

17.18

Ketogenesis

Succinate

-Ketoacyl-CoA transferase
(missing in liver)

Succinyl-CoA
Ketone
bodies
17.24

Acetyl-CoA is key intermediate between fat and carbohydrate metabolism

17.25

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