GRAM VE COCCI

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Neisseria SPP
-Gram Ve diplococci .
-Aerobic.
-acid produce by oxidation ofcarbohydrates.
-Neisseria spp not lactose fermentation.
-None motile, None spores.
-Oxidase +Ve
.
-optimal growth at 35-37C.
-poor survival at cool temperature.

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Neisseria gonorrhoeae
* Gr-ve diplococci(Kidney-shaped).
*Non sporing , Non motile cocci

Characteristics
*Usually non capsulate.
*Aerobic
*Fastidious(need complex media for growth.
Require cystine for growth.
* Obligate parasite of human urogenital tract.

Habitat
*Dies quickly outside human host but may remain viable
in pus for some times

Transmission

* Sexual contact.
*Direct contact.

.
.

* IgAase =Splits IgA(important in mucosal infections)

Pathogenesis

*Pili=Attachment to mucous tissues

*LPS=Damages mucosal cells (lyposacchride)

* Gonorrhoea
*Pelvic Inflammatory Disease

Diseases
*Urethritis
*Infant Eye Infection (Ophthalmia Neonatorum)

Laboratory
Identification

*Gr-ve diplococci (Kidney-shaped)

* Oxidase+Ve
*Catalase +Ve

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Neisseria meningitidis
*Gr-Ve diplococci (kidney-shaped).
* Non Sporing , Non Motile Cocci

Characteristics *capsulate cocci.

* Facultative anaerobic .
*has variable growth on nutrient agar.
*Human nasopharynx(10-25%).

Habitat
Transmission

*Dies quickly outside human host at room temp.

*Droplet spread.
* IgAase =Splits IgA(important in mucosal infections)
*Pili=Attachment to mucous tissues

Pathogenesis
*LPS=Damages mucosal cells (lyposacchride)
*capsule=Antiphagocytosis

Diseases

Meningitis(85% mortality rate when untreated)

Bacteremia.

*Gr-Ve diplococci(kidney-shaped) in CSF.

Laboratory
Identification

*Oxidase +Ve.
*Catalase +Ve
*oxidase glucose +maltose.

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GRAM VE COCCI

Medical Microbiology
Patrick Murray

..

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