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Complex treatment of acute hematogenous osteomyelitis in children


S.V. MINAEV, R.A. MOTORINA, V.V. LESKIN

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(p<0,01) , (92,02,0 /). -1 : 7-
120,030,8 /, 14- 80,015,3 /. 14-
(100,52,4 /). 14- (p<0,05) 22,94,1
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The acute hematogenous osteomyelitis continues to remain at present one of the actual problems to pediatric surgery, being
characterized by severe course, difficulty of the early diagnostics and frequency of unfavourable outcomes, becoming chronic and
complications. We investigated the levels of CRP, IL-1, TNF- in 74 children with acute hematogenous osteomyelitis. In the first
(control) group children had standart therapy, in the second (main) group children had standart therapy with Licopid. The level of
TNF- in the main group on 7 days after operation was 91,84,1 pcg/ml, on 14 days 44,38,3 pcg/ml. The level of TNF- in the
control group on 14 days was 92,02,0 pcg/ml (p<0,01). The level of IL-1 in the main group on 7 days 120,030,8 pcg/ml, on
14 days 80,015,3 pcg/ml. The level of IL-1 in the control group on 14 days 100,52,4 pcg/ml. The level of CRP in the main
group on 14 days 22,94,1 mg/ml. The level of CRP in the control group on 14 days 12,90,4 mg/ml (p<0,05). The use the
complex treatment of acute hematogenous osteomyelitis in children has allowed to obtain a good results of the treatment.
Key words: acute hematogenous osteomyelitis, glucosaminylmuramyldipeptide, Licopid, TNF-, IL-1, CRP, children

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e-mail: sminaev@yandex.ru

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