PERAN GROWTH HORMONE,

TESTOSTERONE DALAM METABOLISME

DEPARTEMEN FISIOLOGI
FAKULTAS KEDOKTERAN USU

Growth hormone (somatotropin)

Synthesized and secreted by the anterior

pituitary

Secretion under circadian control

Stimulates insulin-like growth factors (IGFs)

from liver and other tissues

Secreted in adults and has metabolic effects

unrelated to growth

Growth hormone

Metabolic Actions of GH
Growth hormone has an important
function to increase blood glucose by
decreasing glucose uptake by muscle
GH enhancing breakdown of triglyceride
from adipose tissuefree fatty acid
Muscle use the mobilized fatty acid
instead of glucose as a metabolic fuel
Otherwise brain use only glucose as
metabolic fuel

Functions of GH
Stimulates IGF secretion
protein synthesis and growth
uptake of amino acids by liver and muscle
lipolysis in adipose tissuefatty acids in blood

glucose uptake by muscle blood glucose

Growth hormone

Factors influencing GH secretion :

amino acids in blood GH secretion
fatty acids in blood GH secretion
blood glucose GH secretion
Deep sleep, exercise, stress and hypoglycemia
influence GH secretion
Growth hormone-releasing hormone (GHRH)
stimulates GH secretion
Somatostatin inhibits GH secretion
Growth hormone

Growth hormone pathway

Growth hormone

Testosterone

Steroid Hormone

Major function :
Reproductive function on sprematogenesis
and secondary sex organ development
Other reproductive related effect
Development of sexual libido of puberty and
help maintain the sex drive in the adult male
Non reproductive action

Testosterone
It has a protein anabolic (synthesis) effect
Promote bone growth
Prevent further growth by sealing the
growing ends of the long bone (closing the
epiphyseal plate)
Contribute to the more muscular physique
of male and to pubertal growth spurt

Metabolic Action of Testosterone

Metabolic action of testosterone is protein
anabolism especially the growth of the accesory
sex organ and the kidney
Lipolytic actions
Testosterone affect insulin sensitivity
- Increase insidens of hypogonadism in
diabetes type 2
muscle mass, protein & RNA synthesis
glycogen accumulation in muscle

Summary
Hormon action in metabolic regulation
mostly to maintain blood glucose for brain
function.