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CHAPTER IV

Pathophysiology

Etiology Predisposing factor


H. pylori >Age (46 y/o)
NSAIDS >Genetic
>Stress
>Life style
-smoking (2-3 sticks per day)
-alcohol consumption (occasional)

Invasion of mucosal lining of stomach

mucosal defense weakened

decompensation

damaged of the mucosal lining

increase acid-pepsin concentration

increase secretion of hydrochloric acid

G-cells released gastrin

Inhibits by a high acid

Increase HCL

Nausea and Vomiting Inflammation of mucosal lining bleeding

weightloss irritation of nerve endings melena


hematemesis
Inflammatory response

Pain

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