Muscle Tissue

Dr Farhat Aslam Click to edit Master subtitle style

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Composed of cells _ contraction Microfilaments and associated proteins

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Types

Skeletal muscle Cardiac muscle Smooth muscle

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Skeletal muscle

Muscle fiber 10-100micro meter in diameter

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ORGANISATION:

Epimysium Perimyceum endomysium

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Development

Myoblasts Satellite cells

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Muscle Fibers

Cross stiations Z.lines Sarcomere Nuclei Littlr RER myofibrils

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Myofilaments: Thick filaments

H.zone and CK

M.line__myomesin

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Thin filaments:
F-actin Alpha

actinin

Tropomyosin Troponin

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Depolarisatin Transverse tubule Terminal cystern Triad

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Mech of contraction

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Innervation Mysthenia Gravis Types of muscle fibers

1a 11a 11b

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Cardiac muscle

Develop mesoderm cells primitive heart tube Branch Nuclei Intercalated discs

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Contractile proteins T-tubule 40% Cell vol mitochondria Energy fatty acids lipoproteins glycogen

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Diff b/w atrial and ventriculer muscle

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Smooth muscle

Elongated, tapering, non striated cells Enclosed by thin basal lamina and fine network of reticuler fibers Size 20 -500 micro meter Nucleus Mitochodria, polyribosomes, RER, GA, pinocytic vesicles

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Rudimentary SER No t-tubules Contractile activity

Thick

and thin filmnts-crisscross

Calmodulin MLCK

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Dese bodies
Alpha IF

actinin-------z-lines

and actin

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Nerve supply
multi

unit smooth m smooth ms

Unitary

Also synthesise
Collagen Elastin proteoglycans

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