03.00.

15

2009

.
:
,

:
,

:
-

2009

212.203.05,
: 117198, .
, . -, .8

: 117198, .
, . -, .6

2009

..

,
, , ,

[, 2000, , 2003, ,
2004].

:

[ ., 2006].
: [Nagai et al., 1994, Budowle et al.,
1995, Ciesielka, 1996, Collier et al., 1996, Vieyra et al., 2003],
[Nakatom et al., 1995, Martinson et al., 1997, Shinohara et al., 2004],
[Hutz et al., 1997, Hooper et al., 1999, Mitchell et al., 2000],
[Hixon et al, 1993, Budowle et al., 1995].

:
- [ ., 1995, 1999,
2003, ., 2000, 2002], [ ., 2004,
., 1999, 2002], [ ., 2007,
2008] [, 1993, 2004, .,
1997, ., 1999, 2002, ., 2000,
., 2006].
,
,
.
( 10),
,
[
., 2002, ., 2000, ., 1997, .,
2002]. , , , ,


,

[, 2006].

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.
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.
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4.
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.

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(, 2005),


(, 2006), 71- (, 2006),
, 40-
. .. (, 2006), IX
-
(, 2006),
72- (, 2007), 7-
(, 2007) III
(, 2008).
.
14 , 6
.
.
178 ,
, ,
, , , .
21 24 .
14 . 205
, 81 .

8 ( CCR5, VNTR-
eNOS, DAT1, hSERT, D1S80, PAH ApoB).

:
, ,
,
(. 1).

X-XVIII ..: ,

.
.
: 95-98%.
2-5%.

.1.

( ,
).

484
,
. 176
(86 - , 90

- ), 148 (71 -
, 77 - ), 78 (
) 82 ( ).
49,2 .
,
.

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210 .

( ) ,

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.

.
.. , ..
, .. , .. . ... ..
. .. .

. 8-9 .
,
0,5 (=8,0),
4 .
-
[Mathew C.C., 1984].


[ .., 2001,
.. ., 1999, 2001, .. ., 2002, Das B.et al,
2004, Misrahi M.et al, 1998, Renges H.H. et al, 1992].
,
6,0-7,0%
(CCR5, VNTR-PAH, hSERT, ApoB D1S80) [
., 2002, ., 1999, Misrahi et al., 1998],
2% (, eNOS
DAT1) [ ., 2002, ., 2002].
. ,
,
- (2), (H)
(H), (D)
[, 1983;
., 1996; , 1978]. (IT), (HT),

(HS) (GST, DST)

Nei [1973, 1977].

DJ genetic ( 0,03 beta), ..
.. .

, ;
- [, 2001]
( 6).

1.
.

8

:
ACE*D=0,536,
CCR5*ccr5=0,091, eNOS*B=0,790, DAT1*8=0,005, DAT1*9=0,234,
DAT1*10=0,753, DAT1*11=0,004, hSERT*9=0,028, hSERT*10=0,361,
hSERT*12=0,610,
VNTR-PAH*380=0,355,
VNTR-PAH*500=0,124,
VNTR-PAH*530=0,367, VNTR-PAH*560=0,102, VNTR-PAH*650=0,047,
D1S80*18=0,287, D1S80*20=0,033, D1S80*21=0,015, D1S80*22=0,070,
D1S80*24=0,322, D1S80*25=0,046, D1S80*26=0,014, D1S80*28=0,047,
D1S80*29=0,027, D1S80*30=0,019, D1S80*31=0,064, D1S80*32=0,014,
ApoB*30=0,056, ApoB*32=0,055, ApoB*34=0,264, ApoB*36=0,378,
ApoB*38=0,045, ApoB*40=0,026, ApoB*42=0,045, ApoB*44=0,016,
ApoB*46=0,010, ApoB*48=0,029, ApoB*50=0,039, ApoB*52=0,019.
,
ACE*D, DAT1*10, D1S80*18, D1S80*24, D1S80*30, ApoB*34,
ApoB*36, VNTR-PAH*380, VNTR-PAH*530
- .
-
,

.
D1S80*24,
D1S80*28, ApoB*32. D1S80*28
: (0,07) (0,02)
.
D1S80*24 ApoB*32:
D1S80*24 - (0,37)
- (0,26), ApoB*32 (0,09) - (0,02). (DAT1*9,
DAT1*10, hSERT*10, hSERT*12, VNTR-*530)
,

- - -.
() -
CCR5*ccr5, VNTR-*380, ApoB*36,
-
eNOS*B, D1S80*18, D1S80*31, VNTR-PAH*500.
2.

.
56 8
.
,
G ST =0,0054.
CCR5 (GST=0,0094).

ACE (GST=0,0030) hSERT
(GST=0,0029),
(GST<0.0030). eNOS (GST=0,0052) VNTRPAH (GST=0,0046) - .


56 8 - G ST =0,0054
, ..
[2008] 29
11 - - G ST =0,0035.

,
(, , ) ..
[2006] 29 11 - G ST =0,0052 .. [2007]
59 8 - G ST =0,0059.
,
,
, -
fr*=0,0062 (

), .. [2007] 20
( )
( 60 .
) ( 1. ).
,

( ,
-, )

10

G ST =0,0040,0050,006, , ,

,
, ..
.. [1987]
GST .

3. .


.

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[, 2007]
(. 2). ,
:
-

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).

11

, -

. ,
,

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,

(. 3).
,
- -
(DAT1*9, DAT1*10,
hSERT*10, hSERT*12, VNTR-PAH*530).

. 3.
( ,
,
).


. , [ ,
2002] X-XII .. -
, -
, , ,
.

12

4.
.

.

,
, 15
ACE, CCR5, D1S80 ApoB (

). ,

(d=0,003),
,
d=0,010 (. 4).

, ,

.
.. .[2001, 2006]
, 14
725 (, ,
, , )
.
,

[ ., 2006].

,
(,
)
.
-,

.
.
[ ,2002]
IX-XIII ..
(
) - .
-, ,
,
, .. [2008]
- . ..

13

d=0,002,

(d=0,0040,005).
0,011

0,010

0,009

0,008

0,007

0,006

0,005

0,004

0,003

0,002

. 4.

( 15 ACE, CCR5,
D1S80 ApoB).
5.
.


. 19 5

14

(ACE, CCR5, VNTR-, eNOS ApoB)

(. 5),

.
(
, )
.
.

[ , 2002].

. 5. ,

( 19 5
, CCR5, eNOS, VNTR-PAH ).

1.
(6 , 484 )
56 8
: , CCR5, eNOS, DAT1, hSERT, D1S80, VNTR-PAH
ApoB.

15

2. ,
( G ST =0,005),
- ( G ST =0,004)
(fr*=0,006).
3.
- -,

.
4.
,
.
5.


.

,
:
1.
..

-
R5
/ .. //
-
, 70- . - , 2005. - .1. .54.
2. -
/ .., .., ..,
.., .., .., .., ..,
.., .. //
-
, 70- . - , 2005. - .1. .189-190.
3. ApoB
/ .., ..,
.., .. // . 2005. - .4.
4. - .165 166.
4.
/ .., .., ..,
.., .., .., ..,
.., .. // . 2005. - .4. 6. - .289.
5. .. /
.., .., .. //

16

. , 2006. - 3.
- .126 128.
6.
hSERT /
.., .., .., ..,
.. //
, 40- . ..
. - , 2006. - .27.
..

7.
/
.. // IX -

. - , 2006. - .30.
8.
/ ..,
.., .., .., ..,
.., .., .., ..,
.., .., .. //
. 2006. - .13. 2. - .173-176.
9.
/ .., .., ..,
.., .., .., ..,
.., .., .. // . 2006. .5. 6. - .16-20.
10. /
.., .., .., ..,
.. //

. - , 2006 - . 25-29.
11. (
) /
.., .., .., .. //
72- -
. - , 2007. - .2. - .10-11.
12.

..

VNTR

/
.., .., .. // VII
. - , 2007. - .276-277.
13. ..
/ .., .. // ,
2008. - 2(61). - . 329.
14. ..
/ .., .., .. //
, 2008. - 2(61). - .271-272.

17

(6 , 486 )
56 8 (I/D ,
CCR5del32, VNTR: eNOS, DAT1, hSERT, D1S80, PAH ApoB).
,
( G ST =0,005),
- ( G ST =0,004)
(fr*=0,006).
-
-,
.
,

Vaschilin Vladimir Sergeevich

Studying DNA polymorphism
In populations of the Central Russia
The structure of a genofund of the radical Russian population of the
Central Russia (6 populations, 486 person) on the data on distribution of
frequencies 56 alleles 8 autosomal DNA markers (I/D , CCR5del32,
VNTR: eNOS, DAT1, hSERT, D1S80, PAH ApoB). Genetic heterogeneity
of the population of the Central Russia, appreciated on to
markers ( G ST =0,005), corresponds to the literary data on immunological and
biochemical ( G ST =0,004) and quasigenetic to markers (fr*= 0,006).
Populations of the Central Russia are differentiated on two clasters "southeast" and "northwest", that allows to prove a hypothesis about a various
slavic substratum of these groups of populations. The population of the
Central Russia forms the general claster with a Russian population which is
genetically removed from Ukrainian and Byelorussian populations. Features
of genetic differentiation of populations of the Central Russia in system of the
Euroasian genofund are established.