Bien Ag Nina Ian John “G” Rachel Mark Jocelle Edo Gienah Jho Kath Aynz Je Glad Nickie

Ricobear Teacher Dadang Niňa Arlene Vivs Paul F. Rico F. Ren Mai Revs Mavis Jepay Yana Mayi Serge Hung Tope

S3 CP3: Hepatitis Profile by Dr. Walter Juarez NNoovveem

mbbeerr 2266,, 22001100

INTRODUCTION

Acute Hepatitis Chronic Hepatitis

 May be caused by all hepatitis types (A,B,C,D,E)  May be caused by hepatitis types B,C,D
o Note: HAV can never cause a chronic infection  MOT: parenteral
 MOT: fecal-oral  May have asymptomatic individuals as carriers
 Shortest IP: 2-6 days  Sequelae: Hepatocellular carcinoma (in 1% of patients)

ssRNA dsDNA Acute Chronic Carrier HCC MOT IP

A   - - Fecal-oral route 2-4 weeks
B    + + Parenteral
C    +++ + Parenteral
D    + + Parenteral
E   - - Fecal-oral route 4-6 weeks

SEROLOGY

INTRODUCTION
 HBsAg (Surface Antigen) = (+) in infection (ie. Acute or chronic) and carrier state
 HBeAg (E antigen) = denote active replication; differentiate infection (+) and carrier state (-)
 Anti - HBs(Antibody against surface antigen) = (+) denotes successful vaccination or recovery from infection
 Anti- HBc (Antibody against core antigen) = IgM: acute/recent infection; IgG: current infection
 Anti- HbeAg (Antibody against E antigen) = (+) if organism is no longer replicating

ACUTE GROUP
PATTERN Anti-HAV IgM Anti-HAV IgG HBsAg Anti-HBc IgM Interpretations
1 + - - - Acute HA
+ + - - Convalescent phase
- + - - Previous infection w/ HA w/ immunity
2 - + - Probable HB carrier or possible acute HB
3 - + + Acute HB
4 - - + Recent acute HB
5 - - - Possible non A non B hep

HB MONTORING GROUP
PATTERN HBsAg HbeAg Anti- HBe Anti-HBc Anti-Hbs Interpretations
1 + + - + - Acute HB (if seroconversion to anti-Hbe does not occur, probable progression to
chronic carrier state) or chronic HB (high infectivity)
2 + - + + - Acute HB (probable recovery) or chronic HB w/ seroconversion (↓infectivity)
3 - - + + + Recovery from HB & immunity

HB IMMUNITY GROUP
PATTERN Anti-HBs Anti-HBc Interpretations
1 + + Previous HB w/ recovery
2 + - Previous HB w/ recovery
3 - + Previous exposure to HB w/ acute or chronic infection
4 - - No previous exposure or immunity to HB

INTERPRETATION OF THE HEPATITIS B PANEL

PATTERN HBsAg Anti- HBC Anti-HBc IgM Anti-Hbs Interpretations
1 - - - Susceptible
2 - + + Immune due to natural infection
3 - - + Immune to due HBV vaccination
4 + + + - Acutely infected
5 + + - - Chronically infected

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