CONCEPTUAL FRAMEWORK OF LIVER CIRRHOSIS

CHRONIC ALCOHOLISM TOXINS FROM ALCOHOL RELEASE ACETYLDEHYDE DAMAGE OF HEPATOCYTES INCREAE AST, ALT, ALKALINE PHOSPHATASE

HEPATOCYTE NECROSIS

FIBROSIS

OBSTRUCTION IN BLOOD FLOW

LIVERFUNCTION

LIVER CELLS REGENERATE IN ABNORMAL PATTERN LIVER CELLS LOADED WITH FAT ENLARGEMENT

PORTAL HYPERTENSION

IRRITATES THE GLISSON CAPSULES PAIN

GLYCOGENESIS GLYCOGENOLYSIS GLUCOGENESIS

DECREASE PRODUCTION OF ALBUMIN

DECREASE CHON SYNTHESIS

DECREASE PRODUCTION OF CLOTTING FACTORS

ALTERED IMMUNE FUNCTION & ALTERED HEALING

BLEEDING

DECREASE COLLOIDAL OSMOTIC PRESSURE VULNERABLE TO INFECTION EDEMA, ASCITES

ANEMIA

DECREASE METABOLISM OF STREROID HORMONE ESTROGEN PROGESTERONE TESTOSTERONE MALE: LOSS OF MALE CHARACTERISTICS AND DEVELOPMENT OF SOME FEMININE CHARC. FEMALE: LOSS OF FEMALE CHARACTERISTICS AND DEVELOPMENT OF SOME MALE CHARAC. SODIUM AND WATER RETENTION EDEMA , ASCITES DECREASE FAT ABSORPTION

DECREASE LEVELS OF AMMONIA DECREASE METABOLISM OF DRUGS DECREASE STORES OF VIT.& MINERALS

INCREASE LEVELS OF AMMONIA

HEPATIC ENCEPALOPATHY

ASTERIXIS, FETOR HEPATICUS

DRUG TOXICITY

COMA

DEATH

DECREASE RBC PRODUCTION DECREASE ENERGY PRODUCTION

ANEMIA

OBSTRUCTION OF THE BILE FLOW ALDOSTERONE

DECREASE BILIRUBIN IN GIT BILE SALTS IN THE SKIN

BILE REABSORBED IN THE BLOOD

INCREASE POTASSIUM AND HYDROGEN EXCRETION ALKALOSIS

DECREASE VIT.K ABSORPTION DECREASE CLOTTING FACTORS BLEEDING , ANEMIA

CLAY-COLORED STOOL

JAUNDICE

INCREASE BILE IN KIDNEY

PRURITUS

DARK COLORED URINE

HYPOKALEMIA INCREASE BILIRUBIN LEVEL