Factors Effecting OUALITY And PURITY Of

By: Rahul Malik

December,2015

Introduction:
Crude drugs are the drugs which are obtained
from the natural sources like plants, animals,
minerals.
The quality of crude drug depends on

Endogenous
factors

Exogenous
factors

Quality
of
crude
drugs

Endogenus factors:
Endogenous or genetic factors which effects the
quality and purity of crude drugs from inside.

Endogenous factors
Mutation
Polyploidy
Hybridization
Selection

Mutation:
A mutation generally may cause the gene
to lose its function entirely or in part.

Polyploidy:
Cell nucleus contains chromosomes
more than its normal
complement of chromosomes.

Exogenus Factors:
Exogenous factors are those which effect the crude
drugs from outside 1. By difference in the environmental conditions.
2. Methods used in the collection.
3. Preparation storage of the crude drugs.

Climate and light,

Allelopathy,
Nutrition,
Enzyme activity,
Browning, Light,
Effect of
storage,
Preserving
procedure.

e.g. temperature,
rainfall, length of day
etc.

Latitude and
Altitude,
oxidation,
evaporation,
Parasites,
Racidification.

Exogenous
Factors

Living organisms constantly exerts an

influence upon each other.
It effects upon leaf
development, leaf shedding ,
mutation of the fruits
Spoilage of fats during storage is called
Rancidification.
New Compounds are formed which may
change the therapeutic value of the fat.

Effect of storage:
Chemical changes in the
crude drugs occur most
readily during storage
and the process is
known as Ageing.

This process destroy

therapeutic constituents.

Growth Inhibitors:
Natural Growth inhibitors affect
bud opening, seed germination and
development of dormancy.

Browning:
Many leaves and fruits become brown on
drying and storage. Due to Enzymatic and non-enzymatic reasons.
Presence of oxygen, elevated temperature.

Rahul

Malik