Faculty of Pharmaceutical Sciences

Chulalongkorn University

FACULTY OF PHARMACEUTICAL SCIENCES

CHULALONGKORN UNIVERSITY
Department | Members | Research and Publication
Members:
Somsong Lawanprasert
(Assoc. Prof. Dr.)
Thongchai Sooksawate
(Assoc. Prof. Dr.)
Pithi Chanvorachote
(Assoc. Prof. Dr.)
Pornpimol Kijsanayotin
(Assist. Prof.)
Suree Jianmongkol
(Assist. Prof. Dr.)
Rataya Luechapudiporn
(Assist. Prof. Dr.)
Pasarapa Towiwat
(Assist. Prof. Dr.)
Santad Chanprapaph
(Dr.)
Pisit Khemawut
(Dr.)
Ratchanee Rodsiri
(Dr.)
Varisa Pongrakhananon
(Dr.)
Supannikar Tawinwung
(Dr.)
Visarut Buranasudja

Department of Pharmacology
and Physiology
The Department of Pharmacology and
Physiology is a workplace where three major
disciplines, Physiology, Pharmacology and Toxicology,
combine into a solid companionship. The Department
is responsible for the education of Pharm.D. and
graduate students with an attempt to bridge these
three disciplines with others. Based on the facultys
expertise in both basic and applied research, the
Department research emphasizes two dimensions of
research, basic research and translational research.
Basic and applied researches in physiology and
pharmacology exemplify an interest in molecular
mechanism of cell signaling with an emphasis on
protein expression, modification, and function. Areas
of research include the expression and functional
anal ysis of proteins involving with in cancer
metastasis, chemotherapeutic resistance, anoikis,
cancer progression, stem cell differentiation,
antioxidant mechanism and ROS regulation.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Major Research Areas

Laboratory of molecular and
cellular Physiology (cancer
research, stem cell research,
ROS research)
Bioenergetic research
laboratory
Cellular drug transporter
research laboratory
Drug metabolism research
laboratory
Oxidative stress, lipid and
platelet research laboratory
Neuropharmacology research
laboratory
Neurodegenerative research
laboratory
Pain research laboratory
Silkworm research laboratory
Immunopharmacology
research laboratory

Chulalongkorn University
Translational research will emphasize in both
directions; from benchtop to bedside and from
bedside to benchtop. Pharmacological and
toxicological research will bring real life, bedside
problems into a benchtop research questions and try
to translate the results back to explain or solve clinical
problems. For instance, pharmacogenomics research
wil l tr y to translate genetic and nongenetic
involvement in order to advance current
pharmacotherapy, with the ultimate goal to improve
drug ecacy and safety. Drug metabolism and drug
transporter research emphasizing on cellular eect of
xenobiotics, will provide putative mechanism to
explain or predict therapeutic drug interactices or
drug resistance.
We a r e o n e o f t h e l e a d i n g g r o u p s i n
neuroscience research in Thailand. The research
interests include molecular, cellular, and behavioral
approaches to ner vous system functions, with
particular emphasis on problems relating to pain and
neurosensor y systems, learning, memor y, and
co g n i t i o n , a n x i e t y a n d d e p r e s s i o n , e p i l e p s y,
neurodegenerative disorders, and drug addiction.
These research areas involve a wide range of
methodology, e.g., molecular genetics, cell culture
techniques, neuroanatomical and electrophysiological
techniques, and animal behavioral models.
Research and development of Thai traditional
medicine and synthetic compounds, on the other
hand, facilitate the translation of basic drug discovery
into improved patient care. Recently, in collaboration
with other researchers, we have established the
standardized extract of Centella asiatica ECa 233, with
proofs of its preclinical pharmacological activity and
safety. Subsequent clinical trial on aphthous ulcers (a
type of oral ulcer) clearly demonstrated its ecacy and
safety in patients. Information gained from our
research is now translated into products that will be
commercially available soon.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Major Research Areas

Pharmacogenomics research
laboratory
Preclinical and clinical
evaluation of Thai tradition
medicine laboratory
Preclinical pharmacokinetics
research laboratory
Toxicological research
laboratory

Chulalongkorn University
Another research projects that we and
collaborative researchers had done in recent years id
Development of Herbal Extract for Treatment of
CNS Stimulant addicts. We discovered the semipurified extracts from a Thai herbal plant with
remarked antidepressant property and anti-addictive
property against amphetamines, in experimental
animals. Currently, the collaborative research is
undergoing to validate their ecacy and safety, and to
translate these finding into clinical practice.
The Department of Pharmacology and
Physiology puts more eort to translate research from
ba sic disco ver y to impro ved patient care by
establishing Strategic Research Unit of preclinical
Ecacy and Safety Assessment, a division of the
Project of Chulalongkorn University Drug & Health
Products Innovation & Promotion Center. The
strategic themes of this particular research unit
include (1) Building research capacity to translate
biomedical research into clinical practice; (2)
Establishing animal models to advance translational
research; (3) Establishing technologies to advance
translational research; (4) Building the research
workforce in drug development; and (5) Creating
partnerships to maximize research investments.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Publication
Aphichartphunkawee S, Chinvarun Y and Kijsanayotin P (2014) Association of genetic variants in UGT1A6 genes and non-genetic variant
with valproic acid doses and plasma concentration in Thai epileptic patients. Thai Journal of Pharmaceutical Sciences 38:98-105.
Boonyarikpunchai W, Sukrong S and Towiwat P (2014) Antinociceptive and anti-inflammatory eects of rosmarinic acid isolated from
Thunbergia laurifolia Lindl. Pharmacology Biochemistry and Behavior 124:67-73.
Chanvorachote P, Chunhacha P and Pongrakhananon V (2014) Caveolin-1 induces lamellipodia formation via an Akt-dependent pathway.
Cancer Cell International 14.
Chanvorachote P, Pongrakhananon V and Chunhacha P (2014) Prolonged nitric oxide exposure enhances anoikis resistance and migration
through epithelial-mesenchymal transition and caveolin-1 upregulation. BioMed Research International 2014.
Chaotham C, Pongrakhananon V, Sritularak B and Chanvorachote P (2014) A Bibenzyl from Dendrobium ellipsophyllum inhibits epithelialto-mesenchymal transition and sensitizes lung cancer cells to anoikis. Anticancer research 34:1931-1938.
Charoenrungruang S, Chanvorachote P, Sritularak B and Pongrakhananon V (2014) Gigantol, a bibenzyl from Dendrobium draconis, inhibits
the migratory behavior of non-small cell lung cancer cells. Journal of Natural Products 77:1359-1366.
Charoenrungruang S, Chanvorachote P, Sritularak B and Pongrakhananon V (2014) Gigantol-induced apoptosis in lung cancer cell through
mitochondrial-dependent pathway. Thai Journal of Pharmaceutical Sciences 38:67-73.
Kongrit J, Chinvarun Y, Niwattisaiwong N and Lawanprasert S (2014) Verification of using saliva as an alternative to serum for topiramate
monitoring. Thai Journal of Pharmaceutical Sciences 38:61-66.
Meksawan K, Sermsri U and Chanvorachote P (2014) Zinc supplementation improves anticancer activity of monocytes in type-2 diabetic
patients with metabolic syndrome. Anticancer research 34:295-299.
Pongrakhananon V, Stueckle TA, Wang HYL, O'Doherty GA, Dinu CZ, Chanvorachote P and Rojanasakul Y (2014) Monosaccharide
digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation. Biochemical
Pharmacology 88:23-35.
Powan P and Chanvorachote P (2014) Nitric oxide mediates cell aggregation and mesenchymal to epithelial transition in anoikis-resistant
lung cancer cells. Molecular and Cellular Biochemistry 393:237-245.
Ruanghirun T, Pongrakhananon V and Chanvorachote P (2014) Ouabain enhances lung cancer cell detachment. Anticancer research
34:2231-2238.
Suwannasual U, Pengsuparp T and Luechapudiporn R (2014) Protective eect of deferiprone on 7-ketocholesterol formation in hemininduced LDL oxidation. Thai Journal of Pharmaceutical Sciences 38:14-20.
Wongvaranon P, Pongrakhananon V and Chanvorachote P (2014) Molecular mechanisms of chemotherapeutic resistance in lung cancer. Thai
Journal of Pharmaceutical Sciences 38:1-4.
Aramwit P, Towiwat P and Srichana T (2013) An investigation of the anti-inflammatory potential of silk sericin. Advanced Science Letters
19:3615-3619.
Aramwit P, Towiwat P and Srichana T (2013) Anti-inflammatory potential of silk sericin. Natural Product Communications 8:501-504.
Buathet K, Chinvarun Y, Towanabut S and Kijsanayotin P (2013) Association of ABCB1 polymorphism with lamotrigine-resistant epilepsy in
Thais. Thai Journal of Pharmaceutical Sciences 37:146-151.
Chairuangkitti P, Lawanprasert S, Roytrakul S, Aueviriyavit S, Phummiratch D, Kulthong K, Chanvorachote P and Maniratanachote R (2013)
Silver nanoparticles induce toxicity in A549 cells via ROS-dependent and ROS-independent pathways. Toxicology in vitro : an international
journal published in association with BIBRA 27:330-338.
Chanvorachote P and Chunhacha P (2013) Caveolin-1 Regulates Endothelial Adhesion of Lung Cancer Cells via Reactive Oxygen SpeciesDependent Mechanism. PLoS ONE 8.
Chanvorachote P, Kowitdamrong A, Ruanghirun T, Sritularak B, Mungmee C and Likhitwitayawuid K (2013) Anti-metastatic activities of
bibenzyls from Dendrobium pulchellum. Natural Product Communications 8:115-118.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Chanvorachote P and Pongrakhananon V (2013) Ouabain downregulates Mcl-1 and sensitizes lung cancer cells to TRAIL-induced apoptosis.
American Journal of Physiology - Cell Physiology 304:C263-C272.
Chaotham C, De-Eknamkul W and Chanvorachote P (2013) Protective eect of plaunotol against doxorubicin-induced renal cell death.
Journal of Natural Medicines 67:311-319.
Cheun-Arom T, Chanvorachote P, Sirimangkalakitti N, Chuanasa T, Saito N, Abe I and Suwanborirux K (2013) Replacement of a quinone by
a 5- O -Acetylhydroquinone abolishes the accidental necrosis inducing eect while preserving the apoptosis-inducing eect of renieramycin
M on lung cancer cells. Journal of Natural Products 76:1468-1474.
Choochuay K, Chunhacha P, Pongrakhananon V, Luechapudiporn R and Chanvorachote P (2013) Imperatorin sensitizes anoikis and inhibits
anchorage-independent growth of lung cancer cells. Journal of Natural Medicines 67:599-606.
Chunhacha P, Sriuranpong V and Chanvorachote P (2013) Epithelial-mesenchymal transition mediates anoikis resistance and enhances
invasion in pleural eusion-derived human lung cancer cells. Oncology Letters 5:1043-1047.
Dhumrongvaraporn A and Chanvorachote P (2013) Kinetics of ultraviolet B irradiation-mediated reactive oxygen species generation in
human keratinocytes. Journal of cosmetic science 64:207-217.
Kowitdamrong A, Chanvorachote P, Sritularak B and Pongrakhananon V (2013) Moscatilin inhibits lung cancer cell motility and invasion via
suppression of endogenous reactive oxygen species. BioMed Research International 2013.
Luanpitpong S, Chanvorachote P, Stehlik C, Tse W, Callery PS, Wang L and Rojanasakul Y (2013) Regulation of apoptosis by Bcl-2 cysteine
oxidation in human lung epithelial cells. Molecular Biology of the Cell 24:858-869.
Nisimaru N, Mittal C, Shirai Y, Sooksawate T, Anandaraj P, Hashikawa T, Nagao S, Arata A, Sakurai T, Yamamoto M and Ito M (2013)
Orexin-neuromodulated cerebellar circuit controls redistribution of arterial blood flows for defense behavior in rabbits. Proceedings of the
National Academy of Sciences of the United States of America 110:14124-14131.
Phattanarudee S, Towiwat P, Maher TJ and Ally A (2013) Eects of medullary administration of a nitric oxide precursor on cardiovascular
responses and neurotransmission during static exercise following ischemic stroke. Canadian Journal of Physiology and Pharmacology
91:510-520.
Plaibua K, Pongrakhananon V, Chunhacha P, Sritularak B and Chanvorachote P (2013) Eects of artonin e on migration and invasion
capabilities of human lung cancer cells. Anticancer Research 33:3079-3088.
Pongrakhananon V, Chunhacha P and Chanvorachote P (2013) Ouabain Suppresses the Migratory Behavior of Lung Cancer Cells. PLoS
ONE 8.
Powan P, Saito N, Suwanborirux K and Chanvorachote P (2013) Ecteinascidin 770, a tetrahydroisoquinoline alkaloid, sensitizes human lung
cancer cells to anoikis. Anticancer Research 33:505-512.
Sanuphan A, Chunhacha P, Pongrakhananon V and Chanvorachote P (2013) Long-term nitric oxide exposure enhances lung cancer cell
migration. BioMed Research International 2013.
Sooksawate T, Isa K, Matsui R, Kato S, Kinoshita M, Kobayashi K, Watanabe D, Kobayashi K and Isa T (2013) Viral vector-mediated
selective and reversible blockade of the pathway for visual orienting in mice. Frontiers in Neural Circuits 7.
Sukhaphirom N, Vardhanabhuti N, Chirdchupunseree H, Pramyothin P and Jianmongkol S (2013) Phyllanthin and hypophyllanthin inhibit
function of P-gp but not MRP2 in Caco-2 cells. Journal of Pharmacy and Pharmacology 65:292-299.
Sukketsiri W, Porntadavity S, Phivthong-ngam L and Lawanprasert S (2013) Lead inhibits paraoxonase 2 but not paraoxonase 1 activity in
human hepatoma HepG2 cells. Journal of Applied Toxicology 33:631-637.
Towiwat P, Phattanarudee S and Maher TJ (2013) Comparative study of equimolar doses of gamma-hydroxybutyrate (GHB), 1,4-butanediol
(1,4-BD) and gamma-butyrolactone (GBL) on catalepsy after acute and chronic administration. Food and Chemical Toxicology 51:337-342.
Wanakhachornkrai O, Pongrakhananon V, Chunhacha P, Wanasuntronwong A, Vattanajun A, Tantisira B, Chanvorachote P and Tantisira
MH (2013) Neuritogenic eect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells. BMC Complementary
and Alternative Medicine 13.
Wongvaranon P, Pongrakhananon V, Chunhacha P and Chanvorachote P (2013) Acquired resistance to chemotherapy in lung cancer cells
mediated by prolonged nitric oxide exposure. Anticancer Research 33:5433-5444.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Wongwanakul R, Vardhanabhuti N, Siripong P and Jianmongkol S (2013) Eects of rhinacanthin-C on function and expression of drug eux
transporters in Caco-2 cells. Fitoterapia 89:80-85.
Anannarukan N, Niwattisaiwong N, Warisnoicharoen W, Winitthana T, Pramyothin P, Chaichantipyuth C and Lawanprasert S (2012)
Inhibition of human cytochrome P450 in vitro by Phyllanthus amarus and Phyllanthus emblica aqueous extracts. Thai Journal of
Pharmaceutical Sciences 36:135-143.
Chanvorachote P, Luanpitpong S, Chunhacha P, Promden W and Sriuranpong V (2012) Expression of CA125 and cisplatin susceptibility of
pleural eusion-derived human lung cancer cells from a Thai patient. Oncology Letters 4:252-256.
Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C and Jirawatnotai S (2012) Curcumin extract for prevention of
type 2 diabetes. Diabetes Care 35:2121-2127.
Chuenkitiyanon S, Vardhanabhuti N and Jianmongkol S (2012) A potential benefit of quercetin in preserving tight junction integrity. Journal
of Epithelial Biology and Pharmacology 5:28-31.
Chunhacha P and Chanvorachote P (2012) Roles of caveolin-1 on anoikis resistance in non small cell lung cancer. International Journal of
Physiology, Pathophysiology and Pharmacology 4:149-155.
Chunhacha P, Pongrakhananon V, Rojanasakul Y and Chanvorachote P (2012) Caveolin-1 Regulates Mcl-1 Stability and Anoikis in Lung
Carcinoma Cells. American Journal of Physiology - Cell Physiology 302:C1284-C1292.
Halim H and Chanvorachote P (2012) Long-term hydrogen peroxide exposure potentiates anoikis resistance and anchorage-independent
growth in lung carcinoma cells. Cell Biology International 36:1055-1066.
Halim H, Luanpitpong S and Chanvorachote P (2012) Acquisition of anoikis resistance up-regulates caveolin-1 expression in human nonsmall cell lung cancer cells. Anticancer Research 32:1649-1658.
Lohaphansomboon P, Chanvorachote P and Warisnoicharoen W (2012) Cytotoxicity of gold nanoparticles in human IMR-32 neuroblastoma
cells. Thai Journal of Pharmaceutical Sciences 36:62-65.
Luanpitpong S, Chanvorachote P, Nimmannit U, Leonard SS, Stehlik C, Wang L and Rojanasakul Y (2012) Mitochondrial superoxide
mediates doxorubicin-induced keratinocyte apoptosis through oxidative modification of ERK and Bcl-2 ubiquitination. Biochemical
Pharmacology 83:1643-1654.
Seeka P, Niwattisaiwong N, Warisnoicharoen W, Winitthana T, Tantisira MH and Lawanprasert S (2012) Eects of the standardized extract
of Centella asiatica ECa233 on human cytochrome P450. Thai Journal of Pharmaceutical Sciences 36:30-37.
Sirichanchuen B, Pengsuparp T and Chanvorachote P (2012) Long-term Cisplatin exposure impairs autophagy and causes cisplatin resistance
in human lung cancer cells. Molecular and Cellular Biochemistry 364:11-18.
Songserm T, Pongrakhananon V and Chanvorachote P (2012) Sub-toxic cisplatin mediates anoikis resistance through hydrogen peroxideinduced caveolin-1 up-regulation in non-small cell lung cancer cells. Anticancer Research 32:1659-1670.
Sooksawate T, Yanagawa Y and Isa T (2012) Cholinergic responses in gabaergic and non-gabaergic neurons in the intermediate gray layer of
mouse superior colliculus. European Journal of Neuroscience 36:2440-2451.
Suchaoin W and Chanvorachote P (2012) Caveolin-1 attenuates hydrogen peroxide-induced oxidative damage to lung carcinoma cells.
Anticancer Research 32:483-490.
Tuanthaisong K, Chinvarun Y, Tantisira MH and Kijsanayotin P (2012) Influence of EPHX1 polymorphism and clinical factors on
carbamazepine resistant epilepsy. Thai Journal of Pharmaceutical Sciences 36:24-29.
Wongpankam E, Chunhacha P, Pongrakhananon V, Sritularak B and Chanvorachote P (2012) Artonin E mediates MCL1 down-regulation and
sensitizes lung cancer cells to anoikis. Anticancer Research 32:5343-5351.
Charoenwanthanang P, Lawanprasert S, Phivthong-Ngam L, Piyachaturawat P, Sanvarinda Y and Porntadavity S (2011) Eects of Curcuma
comosa on the expression of atherosclerosis-related cytokine genes in rabbits fed a high-cholesterol diet. Journal of Ethnopharmacology
134:608-613.
Halim H, Chunhacha P, Suwanborirux K and Chanvorachote P (2011) Anticancer and antimetastatic activities of renieramyein M, a marine
tetrahydroisoquinoline alkaloid, in human non-small cell lung cancer cells. Anticancer Research 31:193-201.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Inchoo M, Chirdchupunseree H, Pramyothin P and Jianmongkol S (2011) Endothelium-independent eects of phyllanthin and
hypophyllanthin on vascular tension. Fitoterapia 82:1231-1236.
Luanpitpong S, Nimmannit U, Chanvorachote P, Leonard SS, Pongrakhananon V, Wang L and Rojanasakul Y (2011) Hydroxyl radical
mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism.
Apoptosis 16:769-782.
Luanpitpong S, Nimmannit U, Pongrakhananon V and Chanvorachote P (2011) Emblica (Phyllanthus emblica Linn.) fruit extract promotes
proliferation in dermal papilla cells of human hair follicle. Research Journal of Medicinal Plant 5:95-100.
Ninsontia C, Pongjit K, Chaotham C and Chanvorachote P (2011) Silymarin selectively protects human renal cells from cisplatin-induced
cell death. Pharmaceutical Biology 49:1082-1090.
Pongjit K and Chanvorachote P (2011) Caveolin-1 sensitizes cisplatin-induced lung cancer cell apoptosis via superoxide anion-dependent
mechanism. Molecular and Cellular Biochemistry 358:365-373.
Pongjit K, Ninsontia C, Chaotham C and Chanvorachote P (2011) Protective eect of Glycine max and Chrysanthemum indicum extracts
against cisplatin-induced renal epithelial cell death. Human and Experimental Toxicology 30:1931-1944.
Rungtabnapa P, Nimmannit U, Halim H, Rojanasakul Y and Chanvorachote P (2011) Hydrogen peroxide inhibits non-small cell lung cancer
cell anoikis through the inhibition of caveolin-1 degradation. American Journal of Physiology - Cell Physiology 300:C235-C245.
Sooksawate T, Isa K, Behan M, Yanagawa Y and Isa T (2011) Organization of GABAergic inhibition in the motor output layer of the superior
colliculus. European Journal of Neuroscience 33:421-432.
Warisnoicharoen W, Hongpiticharoen P and Lawanprasert S (2011) Alteration in enzymatic function of human cytochrome P450 by silver
nanoparticles. Research Journal of Environmental Toxicology 5:58-64.
Winitthana T, Niwattisaiwong N, Patarapanich C, Tantisira MH and Lawanprasert S (2011) In vitro inhibitory eects of asiaticoside and
madecassoside on human cytochrome P450. Toxicology in Vitro 25:890-896.
Wongtongtair S, Chanvorachote P, Hutamekalin P, Chaichantipyuth C, Lipipun V, Tiensiwakul P and Meksuriyen D (2011) Barakol-induced
apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. Journal of Ethnopharmacology 137:971-978.
Chomchuen S, Singharachai C, Ruangrungsi N and Towiwat P (2010) Antipyretic eect of the ethanolic extract of Ficus racemosa root in
rats. Journal of Health Research 24:23-29.
Chuenkitiyanon S, Pengsuparp T and Jianmongkol S (2010) Protective eect of quercetin on hydrogen peroxide-induced tight junction
disruption. International Journal of Toxicology 29:418-424.
Jongchanapong A, Singharachai C, Palanuvej C, Ruangrungsi N and Towiwat P (2010) Antipyretic and antinociceptive eects Of Ben-ChaLo-Ka-Wi-Chian remedy. Journal of Health Research 24:15-22.
Kittichanun C, Phivthong-ngam L, Niwattisaiwong N, Piyachaturawat P, Suksamran A, Apipalakul K and Lawanprasert S (2010) Eects of
Curcuma comosa extracts on hepatic cytochrome P450 activities in rats. Journal of Health Research 24:1-6.
Luanpitpong S, Talbott SJ, Rojanasakul Y, Nimmannit U, Pongrakhananon V, Wang L and Chanvorachote P (2010) Regulation of lung cancer
cell migration and invasion by reactive oxygen species and caveolin-1. Journal of Biological Chemistry 285:38832-38840.
Pongrakhananon V, Nimmannit U, Luanpitpong S, Rojanasakul Y and Chanvorachote P (2010) Curcumin sensitizes non-small cell lung
cancer cell anoikis through reactive oxygen species-mediated Bcl-2 downregulation. Apoptosis 15:574-585.
Sritularak B, Tantituvanont A, Chanvorachote P, Meksawan K, Miyamoto T, Kohno Y and Likhitwitayawuid K (2010) Flavonoids with free
radical scavenging activity and nitric oxide inhibitory eect from the stem bark of Artocarpus gomezianus. Journal of Medicinal Plants
Research 4:387-392.
Tungtananuwat W and Lawanprasert S (2010) Fatal 4100; home-made kratom juice cocktail. Journal of Health Research 24:43-47.
Chanvorachote B, Nimmannit U, Muangsiri W and Kirsch L (2009) An evaluation of a fluorometric method for determining binding
parameters of drug-carrier complexes using mathematical models based on total drug concentration. Journal of Fluorescence 19:747-753.
Chanvorachote P, Nimmannit U, Lu Y, Talbott S, Jiang BH and Rojanasakul Y (2009) Nitric oxide regulates lung carcinoma cell anoikis
through inhibition of ubiquitin-proteasomal degradation of caveolin-1. Journal of Biological Chemistry 284:28476-28484.

Department of Pharmacology and Physiology

Faculty of Pharmaceutical Sciences

Chulalongkorn University

Chanvorachote P, Pongrakhananon V, Luanpitpong S, Chanvorachote B, Wannachaiyasit S and Nimmannit U (2009) Type I pro-collagen
promoting and anti-collagenase activities of Phyllanthus emblica extract in mouse fibroblasts. Journal of Cosmetic Science 60:395-403.
Chanvorachote P, Pongrakhananon V, Wannachaiyasit S, Luanpitpong S, Rojanasakul Y and Nimmannit U (2009) Curcumin sensitizes lung
cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation. Cancer Investigation 27:624-635.
Kulthong K, Tantisira MH, Niwattisaiwong N, Apipalakul K, Chevapat S and Lawanprasert S (2009) Eects of the standard extract of
Centella asiatica (ECa233) on rat hepatic cytochrome P450. Thai Journal of Pharmaceutical Sciences 33:91-100.

Department of Pharmacology and Physiology