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  • Patho 2

    Загружено:

    David Dueñas
    23 просмотров3 страницы
    This document discusses the pathophysiology of ischemic stroke. It lists idiopathic etiology and predisposing factors like age, sex, family history, and diabetes. Precipitating factors include smoking, alcoholism, obesity, sedentary lifestyle, diet, hypertension, cholesterol levels, and drug abuse. These factors lead to LDL deposition in artery walls, inflammation, and formation of foam cells and atheroma plaques, restricting blood flow and causing ischemia. This triggers metabolic changes, electrolyte imbalance, acidosis, and increased potassium, eventually damaging cells and tissues in the brain.

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    patho 2

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    This document discusses the pathophysiology of ischemic stroke. It lists idiopathic etiology and predisposing factors like age, sex, family history, and diabetes. Precipitating factors include smoking, alcoholism, obesity, sedentary lifestyle, diet, hypertension, cholesterol levels, and drug abuse. These factors lead to LDL deposition in artery walls, inflammation, and formation of foam cells and atheroma plaques, restricting blood flow and causing ischemia. This triggers metabolic changes, electrolyte imbalance, acidosis, and increased potassium, eventually damaging cells and tissues in the brain.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате DOCX, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    23 просмотров3 страницы

    Patho 2

    Загружено:

    David Dueñas
    This document discusses the pathophysiology of ischemic stroke. It lists idiopathic etiology and predisposing factors like age, sex, family history, and diabetes. Precipitating factors include smoking, alcoholism, obesity, sedentary lifestyle, diet, hypertension, cholesterol levels, and drug abuse. These factors lead to LDL deposition in artery walls, inflammation, and formation of foam cells and atheroma plaques, restricting blood flow and causing ischemia. This triggers metabolic changes, electrolyte imbalance, acidosis, and increased potassium, eventually damaging cells and tissues in the brain.

    Авторское право:

    Attribution Non-Commercial (BY-NC)
    Скачайте в формате DOCX, PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    из 3

    VII.

    PATHOPHYSIOLOGY
    ETIOLOGY >Idiopathic

    PREDISPOSING FACTORS >Age (60-74 y/o) >Sex (Male) >Family history >Diabetes mellitus

    PRECIPITATING FACTORS >Smoking >Alcoholism >Obesity >Sedentary life style >High-fat diet >Hypertension > LDL >HDL >Drug abuse

    LDL deposit in the arterial blood vessel wall Inflammation WBC attacks LDL

    Development of foam cells Atheroma plaques develops increase growth of plaque Bleeding 28

    Formation of thick fibrous cap on the bleeding site blood flow to the brain Anaerobic respirations

    Production of lactic acid

    Insufficient ATP production Depolarization Electrolyte imbalance

    Acidosis Potassium level Manifestation M Muscle weakness U Urine, oliguria, anuria R Respiratory distress D Decrease cardiac contractility E ECG changes R Reflexes, hyperreflexia, or areflexia (flaccid)

    Intracellular calcium and glutamate release


    Damaging pathways activation >Destruction of the cell membrane >More calcium and glutamate are release >Vasoconstriction >Generation of free radicals Cell ceased to function Penumbra region develop (Ischemic brain tissue)

    28

    Induction of inflammatory reaction

    Accumulation of leukocytes to begin phagocytosis of cell debris Lacunar infarction in the right thalamus

    Hemiplegia (L extremities)

    Decrease function of the thalamus like sending their axons to the cerebral cortex Failure to generate action impulses potential in the cerebral cortex Cerebral atrophy Decrease response of the cerebrum to bodily function >Motor functions (teary left eye) >Perception of most sensory information (numbness) >Reception and perception of visual input >Olfactory and auditory sensations >Memory

    28

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