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PAVENDAR BHARATHIDASAN COLLEGE OF ENGINEERING AND TECHNOLOGY COMPUTATIONAL BIOLOGY CYCLE TEST II Department: Biotechnology Time: 90 minutes year

and semester: IV/VII maximum: 50 marks

Part A (10x2=20 marks) 1. Write 4 major Biological databases available in the Internet? 2. Write about GenBank? 3. What is Global alignment? 4. Write comparison between PAM and BLOSUM matrices? 5. Write comparison of FASTA and BLAST? 6. What is Block-Based alignment? 7. What is PROSITE? 8. Write about SMART? 9. What is phylogenetic tree? 10. What is Bootstrapping? Part B (2x15= 30 marks) 11. Write in detail about two phylogentic tree construction methods? Or 12. Write in Detail about motif and Domain databases using statistical model? 13. Write about Markov and Hidden Markov model and its application? Or 14. Explain in Detail about Heuristic algorithms?

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