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Analgesic & Master Click to edit Opioid subtitle style

DRUG INTERACTION

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DRUG INTERACTION

Increasing effect effect effect

Decreasing New

When 2 or more drug used together (combined)

Drug Drug

drug food

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metode
Enzyme

induction - drug A induces the body to produce more of an enzyme which metabolize drug B. This reduces the effective concentration of drug B, which may lead to loss of effectiveness of drug B. Drug A effectiveness is not altered. inhibition - drug A inhibits the production of the enzyme metabolising drug B, thus an elevation of drug B

Enzyme

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Analgesic
Analgesic / Painkiller (Greece: an + Algos)
o

NSAID (Paracetamol, Asam Mefenamat, Aspirin, Ibuprofen, Diclofenac, Piroxicam)

juga punya efek anti inflamasi & antipiretik

o

Opioid (Morfin, Kodein, Thebain)

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Efek nsaid (salisilat)

Merangsang

pernapasan eskresi asam urat masa pendarahan

Menghambat Perpanjangan

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Analgesik opioid

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Increasing effect
Efek depresi SSP beberapa opioid dapat diperhebat dan diperpanjang oleh Fenotiazin, MAO Inhibitor, dan antidepresan trisiklik (imipramin, amitriptilin) Beberapa fenotiazin mengurangi jumlah opioid yang diperlukan untuk menimbulkan tingkat analgesia tertentu. Tetapi efek sedasi dan depresi napas

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Fenotiazin (Phenothiazine)
is

an organic compound that occurs in various antipsychotic and antihistaminic drugs. It has the formula S(C6H4)2NH. This yellow tricyclic compound is soluble in acetic acid, benzene, and ether. The

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Derivat fenotiazin
o

neuroleptic drugs -> chlorpromazine, promazine, levomepromazine antihistaminic drugs -> promethazine anti-emetik Inodilator pada congestive heart failure

o o o

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Monoamine oksidase inhibitor

Antidepressant

-> depresi atipik

Berbahaya Misal: Juga

(potentially lethal) -> last line therapy Selegilin dipakai dalam penanganan Parkinson