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: 30.09.2011 ., : 15.01.2012 .

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O.V. Syresina, Y.A. Zhukova, T.A. Vidmanova, L.V. Korkotashvilly, S.A. Kolesov , O.A. Nefedova
The Nizhniy Novgorod Scientific Research Institute of Childrens Gastroenterology, Nizhniy Novgorod

Melatonin in complex treatment of gastroesophageal


reflux disease in children
The article is devoted to gastroesophageal reflux disease (GERD) in children, which is of great medical and social significance. In spite of
contemporary achievements in therapy, the diseaset is characterized by repeated relapses with complications. Hence it is very important
to search for new pathogenetic schemes of esophagitis treatment. Therefore the efficacy of melatonine in complex therapy of
gastroesophageal reflux disease was evaluated in 20 children. During the treatment a definitely positive dynamics was achieved:
elimination of pain syndrome, absence of palpatory pain in epigastrics and pyloroduodenal region, decrease of the frequency of
dyspeptic tendencies and also a significant decrease of registration of gastroesophageal reflux in control endoscopic investigation,
improvement of acidforming function of the stomach as well as regulatory processes in digestion due to normalization of melatonine
level were confirmed. It was scientifically proved that the use of the medicine in complex treatment of patients with GERD allows
to increase efficacy of the studied therapy in 2,5 times.
Key words: gastroesophageal reflux disease, melatonin, treatment, children.

PF1_2012.indd 77

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