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Types of synapses
1. Axo-dendritic: most numerous, least excitable.
2. Axo-somatic:
(3) Fatigue
Def:
Decrease rate of discharge in post synaptic neuron due to repeated stimulation of
presynaptic neuron. Mainly due to decrease amount of chemical transmitter which stored
in presynaptic terminal.
Importance
It prevents over excitation in CNS.
(It is a gift from the god to the epileptic patients).
Mechanism
Increased Ca++ in pre synaptic neuron → continuous release of chemical transmitter.
B) Habituation
Def
It is the gradual loss of response to a benign stimulus, when it is repeated for several
times at intervals.
Mechanism
Decrease Ca++ in presynaptic neuron caused by unknown gradual inactivation of Ca++
channels → decrease release of chemical transmitter.
C) Sensitization
Def
It is the prolonged augmented response due to application of a noxious stimulus
accompanying the benign stimulus to which the animal has been habituated.
Mechanism
Presynaptic Facilitation
- The 3rd neuron is excitatory neuron; which secretes serotonin.
- Serotonin increase cAMP in the presynaptic terminals.
- cAMP Phosphorylates a protein in the K+ channels and close them.
- This prevents repolarization & prolongs depolarization.
- Depolarization Keeps Ca++ achannels opened → Increase release of the chemical
transmitter.
Neuronal Pool
Def:
A collection of neurons having the same function.
(2) Divergence
One neuron activates many neurons.
Its functions are:
a. Amplification of the response.
b. Distribution (spread) of signals.
Discharge zone= central neurons in which the excitation is above the threshold value so
they discharge. (this part receive large number of synaptic knobs).
Facilitation zone (subliminal Fringe) = peripheral neurons in which the excitation
is below the threshold value (this part receive few number of synaptic knobs).
Weak stimulus → small excitation field formed mainly of subliminal Fringe.
This arrangement leads to the development of 2 other phenomena
Occlusion Facilitation
Simultaneous stimulation of two afferent fibres.
- Close to each other - not close to each other
- by maximal stimuli - by submaximal stimuli
Results in reflex reaction which is
less than the sum more than the sum
of the separate stimulation of the two input fibres.
Cause: Overlap of the
Discharge zones Facilitation zones (subliminal fringe).
@ Occlusion:
This means occurrence of a smaller response when 2 near afferent neurons are
maximally stimulated simultaneously than the algebraic sum of the responses obtained
each afferent.
(6) Recruitment
- Recruitment is the gradual increase to a maximum in a reflex when a stimulus of
unaltered intensity is prolonged .
- There is progressive increase in the activity of the interneurons, leading to an
increase in the excitability of more and more motor neurons, until spatial summation
raises the excitability to the threshold value to discharge.
Synaptic Transmitters
Classified into 2 main groups:
A) Rapidly acting, small molecule neurotransmitters : according to chemical
structure
Class I: Acetylcholine.
Class II: The Amines:
Norepinephrine. Epinephrine. Dopamine. Serotonin. Histamine.
Class III: Amino Acids:
gamma aminobutyric acid (GABA). Glycine. Glutamate. Aspartate.
Class IV: Nitric oxide (NO).
Rapidly acting, small molecule neurotransmitters: generally responsible for acute
responses as sensory and motor signals.
B) Slowly acting, large molecule neurotransmitters : e.g. hypothalamic releasing
hormones
Generally they responsible for prolonged actions as long term opening and closure
of ion channels.
Acetylcholine (ACh)
Sources:
- neurons in many areas of the brain,
- motor neurons that innervate skeletal muscles,
- preganglionic neurons of the ANS,
- postganglionic neurons of the parasympathetic nervous system,
- some of the postganglionic neurons of the sympathetic nervous system.
Effects :
ACh has an excitatory effect, though it has inhibitory effects at some peripheral
parasympathetic nerve endings.
Norepinephrine (NE)
Is secreted by many neurons located in the brain reach widespread areas of the brain.
In most of these areas, NE probably activates excitatory receptors, but in few areas,
it activates inhibitory receptors.
NE is also secreted by most of the postganglionic neurons of the sympathetic neurons
system.
Dopamine
Is secreted by neurons that originate in the substantia nigra and which terminate
mainly in the basal ganglia. The effect of dopamine is usually inhibition.
Serotonin
Is secreted by neurons that originate in the median raphe of the brain stem, and
project to many brain and spinal cord areas. Serotonin is inhibitory.
Glycine
Is secreted mainly at synapses in the spinal cord. It is an inhibitory transmitter.
Glutamate
Is secreted by presynaptic terminals in many sensory pathways, and in many areas in
the cortex. It causes excitation.