APIXABAN

for prophylaxis of stroke and systemic embolism in atrial

fibrillation
reduce dose to 2.5 mg twice daily if creatinine clearance 1529
mL/minute, or if serum-creatinine 133 micromol/litre and age
80 years or body-weight 60kg;
manufacturer advises avoid if creatinine clearance less than 15
mL/minuteno information available
RIVAROXABAN
for prophylaxis of stroke and systemic embolism in atrial
fibrillation
reduce dose to 15 mg once daily if creatinine clearance 1549
mL/minute;
use with caution if concomitant use of drugs that increase plasmarivaroxaban concentration (consult product literature);
avoid if creatinine clearance less than 15 mL/minute;
manufacturer recommends Cockroft and Gault formula to calculate
creatinine clearance
DABIGATRAN ETEXILATE
prophylaxis of stroke and systemic embolism in non-valvular
atrial fibrillation
consider reduced dose of 110 mg twice daily if creatinine clearance
3050 mL/minute, based on individual assessment of
thromboembolic risk and risk of bleeding;
monitor renal function at least annually (manufacturer recommends
Cockroft and Gault formula to calculate creatinine clearance)
Groups: Started by hospital VS started by GP
http://cks.nice.org.uk/anticoagulation-oral#!scenariorecommendation:2
http://cks.nice.org.uk/anticoagulation-oral#!scenariorecommendation:22
http://cks.nice.org.uk/anticoagulation-oral#!scenariorecommendation:12