11.

36 Data for Biomarkers :

voplus vominus oc loc trap ltrap lvoplus lvominus

1606 903 68.9 4.233 19.4 2.965 7.382 6.806
2240 1761 56.3 4.031 25.5 3.239 7.714 7.474
2221 1486 54.6 4.000 19.0 2.944 7.706 7.304
896 1116 31.2 3.440 9.0 2.197 6.798 7.018
2545 2236 36.4 3.595 19.1 2.950 7.842 7.712

a) Statistical model

yi   0  1 xi1   2 xi 2  3 xi 3   i

where, €(i) are independent N(0,s) random variables.

b) Multiple regression result summary:

bone formation 1

The REG Procedure

Model: MODEL1
Dependent Variable: voplus

Number of Observations Read 5

Number of Observations Used 5

Analysis of Variance

Sum of Mean
Source DF Squares Square F Value Pr > F

Model 3 1666015 555338 8.80 0.2417

Error 1 63091 63091
Corrected Total 4 1729105

Root MSE 251.17855 R-Square 0.9635

Dependent Mean 1901.60000 Adj R-Sq 0.8541
Coeff Var 13.20880

Parameter Estimates

Parameter Standard
Variable DF Estimate Error t Value Pr > |t| 99% Confidence Limits

Intercept 1 -8788.24598 16857 -0.52 0.6941 -1081868 1064291

oc 1 -35.57985 137.41005 -0.26 0.8387 -8782.65590 8711.49621
trap 1 2782.32797 6252.95513 0.44 0.7335 -395260 400825
vominus 1 1.14043 0.42494 2.68 0.2271 -25.91011 28.19097
 bone formation 2

The REG Procedure

Model: MODEL1
Dependent Variable: voplus

Output Statistics

Dependent Predicted Std Error

Obs Variable Value Mean Predict 99% CL Mean 99% CL Predict Residual

1 1606 1568 248.2427 -14235 17370 -20913 24048 38.2911

2 2240 2432 161.3791 -7840 12705 -16572 21437 -192.4771
3 2221 2093 216.1713 -11668 15854 -19002 23188 127.9087
4 896.0000 945.5954 246.2335 -14729 16620 -21445 23336 -49.5954
5 2545 2469 239.4452 -12773 17711 -19621 24559 75.8728

Sum of Residuals 0
Sum of Squared Residuals 63091
Predicted Residual SS (PRESS) 5375215

C) Ans :

Parameter Estimates

Parameter Standard
Variable DF Estimate Error t Value Pr > |t| 99% Confidence Limits

Intercept 1 -8788.24598 16857 -0.52 0.6941 -1081868 1064291

oc 1 -35.57985 137.41005 -0.26 0.8387 -8782.65590 8711.49621
trap 1 2782.32797 6252.95513 0.44 0.7335 -395260 400825
vominus 1 1.14043 0.42494 2.68 0.2271 -25.91011 28.19097

yi   0  1 xi1   2 xi 2  3 xi 3   i
y(i) = -8788.24598 + -35.57985 x(i1) + 2782.32797 x(i2) + 1.14043 x(i3)

Standard error ,t-statistics with p-values for the analysis can be seen in the table.

d)