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Action of Histamine

H1-receptors H1-&H2-receptors H2-receptors


EXOCRINE EXCRETION CARDIOVASCULAR SYSTEM STOMACH
Increased production of nasal &
bronchial mucus, resulting in Lowers blood pressure by reducing Stimulation of gastric
respiratory symptoms peripheral resistance. hydrochloric acid secretion
BRONCHIAL SMOOTH Causes positive chronotropism
MUSCLE (mediated by H2 receptors) and a
Constriction of bronchioles positive inotropism (mediated by both
results in symptoms of asthma, H1 & H2 receptors)
decreased lung capacity
INTESTINAL SMOOTH SKIN
MUSCLE Dilation & increased permeability of
Constriction results in intestinal the capillaries results in leakage of
cramps and diarrhea proteins and fluid into the tissues.
SENSORY NERVE ENDINGS In the skin this results in the classical
Cause itch and pain triple responses (wheal formation,
reddening due to local vasodilation, &
flare) / halo

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