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Phosphoacylglycerol

also known as

Glycerophospholipids or Phosphoglycerides Faisal Khatib MD; PhD Faculty of Medicine, University of Jordan

FATTY ACID

G L Y C E R O L
PHOSPHATE

FATTY ACID

ALCOHOL

PHOSPHOACYLGLYCEROL

O CH2O-C-R1 I R2C-OCH I CH2O- P Phosphatidic Acid Can Form Ester with Alchol: - Serine - Ethanolamine - Choline Phosphatidyl - Inositol - Glycerol O

HO-CH2 CH3 Ethanol HO-CH2CH2-NH3+ Ethanolamine HO-CH2 CH2 N(CH3)3+ Choline HO-CH2 CH-NH3+ COOSerine
I

O CH2O-C-R1 I R2C-OCH + I CH3 CH2O- P - O-CH2 CH2 NCH3 CH3 Phosphatidyl Choline (Lecithin) O

Cardiolipin: Two molecules of Phosphatidic Acid


Connected through Glycerol

G L Y C E R O L

FATTY ACID

FATTY ACID

PHOSPHATE

ALCOHOL

Degradation of Phospholipids:
Phospholipase A1 Phospholipase A2 Phospholipase C Phospholipase D

Biosynthesis of Triacylglycerol & Phosphoacylglycerol


F T YA ID AT C
FATTYAC ID

G L Y C E R O L

F T YA ID AT C

F T YA ID AT C

G L Y C E R O L

FATTYAC ID

PH SPHA O TE

A HL LCO O

T IA Y G Y E O R CL LCR L

PH SPH A YLG ER L O O C LYC O

Phosphotadic Acid is Common Intermediate

F A T T Y A C ID

G L Y C E R O L

F A T T Y A C ID

PHOSPH ATE

PHO SPHO ACYLGLYCERO L

G L Y C E R O L

FATTY ACID

FATTY ACID

PHOSPHATE

ALCOHOL

Biosynthesis of glycerophospholipids Alcohol1 Phosphate Alcohol2

Transfer ~(Phosphate-Alcohol1) to Alcohol2 or Transfer ~(Phosphate-Alcohol2) to Alcohol1

Synthesis of Phosphatidyl Inositol


Transfer or Phosphatidic acid to Inositol

CDP-diacylglycerol

Inositol

CMP

Phosphatidyl Inositol

Synthesis of Phosphatidyl Choline


Transfer or Phosphocholine (Ethanolamine) to Diacylglycerol CDP-Choline Diacylglycerol

CMP

Phosphatidyl Choline

Formation of Activated Carrier


Alcohol- P P ~ P ~ P
Ribose-Cytosine

Alcohol- P ~ P P ~ P
Ribose-Cytosine CDP-Alcohol Pyrophosphate

Alteration of Polar Head Group


Exchange of the Polar Head Group Phosphatidyl Ethanolamine Serine

Phosphatidyl Serine

Ethanolamine

Alteration of Polar Head Group


Decarboxylation of Phosphatidyl Serine Phosphatidyl Serine

CO2
Phosphatidyl Ethanolamine

Alteration of Polar Head Group


Methylation of Phosphatidyl Ethanolamine S- Adenosyl Methionine (SAM); Methyl donor Phosphatidyl Ethanolamine
CH3-S-CH2CH2-CH-COOI I Adenosine NH3+ S- Adenosyl Homocysteine

Phosphatidyl Choline

Remodeling Phospholipids: Changing the Fatty Acid

Ether Glycerophospholipids

Platelet-activating Factor

Surfactant Action of Phospholipids