Faculty of Pharmaceutical Sciences

Chulalongkorn University

FACULTY OF PHARMACEUTICAL SCIENCES

CHULALONGKORN UNIVERSITY
Department | Members | Research and Publication
Members:
Nuansri Niwattisaiwong
(Assoc. Prof.)
Pornchai Rojsitthisak
(Assoc. Prof. Dr.)
Warangkana Warisnoicharoen
(Assoc. Prof. Dr.)
Linna Tongyonk
(Assist. Prof. Dr.)
Suyanee Pongthananikorn
(Assist. Prof. Dr.)
Kulwara Meksawan
(Assist. Prof. Dr.)
Bodin Tuesuwan
(Assist. Prof. Dr.)
Vorasit Vongsutilers
(Dr.)
Rossarin Tansawat
(Dr.)
Tippawan Siritientong
(Dr.)
Chalada Suebsuwong
Patthanachai Limpikirati

Department of Food and

Pharmaceutical Chemistry
The Department of Food and Pharmaceutical
Chemistry is an intellectual hub for high-quality
educational and research programs to educate our
students to develop ideas and solutions beyond the
obvious. Our faculties are not just instructors, they
stride to inspire our students to think analytically as
well as creatively. Our graduates are highly respected
and many are holding key positions in academics,
research institute, private industry as well as in
governmental policy making related functions. The
faculties are actively engaged in diverse topics of
researches as well as public services. In addition, our
location in the heart of Bangkok is very beneficial to
successful collaboration with government branches,
hospitals, private industry and foremost research in
institutions with regards to researches and regulations
in pharmaceutical industry.

Department of Food and Pharmaceutical Chemistry

Faculty of Pharmaceutical Sciences

Major Research Areas

Pharmaceutical Chemistry

Chulalongkorn University
The department oers various researches in the
area of pharmaceutical chemistry, food chemistry and
medical nutrition. In the field of pharmaceutical
chemistry, the researches include qualitative and
quantitative analysis, structural elucidation, molecular
mechanism of action as well as advanced topics in drug
discovery, computational-aided drug design and
synthesis and biological e valuation of active
compounds. Currently, we mainly focus on the design
of drugs targeted to DNA as well as analytical and
bioanalytical method development.

Design and synthesis of

G-quadruplex binding ligands
Design and synthesis of
prodrugs as anticancer agents
Design and development of ZDNA biosensor
Synthesis of modified
nucleosides and
oligonucleotides
Analysis of anticancer drugDNA interactions
Determination of
physicochemical and
biopharmaceutical properties
of bioactive compounds
Analytical and bioanalytical
method development and
Validation of bioactive
compounds

In the area of food chemistry and medical

nutrition, the researches include food chemistry, fooddrugs interrelation, food toxicology, human nutrient
requirements, metabolism and molecular mechanism
that govern health, as well as the role of nutrition in
prevention and treatment of diseases.

Food Chemistry and Medical

Nutrition
Immunomodulatory and
antiviral activities of natural
products
Lipase inhibitors from Thai
medicinal plants
Fibrinolytic bacterial enzymes
Antimutagenic activity from
natural products

Department of Food and Pharmaceutical Chemistry

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Publication: Pharmaceutical Chemistry

Kongrit J, Chinvarun Y, Niwattisaiwong N and Lawanprasert S (2014) Verification of using saliva as an alternative to serum for topiramate
monitoring. Thai Journal of Pharmaceutical Sciences 38:61-66.
Train BC, Bilgesu SA, Despeaux EC, Vongsutilers V and Gannett PM (2014) Single C8-arylguanine modifications render oligonucleotides in
the Z-DNA conformation under physiological conditions. Chemical Research in Toxicology 27:1176-1186.
Romero RM, Rojsitthisak P and Haworth IS (2013) Electrophoretic mobility of duplex DNA crosslinked by mechlorethamine at a cytosinecytosine mismatch pair. Electrophoresis 34:917-924
Anannarukan N, Niwattisaiwong N, Warisnoicharoen W, Winitthana T, Pramyothin P, Chaichantipyuth C and Lawanprasert S (2012)
Inhibition of human cytochrome P450 in vitro by Phyllanthus amarus and Phyllanthus emblica aqueous extracts. Thai Journal of Pharmaceutical
Sciences 36:135-143.
Kongkamnerd J, Cappelletti L, Prandi A, Seneci P, Rungrotmongkol T, Jongaroonngamsang N, Rojsitthisak P, Frecer V, Milani A, Cattoli G,
Terregino C, Capua I, Beneduce L, Gallotta A, Pengo P, Fassina G, Miertus S and De-Eknamkul W (2012) Synthesis and in vitro study of
novel neuraminidase inhibitors against avian influenza virus. Bioorganic and Medicinal Chemistry 20:2152-2157.
Seeka P, Niwattisaiwong N, Warisnoicharoen W, Winitthana T, Tantisira MH and Lawanprasert S (2012) Eects of the standardized extract
of Centella asiatica ECa233 on human cytochrome P450. Thai Journal of Pharmaceutical Sciences 36:30-37.
Lertsutthiwong P, Haworth IS and Rojsitthisak P (2011) Alginate: A promising polysaccharide for delivery of essential oils, in Handbook of
Carbohydrate Polymers: Development, Properties and Applications pp 621-638.
Lertsutthiwong P and Rojsitthisak P (2011) Chitosan-alginate nanocapsules for encapsulation of turmeric oil. Pharmazie 66:911-915.
Rojsitthisak P, Jongaroonngamsang N, Romero RM and Haworth IS (2011) HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the
mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. PLoS ONE 6.
Rungphanichkul N, Nimmannit U, Muangsiri W and Rojsitthisak P (2011) Preparation of curcuminoid niosomes for enhancement of skin
permeation. Pharmazie 66:570-575.
Warisnoicharoen W, Hongpiticharoen P and Lawanprasert S (2011) Alteration in enzymatic function of human cytochrome P450 by silver
nanoparticles. Research Journal of Environmental Toxicology 5:58-64.
Wichitnithad W, Nimmannit U, Callery PS and Rojsitthisak P (2011) Eects of dierent carboxylic ester spacers on chemical stability, release
characteristics, and anticancer activity of mono-PEGylated curcumin conjugates. Journal of Pharmaceutical Sciences 100:5206-5218.
Wichitnithad W, Nimmannit U, Wacharasindhu S and Rojsitthisak P (2011) Synthesis, characterization and biological evaluation of succinate
prodrugs of curcuminoids for colon cancer treatment. Molecules 16:1888-1900.
Winitthana T, Niwattisaiwong N, Patarapanich C, Tantisira MH and Lawanprasert S (2011) In vitro inhibitory eects of asiaticoside and
madecassoside on human cytochrome P450. Toxicology in Vitro 25:890-896.
Thomsen NM, Vongsutilers V and Gannett PM (2011) The synthesis of C8-Aryl purines, nucleosides, and phosphoramidites. Critical
Reviews in Eukaryotic Gene Expression 21:155-176.
Vongsutilers V, Phillips DJ, Train BC, McKelvey GR, Thomsen NM, Shaughnessy KH, Lewis JP and Gannett PM (2011) The conformational
eect of para-substituted C8-arylguanine adducts on the B/Z-DNA equilibrium. Biophysical Chemistry 154:41-48.
Nusuk C, Patarapanich C and Tuesuwan B (2011) Development of Modified Extract and HPLC Analytical Method for Determination of
Rutin in Modified Extract of Longan seed. Isan J of Pharm. Sci. 7:15-21
Wongsrisakul J, Wichitnithad W, Rojsitthisak P and Towiwat P (2010) Antinociceptive eects of curcumin diethyl disuccinate in animal
models. Journal of Health Research 24:175-180
Jongaroonngamsang N, Romero RM, Haworth IS and Rojsitthisak P (2010) HPLC-UV determination of a mechlorethamine crosslink in a
DNA duplex containing a cytosine-cytosine mismatch pair. Journal of Health Research 24:155-160
Lertsutthiwong P, Rojsitthisak P and Nimmannit U (2009) Preparation of turmeric oil-loaded chitosan-alginate biopolymeric nanocapsules.
Materials Science and Engineering C 29:856-860.

Department of Food and Pharmaceutical Chemistry

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Wichitnithad W, Jongaroonngamsang N, Pummangura S and Rojsitthisak P (2009) A simple isocratic HPLC method for the simultaneous
determination of curcuminoids in commercial turmeric extracts. Phytochemical Analysis 20:314-319.
Vongsutilers V, Daft JR, Shaughnessy KH and Gannett PM (2009) A general synthesis of C8-arylpurine phosphoramidites vorasit
vongsutilers. Molecules 14:3339-3352.
Tuesuwan B, Phutong N and Pathipvanic M (2009) Comparative Study of Three Multiple Linear Regression Software Programs. Isan J of
Pharm. Sci. 5:131-139
Plyler J, Jasheway K, Tuesuwan B, Karr J, Brennan JS, Kerwin SM and David WM (2009) Real-time Investigation of SV40 Large T-antigen
Helicase Activity Using Surface Plasmon Resonance. Cell biochem Biophys. 53:43-52

Department of Food and Pharmaceutical Chemistry

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Publication: Food Chemistry and Medical Nutrition

Brogna DMR,Tansawat R, Cornforth D, Ward R, Bella M, Luciano G, Priolo A and Villalba J (2014) The quality of meat from sheep
treated with tannin- and saponin-based remedies as a natural strategy for parasite control.Meat Science 96: 744749.

Maughan B, Provenza FD,Tansawat R, Maughan C, Martini S, Ward R, Clemensen A, Song X, Cornforth D and Villalba JJ (2014)
Importance of grass-legume choices on cattle grazing behavior, performance, and meat characteristics. Journal of Animal Science 92:
2309-2324.
Meksawan K, Sermsri U and Chanvorachote P (2014) Zinc supplementation improves anticancer activity of monocytes in type-2 diabetic
patients with metabolic syndrome. Anticancer research 34:295-299.
Siritientong T, Angspatt A, Ratanavaraporn J and Aramwit P (2014) Clinical potential of a silk sericin-releasing bioactive wound dressing for
the treatment of split-thickness skin graft donor sites. Pharmaceutical Research 31:104-116.
Kongsuwan C and Warisnoicharoen W (2013) Particle size characteristics of gold nanoparticles. Thai Journal of Pharmaceutical Sciences
38:229-233.
Siritientong T, Ratanavaraporn J, Srichana T and Aramwit P (2013) Preliminary characterization of genipin-cross-linked silk sericin/poly(vinyl
alcohol) films as two-dimensional wound dressings for the healing of superficial wounds. BioMed Research International 2013.
Wasutrasawat P, Al-Obaidi H, Gaisford S, Lawrence MJ and Warisnoicharoen W (2013) Drug solubilisation in lipid nanoparticles containing
high melting point triglycerides. European Journal of Pharmaceutics and Biopharmaceutics 85:365-371.
Aramwit P, Siritientong T and Srichana T (2012) Potential applications of silk sericin, a natural protein from textile industry by-products.
Waste Management and Research 30:217-224.
Chalothorn K and Warisnoicharoen W (2012) Ultrasonic emulsification of whey protein isolate-stabilized nanoemulsions containing omega-3
oil from plant seed. American Journal of Food Technology 7:532-541.
Lohaphansomboon P, Chanvorachote P and Warisnoicharoen W (2012) Cytotoxicity of gold nanoparticles in human IMR-32 neuroblastoma
cells. Thai Journal of Pharmaceutical Sciences 36:62-65.
Siritientong T and Aramwit P (2012) A novel silk sericin/poly (vinyl alcohol) composite film crosslinked with genipin: Fabrication and
characterization for tissue engineering applications, in Advanced Materials Research pp 359-362.
Kulnawan N, Jiamjarasrangsi W, Suwanwalaikorn S, Kittisopee T, Meksawan K, Thadpitakkul N and Mongkung K (2011) Development of
diabetes telephone-linked care system for self-management support and acceptability test among type 2 diabetic patients. Journal of the
Medical Association of Thailand 94:1189-1197.
Pendergast DR, Meksawan K, Limprasertkul A and Fisher NM (2011) Influence of exercise on nutritional requirements. European Journal of
Applied Physiology 111:379-390.
Siritientong T, Srichana T and Aramwit P (2011) The eect of sterilization methods on the physical properties of silk sericin scaolds. AAPS
PharmSciTech 12:771-781.
Wangcharoenrung L and Warisnoicharoen W (2011) Change in mRNA expression of human cytochrome P450 by gold nanoparticles. Journal
of Biological Sciences 11:173-180.
Aramwit P, Siritientong T, Kanokpanont S and Srichana T (2010) Formulation and characterization of silk sericin-PVA scaold crosslinked
with genipin. International Journal of Biological Macromolecules 47:668-675.
Kittichanun C, Phivthong-ngam L, Niwattisaiwong N, Piyachaturawat P, Suksamran A, Apipalakul K and Lawanprasert S (2010) Eects of
Curcuma comosa extracts on hepatic cytochrome P450 activities in rats. Journal of Health Research 24:1-6.
Sap-Lam N, Homklinchan C, Larpudomlert R, Warisnoicharoen W, Sereemaspun A and Dubas ST (2010) UV irradiation-induced silver
nanoparticles as mosquito larvicides. Journal of Applied Sciences 10:3132-3136.
Soisuwan S, Warisnoicharoen W, Lirdprapamongkol K and Svasti J (2010) Eco-friendly synthesis of fucoidan-stabilized gold nanoparticles.
American Journal of Applied Sciences 7:1038-1042.

Department of Food and Pharmaceutical Chemistry

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Sritularak B, Tantituvanont A, Chanvorachote P, Meksawan K, Miyamoto T, Kohno Y and Likhitwitayawuid K (2010) Flavonoids with free
radical scavenging activity and nitric oxide inhibitory eect from the stem bark of Artocarpus gomezianus. Journal of Medicinal Plants
Research 4:387-392.
Sumpavapol P, Tongyonk L, Tanasupawat S, Chokesajjawatee N, Luxananil P and Visessanguan W (2010) Bacillus siamensis sp. nov., isolated
from salted crab (poo-khem) in Thailand. International Journal of Systematic and Evolutionary Microbiology 60:2364-2370.
Wongwattanasathien O, Kangsadalampai K and Tongyonk L (2010) Antimutagenicity of some flowers grown in Thailand. Food and
Chemical Toxicology 48:1045-1051.
Kulthong K, Tantisira MH, Niwattisaiwong N, Apipalakul K, Chevapat S and Lawanprasert S (2009) Eects of the standard extract of
Centella asiatica (ECa233) on rat hepatic cytochrome P450. Thai Journal of Pharmaceutical Sciences 33:91-100.
Plyler J, Jasheway K, Tuesuwan B, Karr J, Brennan JS, Kerwin SM and David WM (2009) Real-time investigation of SV40 large T-antigen
helicase activity using surface plasmon resonance. Cell Biochemistry and Biophysics 53:43-52.
Warisnoicharoen W and Wangcharoenrung L (2009) Disorder of Cytochrome P450 expression is inducible by gold nanoparticles? Bioscience
Hypotheses 2:184-185.

Department of Food and Pharmaceutical Chemistry