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Myocardial Infarction

Coronary atherosclerotic heart disease Coronary thrombosis/embolism Decreased blood flow with shock Direct trauma

Decreased myocardial O2 supply

Cellular hypoxia
Altered cell membrane integrity Decrease myocardial contractility Decreased cardiac output Decreased arterial pressure

Stimulation of baroreceptors

Stimulation of sympathetic receptors


Increased Peripheral vasoconstriction Increased myocardial contractility

Increased afterload

Increased heart rate

Decreased diastolic filling

Decreased coronary tissue perfusion Increased myocardial demand

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