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..,

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CONTENTS

LEADING ARTICLE
Yu.I.Bubnov,

G.G.Arabidze,

A.A.Pov

Familial Arterial Hypertension

N.A.Gratsiansky

..

Unstable Angina Acute Coronary Syndrome. Contemporary

II.

Trends in Therapy

..,

..,

..,

..,

..,

..

ARTERIAL HYPERTENSION
O.V.Lerman,
sheva,

V.I.Metelitsa,

N.P.Filatova,

S.G.Duda,

N.V.Maly-

V.A.Vygodin

Effect o f L o n g - T e r m ,

o n E c h o c a r d i o g r a p h i c Signs o f H y p e r t r o p h y o f t h e Left H e a r t

Controlled Antihypertensive Treatment

in Patients W i t h Mild to Moderate Arterial Hypertension

..,

..,

..,

..,

..

G.L.Strongin,

N.B.Makarova,

A.S.Turetskaya,

N.V.Yakimovich,

M.G.Sinitsina

Analysis of Side Effects D u r i n g T r e a t m e n t of H y p e r t e n s i o n W i t h

A t e n o l o l , V e r a p a m i l a n d E n a l a p r i l i n O p e r a t o r Professionals

..,

..,

..,

..,

..,

..

MYOCARDIAL INFARCTION
A.B.Khadzegova,

T.A.Ayvazyan,

A.A.Gabrielyan,

V.P.Pomerantsev,

Yu.A.Vasyuk,

E.N.Yuschuk

D y n a m i c s of P s y c h o l o g i c a l S t a t u s a n d Q u a l i t y of Life of Pa

tients W i t h M y o c a r d i a l Infarction in R e l a t i o n to Severity of

Course of Postinfarction Period

..,

..,

..,

..,

..

A.A.Nikolaeva,

G.I.Lifshits,

I.Sh.Shterental,

K.Yu.Nikolaev,

V.G.Snegurova

R e l a t i o n s h i p s B e t w e e n C h a n g e s of H i s t a m i n e - S e r o t o n i n Sys

t e m a n d Severity of C l i n i c a l C o u r s e of A c u t e M y o c a r d i a l Inf

arction

..,

..

V.V.Konstantinov,

L.I.Mazur

I s c h e m i c H e a r t Disease a n d Risk F a c t o r s i n C a r Drivers

EPIDEMIOLOGY
OF ISCHEMIC HEART DISEASE

..,

..,

..,

EXPERIMENTAL CARDIOLOGY
V.I.Kapelko,

A.N.Khatkevich,

Pathogenesis of Early Stage

..

N.N.Beskrovnova,

V.G.Tsyplenkova

of A d r i a m y c i n C a r d i o m y o p a t h y .

P u m p F u n c t i o n and Ultrastructure of the Heart

..,

..,

..

MISCELLANEOUS
V.L.Karpman,

V.R.Orel,

A.Ya.Farber

D e t e r m i n a t i o n o f t h e C h a r a c t e r i s t i c A o r t i c I m p e d a n c e Basing

on Noninvasive

..,

..,

..,

..

Measurements

SYMPOSIUM ON ECHOCARDIOGRAPHY
I.E.Rykunov,

V.A.Sandrikov,V.A.Ivanov,

S.L.Dzemeshkevich

Intraoperative Transesophageal Echocardiography in Evaluation

of Results of R e c o n s t r u c t i v e

Surgery of C a r d i a c Valves

, 1997

..,

..

I.N.Mitina,

Yu.I.Bondarev

D o p p l e r E c h o c a r d i o g r a p h y i n P o s t o p e r a t i v e D i a g n o s i s o f Com

p l i c a t i o n s i n P a t i e n t s W i t h C o n g e n i t a l H e a r t Defects

..,

..,

..

L.V.Popov,

A.M.Kirillov,

G.M.Soloviev

E c h o c a r d i o g r a p h i c A s s e s s m e n t of Efficacy of S u r g i c a l C o r r e c

t i o n o f Valvular H e a r t Defects

..

REVIEW

66

V.M.Gorbunov
Significance of I n v e s t i g a t i o n of Different T y p e s of B l o o d Pres
sure Variability i n P a t i e n t s W i t h A r t e r i a l H y p e r t e n s i o n

..,

..,

..,

..

SHORT COMMUNICATIONS

70

S.N.Petunin,

N.K.Merkulova,

B.B.Bondarenko,

V.D.Shurygina

C o m p a r a t i v e S t u d y o f Efficacy o f T r e a t m e n t o f P a t i e n t s W i t h

Mild Arterial Hypertension By Atenolol and C o m b i n a t i o n of

Atenolol Chlorthalidone

36 JUBILEES

..,

..,

PRACTICAL CARDIOLOGY

SUPPLEMENT

..

REVIEWS

72

FOR

PRACTITIONERS

OF ACTUAL

V.V.Kondratiev,

CLINICAL

E.V.Kokurina,

PROBLEMS
E.V.Bochkareva

Painless M y o c a r d i a l I s c h e m i a . P r e s e n t State of t h e P r o b l e m a n d

. I.

Clinically Significant A s p e c t s of Its Progress. I. P r e v a l e n c e a n d

P r o g n o s t i c Significance o f P a i n l e s s M y o c a r d i a l I s h e m i a

..,

..

: -

82

P.P.Malyshev,

A.V.Susekov

Management of Familial Hypercholesterolemia: Contemporary


Aspects

..,

..

METHODS
87

OF

A.A.Grosu,

TREATMENT

S.E.Tsurkan

: ,

R a d i o f r e q u e n c y C a t h e t e r A b l a t i o n : T e c h n i q u e a n d C l i n i c a l Ef

ficacy i n A t r i o v e n t r i c u l a r a n d V e n t r i c u l a r T a c h y c a r d i a s

..

CASE

92

94

..,

..,

..

(KARDIOLOGIYA),

""
1996

1,

1997

REPORTS

L.B.Lazebnik
R i g h t Atrial I n f a r c t i o n W i t h C o n s e q u e n t Atrial R u p t u r e
N.B.Gumbatov,

V.A.Azizov,

G.A.Tarverdieva

D i a g n o s i s of T u b e r c u l o u s P e r i c a r d i t i s

96

INDEX OF PAPERS PUBLISHED


KARDIOLOGIA IN
1996

IN

THE JOURNAL

,1997


.., .., ..
FAMILIAL ARTERIAL HYPERTENSION
YU.I.BUBNOV, G.G.ARABIDZE, A.A.PAVLOV
. .. ,
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1,

1997

..

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1997

..

...

1.

. . , .., . . .

6.

C o r v o l P., J e u n e m a i t r e X., C h a r r u A. et al. Am J C a r d i o l

7.

Duru

1992;70:12:14D

1993;12:16 19.
2.

. . , .. 1990;7:101

20D.

F a r r o w S., W a n g J . - M .

et al. Am J H y p e r t e n s

1994;7:8:759 7 6 2 .

105.
3.

K.,

8.

. . 1994;11:34 37.

4.

M i u r a K., N a k a g a w a H . , N a k a m u r a H. et al. Am J H y p e r t e n s

5.

P i c k e r i n g T . G . I b i d ; 4 8 3 484.

..
: . . ... - . . 1992.

9.

1994;7:5:390 3 9 5 .

M u l d o o n M . F . , Terrell D . F . , B u n k e r C . H . e t al. A m J Hypertens

1993;6:1:76 88.

23.06.96

-

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C 7971/7971

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: (095) 4 1 4 - 0 5 - 1 7 .

(KARDIOLOGIYA),

1,

1997

..,1997

.
II.
..
UNSTABLE ANGINA ACUTE CORONARY SYNDROME. CONTEMPORARY TRENDS IN THERAPY
N.A.GRATSIANSKY
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1997

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1997

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1997

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1997

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1997


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1997

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18

(KARDIOLOGIYA),

1,

1997

..

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(KARDIOLOGIYA),

1,

1997

., 1996).

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21

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during t r e a t m e n t with low dose aspirin a n d intravenous h e p a r i n

40.

F u c h s J., M c G a b e C . H . , A n t m a n E . M . , Borzak S., Palisaitis


D . , H e r s o n S . e t al. for t h e T I M I 7 investigators. H i r u l o g i n

. 1993; 33 ( 5 ) : 4 9.

39.

.., . . , . .
- ,
38.

56.

S i m p f e n d o r f e r C . , K o t t k k e e - M a r c h a n t K., T o p o l E . J . F i r s t
e x p e r i e n c e w i t h c h r o n i c p l a t e l e t G P I I b / I I I a r e c e p t o r block
a d e : a p i l o t study of xemlofiban an orally active a n t a g o n i s t in
u n s t a b l e a n g i n a p a t i e n t s eligible for P T C A ( a b s t r a c t ) . J A C C
1996; 27:242A.

20.09.96

23

,1997

.., .., .., .., .., ..


EFFECT OF LONG-TERM CONTROLLED ANTIHYPERTENSIVE TREATMENT ON ECHOCARDIOGRAPHIC SIGNS
OF HYPERTROPHY OF THE LEFT HEART IN PATIENTS WITH MILD TO MODERATE ARTERIAL HYPERTENSION
O.V.LERMAN, V.I.METELITSA, N.P.FILATOVA, S.G.DUDA, N.V.MALYSHEVA, V.A.VYGODIN
- ,

-


110
. , 8- , , .

.
. ,
;
.

" ".

Representatives of four modern groups of antihypertensive drugs were used in mono- and combination
therapy of 110 patients with mild to moderate arterial hypertension and their effects on echocardiographic
signs of hypertrophy of the left heart and on hemodynamic parameters were evaluated. Monotherapy for 8
months with captopril, nifedipine, hydrochlothiazide, or propranolol produced equal hypotensive action.
Captopril and nifedipine decreased left ventricular myocardial mass index at the account of reduction of
left ventricular wall thickness and of end-diastolic dimension. Hydrochlorothiazide caused less pronounced
decrease of left ventricular myocardial mass index exclusively at the account of reduction of left ventricu
lar end-diastolic dimension. Propranolol caused decrease of ventricular septal thickness without effect on
left ventricular myocardial mass index; in some patients increase of left ventricular end-diastolic dimen
sion was observed. Combination treatment and monotherapy by drugs from four main groups of antihyper
tensive medications produced equal positive effects on echocardiographic signs of "hypertensive heart
disease".
Key

words:

hypertension,

essential;

echocardiography;

left

-
, 70%
[1].

"
" , " " "

" [2].
,
" " ,

24

atrial

hypertrophy;

left

ventricular

hypertrophy.


-
[3, 4].

,


.

( ) , , ,

(KARDIOLOGIYA),

1,

1997

..

...

"Mark-500A"

3 ,

90) A T L ( ) .

110

M -

( I II

) 95

. 3

114 . . ,

).

( , ),

48,40,7

, 12,5

0,8 . 6 8 % , 32%

( , ) ( P e n n - c o n v e n t i o n ) [5, 6].

( 30 )

( ,

) L.Teichholtz

22%

. [7].

"

(, ),

" , ,

( , / ) ,

, ,

(, / ), ( ,

, 9 : 1

/-

, 8

( % A S ) ,

-2

) , ( , % )

( , --

-5

, -

( ,

, .

) P e n n - c o n v e n t i o n

: 50 /

[8,

, 60 /, 25

: .

9].

(,

/ )

/, 8 0 /.

140/90 . . ) 1

[5, 10, 11]:

: 100 / , -

( / ) , 1,1

90 /,

50

/, 240 /.

; 266 ;
134 /

( 140/90 . .

) ,

4 .

.. 8 ,

: + ;

+ ; + -

; + ; -

+.

,
, , 1
.

4 8

35%

110 ( 2 5 % , 54%

) ,

8- .

19% 96 .

B-

M- -

. 110 , -

(KARDIOLOGIYA),

1,

1997

25

, 8-

82 (74%) , 72%
28% .
8
19 ( 2 3 % ) , 26 ( 3 2 % ) , 18 ( 2 2 % ) ,
19(23%) .
.1,
4 8
.

.

4-
-

.

8- .
,
8


.

4- ( p < 0 , 1 ) ,
8-
(p>0,1), (.2).

8-
(
; p<0,01).

1. 8- , ,

(Mm)

(n=19)

(n=26)

(n=18)

(n=19)

, . .

146,8+2,9

129,5+1,9***

128,7+2,8***

, . .

100,1+1,2

87,0+1,6***

83,8+2,0***

62,0+2,0

62,7+2,0

63,3+2,0

, . .

155,6+2,8

126,6+1,6***

125,8+2,0***

, . .

102,2+1,2

83,8+1,1***

83,3+1,3***

63,6+1,9

67,5+1,9*

67,2+1,8*

125,8+2,5***

123,6+2,3***

..

148,2+2,4

, . .

101,1+1,1

85,7+1,5***

84,8+1,5***

66,1+2,5

67,4+2,0

64,8+1,9

128,6+2,1***

129,3+1,9***

101,3+1,1

85,5+1,1***

84,7+1,1***

63,7+1,7

58,2+1,3**

53,7+1,7*** #

, . .
,

149,2+2,5

..


. ,

. :

p < 0 , 0 0 1 ; # p < 0 , 0 1 4 8 ;

* p < 0 , 0 5 , ** p < 0 , 0 1 ,

p<0,1,

p<0,05

, .

2. 8- ,
, ( M m )
, --

-5

(n=19)

(n=26)

1393,6+62,6

1490,3+45,6

1534,3+83,4

1465,4+65,0

1263,8+66,7*

1211,1+46,0***

1335,9+58,8**

1345,6+55,3

1247,5+62,1**

1248,2+43,9***

1400,8+70,7*

1406,6+49,1

(n=18)

(n=19)

. : * p < 0 , 0 5 , * * p < 0 , 0 1 , *** p < 0 , 0 0 1 .

26

(KARDIOLOGIYA),

1,

1997

..

8- ,




(
) , .


(.3).

4 - 8-

( 8
12,8 9,9% ; -

...

p < 0 , 0 0 1 ; . ) .


(
)
,
,

( ) (..3). ,
,
.
8

4 , 3 % ,
-

3. , ,
, 8-
, , (Mm)

(n=19)

(n=26)

(n=18)

(n=19)

3,72+0,07

3,63+0,09

3,59+0,07

3,60+0,08

3,67+0,06**

3,61+0,08*

3,58+0,07

3,61+0,08

5,81+0,10

5,63+0,08

5,47+0,10

5,66+0,09

, :


, :
A
B

5,73+0,10

5,67+0,11 **

5,53+0,08*

5,45+0,08#

5,38+0,09

5,69+0,09

5,35+0,10*

5,75+0,09


, :
A

1,00+0,02

0,99+0,02

0,97+0,02

0,99+0,02

0,96+0,02**

0,94+0,02#

0,96+0,02

0,97+0,01

0,92+0,02# "

0,90+0,02# "

0,96+0,03

0,95+0,01*

0,90+0,01

0,90+0,02

0,92+0,02

0,90+0,02

0,91+0,02

0,89+0,02

0,91+0,02

0,88+0,02

232,2+10,9

246,2+7,8


, :
A
B

0,88+0,01*

0,85+0,01# '

0,89+0,01*
0,87+0,01**

, :
262,0+10,8

246,0+10,4

244,7+9,6**

226,4+8,9#

222,6+10,7*

243,5+9,0

226,8+8,6# "

210,6+7,7# "

219,8+11,4**

243,7+8,3

/ :

132,4+5,0

127,2+4,5

116,4+5,4

124,0+3,8

124,0+4,7**

117,0+3,9#

111,3+4,9*

122,4+4,3

115,0+4,4# "

108,8+3,4# "

109,8+5,2**

122,6+4,0

. : *

p<0,05,

** p < 0 , 0 1 ,

# p < 0 , 0 0 1 ,

p < 0 , 0 5 , ' p < 0 , 0 1 , " p < 0 , 0 0 1 4 .

(KARDIOLOGIYA),

1,

1997

27



,

(.
.3).

4 8

,


( , ).

,

(
).
,

,
(p<0,001).
%

...

++

+ + + *** # # #
+ + + *** # # #

.
8- . 8 .
.
+ + p < 0 , 0 1 ; + + + p < 0 , 0 0 1 . *** p < 0 , 0 0 1
; # # # p < 0 , 0 1
.



.


;


(p>0,1).

8 -
16,9 12,7% (p>0,1);

30,5 1 7 , 1 % ( p < 0 , 0 1 ;
.4).

(
%AS)

.
%AS
4- (p<0,05),

; % A S
8- .

8
.

.
, % A S
, ,


.
. 28 ( 2 6 % ) 110
,

.

4. ( ) ( )
8 ()

( n = 1 1 0 )

18 (18,8%)

38 (34,6%)

12 (12,5%)*

18 (16,4%)***

(n=82)

12 (16,9%)

25 (30,5%)

9 (12,7%)

14 (17,1%)**

(n=28)

6 (24,0%)

13 (46,4%)

3 (12,0%)

4 (14,3%)*

. * p < 0 , 0 5 , ** p < 0 , 0 1 , * * * p < 0 , 0 0 1 .

28

(KARDIOLOGIYA),

1,

1997

..

5,1+0,2 . 50%
, 50
.
2 4 % ,
4 6 % .

,
.

8 , -
,
.

8

(p<0,05)
:

-5
37 - - ,
154
-5
-- .

8
.

28 ,
,
(p>0,1), 82
. 8

(224 ).
8
,
, 24 12%
( p > 0 , 1 ) ,
46,4 14,3% ( p < 0 , 0 1 ;
. .4).


(%AS ) ,

,
.
, 8 -
"
"
(- ),
, .


[12, 13],

(KARDIOLOGIYA),

1,

1997

...



"
"
.

8 -
, , ,
,

,

.
,
(
)
( )
, ,
[14, 15],
-
.
8
, ,

.

, ,
,
.

(
)
,

, J.Julien
. [16] - B.Dahlof . [12].
,
(

) (
),

.
J . O t t e r s t a d . [17].
,
,
.

,
,

,
[18].

29

8



.

-
, 8-
,
,
.

1.


8-

(,
, )


:
) , ,

,


(

)
4 ;
,
;
)
,

,

,
;
)

,

;

.
2.
8


.
3. -

,
,

.

1.

G r o s s m a n E., M e s s e r l i F . H . E n d - o r g a n disease i n h y p e r t e n
sion: w h a t have we learned? Oardiovasc P h a r m a c o l 1992;20:10:
S1 S6.

2.

Frohlich E . D . Practical m a n a g e m e n t of hypertension. Curr

c a t i o n s o f e c h o c a r d i o g r a p h i c d e t e r m i n e d left v e n t r i c u l a r m a s s
the

Framingham

Heart

Study.

New

Eng

Med

1990;322:1561 1566.
5.

t r i c u l a r h y p e r t r o p h y r e g r e s s i o n d u r i n g a n t i h y p e r t e n s i v e treat
14. S c h m i e d e r R . E . , Messerli F . H . , Sturgill D . e t al. C a r d i a c p e r f o m a n c e after r e d u c t i o n of m y o c a r d i a l h y p e r t r o p h y . Am J M e d

1230.

1989;87:1:22 2 7 .

D e v e r e u x R . B . , C a s a l e P . N . , H a m m o n d I.W. e t al. E c h o c a r -

15. H o l z g r e v e H . , D i s t e r A., M i c h a e l i s J . e t al. H y d r o c h l o r o t h i -

diographic d e t e c t i o n of pressure-overload left ventricular hyper

azide a n d v e r a p a m i l in t h e t r e a t m e n t of h y p e r t e n s i o n . J C a r d i ovasc P h a r m a c o l 1991;18:6:S33 S 3 7 .


16. J u l i e n J., Dufloux M . - E . , Prasquvier R. et al. Effect of c a p t o -

T e i c h h o l t z L . E . , K r e u l e n T . , H e r m a n M.V., G o r l i n R . Prob

pril a n d m i n o x i d i l o n left v e n t r i c u l a r h y p e r t r o p h y i n r e s i s t a n t

lems in echocardiographic volume determinations: echocardi-

hypertensive patients: a 6 m o n t h double-blind comparison. J

o g r a p h i c a n g i o g r a p h i c c o r r e l a t i o n s in t h e p r e s e n c e ot ab

Am C o l l C a r d i o l

sence of asynergy. Am J C a r d i o l 1976;37:7

11.

1990;16:137

142.

17. O t t e r s t a d J . E . , F r o e l a n d G . , S o e y l a n d A . K . W . e t al. C h a n g e s

D e v e r e u x R . B . , A l o n s o D . R . , L u t a s E . M . e t al. E c h o c a r d i o -

in left ventricular dimensions a n d systolic function in 100 mildly

graphic assessment

hypertensive m e n during one year's treatment with atenolol

of left v e n t r i c u l a r h y p e r t r o p h y : compari

s o n to n e c r o p s y findings. Am J C a r d i o l 1986;57:450 4 5 8 .
9.

100.

D e v e r e u x R . B . , L u t a s E . M . , Casale P . N . et al. S t a n d a r t i z a t i o n

t e n s 1987;3:66 7 8 .

8.

13. E i c h s t a e d t H . , D a n n e O., S c h r o e d e r R.J., K r e u z D. Left ven

of M - m o d e e c h o c a r d i o g r a p h i c left v e n t r i c u l a r a n a t o m i c meas

t r o p h y : Effect o f c r i t e r i a a n d p a t i e n t p o p u l a t i o n . C l i n H y p e r 7.

12. D a h l o f B., P e n n e r t K., W a n s s o n L. Reversal of left ventricular

m e n t . C l i n I n v e s t 1992;70:S79 S86.

u r e m e n t . J Am C o l l C a r d i o l 1984;4:1222
6.

d e t e c t i o n of left ventricular h y p e r t r o p h y : a p p l i c a t i o n to hyper

h y p e r t r o p h y in hypertensive patients. Am J Hypertens 1992;5:95

Levy D . , G a r r i s o n R.J., Savage D . D . e t al. P r o g n o s t i c impli


in

1986;622.

tensive h e a r t disease. E u r H e a r t J 1 9 9 3 ; 1 4 : D : 8 15.

G r o s s m a n W. C a r d i a c h y p e r t r o p h y : useful a d a p t a t i o n s or path
ologic p r o c e s s ? Am J M e d 1990;69:576 584.

4.

Philadelphia

1 1 . D e v e r e u x R . B . , K o r e n M.J., D e S i m o n e G . e t al. M e t h o d s for

P r o b l C a r d i o l 1985;10:4 6 1 .
3.

10. F e i g e n b a u m H . E c h o c a r d i o g r a p h y . 4 - t h E d . L e a & F e b i g e r .

R e i c h e k N . , D e v e r e u x R . B . Left v e n t r i c u l a r h y p e r t r o p h y : re
lationship of anatomic, echocardiographic and electrocardiog r a p h i c findings. C i r c u l a t i o n 1981;63:1391

1398.

vs. h y d r o c h l o r o t h i a z i d e a n d a m i l o r i d e ( m o d u r e t i c ) : a d o u b l e b l i n d , r a n d o m i z e d study. J I n t e r n M e d 1992;231:493 501.


18. T a r a z i R . C . T h e h e a r t in h y p e r t e n s i o n . N E n g l J M e d 1985;
312:308 320.

30

(KARDIOLOGIYA),

1,

13.05.96
1997

,1997


,

.., .., .., .., ..
ANALYSIS OF SIDE EFFECTS DURING TREATMENT OF HYPERTENSION WITH ATENOLOL, VERAPAMIL
AND ENALAPRIL IN OPERATOR PROFESSIONALS
G.L.STRONGIN, N.B.MAKAROVA, A.S.TURETSKAYA, N.V.YAKIMOVICH, M.G.SINITSINA
.
..


. 41
(32 55 )
, .
, . ,
()
, , 3 0 0 0 .
7 7 % .
( 145/94 .. 1 ) 10, 18 16%
, .
3, 7 13%.
.

The aim of the study was to determine feasibility of the use of verapamil and enalapril for systematic treat
ment of arterial hypertension in professional operators. Atenolol, verapamil and enalapril were given in
different sequences to 41 men aged 32-55 years with uncomplicated arterial hypertension. Results of 24hour blood pressure monitoring and bicycle exercise tests were used for assessment of efficacy of treat
ment. Subjective symptoms of intolerance were registered. Orthostatic stability and the state of specific
operator psychological (cognitive) abilities were evaluated by means of Cogscreen battery of tests includ
ing tests performed under conditions of hypoxic hypoxia corresponding to the altitude of 3 0 0 0 meters.
Monotherapy was effective on the average in 7 7 % of cases. Satisfactory blood pressure control (blood
pressure level 145/94 mm Hg or less for at least 1 month) was not achieved in 10, 18 and 16% of patients
during treatment with atenolol, verapamil and enalapril, respectively. Individual intolerance occurred in 3,
7 and 1 3 % of patients, respectively. There were cases of lowering of orthostatic stability or pronounced
derangement of cognitive functions.

words:

arterial

hypertension,

treatment;

working

capacity;




,

[1, 2].


.

-
. ,

( )

(KARDIOLOGIYA),

1,

1997

operator

functions.

()

[3].



.


41
32 55 ( 44,7 )
, ,
, .

31

1 30 (
9,7 ) .

.


2 .
3
,
: 1- : ; 2- :
; 3- :
.
1-
( 100 /,
80 /, 20 /).

.
" " ,

145/94 .. ,
1
. "
"
/
( 145/94 ..).


,

.
"Medilog Oxford" ().

.

3 .
60 ,
30 .
12
5
.

( )
.

, 14,5% ,

3000 .

" " ,
.
,
.

32

1 0 - , (
5 )
6 .

.
1 0
3 5 .

10 ,

5 .
,
Dorsalis, .

, 1
1-
.



26 . 15

,
,


. 89 ,
69 .

, 7-

, 7-

,
( )
.


. 126 , 237
30,5 .

77% ,

[4, 5].
7 ,
- .

( ) , , ( ) , , , ,
4
.
1-

(KARDIOLOGIYA),

1,

1997

..

... ,

.


.

9,7%, 18%,
16%.



(.1).

,
,
.
,
.
18,6
( 2 3 , 4 % ) ,
.
,

,
"
" , P . Z a c h a r i a n . [6].
,

.

,
(.
) .
, -

> 1 4 0 .

> 9 0 . .

. ( % )
.
, .

, 2 , 3 , 4
.

.

, .


,
. . 2
,
.
,

,

( 250 . . /
130 ..),
.
, 79%
-
.
9%

1. (
, , )

, ..:

141,165

125,361*

129,779*

125,365*

18,049

14,398

12,714

15,176

3,242

3,394

3,398

3,681

89,329

81,383*

82,764

82,200

10,319

7,598

9,281

12,606

1,853

1,791

2,481

3,057

79,423

60,861*

75,667

77,748

9,416

7,415

6,366

8,069

1,691

1,748

1,644

1,761

* p<0,001 .

(KARDIOLOGIYA), 1, 1997

3 3

2. ,

133,3

28,0

, ..

153,1

238,8

118,7

15,8

18,3

10,5

5,39

3,0

3,53

1,95

151,5***

115,7***

194,7***

97,7***

25,4

16,6

21,6

8,4

5,83

3,54

4,6

1,79

150,0***

141,0*

212,6***

103,3***

23,8

17,2

22,0

9,26

5,33

3,76

4,8

2,02

145,0

150,7

210,0***

106,0***

21,2

13,4

20,7

11,87

5,0

2,99

4,68

2,65

. * p < 0 , 0 5 , ** p < 0 , 0 1 , * * * p < 0 , 0 0 1 .

, 15%
,

.




.
,

.
,
,
(
2 4 % ) , ,
7,8%
,
.
,
,
ST,
, ..


.



7-

. (
,

34

)
, ,
.

,
.


.

,
,
.
,
,
( 6 2 , 8 % ; p < 0 , 0 5 ) .

(p<0,01).

,

.

(p<0,05),
,
.

( ,
; p < 0 , 0 5 )

(KARDIOLOGIYA),

1,

1997

..

... ,

[3].

20%,

3 0 %

4 0 % 6- ;

1 4 % , 6-

3 2

3 4 % ;

3-

7-

32%, . ,

. -

, .

7- ,

. ,

8%), ( 13%

. ,

18% 6- ) ,

( 10

19%; p < 0 , 0 1 ) ,

( 9

17%; p<0,05).

95%

" " ,

82+1,8%.

( 4 5%) , , -

. ,

10%. -

" " ,

, ,

" ,

(KARDIOLOGIYA),

1,

1997

"

35


,

.


,

,
.

80% ,

.

1.

4 6 .
.

,
,
.
2.

, ,
1
2 .
3 .
,
6 .

1.

. . , . . , .., . .

2.

5.

1987.

B r u n n e r H . R . , W a e b e r B., N u s s b e r g e r G . S t r a t e g i e s for t h e

. 1988;10:118

m a n a g e m e n t of h y p e r t e n s i o n in aircrew. E u r H e a r t J 1992;13:

6.

123.

Z a c h a r i a n P.K., S h e p s S . G . e t al. A m b u l a t o r y b l o o d pressure


a n d pressure load in n o r m a l subjects. Am J Hypertens 1989;2:50

H : 4 5 49.
3.

. 1985.

4.

Beevers D . G . , M a c G r e g o r G.A. H y p e r t e n s i o n in p r a c t i c e .
L o n d o n 1987;133

56.
25.05.96

135.

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(1847).

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. 48

36

(KARDIOLOGIYA),

1,

1997

,1997




.., .., .., .., .., ..
DYNAMICS OF PSYCHOLOGICAL STATUS AND QUALITY OF LIFE OF PATIENTS WITH MYOCARDIAL
INFARCTION IN RELATION TO SEVERITY OF COURSE OF POSTINFARCTION PERIOD
A.B.KHADZEGOVA, T.A.AYVAZYAN, V.P.POMERANTSEV, YU.A.VASYUK, A.A.GABRIELYAN, E.N.YUSCHUK
N 1 ,
,


164 (5 6- 28
30- , 3 12 ). , ,
" " " ". ,

.
.
.
: ,
,
, , .

The aim of the study was to investigate relationship between quality of life and severity of the course of
postinfarction period. Psychological tests including Mini-Mult, Clinical Scale and Quality of Life were used
in 164 patients on days 5-6 and 28-30 and after 3 and 12 months of myocardial infarction. There was
direct linear relation between somatic and psychological statuses and quality of life. Some of the patients
despite satisfactory clinical condition experienced pronounced decrease in quality of life while in some of
patients with unfavorable course of the disease indices of quality of life remained normal. There was
relation between structure of psychopathological disorders and course of myocardial infarction. In the
acute stage of the disease anxiety and cardiofobic syndromes were the leading traits irrespective of clini
cal severity while in postinfarction period prevailed hypochondria, asthenia and depression.

words:

myocardial

infarction;

quality

of life; psychological


,

,
.




.

,


[1 5].

(KARDIOLOGIYA),

1,

1997

testing.


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(p<0,05)


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(KARDIOLOGIYA),

1,

1997

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(Mm)


(n=71)

(n=41)

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55,4+1,1

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55,0+1,5

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52,9+1,0

51,6+1,1**

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54,5+1,6*

1-

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2-

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49,8+1,1

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3-

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56,4+1,5*

55,8+1,4

4-

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52,8+1,3

59,4+2,0*

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52,8+1,6

54,4+1,6**

6-

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53,5+1,6

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52,8+1,3

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54,9+1,8*

55,6+2,2

7-

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48,3+1,2**

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55,3+1,9

8-

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56,3+2,7

57,4+1,6*

54,3+1,8

9-

58,7+1,4

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51,6+1,3**

53,0+1,3**

55,9+2,1

57,1+2,9

54,8+1,9

52,8+1,9**

. n . (p<0,05): * , **

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(KARDIOLOGIYA)),

1,

1997

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1993;130

25.04.96

(KARDIOLOGIYA),

1,

1997

,1997

-


.., .., .., .., ..
RELATIONSHIPS BETWEEN CHANGES OF HISTAMINE-SEROTONIN SYSTEM AND SEVERITY OF CLINICAL
COURSE OF ACUTE MYOCARDIAL INFARCTION
A.A.NIKOLAEVA, G.I.LIFSHITS, I.SH.SHTERENTAL, K.YU.NIKOLAEV, V.G.SNEGUROVA
- ,

,

[2, 4].
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1997

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1997

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1997



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44

(KARDIOLOGIYA),

1,

1997

.., ..,1997

.., ..
ISCHEMIC HEART DISEASE AND RISK FACTORS IN CAR DRIVERS
V.V.KONSTANTINOV, L.I.MAZUR
- ,


, ,
.
,
.
, , .


,
.

Levels and prevalence of risk factors, prevalence of ischemic heart disease and their relationships were
studied in randomly selected representative sample of professional drivers. High prevalence of hy
pertension, hypercholesterolemia and smoking either separately or in combinations was observed. Pres
ence of ischemic heart disease correlated positively with hypertension, hypercholesterolemia, body mass
and smoking. Unfavorable epidemiological situation relative to ischemic heart disease morbidity and mor
tality revealed in this professional group demands urgent preventive measures.

words:

ischemic

heart

disease;

risk factors;

epidemiology.


, -
, , XX
-

,
[ 1 1 , 13, 20,
26, 2 9 ] .

,
-
(, ,
)
,
, ,
- . [4, 17].
,
,
-
,

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[4, 7, 22, 2 7 ] .

(KARDIOLOGIYA),

1,

1997

[13],



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10,4 12,2%.


,
,


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.


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-

45

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,

.

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. 20 59 .
460 (
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;
;

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.

( 10 12
) : , ,
,

.




2 2 , 2 % ,
.


32,7%.

.
30 39
: 2,6 , 20 29 (p<0,01).

20 29 50 59 .

46


20 29 40 49 (p<0,01).

45%.


5,7%.
30 39 ,
( 3,3 ) 50 59 (p<0,01).

70%.

(p<0,01).

12%.

30 39 50
59 ( p < 0 , 0 5 ) .
10,6%
88,9%

.
(20
39 ), ,
2, 3, 4 ,

(40 59 ).

20 59
11,8%.

20 39 50 59 ( p < 0 , 0 1 ) .

7 17 ,
.


1,8 7,9%.
2
(3,9 8,2% ; p < 0 , 0 5 ) .


30 59 (p<0,05).

2 (31,9 16,3%
; p<0,01),
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2,3 (23,7 10,0%
; p<0,01) 2,7
(17,6 6,5% ; p < 0 , 0 1 ) ,
.
,

,

.

(KARDIOLOGIYA),

1,

1997

..

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59 [ 3 ] .

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.
[5, 6 ] .

1.

. .

( ) . 1989;73

74.

- : . . ... . . . 1987.
2.

: .
. . 1995;404.


8.

2 0 6 9 : . . ... . .

. 1984;27.
9.

.., .., . . .

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1989;29 3 0 .

. . . . - - 1988;13.

. .
: . .
... - . . 1992.

40 59 (
) . 1981;9:66 72.
.., . . , . .
.
(
).

(KARDIOLOGIYA),

10. . . , ..
.

1976;166.

1 1 . . .

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4.

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. 1983;1:3 7.
3.

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1,

1997

1990.

12. . , . , . .
.
,

2 - :

. 1984;531.
13. . . , . . , . . .
: .
. 1983.

47

14. ..

. 1985;12:9

11.

15. .., .., ..

t r e n d s i n c o r o n a r y h e a r t disease risk, a s s o c i a t i o n s w i t h educa


t i o n a n d i n c o m e . C i r c u l a t i o n 1990;81.
2 3 . M e n o t t i A., Keys A., K r o m h o u t D . e t al. I n t e r c o h o r t differ
e n c e s i n c o r o n a r y h e a r t disease m o r t a l i t y i n t h e 25-year fol

low-up

1994;49:121.

(
) . 1989;156 157.
risk f a c t o r s for c o r o n a r y h e a r t d i s e a s e i n m i d d l e - a g e d m e n :
c o m p a r i s o n of two c o h o r t s 15 years apart. C V D Epidemiol
1992/93;48:62.

seven

countries

study.

CVD

Epidemiol

Risk

factor

changes

and

mortality

results.

JAMA

1 9 8 2 ; 2 4 8 : 1 4 6 5 1477.
25. P o o l i n g p r o j e c t r e s e a r c h g r o u p . R e l a t i o n s h i p o f b l o o d pres
s u r e , s e r u m c h o l e s t e r o l , s m o k i n g h a b i t s , relative w e i g h t , a n d
E C G abonormalities to incidence of major coronary events.

17. E p s t e i n F . H . C o r o n a r y h e a r t disease e p i d e m i o l o g y r e v i s i t e d .
C i r c u l a t i o n 1973;48:184

194.

disease. M o d e r n c o n c c a r d i o v a s c dis 1979;48:7

F i n a l r e p o r t o f t h e P o l l i n g P r o j e c t . J C h r o n D i s 1987;31:201

18. Epstein F. Predicting, explaining a n d preventing c o r o n a r y heart


12.

306.

26. P y o r a l a K .
. Ed.ross. Cor

19. Keys A. C o r o n a r y h e a r t disease in seven c o u n t r i e s . C i r c u l a t i o n


1970;41:1:1 2 1 1 .

et vasa 1991;33:2:91 103.


2 7 . S t a m l e r J . , W e t h w a r t h D . , N e a t o n J . D . I s r e l a t i o n s h i p be

20. Keys A. S e v e n c o u n t r i e s : a m u l t i v a r i a t e analysis of d e a t h a n d


c o r o n a r y h e a r t disease. L o n d o n 1980;381.
2 1 . K o n s t a n t i n o v V., Z h u k o v s k i G . , Burlutski G . e t al. Prevalence
o f c o r o n a r y h e a r t disease, a r t e r i a l h y p e r t e n s i o n a n d excessive
b o d y m a s s w i t h r e s p e c t t o d i e t a r y h a b i t s a m o n g m e n residing
i n v e r i o u s cities o f t h e U S S R ( c o o p e r a t i v e s t u d y ) . C V D Epi
demiol

the

24. M R F I T R e s e a r c h G r o u p : m u l t i p l e risk factor i n t e r v e n t i o n tri


al.

16. D a n z i n g V., T o m e c k o v a M . , S i m e k S. et al. C o m b i n a t i o n s of

of

1989:45:39.

t w e e n c h o l e s t e r o l a n d risk o f p r e m a t u r e d e a l t h from c o r o n a r y
h e a r t disease c o n t i n o u s a n d g r a d e d ? J A M A 1 9 8 6 ; 2 0 : 2 8 2 3

2828.
2 8 . T h e C H D R i s k - m a p o f E u r o p e . T h e 1st R e p o r t o f t h e W H O E r i c a P r o j e c t s . E u r H e a r t J 1988;9:1:1 36.
29. U e m u r a K., Pisa Z . T r e n d s i n cardiovascular disease m o r t a l i t y
i n i n d u s t r i a l i z e d c o u n t r i e s since

1950. W H O

1988;41:3/4:155.

22. L u e p k e r R.V., R o s a m o n d W . , S p o r a f k a M . e t al. P o p u l a t i o n

28.03.96

1 9 9 7 .

100

(1897

1987, ) ,

100

( 1 8 9 7

1980, ) ,

, ,

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. 1948 .

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.: . , 3- . ; , 3- .
.: . , 3- . ; . . . . .
1988. N 3. . 1 5 4 157; .., ..
. . . .

1 9 8 8 . N 3. . 1 5 3

157;

. . . . 1988. N 12. . 1 2 8 .

48

(KARDIOLOGIYA),

. . 65

1,

1997

,1997


1
.., .., .., ..
PATHOGENESIS OF EARLY STAGE OF ADRIAMYCIN CARDIOMYOPATHY. PUMP FUNCTION
AND ULTRASTRUCTURE OF THE HEART
V.I.KAPELKO, A.N.KHATKEVICH, N.N.BESKROVNOVA, V.G.TSYPLENKOVA
- ,
(2 /) .
8 16 .
(2 8 % ) .
, , , - ,
. ,
, . ,
, ,
.
, .
, , .

Rats were given 3 injections of 2 mg/kg of doxorubicin (Adriamycin) with daily intervals. In 8 16 days after
last injection hearts were excised and pump function of isolated hearts and myocardial ultrastructure were
studied. Cardiomyocytes were changed in small proportion of cells (2 8 % ) . The following changes were
observed: margination of nuclear chromatin, vacuolisation of outer nuclear membrane, vesiculation of sar
coplasmic reticulum, swelling of mitochondria with internal accumulation of electronic-dense material,
occasional overcontraction or lysis of myofibrils. These changes characteristic of moderate calcium over
loading of cells were not accompanied by depression of pump function cardiac output was somewhat
higher than in control at any filling pressure but the difference was not significant. The curve representing
myocardial distensibility was somewhat shifted to the right in the direction of higher distensibility. With
increase in resistance the work of the heart rose more in the group of adriamycin treated rats. Normal or
slightly elevated level of cardiac pump function in adriamycin treated rats in the presence of impaired ultrastructure of a part of cardiomyocytes implied augmentation of function of uninjured cells.
Key

word:

cardiomyopathy;

adriamycin;

isolated

heart;

distensibility

()
.


,
.
( 6 /)


[1].
,
,

1

96-04-49831.

(KARDIOLOGIYA),

1,

1997

of the

heart.

[2].


. ,
.


350
430 , (Doxorubicin, "Farmitalia Carlo Erba")
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g u i n e a - p i g h e a r t . E u r J P h a r m a c o l 1993;234:173

1990;206.

. . , . . , . . .

7.

Sigurdson W.,

R u k n u d i n A.,

8.

Sachs F.

Calcium imaging of

Circul Physiol 31):H1110 H1115.


4.

H a n e d a T . , W a t s o n P.A., M o r g a n H . E . E l e v a t e d a o r t i c pres
sure, c a l c i u m u p t a k e , a n d p r o t e i n synthesis in r a t h e a r t . J M o l
Cell C a r d i o l 1989;21:1:131

5.

138.'

Ca +
.

B r o w n K.A., B l o w A . J . , W e i s s R . M . e t a l . A c u t e effects o f
f u n c t i o n . Am H e a r t J 1989;118:979 982.

9.

M c C o r m a c k J . G . , H a l e s t r a p A . P . , D e n t o n R . M . R o l e o f cal
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10. Aversano R., B o o r P.J. H i s t o c h e m i c a l a l t e r a t i o n s of a c u t e a n d


chronic

.., ., . .

1996;12.

Effects o f d o x o r u b i c i n o n e x c i t a t i o n -

d o x o r u b i c i n o n h u m a n left v e n t r i c u l a r systolic a n d d i a s t o l i c

m e c h a n i c a l l y i n d u c e d fluxes in tissue-cultured chick h e a r t : role


of stretch-activated i o n channels. Am J Physiol 1992;262 ( H e a r t

K o r t h M.

C i r c u l a t R e s 1995;76:645 6 5 3 .

.
. .

W a n g Y.X.,

181.

c o n t r a c i o n c o u p l i n g i n g u i n e a pig v e n t r i c u l a r m y o c a r d i u m .

3.

T e m m a K., Akera . , C h u g u n A. et al. C o m p a r i s o n of cardiac

doxorubicin

cardiotoxicity.

Moll

Cell

Cardiol

1983;15:543 5 5 3 .
1 1 . K a p e l k o V . I . , P o p o v i c h M . I . , S h a r o v V . G . e t al. T h e u l t r a s tuctural, metabolic and functional alterations of the heart at
prolonged adriamycin treatment. J Appl Cardiol

1989;4:79

89.
15.08.96

(KARDIOLOGIYA),

1,

1997

53

,1997

.., .., ..
DETERMINATION OF THE CHARACTERISTIC AORTIC IMPEDANCE BASING ON NONINVASIVE
MEASUREMENTS
V.L.KARPMAN, V.R.OREL, A.YA.FARBER
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14. Laskey W . R . , R u s s m a u l W . G . , M a r t i n J . L . e t al. C i r c u l a t i o n

1981;624.

1985;72:61 7 1 .

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1965;275.

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4.

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1980; 4:12 13.

5.

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M c D o n a l d D.A. J P h y s i o l ( L o n d o n ) 1955;127:533 552.

M c D o n a l d D.A. B l o o d flow i n arteries, 2 - n d . L o n d o n : A r n o l d


1974;496.
17. M c D o n a l d D.A., Taylor M . G . Progr Biophys C h e m 1959;9:107
173.
18. M e r i l l o n J . P . , M o t t e G . , F r u c h a u d J . e t al. C a r d i o v a s c R e s

271.

1978;12:401 406.

6.

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7.

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19. M i l n o r W . R . C i r c u l a t R e s 1975;36:365 370.

. 1986;42 80.

20. M u r g o J . P . , W e s t e r h o f N . , G i o l m a J . P . e t al. Ibid 1981;48:334

.., . . . 7 5

343.
2 1 . N i c h o l s W.W., C o n t i C.R., Walker W . E . et al. Ibid 1977;40:451

8.

. . 1993;262 2 7 1 .
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. 1984;2:121

122.

458.
22. N i c h o l s W . W . , P e p i n e C.J. P r o g r C a r d i o v a s c D i s 1982;24:293
306.
2 3 . O ' R o u r k e M . F . P h y s i o l R e v 1982;62:570 6 2 3 .

10. . . , . . , ..
1969;6:1108 1113.

2 4 . S p e n c e r K . T . , L a n g R . M . , N e u m a n n A . e t al. C i r c u l a t R e s

1 1 . C l a r k J.W., Ling R.Y.S., Srivasan R . e t al. I E E E T r a n s B M E

2 5 . T a y l o r M . G . P h y s M e d Biol 1957;1:258 269.

1980;27:20 29.
12. K a r p m a n V . L .

Cardiovascular system a n d physical exercise.

B o c a R a t o n F l o r i d a : C R C Press I n c 1987;196.

56

1991;68:1369 1377.
2 6 . T a y l o r M . G . B i o p h y s J 1966;6:29 5 1 .
27. Womersly J.R. J Physiol ( L o n d o n )

1955;127:553 5 6 3 .

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10.02.95
1997

,
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27 30 1995 .

,1997


.., .., .., ..
INTRAOPERATIVE TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN EVALUATION OF RESULTS
OF RECONSTRUCTIVE SURGERY OF CARDIAC VALVES
I.E.RYKUNOV, V.A.SANDRIKOV,V.A.IVANOV, S.L.DZEMESHKEVICH
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27.08.95

(KARDIOLOGIYA),

1,

1997

59

.., .., 1997

-

.., ..
DOPPLER ECHOCARDIOGRAPHY IN POSTOPERATIVE DIAGNOSIS OF COMPLICATIONS IN PATIENTS
WITH CONGENITAL HEART DEFECTS
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62

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1997

,1997



.., .., ..
ECHOCARDIOGRAPHIC ASSESSMENT OF EFFICACY OF SURGICAL CORRECTION OF VALVULAR HEART
DEFECTS
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(KARDIOLOGIYA),

1,

1997

65

..,1997



..
SIGNIFICANCE OF INVESTIGATION OF DIFFERENT TYPES OF BLOOD PRESSURE VARIABILITY IN PATIENTS
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1997

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6 9 , 4 0 , 3 * **

67 5 0 3* ** *** +

68 1 0 3* ** ***


, . .

158,60,6**

160,10,6

156,60,6* **

154,50,6* ** ***

154,30,6* ** ***

, . .

105,30,4**

106,20,4

105 1 0 4* **

104 9 0 4* ** ***

105,10,4* **

74,00,3**

74,50,3

71 7 0 4* **

70 2 0 4* ** *** +

70 5 0 3* ** ***

. , ; .
* , , 1, ** 2, ***
3, # 4, + , , 5.

68

(KARDIOLOGIYA),

1,

1997

..

. -

. ,

, 15

. ,

, ,
.

1.

Imholz B.R.M., Langewouters G . S . , van Montfrans G.A. et


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2.

M a n c i a G . , P a r a t i G . , P o m i d o s s i G . e t al. Arterial b a r o r e c e p -

blood pressure and silent cerebrovascular damage in elderly


h y p e r t e n s i v e p a t i e n t s . A d v a n c e d s i l e n t c e r e b r o v a s c u l a r dam
age in e x t r e m e d i p p e r s . H y p e r t e n s i o n 1996;27:130 135.

.., .., . . . -

15. Davies R . J . O . , J e n k i n s N . E . , S t r a d i n g J . R . Effects of measur

ing a m b u l a t o r y b l o o d pressure o n sleep a n d o n b l o o d pressure

" "
. 1992;11 12: 15
18.
4.

h u m a n s . H y p e r t e n s i o n 1990;16:414 4 2 1 .
D i R i e n z o M . , C a s t i g l i o n i P . , M a n c i a G . e t al. 2 4 - h o u r se
interval in free-moving subjects.

I E E E T r a n s Biomed Eng

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T o c h i k u b o O., M i y a z a k i N . , Y a m a d a Y . e t al. M a t h e m a t i c a l
evaluation of 2 4 - h o u r b l o o d pressure variability in y o u n g , mid
dle-aged and elderly hypertensive patients. Jap
1987;51:1123
7.

Circulat J

1129.

D i R i e n z o M . , C a s t i g l i o n i P . , F r a t t o l a A . e t al. E v a l u a t i o n o f
the

1/f m o d e l t o d e s c r i b e 2 4 - h o u r b l o o d p r e s s u r e ( B P ) a n d

h e a r t r a t e ( H P ) profiles i n m a n . J H y p e r t e n s 1992;10:4:S18.
8.

Di R i e n z o M . , P a r a t i G . , Castiglioni P. et al. Role of sinoaortic afferents in m o d u l a t i n g BR a n d pulse interval spectral char


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H1818.

9.

e r r o r s in n o n - i n v a s i v e a u t o m a t e d b l o o d p r e s s u r e r e c o r d i n g s . J

S c h n a l l P . L . , P i c k e r i n g T . G . , K a r a s e k R.A. T h e r e l a t i o n s h i p
of j o b characteristics, social s u p p o r t a n d psychological traits to
ambulatory blood pressure-initial results of a case-control study.
C i r c u l a t i o n 1987;76:4:396 4 0 1 .

10. S u n d b e r g S., K o h v a k k a A., G o r d i n A. R a p i d r e n e w a l of circad i a n b l o o d p r e s s u r e in shift w o r k e r s . J H y p e r t e n s 1988;6:393


396.
1 1 . T a s e m e n t z i s S.A., G i l l J . S . , H i t c h c o c k E . R . e t al. D i u r n a l
v a r i a t i o n o f activity d u r i n g t h e o n s e t o f s t r o k e . N e u r o s u r g e r y
1985;17:901

17. S t a e s s e n J . , Bullpitt C.J., O ' B r i e n E. et al. T h e d i u r n a l b l o o d


p r e s s u r e p r o f i l e : a p o p u l a t i o n study. Am J

H y p e r t e n s 1992;

5:386 392.

q u e n t i a l s p e c t r a l analysis o f a r t e r i a l b l o o d p r e s s u r e a n d p u l s e

6.

d u r i n g sleep. Br M e d J 1994;308:820 8 2 3 .
16. S c h w a n A., P a w e k K . C h a n g e i n p o s t u r e d u r i n g sleep c a u s e s
H y p e r t e n s 1989;7:6:S62 S 6 3 .

P a r a t i G . , Castiglioni P., Di R i e n z o M. et al. S e q u e n t i a l spec


tral analysis of 2 4 - h o u r b l o o d pressure and pulse interval in

5.

p e r s ( l e t t e r ) . L a n c e t 1988;2:397.
14. K a r i o K., M a t s u o T . , K o b a y a s h i H . e t al. N o c t u r n a l fall o f

t o r reflexes a n d b l o o d p r e s s u r e a n d h e a r t r a t e variabilities i n
h u m a n s . Ibid 1986;8:147 153.
3.

13. O ' B r i e n E . , S h e r i d a n S., O ' M a l l e y K . D i p p e r s a n d n o n - d i p

904.

18. M a n c h i a G . , D i R i e n z o M . , P a r a t i G . A m b u l a t o r y b l o o d pres
sure m o n i t o r i n g use in h y p e r t e n s i o n r e s e a r c h a n d clinical prac
tice. H y p e r t e n s i o n 1993;21:510 524.
19. V e r d e c c h i a P . , S c h i l l a c i G . , B o l d r i n i F . e t a l . Q u a n t i t a t i v e
a s s e s s m e n t of d a y - t o - d a y s p o n t a n e o u s variability in non-inva
sive a m b u l a t o r y b l o o d p r e s s u r e m e a s u r e m e n t i n e s s e n t i a l hyp e t e n s i o n . J H y p e r t e n s 1991;9:6:S322 S 3 2 3 .
20. T r a z z i S., M u t t i E., F r a t t o l a A. et al. R e p r o d u c i b i l i t y of n o n invasive a n d i n t r a - a r t e r i a l b l o o d pressure m o n i t o r i n g : implica
t i o n for studies on antihypertensive t r e a t m e n t . Ibid;115 119.
2 1 . G e r i n W . , Rosofsky M . , P i e p e r C. , P i c k e r i n g T . C . A t e s t of
r e p r o d u c i b i l i t y of b l o o d p r e s s u r e a n d h e a r t r a t e variability us
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1131.
22. G i a c o n i S. S e a s o n a l influences on b l o o d pressure in h i g h nor
m a l t o m i l d h y p e r t e n s i v e r a n g e . H y p e r t e n s i o n 1989;14:22
27.
2 3 . I z z o J . L . . , L a r r a b e e P . S . , S a n d e r E . , Lillis L . M . H e m o d y n a m i c s of seasonal a d a p t a t i o n . Am J H y p e r t e n s 1990;3:405
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24. K e a t i n g e W . R . , C o l e s h a w S.R.K., C o t t e r F . e t al. I n c r e a s e s i n
p l a t e l e t a n d r e d cell c o u n t s , b l o o d viscosity a n d a r t e r i a l pres
sure during m i l d surface cooling; factors in m o r t a l i t y from
c o r o n a r y a n d cerebral trombosis in winter. Br M e d J 1984;289:
1405 1408.

12. V e r d e c c h i a P. C i r c a d i a n b l o o d pressure c h a n g e s a n d left ven


tricular hypertrophy in essential hypertension.
1990;81:528 530.

(KARDIOLOGIYA),

Circulation

1,

1997

20.05.96

69

,1997



.., .., .., ..
COMPARATIVE STUDY OF EFFICACY OF TREATMENT OF PATIENTS WITH MILD ARTERIAL HYPERTENSION
BY ATENOLOL AND COMBINATION OF ATENOLOL CHLORTHALIDONE
S.N.PETUNIN, N.K.MERKULOVA, B.B.BONDARENKO, V.D.SHURYGINA
, -

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29.03.96

70

(KARDIOLOGIYA),

1,

1997

(KARDIOLOGIYA),

1,

1997

71

,1997

,
.
I.

.., .., ..
PAINLESS MYOCARDIAL ISCHEMIA. PRESENT STATE OF THE PROBLEM AND CLINICALLY SIGNIFICANT
ASPECTS OF ITS PROGRESS. I. PREVALENCE AND PROGNOSTIC SIGNIFICANCE OF PAINLESS
MYOCARDIAL ISHEMIA
V.V.KONDRATIEV, E.V.KOKURINA, E.V.BOCHKAREVA
- ,

1938 . S . M a r t i n L . G a r h a m [1]
,
,
,
. 1950 .
P . W o o d . [2]
ST

. 1974 . S.Stern . [3]

ST, 2 4 -
. 80-

(
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,

S T
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[4, 5].


,
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[6 11].



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P . C o h n ,
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72


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.
I I I

.



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,

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[14].


,
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ST [15].

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1997

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...

, ST

1 0,08 j

ST,

201

Tl

[16, 17].

, ,

[14, 2 2 , 2 3 ] .

[18]. ,

, , -

ST ,

),

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201

Tl,

82

Rb [19, 2 0 ] .

.1 ,
24- 5374 , 5

ST

20 65 .

ST 0,8 2 4 %

[21]. , -

( 1,8%).

ST

ST

R.Kohli .

[20].

[24], P . F a z z i n i . [25], -

ST

1.
I

.
,

, %


ST

ST

[14]. ,

W.Armstrong

. [26]

A.Quyyumi

. [71]

95%. ,

A. Ostersprey

. [72]

R.Kohli

50%.

. [24]

P.Fazzini

. [25]

50

35 49

24

120

20 60

8,3

88

31 65

7,4

106

20 67

16

0,9

Tl

4842

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0,8

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5374


,
,

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1997

. . 2 8:
; Tl

201

Tl

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.

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0,5%
.
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23 997 35 68 ,

. ST
1,7 12%
( 3,6% ),

, ..
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. [26], E.Giagnoni . [27]
,


,
2%
.
,

2.
I

, %

V.Froelicher

ST

2533

25 55

3,0

1,3

1974

40 59

3,8

1,3

101

41 56

8,9

8,9

50

35 49

12,0

12,0

10723

18 56

1,7

1,7

916

25 55

6,6

1,7

256

31 65

5,5

1,2

Tl

407

40 96

5,6

5,6

Tl

2175

455,6

8,9

6,6

4842

40 59

4,8

0,5

3,6

1,9

. [73]
J.Erikssen
. [74]
R.Langou
. [75]
W.Armstrong
. [26]
E.Giagnoni
. [27]
P.McHenry
. [54]
A.Ostersprey
. [72]
J.Fleg
. [7]
R.Schwarzt
. [76]
P.Fazzini
. [25]

74

23997

(
) 0,5 1,9%,


,
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,
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"", ,
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. 5 6
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72%
3 45%
.
II 34 4 1 %
,
,
. . 6,

(KARDIOLOGIYA),

1,

1997

..

...

3. II

, %

S.Gottlieb . [8]

103

46 77

75

26

82

25

T . K o h y a . [34]

92

5511

P.Currie, S.Saltiss [77]

201

34 76

97

12

P.Currie S.Saltiss [77]

177

34 76

95

28

P.Ouyang . [58]

59

614

100

46

H.Mickley . [78]

123

558

84

19

90

23

755

4. II

, %

M . H a n d s . [79]

13

457

92

17

D.Tzivoni . [80]

224

61

32

E.Trzos . [81]

150

51 ( )

56

32

53

41 63

67

16

118

558

100

17

90

26

. . . [82]
H.Mickley . [83]

588

5. II

, %

P . T h e r o u x . [84]

210

R . G i b s o n . [85]

190

18 70

80

22

75

30

60

558

63

100

395

31 70

65

40

E.Van der Wall . [87]

56

5410

100

36

H.Mickley . [78]

123

558

99

16

C . M i r a h d a . [88]

216

57,8

68

39

S.Koyahagi . [89]

229

84

37

X.Bosch . [90]

413

549

53

26

P.Ouyang . [86]
K . F o x . [56]

B.Caro . [91]

25

40 66

80

50

L.Bolognese . [55]

211

29 70

93

33

T . T o y o d a . [92]

157

529

89

36

74

34

2285


,

.

,

(KARDIOLOGIYA),

1,

1997

, 3 8 % ,

.
,
,
, -

75

6. II

, %


J.Tubau . [93]

118

<65

H.Yamabe . [94]

38

33 71

G . S a n z . [95]

403

<60

T . S a i t o h . [61]

160

42

50

68

34

34

17

100

38

T . T a k e u c h i . [96]

157

559

71

40

A . F u b i n i . [97]

186

538

100

30

G.Casella . [98]

777

>50

30

68

. . . [99]

40

41 63

32

46

. . . [82]

53

41 63

68

25

45

41

1882

7. III

, %

ST

a
ST

J . D e t r y . [100]

107

27 65

100

20

E.Amsterdam . [101]

92

32 79

68

40

D . M a r k . [102]

1698

44 59

50

29

F.Visser . [103]

245

538

100

20

S.Aggelakas . [104]

278

100

39

F . R o m e o . [41]

406

48,3

100

24

93

559

85

57

360

35 69

63

39

14

61,1

85

42

85

37

70

27

H.Kishida T.Saito [57]


J . D e t r y . [66]
R.Davies . [105]
K . F u k a m i . [106]

347
3640

,
, ,
,
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, .

.
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-
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.


.
. 7
,

76

3640
, 34 69 .
ST
70% ,
2 7 % .

,
,

20 3 9 % ( 2 7 % ) .
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S T
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. ,

,
. 82%

(KARDIOLOGIYA),

1,

1997

..

...

8. III

, %

ST

ST
70

H.Kishida . [48]

127

539

100

T . K o h y a . [34]

78

5310

79

61

D . D e e d w a n i a E.Carbajae [45]

105

45 79

43

100

J.Barry . [44]

117

62

100

40 65

70

86

41

557

85

97

96

34 70

52

88

70

82

K . N o r r e g r a a d - H a n s e n . [49]

10

K.Egstrup P.Anderson [46]


M . G a n d h i . [47]

574

ST, ,
.
15
1510
( ) ,

[9, 29 4 2 ] . ,
, ,

ST
[ 3 1 , 33 37, 40 43]
[44 50]
74%.


, , -
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,

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, P . C o h n [52],
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4229 3 5

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1997

65 , ,
,
, (
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2 12 1,6 13,4 ,

[7, 15, 27, 53, 54].

0,1 1,6 0 0,3% .

, ,
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30%
, .
II
,


. ,


1,2 13,5 2,6 10
[8, 11, 55
60].
0,4 27 0,2 2%,
S.Gottlieb . [8], P . T h e r o u x
. [11], E.Trzos . [60]
.
""

,

ST,
[11, 55, 56, 59 61]
.

77

,

, L.Bolognese
. [55], P.Ouyang . [58], H . K i s h i d a
T . S a i t o [57]
, ,
,
,
.
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, ,
.


,
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, 1080 58 63


2,8
6 1,7 5,5

ST [6, 9, 62 6 4 ] .

4,2 12 1 4% .
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ST ,

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4 1 , 57, 65 6 9 ] . ,


.
,

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.
ST,
,

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. " " ,
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,

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.
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(, 201

Tl
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2.



.
3.

( 82%),
74% ,
,
.
4.
, ,

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,
,
.
ST ( ,
)
,
.

1.

M a r t i n S., G r h a m L . C a r d i a c p a i n . A r c h I n t e r n M e d 1938;
62:840 852.

78

2.

W o o d P., M c G r e g o r M., M a g i d s o n O., W h i t t a k e r W. T h e


effort test in a n g i n a p e c t o r i s . Br H e a r t J 1950;12:363 3 7 1 .

(KARDIOLOGIYA),

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1997

.. ...

3.

S t e r n S., G a v i s h A., W e i s z G. et al. C h a r a c t e r i s t i c s of silent

24. K o h l i R., C a s h m a n P . , L a h i r i A., Rafferty E . T h e S T s e g m e n t

a n d s y m p t o m a t i c m y o c a r d i a l i s c h e m i a d u r i n g daily activities.

of the ambulatory electrocardiogram in a n o r m a l population.


Br H e a r t J 1988;60:4 16.

Am J C a r d i o l 1988;61:1223 1228.
4.

C o h n P. S i l e n t m y o c a r d i a l i s c h e m i a 1988; 109:312 317.

5.

S t e r n S., T z i v o n i D . E a r l y d e t e c t i o n o f s i l e n t i s c h e m i c h e a r t
disease b y 2 4 - h o u r e l e c t r o c a r d i o g r a p h i c m o n i t o r i n g o f active
subjects. Br H e a r t J 1974;36:481 486.

6.

D e e d w a n i a D . , Carbajae E. Usefulness of ambulatory S M I


p r e d i c t i n g risk o f c a r d i a c d e a t h i n p a t i e n t s w i t h stable a n g i n a
pectoris and exercise i n d u c e d m y o c a r d i a l i s c h e m i a . Am J
C a r d i o l 1991;68:1279

1286.

b y t h a l l i u m s c i n t i g r a p h y a n d e l e c t r o c a r d i o g r a p h y i n asympto
m a t i c v o l u n t e e r s . C i r c u l a t i o n 1990;81:428 436.
G o t t l i e b S., G o t t l i e b S . H . , Achuff S. et al. Silent i s c h e m i a on
t i o n p a t i e n t s . J A M A 1988;259:1030

1035.

p h y . Ibid 1982;49:1638 1642.


27. G i a g n o n i E., S e c c h i M . , Wu S. et al. P r o g n o s t i c value of
A prospective m a t c h e d study. N Engl J M e d 1983;309;1085
1089.
28. . . , . . , . .
1987;1:38 42.
2 9 . .., . . , ..

N y m a n G . , L a r s s o n A., R e s k o y M . e t al. T h e p r e d i c t i v e value


o f s i l e n t i s c h e m i a a n e x e r c i s e t e s t before d i s c h a r g e , after a n
episode of unstable

a n d m a g n i t u d e of ST s e g m e n t a n d T wave a b n o r m a l i t i e s in
n o r m a l m e n during continuous ambulatory electrocardiogra-

H o l t e r m o n i t o r i n g p r e d i c t s m o r t a l i t y in h i g h risk posinfarc9.

E C C I S p r o j e c t ) . Am J C a r d i o l 1993;72:1383 1388.

exercise E C G testing i n a s y m p t o m a t i c n o r m o t e n s i v e subjects:

Fleg J., G e r s t e n b l i t h G . , Z o n d e r A. et al. Prevalence a n d prog


n o s t i c significance of exercise i n d u c e d m y o c a r d i a l d e t e c t e d

8.

myocardial ischemia in symptomatic middle-aged m e n (the


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15 30 30 40

, ,

, 5 6


, 30 60
. J . P e r r y .

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[ 6 3 ] .

, 5

15 16 .

[64 66].

( 1 14

) 5 30% .

15 35

[35, 4 2 ] .

[9, 67].

m a c r o - r e - e n t r y ,

60

8 0 % [17, 67].

) ,

[49 5 1 ] .

, -

: 1 )

P ; 2)

100% [68, 69].

[50,

. M.Brignole .

52]. " "

3 -

" "

, [49, 53, 54],

23

[70]

[52]. ,

- .

NYHA),

( 15%),

/3

[55].

. -

[9].

[56].

[71].

, 8 0 100%

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[35, 57, 58].

17 4 9 % [50, 59].

R [72].

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62. K a t r i t s i s D . , I o d r o m i t i s E., F r a g a k i s N . , K r e m a s t i n o s D . T h .
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l a t i o n of t h e a t r i o v e n t r i c u l a r j u n c t i o n . I b i d ; 2 1 ( 1 ) : 1 0 2 109.
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atrioventricular junction.

Ibid

1992;

70(7):765 768.

51. N u n e z A., Arribas F . , L o p e z - G i l M. et al. A study of the


m e c h a n i s m of atrial flutter a n d atrial t a c h y c a r d i a c in adults by
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Am

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53. Feld G . K . , S h a h a n d e h R . F . M e c h a n i s m s o f d o u b l e p o t e n t i a l s
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c o m p a r i s o n of t h e right- a n d left-sided a p p r o a c h e s to a b l a t i o n
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52. Calkins H . , L e o n A . R . , D e a m A . G . e t al. C a t h e t e r ablation o f


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Coll Cardiol

2032.

55. Cosio F . G . , G o i c o l e a A., L o p e z - G i l M . , A r r i b a s F . C a t h e t e r


ablation of atrial flutter circuits.

PACE

1993;16(3):2:637

642.

6 9 . S o u z a O., G u r s o y S., S i m o n i s F. et al. Right-sided versus leftsided

radiofrequency

ablation

of

the

His

bundle.

Ibid

1992;15(10):1:454 459.
7 0 . B r i g n o l e M . , G i a n f r a n c h i L., M e n o z z i C . e t al. I n f l u e n c e o f
atrioventricular junction radiofrequence ablation in patients
w i t h c h r o n i c atrial fibrillation a n d flutter on quality of life a n d
c a r d i a c p e r f o r m a n c e . Am J C a r d i o l 1994;74(3):242 246.
7 1 . P a r a v o l i d a k i s K., K o l e t i s T . , T h e o d o r a k i s G . e t al. Effects o f
a t r i o v e n t r i c u l a r n o d a l m o d i f i c a t i o n of left v e n t r i c u l a r f u n c t i o n
a n d exercise t o l e r a n c e i n p a t i e n t s w i t h c h r o n i c a t r i a l fibrilla
t i o n w i t h r a p i d v e n t r i c u l a r r a t e . E u r H e a r t J 1995;16:321.

56. S a o u d i N . , P o t y H . , D a o u A . e t al. Successful e l e c t r o p h y s i o logically guided radiofrequency c a t h e t e r ablation of type I atrial


flutter d u r i n g sinus r h y t h m . E u r H e a r t J 1995;16:16.

72. Shenasa M., Shenasa H. Distinct "bimodal distribution" in R


R interval h i s t o g r a m s d u r i n g atrial fibrillation: i m p l i c a t i o n s
for r a d i o f r e q u e n c y c u r r e n t m o d i f i c a t i o n of t h e a t r i o v e n t r i c u l a r
n o d e . Ibid; 3 2 1 .

(KARDIOLOGIYA),

1,

1997

07.05.96

91

..,1997

,
..
RIGHT ATRIAL INFARCTION WITH CONSEQUENT ATRIAL RUPTURE
L.B.LAZEBNIK
,

1967 . . . .

,

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92

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1,

1997

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1. P

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. . , . .

.., . . , . . ,
.. ,

. 1969;2:155

157.

. 1978;1:124

.., .., ..
. .
., . . .
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1974;25.

(KARDIOLOGIYA)),

5.

126.

.., ..

1989;12:63 6 6 .
3.

4.

. 1976;5:52 54.
16.06.96

1,

1997

93

,1997

.., .., ..
DIAGNOSIS OF TUBERCULOUS PERICARDITIS
N.B.GUMBATOV, V.A.AZIZOV, G.A.TARVERDIEVA
,

[1].

. 9

(, ,

) . , ,

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, 1 1 %

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.,

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, , , ,

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1995 .

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94

(KARDIOLOGIYA),

1,

1997

14,2 c , 3 2 / , C -

+ + + ,

. (

, 2 ) .

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F o w l e r N . O . J A M A 1991;266:99

2.

.., .., ..

103.

3.

.., . .

Q u a l e J . M . , L i p s c h i k G . Y . , H e u r i c h A . E . A n n T h o r a c Surg
1987;43:653 6 5 5 .

1990;2:111 112.
- .

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04.01.96

23 25 1997 -

II
" - "

2 1997 .
, 1

:
1 0 1 9 5 3 , , .,10,


.:

924-01-15

: 9 2 8 - 5 0 - 6 3 .

(KARDIOLOGIYA)),

1,

1997

95

, "" 1 9 9 6
INDEX OF PAPERS PUBLISHED IN THE JOURNAL KARDIOLOGIA IN 1996

..,

1,4


( )
. 6,4
..

.

. 11,4

. ..

. 4,4
..

. . 12,4

..,

..,

..,

..,

..,

..,

..,
..

:
. 2,4

..,

..

12,18

..,

..,

..,

..,

..,

..

,
( ) ? 9,31

..,

..,

..,

..,

..,

..,

..

..,

..,

..,

..

- -

. 5,18

..

..,

..

..

..,

5,22

..,

..


. 4,9

..,

..,

..,

..,

..,

..,

..

..

-, ,

: , ,

. 3,4

. 5,30

..,

..

..,

.,,

..,

..

. 5,4

..,

..,

..,

..,

1,34

..,

..,

..,

..

..,


. 4,12

..

. 8,4

..,

..,

..,

..

..,

..,

..,

..,

..,

.
..,

..,

5,11

..,

10,26

..,

8,13

..,

..,

..,

..,

..,

..,

..

..,

5,27

..,

..


,
, . 5,35

..,

..,

..,

..,

..,

..

..,


: . 7,4
..,

..

..,

..,

..

,
-
.

..

. 7,11

..

5-
.

.,

..

: . 10,22

.,

8,8

..


. 8,17

..


. 9,27

..,

..

- -
.

12,22

. 2,25

. 7,38

96

..,

..,

..,

(KARDIOLOGIYA),

..

1,

1997

..,

..,

.., ..,

..,

..

..,

..,

..,

..

..,

8,25

..,

..,

..

7,42

..,

..,

..,

..,

..,

..,

..,

20

. 8,28

..,

..,

..

A d a l a t S L
. 10,41

..,

..,

59

.9,9
..,

..

..,

..,

..

8,32

..

- -

. 7,27

. 8,21

..,

..

..,

..,

..,

..,

..,

..,

.,

..,

..

) . 10,36

..,

..,

..,

..

. 9,13



. 7,36

..,

..,

..,

..,

..,

..,

..



. 7,46

..,

..,

..,

..

..,
..,

..,

..,

..,

..,

..

5,59

2,43

..,

..,

..,

..,

..,

..,

..,

..,

..
10,18

..

Na, -

..

..,

. 9,18

..,

..,

..,

..,

..,

12,32

..,

..,

..,

..,

..,

..


. 10,4

..

1,18

..,

..,
.,

..,
..,

..,

..,

..,

..,

2 -

..

..,

..,

..,

..

. 10,10

..\

5,40
..,

..,

..,

..,

..,

..,

..,

..,

..,

..

4 5- .

2,36

..,

..,

..,

..,

..,

..,

..,

..,

11,38
..,

..

..

. 9,34

. 9,22

..,

..,

..,

..,

..,

..,

..,

..,

..,

..,

..

..

. 5,44

10,29

..

..,

..,

..,

..,

..

10,32
..,

..,

..,

..,

,
. 12,26

..

, -

. 2,31

(KARDIOLOGIYA)),

1,

1997

..,

..,

..,

..

10,14

97

""

..,

..,

..,

..,

..,

..,

- .

..,

..,

..

7,16

..,

..,

..,

..

. 4,23

..

..,

..,

..,

..,

..,

..,

..,

..

1,30

..,

11,17

..,

..,

..

..,

1996

..,

..

6 15

. 2,17

6,52

..,

..,

..,

..,

..,

..,

..,

..,

..

..

..,

10,48

..

()

11,25

..,

..,

..,

..,

..,

..,

,
.

..

12,49

. -

..,

..,

1,24

..,

..,

..,

..,

..

..
6,19

..,

..,

..,

..,

..,

..,

..

I I I . 2 .

10,44

..,

..,

..,

..,

..,

..,

..,

..

. 6,28

..,

..

..,

..,

..,

. 11,32

. 4,47

..,

..,

..,

..,

12,37

10,53
..,

..,

..,

..

..,

12,54

..,

..

..,

..,

..,

..,

..,

..

, -

. 6,58

..

. 4,28

..

..,

..,

..,

..,

..


.
. 4,37

..

..,

..,

..,

..,

..

. 1,12

- -

..,

..,

..,

..,

..,

..

4,15

- QRS

. 7,20

..,

..,

..,

..,

..,

..,

..,
..

..,

..,

..

: --

. 9,38

..,

..,

11,43

..

..

. 4,42

..,

..,

..,

..

1,47
..

. 9,4

..,

..,

..,

..,

..,

..,

..

..,

6,72

..

III -

98

6,38

5,50

(KARDIOLOGIYA),

1,

1997

..,

..,

..

1,37

10,57

..,

..,

..,

..


.,

.,

.,


15 2 0 - . 1,42

..,

..,

..,

..

..,

..,

11,49

..,

..,

..,

..,

..


; . 12, 13

..,

..,

..,

..,

..,

..,

..,

..,

..,

..,
-

..\

. 6,74

..,

..,

..,

..


. 4,53

..,

..,

..,

..,

..



. 4,57

..,

..,

..,

..,

..,

..


. 8,35

..,

..,

..,

..,

..,

..,

..,

..


11,63

..,

..,

..,

..,

..,

..,

..

..,

11,54

..,

..,

..

..,

..,

..,

..,

..,

:
?

3,57

..

-
.

3,18

..

-

.

..,

..,

3,39

..,
..,

..,

..,

..,
..,

..,

..,

..,

..,

. 3,8

..,

..,

..


. 3,22

..,

..,

..


- .

..,

..,

..,

3,53

-
. 3,68

..


3,27

..

..,

..,

..

..

..

Ca +

1994 . ) . 3,47

..,

12,57

..

10,63


. 12,62

..,

..,

..,

..,

..,

..,

..,

..,

..,

..,

..,

..,

..,
..,

..,
..,

3,35

..,

..

3,44
..,

..,

..,

..

..

(KARDIOLOGIYA),

..,

..

..,

(CINDI) .

..

..,

..

..,
..

. 3,63

.,

11,59

..,

..,

..,

..,


..,

..,

..,

- -

..,

..,

..,

, ,

. 5,55

..,

1,

1997

. 8,56

99

..,

""

..,

..,

.., ..
-
. 8,52

..,

..,

..

..,

..,

..,

..,

199

..,

..,

1996

..

10,79

..,

..

. 8,60

.,

.,

. 5,63


. 9,51

..,

..

..,

..,

..

. 2,65

6,78

..,

..,

..,

..,

..

10,73

..

..,

..

..,

..,

11,71

..

. 2,54

. 7,52

5,68

..,

..

..,

..

..,

..,

..,

..,

..,

..,

..

..,

..,

- . 2 . 2,59

. 8,47

..,

..,

..

..,

..,

..,

, -, -

) . 4,62
.,

..,

..,

..,

..,

..,

..,

..,

10,76

..

. : , ,
.

11,80
..

..

..

..,

..,

..

- . 1. 1,57

. 9,59

..,

1,51

. 9,74

..,

8,43

..

..
..

. 1,61

. 4,70

. 7,57

. 3,70

..,

..

..,

..,

( -

) .

. 3,75

..,

..,

12,66

..

..,

II

..
..,

..,

..,

..

..

..

. 4,74

.,

2,50

- " "
. 9,64

..

..,

12,79

..

..,

..

- .

. 8,39

. 8,64

..,

..,

..,

..

-
. 9,67

..,

..,

..,

..,

..

201

. 10,68

..



. 9,55

100

..,

..

12,72

..

. 9,71

..,

..,

..,

..,

..


, .
6,83

(KARDIOLOGIYA),

1,

1997

..,

..,

..,

..

1996 . 1,66

. 4,67

..,

..,

..

( 7 0 -

..,

..

) . 7,60

. 4,65

( 90- ).

..

10,84

10,85

12,91

. 11,69

( 75- ).

..,

..,

..,

..

12,92

QRS

12,70

..


. 7,63

..,

..

11,68

..,

..,

..,

..

. 8,71

..,

..,

11,70
..,

..,


. 3,80
..



. 7,62

..,

..,

..,

..

. 3,79

..

5,86

..,

..,

..,

..

,

. V I I . 7,77
..,

..

. V I I I .
.

8,94

..

. 8,86

..,

..

,
- ( I).

..,

1,68

..

,
- ( I I ) . 2,76

..,

..

,
- . ( I I I ) . 3,82

..,

..

..,

..

. 4,95

..

..

..


..,

. V I .

. 7,61

..,

. V.

- ( IV).
..

..,

5,74

..

. . . "

".

- ( V).

..,

5,54

..

..,

. . . "

".

3,94

..

..,

10,87

..

.,

...

. 10,83

..,

7,66

..

..

.. "

6,88

..

" . - , 1 9 5 5 . 6,85

..

. . "
".

. 9,83

12,90

..

: ? 10,98

..

"
" . 11,92

..


. 64-

..

(
) . 8,74

..,

..,

..,

..,

..

11,95

. 2,71

(KARDIOLOGIYA),

1,

1997

101

..,

""

..,

..

..,

1,84

..,

1996

..,

..,

..

. 9,94

..,

..


? 3,95

..,

..,

..,

..,

..,

..


. 4,99

..

..,

..,

..,

..

12,95

..,

..,

..

..,
..

..

..,

..,

..,

..,

..,

..



..,

..,

..,

..,

..,

..

. 5,90

..

. 9,95

. 7,85

..,

Q. 11,103

. 4,103

12,102

..,

..,

..,

..,

..

10,104


. 4,102

..,

..,

..

. 3,98

..,

..,

..,

..


. 2,95
..,

..,

.,

..,

..,

..,

..,

..,

..


. 3,103

..,

..,

..

3,102

..,

..,

..,

..


. 7,83

..,

..,

..,

..,

..


. 9,90

..

. 2,88

..,

..

. .

4,80

( ) . 5,92

( ) . 6,97

. 7,87

7,90

102

(KARDIOLOGIYA),

1,

1997

, "" 1 9 9 6 .

, 1,51.
, ,
10,41.
, , 7,52.
, ,
11,71.
(), , 6,28.
, , 6,38.
, 6,19.

1,68, 2,76, 3,82, 5,74, 7,66.
, , 7,83.
, 8,25.
,
9,4.
, , , ,
- 11,43.
, , , , 4,37.
, , -
QRS 7,20.
, ,
6,83.
, , 8,71.
, ,
6,4.
,
, 11,17.
, , - 8,43.
, , , ,
11,25.
, , , , 1,24.
, 64-
6,71.
, 5,68.
, 2,65.
, , , 3,80.
, 8,13.
, , ,
10,44.
, , , 11,32.
( - ) , , 11,70.
, , ,
7,36.
, , , 7,42.
, , , , 7,46.
, , , 9,9
, , , 11,80.
, , , 10,32.
, ,
8,86.
, , , 8,21.
, , ,
, 4,80.
, , , , 9,18.
, , , 3,63.
, , ,

,
2,43.
, , 4,70.
, , , , 3,39.
, , , , 10,29.
, ,
9,22.
,
,
,
,
,
,

,
8,56.
,
7,38.
, 8,28.
, ,
12,49.
, 7,27.
10,36.

(KARDIOLOGIYA),

1,

1997

,
,
,

11,68.
, 3,79.
, 2,36.
, , , -
9,13.
, , , , 2,31.
, , 9,83.
, , 10,98.
, 9,74.
, - , 1,18.
, , 12,62.
,
, , 4,42.
, ,
7,62.
, ,
9,67.
, , 11, 63.
,
10,4.
, 3,70.
, , Na, 12,32.
, , , 11,103.
, , , 10,22.
, , 10,10.
, , , 2,95.
, , 10,79.
, , , , 5,44.
, , 11,38.
,
, 10,14.
, , 9,34.
, , 9,71.
, , ,
12,26.
, , , 10,18.
, 4,65.
( ) ,
, 5,4.
, , , 11,54.
, , 12,79.
, 10,73.
, , 3,47.
, , 9,51.
, , ,
5,4.
, , -199 8,60.
, , 1,4.
, , 4,67.
, , 5,27.
, , 3,98.
, , , 8,8.
, ,
3,27.
, , 8,4.
, , 3,98.
, , ,
1,30.

, ( ) , , 9,31.
, , 3,22.
, ,
7,61.

, - 8,52.
, , 7,11.

103

""

, ,
4,53.
, , 4,57.
, , 5,36.
, , 1,37.
, 3,8.
,
4,9.
, 10,63.
, , 5,40.
,
4,4.
, 12,102.
, ,
2,4.
, , , , 3,4.
, 1,66.
, 2,76.
, , 8,74.
, ++ 12,57.
, , ,
5,55.
, 1,42.
, , 7,85.
, 6,74.
, -
12,22.
, ,
7,42.
, , ,
9,55.
, , 10,68.
, , 5,59.
, , 6 15 2,17.
, 8,64.
, 1,84.
,
5,30.
,
11,59.
, , 1,12.
, ,
11,69.
, ,
8,32.
, ,
2,54.
, , 9,59.
, ,
10,48.
, 4,23.
( ) ,
, - 1,47.
, , 12,4.
, , , 12, 37.
, , 6,58.
, ,
10,57.
,
, - 4,15.
, , , ,
9,38.
, , 5,50.
, I I 2,50.
, 4,62.
, 11,95.
, , " " 9,64.

104

1996 .

, , 4,95.
, - , 7,77.
, - , ,
5,86.
, - , 8,94.
, 12,54.
, -
8,39.
, 7,63.
, , 6,78.
- , ,
3,35.
, 4,74.
, , 3,18.
, 3,53.
, ,
3,57.
, 4,47.
, 10,98.
, 10,53.
, , 9,95.
, , 5,18.
, , 5,22.
, , () 12,66.
, ,
10,26.
, , 3,68.
, , 1,34.
, , 4,12.
, , , 11,4.
, , , 11,49.
, , , , 1,25.
, - ,
7,96.
, , , , 8,17.
, , , 9,27.
, 4,103.
- , 12,18.
- 1,57, 2,59.
, 5,90.
(-), , ,
7,90.
, , , ,
6,52.
, , 4,28.
, 7,16.
, , -

3,102.
,
5,63.
, 8,47.
, 1,61.
, 9,94.
, 10,76.
, , 4,102.
, 12,13.
, 10,104.
, QRS
12,72.
,
12,95.
, , 3,95.
, 8,35.
, 3,75.

(KARDIOLOGIYA),

1,

1997