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Gestational Diabetes Pathophysiology

Pregnant woman with pre-


diabetic/ diabetic state

Fetus relies on maternal


glucose as primary fuel source Elevation of stress hormones Increased hormone production
Increased insulin requirement
due to pregnancy (cortisol, epinephrine, and (placental lactogen, estrogen,
glucagon) and progesterone)

Pre- diabetic/ diabetic woman


can’t produce sufficient insulin As compensatory mechanism, Pregnancy triggers protective
counterbalanced by increased mechanisms (anti- insulin effect)
insulin production

Prolonged elevation of stress


hormones cortisol, epinephrine,
Insulin resistant Insulin antagonizing effect gucagon
tissues not overcome

Increased blood glucose level


(hyperglycemia) Insulin administration
Unable to transport
blood glucose to cell
for use as energy If not controlled, may lead
to GESTATIONAL DIABETES
Dietary management

Still birth Fetal anomaly Birth of infant large/ Premature delivery


small for gestational age

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