Characteristics of Patients Referred to a Pediatric Infectious

Diseases Clinic With Unexplained Fever

Victoria A. Statler and Gary S. Marshall
Abstract
Background Older case series established diagnostic considerations for
children meeting a priori definitions of fever of unknown origin (FUO). No
recent study has examined the final diagnoses of children referred for
unexplained fever.
Methods This study was conducted with a retrospective chart review of
patients referred to a pediatric infectious diseases clinic from 2008
to 2012 for unexplained fever.
Results Sixty-nine of 221 patients were referred for prolonged
unexplained fever. Ten of these were not actually having fever, and 11 had
diagnoses that were readily apparent at the initial visit. The remaining 48
were classified as having FUO. The median duration of reported fever for
these patients was 30 days; 15 had a diagnosis made, 5 of which were
serious. None of the serious FUO diagnoses were infections. Of 152 patients
with recurrent unexplained fever, 92 had an intermittent fever
pattern, and most of these had sequential, self-limited viral illnesses or
no definitive diagnosis made. Twenty of the 60 patients with a periodic
fever pattern were diagnosed with periodic fever, aphthous stomatitis,
pharyngitis, and adenitis syndrome. Overall, 166 patients either were
not having fever, had self-limited illnesses, or ultimately had no cause of
fever discovered. Only 12 had a serious illness, 2 of which were infections

Pertanyaan klinis :
Apakah penyebab tersering dari
prolong fever?
P : anak dengan demam lama
I:C:O : penyebab demam lama