Product Forms cosmetics ingredients AQUAMERE hydrogel

The Aquamere product line consists of four different formulation groups or grades. U.S. Patents: 4,642,267 4,769,013 and corresponding foreign patents

AQUAMERE H-SERIES
INCI NAME: PVP/Polycarbamyl/Polyglycol Ester H-1212, H-1511, H-2012

AQUAMERE A-SERIES
INCI NAME: PVP/Polycarbamyl/Polyglycol Ester A-1212

AQUAMERE C-SERIES
INCI NAME: PVP/Dimethylaminoethylmethacrylate/Polycarbamyl/Polyglycol Ester C-1011, C-1031

INNOVATIONS IN POLYMERIC HYDROGELS

specialty products from hydromer

AQUAMERE S-SERIES
INCI NAME: PVP/Dimethyiconylacrylate/Polycarbamyl/Polyglycol Ester S-2011, S-2012

AQUATRIX II hydrogels
INCI NAME: PVP/Chitosan , PVP/Polyethyleneimine Aquatrix II hydrogels are available as two aqueous solutions. Part A is comprised of water and PVP. Part B contains water, preservative, and either Chitosan or Polyethyleneimine. U.S. Patents: 5,420,197, 5,306,504, 5,645,855 and corresponding foreign patents

DERMASEAL allergen-blocker
INCI NAME: Hydroxypropylcellulose/Methyl Gluceth-20 Dermaseal allergen-blocker is available in a water or ethanol (SDA-40) solvent system. The water-based system is referred to as #100-1 and the ethanol based system is referred to as a # E-100. Patents: 5,837,266, 5,851,540 and pending patents

TOXICOLOGY, HANDLING & SAFETY:

Toxicology informations and Material Safety data Sheets are available upon request from Hydromer Inc.

Product Information & Formulations

Aquatrix II Aquamere Dermaseal
FURTHER INFORMATION: For further information contact: Hydromer Inc. 35 Industrial Parkway, Branchburg, NJ 08876-3518 Phone: (908) 526-2828 Fax: (908) 526-3633 www.hydromer.com email: sales@hydromer.com In U.S. Toll free 1-877-HYDROMER

HYDROMER
Company Profile
of inventing, developing, patenting,

specialty products

AQUATRIX II hydrogels

Cosmetic and Personal Care Polymers

Hydromer is an innovative technologyfocused company engaged in the business

licensing, manufacturing and selling hydrophilic polymer based products for commercial markets. The goal of Hydromer is to be the leading provider of hydrophilic surface modifications and specialty hydrophilic polymers to industry. While maintaining its industry leadership position in permanent lubricious coatings for medical devices, Hydromer constantly strives to create new, value added technologies and to build upon its current technologies- successfully expanding its technology and product base to include anti-fog and condensation control coatings for optical plastics and packaging, water resistant film formers for cosmetics, pharmaceutical and animal health products, unique hydrogels for medical and cosmetic applications, and barrier films for the protection of skin from allergens.

Aquatrix II is a complete line of hydrogel products developed and patented by Hydromer Inc. The gels consist of two highly biocompatible, watersoluble polymers supplied individually in aqueous solution, so that additional ingredients may be formulated into the finished product. The gel is formed when the two solutions are mixed together - no other process steps or additives are needed. This unique capability makes the Aquatrix II hydrogels extremely versatile for cosmetic formulations as compared to other commercially available hydrogels that often require irradiation, heat, or chemical catalysts, which destroy many cosmetic actives. The Aquatrix II hydrogels are ideal for a wide range of cosmetic treatments including facial masks, moisturizers, lotions, and therapeutic patches or wraps. They have also found extensive use in the medical field for wound care, burn dressings, and drug delivery products. Hydromer has the capability to support your development from concept to finished product, including process development of coated products using our new pilot coating line.

AQUAMERE hydrogel cosmetic ingredients

Hydromer Inc. has invented synergistic blends of polyurethane and PVP, called Aquamere" Hydrogel Cosmetic Ingredients, which form water and rub resistant films. The unusual property imparted by the Aquamere polymer family is what makes them such excellent choice for a wide variety of cosmetic applications. Based on their hydrophobic film forming properties and affinity to skin, they can impart water and rub resistance and rheological modification to cosmetic formulations from the water phase. The Aquamere film forming polymers assists formulators in fulfilling their new product development requirements and delivering breakthrough product attributes in a wide variety of cosmetic products such as sun care, skin care, color cosmetics, mascara, hair care and other skin treatment products.

NH

DERMASEAL allergen-blocker

CH2

Dermaseal allergen-blocker polymer system is comprised of a patented synergistic combination of biocompatible naturally derived ingredients, which provide thin cosmetically elegant invisible continuous film on the skin, delivering outstanding value-added properties in skin care products and improving the spreadability and consistency of foundations and makeup. While lubricating and moisturizing the skin, protects the skin against harmful influence of environmental factors such as contact allergens, pollutions, poisonous plants and chemicals. Dermaseal allergen-blocker is ideal especially for baby and childcare products, sunscreens and lotions and is currently being sold to major cosmetic companies as a base for foundation and as a Hydromer Poison Oak and Ivy barrier. Dermaseal allergen-blocker has shown to enhance the efficacy and desirability of cosmetic creams and lotions by its action as a skin protectant for the people with sensitive skin.

NH C=0

AQUATRIX II
hydrogels
Aquatrix II is a family of patented, hydrophilic polymer gels developed by Hydromer Inc. The Aquatrix II hydrogels are based on combinations of Polyvinylpyrrolidone (PVP) with either Chitosan or Polyethyleneimine (PEI). The PVP binds with the Chitosan or PEI to form a hydrogel Eye patches / Face masks Moisturizers, Shampoos, Conditioners, Styling products Wound and Burn care treatments Exfoliants Gelling agent / Viscosity modifier / Emulsion stabilizer Transdermal Drug Delivery vehicles

Performance Characteristics

Product Description

Applications

having a three-dimensional structure that results in superior cohesive and elastic properties. The gel formation requires no irradiation, so active ingredients that are light and or heat sensitive can easily be formulated into the finished gel without loss of activity or therapeutic value. Aquatrix II hydrogels can be molded into shapes to fit an existing product design, used as film-formers to create thin, flexible films, or be coated onto a substrate
Cosmetics Moisturizers Skin Treatments Patches & Masks Drug Delivery Wound/Burn Care Hair Care Exfoliants

Compatible with a broad range of cosmetic and drug ingredients Excellent moisturizing properties Smooth, silky, non-greasy, residue-free feeling on the skin Moisture barrier / Cooling / Soothing Imparts soothing and enhances healing of dry and damaged skin Improve conditioning performance of shampoos and conditioners

and laminated. The finished gels have absorbent properties and can absorb water or saline to become lubricious. They can also be used to stabilize emulsions and, in the Chitosan formulations, add the conditioning and therapeutic benefits of Chitosan to the finished product.

Aquatrix II hydrogels are manufactured as two separate, water-based solutions, one containing PVP and one containing Chitosan or Polyethyleneimine. The solutions are mixed together and the gel forms over a period of time ranging from a few seconds to a few minutes, depending on formulation. Aquatrix II hydrogels can accept a wide range of active ingredients soluble in water, glycerol, or glycol. Ingredients that are soluble in alcohol or oil may also be used with slight formulation modifications. Active ingredients can be incorporated into the formulation prior to forming the gel, so that they will be evenly dispersed in the gel matrix and released over time. The gel formulations are versatile and their physical properties can be modified to suit a variety of applications. Physical properties that are typically modified for customers are tack level, gel strength, and gel time. The tack level changes between formulations, and can be increased or decreased to suit a particular application. Aquatrix II hydrogels are often used as bioadhesives, since they can be applied to and removed from the skin without irritation or residue. The unique chemistry of the Aquatrix II hydrogels allow them to be processed in many ways, such as molding the gel into a shape or applying it between films as a laminate. Examples of uses for laminated are as facial masks for delivering cosmetic actives or sports wraps to reduce swelling. Aquatrix II hydrogels are viscoelastic materials, and gel strengths are different for each formulation. Higher % solids formulations yield stiffer, more elastic gels, while varying the ratio of PVP to Chitosan or PEI changes the gel strength and gel time.

Product Benefits

Effect of PVP: Chitosan Ratio on Gel Strength

PVP Chitosan Ratio Concentration % Concentration % A:B (weight) (A) (B) 20.0 20.0 20.0 20.0 2.0 2.0 3.0 3.0 1:1 2:1 1:1 2:1 Gel Strength (Pa) 500 380 500 750

AQUAMERE
Product Description
Aquamere polymer systems are a patented class of polymer blends developed by Hydromer Inc. This class of hydrophobic polymers is comprised of Polyurethane and PVP polymers or copolymers of PVP. These biocompatible materials form interpolymers with unique rheological and film forming properties, plus the ability to complex with a wide range

cosmetic hydrogel ingredients

Applications

Skin Care and Sun Care products Color Cosmetics Hair products (Shampoos, Conditioners, Hairspray, Mousses and Dyes/Colorants) Mascara Topical Drug or Active Delivery

Hydrophobicity: Contact angles for various film forming Aquamere polymers were measured, and the data is shown below. These film forming hydrophobic characteristics from a water phase polymer are exactly what makes the Aquamere polymer family such an excellent choice for a wide variety of cosmetic film former applications.

of organic molecules such as dyes, and UV absorbers.

Aquamere technology is ideal for various cosmetic applications, providing multifunctional capabilities that can satisfy unique cosmetic function requirements such as water and rub resistance, adhesion to skin, flexibility, styling, tack reduction, gloss,
Sun Care Skin Care Color Cosmetics Hair Conditioners/Styling Mascaras Hair Dyes/Colorants Topical Drug or Active Delivery

durability, moisture barrier, actives and pigment binding capabilities from

Water resistance Film former Impart luster and sheen to skin care products Immobilize dyes in hair colorant and UV absorbers in sunscreen or dyes Add body and richness to skin lotions and hold to hair care products Provides long-lasting moisturization Compatible with a wide range of cosmetic ingredients Wide range of product viscosities available Substantivity of actives, and pigments for rub and water resistance in water phase.

Shine and Gloss: A class of Aquamere polymer, Aquamere S- Series contains a unique silicone copolymer of PVP/Dimethiconylacrylate, which improves the lubricity of formulations and adds shine to hair care products. It also has good spreading properties, which assist in the formation of coherent, continuous films. When used in shampoos, conditioners, mousses and gels, the polymer evenly coats the hair. The higher the silicone content, the greater the lubricity or shine. When used in lipsticks it imparts to the consumer a perceivable and desirable increase in gloss. It is ideal for sandproofing sun care products and reduction tack in lotions in addition to helping retain water-phase UVA absorbers and inorganic pigments, like Ti02 and Zn0. Rheology Modifier: Aquamere ingredients act like rheology modifiers in cosmetic formulations. In contrast to other modifiers, the viscosity in the end use formulation is not dependent on pH. The viscosity of the final formulation depends, however, on the interaction of the polymer hydrophobes with specific moieties present in the formulation. This property adds body and richness to skin lotions, hold and moisture resistance to hair care products. Depending on the specific Aquamere series, these formulations impart different degrees of viscosity changes.

Performance Characteristics

Product Benefits

the water phase. Aquamere polymers possess excellent spread properties, which assist in forming coherent, continuous films.

Water Resistance: Aquamere film forming properties and affinity to skin provides water resistance from the water phase to cosmetic formulations. This is the most important property in sun care products when claims of water resistance are desirable. Water resistance of these film forming class of polymers is shown below.

DERMASEAL
allergenblocker

Product Description

Properties

The Dermaseal allergenblocker polymer system is comprised of a patented synergistic combination of biocompatible, naturally derived ingredients, which form a thin, continuous film on skin. Dermaseal allergen-blocker was developed by Hydromer Inc. for use in lotions, creams,

Dermaseal allergen-blocker is a moisturizing polymer system providing an invisible film, tack free, flexible, non-greasy, non-oily feel, and easily incorporated in cream and lotions. The films exhibit a gloss or sheen, identifying their presence. For many individuals, contact with common environmental allergen results in blemished, irritated and inflamed skin. A number of materials encountered on a daily basis produce such reactions. These include cosmetic products, jewelry, poisonous plants, latex gloves, detergents or industrial chemicals. Sensitive individuals benefit from a cream or lotion that provides the skin with a shield or barrier against these common environmental irritants.

Performance Characteristics

Dermaseal allergen-blocker has been developed to serve as a barrier for skin to common irritants. Upon contact with the skin, allergens promote an immune response resulting in visible skin irritation. In order to examine its potential effectiveness as a barrier, Dermaseal allergen-blocker has been tested using Attenuated Total Reflectance Infrared Spectroscopy (ATR-IR). The technique (illustrated below), measure the rate of permeation of an allergen or other irritant through the barrier film. Upon passage through the film layer, irritants are detected using infrared radiation. Using the ATR-IR technique, films of several currently marketed products, which claim skin protection and several formulations developed in the laboratory including Dermaseal were examined for permeability to the following known irritants Disulfides (Benzyl disulfide) Detergents (Sodium Lauryl Sulfate) Rubber Constituents (1,4 Phenylenediamine) Plant Derivatives (Catechol) Differences in breakthrough times (or protection) through films of the above formulations were noted for each irritant. For the plant irritant, protection times ranged from 0.5 hr for commercial products A to C claiming Poison Ivy protection from 2-4 hrs for laboratory formulations and greater than 8 hrs for Dermaseal allergen-blocker. These barrier compounds were put into a lotion form and tested on volunteers in a clinical environment. The ATR-IR results indicated barrier performance protection for 6 hours or more against the common irritants listed in the lotions that contained 50% Dermaseal base material.

Applications Product Benefits

sprays or ointments. The dermatologically compatible barrier film composition, comprises a hydrophilic, nonionic, film forming polysaccharides (hydroxypropylcellulose) and a barrier film enhancer comprised of a low molecular weight synergistic monosaccharide,
Hypo-allergenic/ Sensitive Skin Products Skin Care products Sun Care Products Color Cosmetics Industrial Hygiene and Safety Topical Drug delivery

Hypo-allergenic/Sensitive Skin Products Skin Care products Sun Care Products Color Cosmetics Industrial Hygiene and Safety Topical Drug delivery

solvent and optionally additive materials.

Improved substantivity of actives in foundation makeup and sunscreen Provides unique after feel and sheen characteristic in skin care products Reduces tackiness in formulation Improves the lubricity of formulations Shine enhancement to cosmetic products Excellent affinity to skin Film-forming barrier to common irritants stains, grease and oil Excellent protection properties against allergens and chemical irritants

Formulary

Moisturizing Cream
Phase A. Ingredient Aquatrix II Part A Propylene Glycol Methyl Paraben Water Triethanolamine 99% Aquatrix II Part B Glyceryl Sterate& PEG 100 Stearate Stearic Acid Cetyl Alcohol Isopropyl Myristate Propyl Paraben Dimethicone Fragrance % Wt. 2.0 4.0 0.2 58.9 1.8 4.0 6.0 6.0 1.0 15.0 0.1 1.0 TBD Supplier Hydromer Inc. BASF Inolex BASF Hydromer Inc. Inolex Spectrum Henkel Henkel Bayer AG BASF INCI Name

Aquatrix
PVP/Water Propylene Glycol Methyl Paraben Triethanolamine Chitosan/ Water Lexemul 561 Stearic Acid Cetyl Alcohol Isopropyl Myristate Propyl Paraben Dimethicone

Sunscreen Lotion-SPF 15
Phase A. Ingredient Water Acrylate/C10-30 Alkyl Acrylate Crosspolymer Glycerin Methyl Paraben Aquamere S-2011 Triethanolamine 99% PerformV 1608 Polymer Octyl Methoxycinnamate Benzophenone-3 Octyl Salicylate Caprylic/Capric Triglyceride Emulsifying Wax NF Propyl Paraben Cetyl Alcohol % Wt. 60.2 0.1 3.0 0.2 10.0 0.1 0.8 7.5 6.0 5.0 4.0 0.1 0.1 1.0 Supplier BF-Goodrich Dial Corp. Bayer AG Hydromer Inc. BASF New Phase ISP BASF ISP Henkel Croda Inc. Bayer AG Croda Inc.

Aquamere
INCI Name Acrylates/C10-30 Alkyl Acrylate Crosspolymer Glycerin Methyl Paraben PVP/Dimethiconylacrylate/ Polycarbamyl/Polyglcol Ester Triethanolamine Decene/Isopropyl Maleate/MA Copolymer Octyl Methoxycinnamate Benzophenone-3 Octyl Salicylate Caprylic/Capric Triglyceride Polawax Propyl Paraben Cetyl Alcohol

B.

B.

Procedure: Add Aquatrix II Part A to the water-glycol solution and dissolve, mix constantly. Then add Aquatrix II Part B and TEA. Heat Phase A in batch tank to 70C. Heat Phase B in separate container to 75C. Add Phase B to A at this temperature, begin cooling to room temperature, and qs to volume with cold water at 50C.

Procedure: Heat Phase A in batch tank to 82C. In a separate container, heat Phase B to 85-90C. Then add Phase B to A. Begin cooling to room temperature and qs with cold water at 45C.

Facemask Gel
Phase A. B. Ingredient Aquatrix II Part A Aquatrix II Part B Cosmetic ingredient (optional) Fragrance % Wt. 50.0 50.0 TBD TBD Supplier Hydromer Inc. Hydromer Inc. INCI Name PVP/Water Chitosan/Water

Moisturizing Cream

Benefits: This day cream is made for dry skin Phase Ingredient A. Water Glycerin Aquamere H-1212 Uniphen B. Sisterna SP 30 C Sisterna SP 70 C Cetiol SN Cegesoft C 24 Cetiol OE Naturechem CR Lanette O Uniphen

% Wt. 62.55 4.00 5.00 0.20 3.00 1.00 3.00 5.00 6.00 2.50 3.00 0.50

Supplier Dial Corp. Hydromer Inc. Induchem Mitsubishi Corp. Henkel Henkel Henkel Cas Chem Henkel Induchem

INCI Name Glycerin PVP/Polycarbamyl/Polyglycol Ester Phenoxyethanol/Methylparaben/ Ethylparaben/Propylparaben/Butylparaben Sucrose Distearate Sucrose Stearate Cetearyl Isononanoate Octyl Palmitate Dicaprylyl Ether Cetyl Ricinoleate Cetearyl Alcohol Phenoxyethanol/Methylparaben/ Ethylparaben/Propylparaben/Butylparaben Octyl Methoxycinamate Perfume

Procedure: Add phase A, begin agitation. Add cosmetic additive into phase B if needed. Mix phases A and B in a 1:1 ratio. Apply to substance or release liner.

Liquid Makeup
Phase A. Ingredient Water Cellosize PCG-10 Centrolex D Disodium EDTA Chroma Philic TiO2 Chroma Philic Yellow Chroma Philic Red Chroma Philic Black Chroma Philic Kaolin Emerest 2384 Lambent F-60,000cst OsoFine Nuka-Bijin Oil Cetyl Alcohol Stearyl Alcohol Parsol MCX DC 345 Fluid Sepigel 305 Germaben IIE Dermaseal 100-1 % Wt. q.s. 0.1 0.2 0.1 7.5 0.6 0.3 0.1 3.0 0.5 2.2 2.2 10.0 0.3 0.2 5.0 1.0 1.25 1.0 10.0 Supplier Amerchol Central Soya Enhance Technologies Enhance Technologies Henkel Lambent Enhance Technologies Enhance Technologies Croda Inc. Henkel Givaudan-Roure Dow Corning Seppic Sutton Labs Hydromer Inc.

Dermaseal
INCI Name Hydroxyethylcellulose Lecithin Disodium EDTA Titanium Dioxide/Dimethicone Copolyol Iron Oxide/Dimethicone Copolyol Iron Oxide/Dimethicone Copolyol Black Iron Oxide/Dimethicone Copolyol Kaolin/Dimethicone Copolyol Propylene Glycol Isostearate Dimethicone Colloidal Oatmeal Rice Branoil Cetyl Alcohol Stearyl Alcohol Octyl Methoxycinnamate Polyacrylamide/C13-14 Isoparaffin/Laureth-7 Propylene Glycol/Diazolidinyl Urea/ Methylparaben/Propylparaben Hydroxypropylcellulose/Methyl Gluceth 20

Parsol MCX 4.00 Givaudan-Roure C. Perfume 0.25 TBD Procedure: Mix Phase A and heat to 75C. Mix Phase B and heat to 75C. Mix intensively with homogenizer. Cool down to 45C while stirring. Add Phase C mix with homogenizer. Cool down to 30C while stirring.

Water Proof Gel Mascara

Phase A. Ingredient Water Carbopol 980 Hydro Wrap Black IO Hydrophilic Kaolin Propylene Glycol PEG-20 Beeswax Carnauba Wax Beeswax Candelilla Stearic Acid Water Triethanolamine Syntran 520 Aquamere S-2011 E. Germaben II-E

Properties: Excellent application, waterproof washes off with just soap and water, lengthens and thickens lashes % Wt. QS 0.3 10.0 3.0 3.0 2.0 6.0 3.0 6.0 2.0 2.0 1.3 7.0 3.0 1.0 Supplier BF Goodrich Enhance Technologies Enhance Technologies BASF Koster Keunen Koster Keunen Koster Keunen Spectrum BASF Interpolymer Corp. Hydromer Inc. Sutton INCI Name Carbomer Black Iron Oxide/Dimethicone Copolyol Kaolin Propylene Glycol Carnauba Wax Beeswax Candelilla Stearic Acid Triethanolamine Acrylates Copolymer/Propylene Glycol/ Sodium Laureth-12 Sulfate PVP/Dimethiconylacrylate/Polycarbamyl/ Polyglycol Ester Propylene Glycol/Diazolidinyl Urea/ Methylparaben/Propylparaben

B.

B.

C. D.

C. D. E.

Procedure: In the final mixing kettle, charge with water and disperse in the Carbopol; mix for 15 minutes. Add remaining Phase A ingredients in order listed; begin heating to 80C. In a separate container, weigh out Phase B ingredients, and begin heating to 82C. When both Phases are at the proper temperature, combine Phase B into Phase A, and mix for 5 minutes. Now add pre-mixed Phase C to combined Phase A and B with side-sweep and homogenizer mixing, and mix for 5 minutes. Begin cooling Phase A and B with side-sweep and homogenizer mixing, and mix for 5 minutes. Begin cooling batch with side-sweep agitation down to 40C. At 40C add Phase D ingredients in order listed, and resume cooling. At 30C add Phase E and mix for 5 minutes. Batch is complete.

Procedure: In final mixing kettle, with adequate mixing add Phase A ingredients in order listed. Begin heating after the addition of the Centrolex D. Continue heating, with combined homogenizer and side sweep mixing and add remainder of Phase A ingredients. In a separate vessel combine Phase B ingredients and begin heating to 80C with gentle mixing. When Phase A reaches 78C, add Phase B (80C) into Phase A. Mix for 15 minutes and begin cooling down to 65C and add Phase C. After Phase C has been added, resume cooling down to 60C, then switch to only side sweep mixing. At 30C add Phase D, then Phase E. Continue cooling down to room temperature. Kettles must remain covered at all times.