ENDOKRINOLOGI REPRODUKSI

overview

Laksmindra Fitria Edit by Ali Machrus a5krus@yahoo.co.id

Regulasi hormone

Aksis HPT

Aksis HPO

= fase proliferatif

= fase sekretorik

Note

Tubulus Seminiferus

Genitalia interna (M)

Spermatozoon

Spermatogenesis

Gonad
Gonad jantan Gonad betina testis ovarium gamet:

Gonad Sistem reproduksi - Testis spermatozoa - Ovarium ova

Gonad Sistem endokrin hormon seks: - Testis androgen - Ovarium estrogen, progestogen

Aksis HPT
Hipotalamus GnRH Hipofisis Gn (FSH, LH) FSH target: sel Sertoli - ABP: T B DHT tub.seminiferus spermatogenesis - inhibin/folikulostatin/SCF B sirkulasi darah feedback LH (ICSH) target: sel Leydig steroidogenesis - androgen (T) B sel Sertoli spermatogenesis - androgen B sirkulasi darah efek androgenik

- Virilisasi/Maskulinisasi (Androgenik) - Tropik/Metabolisme (Anabolik) - Rekreasi (Dopping)

Efek Testosteron

Aksis HPO
Hipotalamus GnRH Hipofisis Gn (FSH, LH) FSH target: sel granulosa (folikel ovarium) - estrogen B folikulogenesis, oogenesis - inhibin B sirkulasi darah feedback LH target: - sel teka interna steroidogenesis ~ androgen B sel granulosa estrogen ~ estrogen B sirkulasi darah efek estrogenik, feedback ~ pregnenolon B sel granulosa progesteron (fase folikuler) - korpus luteum progesteron (fase luteal)

Efek Estrogen

Siklus ovarium Oogenesis

Genitalia interna (F)

Kondisi Hormonal Siklus Menstruasi

Singkatan
ABP = Androgen-Binding Protein DHT = Dihydrotestosterone FSH = Follicle-Stimulating Hormone Gn = Gonadotropin GnRH = Gonadotropic-Releasing Hormone ICSH = Interstitial Cell-Stimulating Hormone LH = Luteinizing Hormone SCF = Sertoli Cell Factor T = Testosterone