1- Ondansteron HCl is used for : a-hypertension b-angina pectoris c-prophylaxis of migraine d-anti-emetic It is used as anti-emetic with patients receiving

cytotoxics due to its serotonin antagonism Ondansetron is ( Zofran 4 , 8 mg tab. & amp ) 2- All of these are side effect of Chloramephenicol except : a-irreversible aplastic anaemia b-optic neuritis c-peripheral neuritis d-iron deffeciency anaemia 3- Ticlopidine is used for : a-anticoagulant b-antibiotic c-anticholinergic d-antiplatelets 4- All these drugs are fibrinolytics except : a-dipyridamole b-streptokinase c-urikinase
Anti-Coagulants : vit. K antagonists , heparin , warfarin Fibrinolytics : streptokinase , alteplase , reteplase Antiplatelets :aspirin,clopidogrel,tirofiban,eptifibatide, abciximab,dipyridamole

5- All these drugs can be used for parkinsonism except: a-seligiline HCl b-carbidopa c-pergolide d-nedocromil sod.

Drugs used in Parkinson`s disease

Anticholinergic drugs : (Muscarinic Antagonists) Benzatropine,trihexphenidyl,orphenadrine MAOB inhibitors : Selegiline COMT inhibitors : Entacapone Dopamenergic drugs : *Dopamine precursor : levodopa (+ carbidopa or Beserazide) *Releases dopamine : amantadine *Dopamine agonists : bromocriptine,cabergoline,pergolide,ropinirole
6- All these cases not cure with thiazides except: a-hypernatrimia b-hyperglycemia c-hypokalaemia d-hyperuricaemia 7- Cardiac arrest could be managed by the following except : a-ephedrine b-lidocaine c-propranolol d-normal saline 8- Insulin which can be given I.V. is : a-regular type b- 30/70 type c- NPH type d-non of the above 9- Drug that used for leishmania is: a-sod. stiboglyconate b-mebendazole c-sod. cromoglyconate 10- All these drugs are antibacterial except: a-zalcitabine b-lomefloxacin c- cefopyrazone 11- All these are natural Estrogens except : a-mestronol b-oestrone c-oestriol d-oestradiol
Natural Estrogens : Oestrone , Hydroxyoestrone , Oestradiol , Oestriol

Deriv. of nat. Estrogens : Ethenylestradiol , Mestronol Synth. Estrogens : Stilbesterol , Hexanosterol , Trianiselchlorethylene , Propanestriol , Clomifen

12- Co-Trimethoxazole contains :

( Trimethoprim + Sulphamethoxazole )

13- Which of the following has vasodilator effect ? a-nicotine b-cholestyramine c-urokinase d-vit. A 14- One of the following is not from Quinolone group : a-naldixic acid b-quinine c-eoxacin d-norfloxacin 15- One of the following is not for epilepsy : a-clorizepam b-phenytoin c-primidone d-imipramine
(antidepressant)

16- All of these can be used for leprosy except : a-dapson b-rifampicin c- clofazinine d- INH 17- Sumatriptan is used for : a-hypertension b-treatment of migraine c-angina pectoris d-control of epilepsy
( 5-HT1 agonist )

18- Which is enzyme inducer ? a-rifampicin b-cimetidin c-vit. C d-chloramephenicol

Enzyme Inducers: Phenobarbital,carbamazepine,ethanol,rifampicin,polycyclic aromatic hydrocarbons in tobacco smokers Enzyme Inhibitors : Cimetidine ,erythromycin 19- All of the following for prophylaxis of asthma except :

a-ketotifen c-sod. cromoglycate

b-nedocromil sod. d-salbutamol

20- All of the following is NSAH ( Non Sedating AntiHistamine ) except : a-loratadine b-cetrizine c-astimazole d-azotodin 21- All of the following are controlled drugs except : a-rivotril b-epanutin c-sresolid d-diazepam 22- All these drugs are anti-viral except : a-amantadine b-zidovudine c-acyclovir d-aluerin ( it is antispasmodic ) 23- Which one of these symptoms not occur with morphine ? a-diarrhea b-respiratory depression c-constipation d-vomiting 24- Which one of these drugs not used for acute pain ? a-naproxen b-colchicine c-codeine d-prednisolone 25- Which is drug of choice for myxodema ? (hypothyroidism) a-carbimazole b-iodine c-thyroxin sod. d-propyl thiouracil 26- Benzyl peroxide is a local treatment for Acne volgaris 27- Vit. A daily dose is 30`000 50`000 IU for the correction of deficiency and 100`000 200`000 IU for therapy
28- The drug of choice for treatment of amoebae : a-chloramephenicol b-tetracycline c-gentamycin d-metronidazole

29- To prevent more absorption of the toxic drug we use : a-water b-salt sol. c-saline d-charcoal 30- Hepatitis vaccine dose is : a-once/year b-twice/year c-three times/year 31- Which one is OTC drug : a-simple analgesic b-warfarin c- ciprofloxacin 32- Anticoagulant effect of warfarin is decreased by : a-rifampicin b-aspirin c-vit. K d-verapamil 33- One of the following is given once daily : a-amorphous insulin b-protamine zinc insulin(isophan) c-neutral insulin d-regular insulin 34- The steady state conc. Of drug in plasma depends on : a-dirct proportion to the rate of administration b-~~~~~~~~~~~~~~~~~~~~~~~~ elimination c-Indirect ~~~~~~~~~~~~~~~~~~~~~~~~~ d-~~~~~~~~~~~~~~~~~~~~~~~~ administration 35- All these are anticoagulants except : a-warfarin b-ancord c-heparin d- dipyridamol
( anti-platelet )

36- All these are anti-platelets except : a-dipyridamol b-aspirin c-streptokinase

(antifibrinolytic)

d-presantin 37- Ferrograde is : a-ferrous sulphate c- ferrous gluconate

e-ticlopidine b- ferrous citrate d- ferrous fumarate

 ... ... .
38- Procainamide is : a-Na channel blocker c-lisinopril b-nifedipine d-quinidine

39- Mechanism of action of vit. K ?

Vit. K has an essential role in the synthesis of coagulation factors by hepatic cells.
40- Thiazide diuretics cause all the following except : a-hypokalaemia b-hypercalcemia c-hyperuricaemia d-hyponatremia e-hyperglycemia f-hypernatremia 41- Treatment with anti-arrhythmic drug depends on the following except : a-type of medication b-period of medication c-patient sex 42- Elimination of digoxin is mainly by : a-kidney b-liver c-both them 43- Dobutamine is given I.V. because : a-it is not stable in the gastric PH c-it is eliminated very quickly 44- Amloride as trimetren causes : a- CNS disturbance b-hyperkalaemia c-hypokalaemia d-not affect K ( potassium ) 45- What is the most drug can causes damage if it is given OTC ? a-captopril b-warfarin
b-it is needed in large quantities in case of oral route

d-non of

c-chlorothiazide d-rifampicin 46- Drug physical dependence is as same as drug abuse a-true b-false 47- Mention two thiazide diuretics ? a-chlorothiazide b-hydrochlorothiazide 48- What is the difference between Q.I.D & Q.6H ?

Q.I.D = 4 times /day Q.6H = every 6 hours

49- What is the difference between the following antifungal ?

Miconazole = local & systemic Amphotericin = parentral only Griseofulvin = oral

50- Give the indication of the following :
a- gimfibrazole -------> for hyperlipidaemia b- cisapred ------------> for gastroesophegyl reflux c- fluexiten SSRI ( selective serotonin reuptake inhibitor ) -----------Antidepressant d- carbimazole ---------> for hyperthyroidism e- imipramine -----------> tricyclic antidepressant f- ibratrobium Br ----> antimuscarinic as bronchodilator

51- All are antimetabolites except : a-methotrexate b-flurouracil c- cytarabine d-azathioprine(Imuran) e-cyclophosphamide
(alkylating agent)

52- Cefaclor is : a- 1st generation cephalosporin b- 2nd generation cephalosporin c- 3rd generation cephalosporin d- non of the above 1st gen. : cefadroxil(Duricef),cefazolin(Totacef),cephalexin(Ceporex), cephalothin ,cephradine(Velocef),cephapirin(Cefatrexyl) 2nd gen. :

cefaclor,cefoxitin,cefotitan,cefuroxime(Zinnat),cefprozil(Cefzil), loracarbef 3rd gen. : cefotaxime(Claforan),cefoperazone(Cefobid), cefotriaxone(Rocephin),cifixime(Suprax), ceftizoxime(Cefizox),proxetil,cefdinir, cefditoren,pivoxil,ceftazidime(Fortum),ceftibuten,ceftizoxime 4th gen. : cefepime(Maxipime),cefpirome(Cefrom),cefpodoxime 53- Which aminoglycoside antibiotic can be taken orally a-gentamycin b-neomycin c-amikacin d-tobramycin 54- Teicoplanin antibiotic has similar effect on G+ve as a-vancomycin b-jamicacin c-gentamycin d-kanamycin 55- Which is not tetracycline ? a-minocyllin b-demeclocycline c-doxycycline d-clindamycin 56- Which is not Ca++ channel blocker ? a-verapamil b-deltiazem c-amlodipine d-cinnarizine

57- Mesalazine is used for treatment & maintainance of remission of ulcerative colitis
58- Mention 4 lipid-soluble vitamins ?

vit. A , D , E & K
59- Imipenam ( carbapenam )

It is the 1st thiemamycin beta-lactam antibiotic

60- All these medications are used in ttt of TB except a-cyclosporin b-INH c- cycloserin d-rifampicin Treatment of TB : st 1 line or primary drugs : Isoniazide(INH) & Rifampicin

2nd line or secondary drugs : Ethambutol , Streptomycin & Pyrazinamide. rd 3 line or tertiary drugs : Ethionamide , Cycloserine & Capreomycin 61- All these drugs are anti-cholinergic except : a-ipratropium b-atropine sulphate c-benzatropine methylate d-dobutamine 62- All are antibiotics except : a-zalcitobin (ttt of AIDS) b-cefaprozil c-lomefloxacin d-cefopodoxin 63- There is one drug used for HIV : a-zalcitabin b-kinasterdin c-cefaprozil d-enoxocin 64- Which one is Suprax ? a-cefixime b-itraconazole 65- Which is Sporanox? a-cefixime b-itraconazole 66- All of these drugs can be used in ttt of leprosy except : a-dapson b-rifampicin c-clofazimin d- INH 67- One of these is not like others : a-timolol b-acebutalol c-labetolol d-betaxolol
(selective B1 blocker)

68- Betahistine HCl :(betaserc) a-for mieniere`s disease b-antihistamine 69- Which one is not 5HT3 antagonist? a-tropisetron b-ondansetron c-domperidone d-gransetron 70- Which is not oral anti-coagulant? a-warfarin b-enoxaprine c-phenidione d-nicoumolone

 .. ...
71- Which is correct for Diazepam? a-can cause muscle spasm b-it is taken IM only c-it is a derivative from morphine d-it is not used for long term 72- Maximum dose of paracetamol is : 4gm / day 73- The duration of treatment of TB by CTC is : a-one week b-two months c-one month d-six months
( CTC = Tuberculosis Committee Thoracic Society )

74-

Metoclopramide is a dopamine antagonist acts centrally by blocking vomiting center and peripherally acts on the chemo-receptor trigger zone (CTZ) to be used as antiemetic

75- Which one is contra-indicated in pregnancy ? a-sucralfate b-ethambutol c-chlorpheneramine d-ciprofloxacin

76- What is the definition of Bioavailability of

drug?

The quantity of the active constituent of the drug absorbed by the blood through the intestine or any other route in a certain period of time OR : The conc. of drug in blood in a certain time

77- Give ex. of a drug induces hepatotoxicity paracetamol,ketokonazole,rifampicin,quinolones 78- Give ex. of a drug induces nephrotoxicity Aminoglycosides( as gentamycin ) 79- What is the generic name of vit. B12 ? Cyanocobalamine 80- Zidvudine ( Zalacitabin ) is used for HIV

 ... ...
81- What is the meaning of poor patient compliance? The patient didn`t take the medication properly ( not properly dose , not proper time ) may be due to the dose regimen is not easy or the dose is high , or the side effect is clear 82- Fluxetine ( Prozac ) is : Selective serotonin re-uptake inhibitor ( SSRI ) 83- Omeprazole ( Losec ) is : Proton pump inhibitor 84- Mention two diseases cause Edema? Renal failure Congestive heart failure 85- Give examples of Drug-Drug interactions ? Warfarin--------- ----Aspirin Insulin --------------- B-Blocker Heparin -------- -----Aspirin & Ampicillin Warfarin -------- ----Vit. K Warfarin ------------ Phenobarbital Spironolactone ----- Digoxin ACEIS --------------- K-Sparing diuretics 86- Generic name of : Vit. B1 ------------- Thiamine Vit. B2 ------------ Riboflavin Vit. B6 ------------- Pyridoxin Vit. B12 ----------- Cyanocobalamine

87- All of these are the components of calamine lotion B.P except: a- ZnO b-calamine c-sod. citrate

d-bentonite e-sod. sulphate 88- Terbinafene is used topically for : a-eczema b-candida c-fungal infections 89- Which one is not contra-indicated in pregnancy ? a-captopril b-enalapril c-lisinopril d-methyldopa 90- PCP ( pneumocystis corin pneumonia ) a-virus b-bacteria c-parasite d-mycobacterium 91- Which of the following is not antibiotic ? a-erythromycin b-cifixim c- cefprozil d- finasteride
( anti-cancer )

92- Which one is used for benign prostatic hyperplasia

(BPHP)

a-flumazenil b-cefprozil c-mivacurim d-finasteride rd 93- All of these are 3 generation cephalosporin except: a-cifixime b-cefopodoxime c-cefotriaxone d-cefotaxime
94- Which of the following is not mucolytic? a-bromohexin b-carbocistene c-ambroxol d-guaphenesin e-dextromethorphan

95- Which one is anti-platelet? a-ticlopidine c-aldesleukin

b-desfluron d-atovouon

96- All of these are anti-neoplastic except? a-aldesleukin b-taniposide c-pentostatin d-amlodipine
(Ca++ channel blocker)

97- Which is not benzodiazipne ? a-temazepam b-nitrozepam c-loprazepam d-clozapine 98- Potassium supplement must not be given with triametrin a-false b-true 99- MMR vaccine is ?
Measles-Mumps-Rubella vaccine BCG=Bacillus Calmette Guerin DTP=Diphteria&Tetanus toxoids and Pertussis V. Td =Tetanus & diphtheria toxoids OPV=Oral Poliovirus Vaccine HIbV=Haemophilus Influenzae type b,conjugated Virus HAV=Hepatitis A Virus 100- Oral re-hydrate solution(ORS) is one of the following :

a- sod. citrate,pot. chloride & glucose b- sod. citrate,pot. chloride & sod. chloride c- sod. chloride,pot. citrate, sod. citrate & glucose d- sod. chloride,pot. chloride, sod. bicarbonate & citric acid : The major action of sodium chromoglycate is -101 a-mast cell stabilization b-bronchodilator c-prostaglandins modifier d-leukotrienes modifier e-non of the above : The action of histamine is-102
a-capillary constriction b-elevation of blood pressure c-stimulation of gastric secretion d-skeletal muscle paralysis e-slowing the heart rate

One of the following antibiotics is resistant to-103 : penicillinase a-penicillin V b-penicillin G c-floxapen d-ampicillin e-amoxicillin
: Penicillinase Resistant Penicillins

Dicloxacillin,Naficillin,Oxacillin

**** / : Inderal is -104 a-similar in action to ergotamine b-similar in action to tubocurarine c-used as an antihistamine d-pure e- and adrenergic receptor blocker : Rifampicin is indicated for treatment of -105 a-impaired fat absorption b-pulmonary emboli c-tuberculosis d-neoplastic disorders e-psoriasis ? Which of the following is selective 1 blocker -106 a-labitolol b-terazosine c-cloridine d-captopril e-verapamil

-adrenergic receptor blocker

Drugs acting on the sympathetic system

:I-Sympathomimetics : Indirectly acting * ephedrine,amphetamine(tyramine),cocaine : Directly acting * :Agonists .1 / 2 : norepinephrine , epinephrine .2 : clonidine , -methylnorepinephrine .1 : phenylephrine , methoxamine : Agonists .1 / 2 : epinephrine,isoprenaline .2 : salbutamol,terbutaline .1 : norepinephrine,dobutamine


: II- Adrenergic neurone blockers
Reserpine, guanethidine,bethanidine

: III- Adrenoceptor antagonists

: - Blockers * 1 / 2 : phenoxybenzamine,phentolamine 1 : prazocin : - Blockers * , 1 / 2 : propranolol,madolol,timolol pindolol,oxprenolol,carvedilol ,1 (cardioselective) : atenolol metoprolol,acebutolol : The latabbreviation for " After Meals " is -107 .a- a.c. b- a.a. c- p.c. d- i.c. e- c.c : The latin abbreviation for " Four Times Daily " is -108 .a- a.c. b- a.a. c- p.c. d- q.i.d. e- c.c The latin abbreviation for " Every Night " is : -109 .a- a.c. b- o.n. c- p.c. d- i.c. e- c.c : Erythroped A -110 a-is effective against G +ve Cocci b-is a macrolide antibiotic c-can increase g.i.t. motility d-could be used in pregnant women if need e-all of the above : For the treatment of anaphylactic shock use -111 a-salbutamol b-diphenhydramine c-acetazolamide d-epinephrine e-aminophylline

: Allopurinol is used as -112 a-analgesic agent b-uricosuric agent c-antiinflamatory agent d-antipyretic agent e-agent which increases renal tubular reabsorption Which of the following is NOT betamethasone side -113 ? effect a-cataract b-hypoglycemia c-skeletal muscle weakness d-sodium retention e-lowered resistance to infections : A disease which is due to viral infection -114 a-poliomyelitis b-rabies c-chicken pox d-herpes e-all of the above : The mechanism of action of atropine is -115 a-muscarinic antagonist b-muscarinic agonist c-nicotinic antagonist d-nicotinic agonist e-non of the above Myocardial muscle tissue property to generate -116 : electrical is a-inotropy b-chronotropy c-automaticity d-contractility e-non of the above : The heart`s dominant pacemaker is -117 a- AV node b- SA node c-pukinje fiber d-internodal pathways e-non of the above : Adenosine is used for -118 a-ventricular arrythmias b-atrial bradycardia c-supraventricular tachycardia

d-supraventricular bradycardia e-non of the above : Adenosine P produces which of the following -119 a-facial flushing b-dyspnea c-marked tachycardia d- a and b e- a , b and c

Which of the following is responcible for -120 buffering a-magnesium b-chloride c-bicarbonates d-potassium e-troponin : Respiratory acidosis is due to -121 a- O2 removal b- O2 retention c- CO2 removal d- CO2 retention e-non of the above ? Which of the following is NOT colloid solution -122 a-albumin 5% b-ringer`s solution c-dextran d-beta starch e-albumin 20%
Some examples of hydrophilic colloids used in pharmacy are acacia, .methylcellulose, and proteins, such as gelatin and albumin examples of substances which form hydrophobic colloids in water are silver iodide, hydrated ferric oxide, sulfur, and gold. arsenous sulfide, aluminum chloride magnesium chloride
:The term shock signifies -123 a-hyperperfusion b-hypoperfusion c-tachycardia d-bradycardia e-non of the above ?In treatment of shock , which of the following a-airway control b-IV of crystalloid solution c-dopamine to support blood pressure d-monitor heart rhythm e-all of the above

should be considered -124

 .... ....

Which of the following is released by bacterial -125 (infection? (. by bacterial cell wall during there growth a-endotoxin b-exotoxin c-antibiotics d-cytotoxin e-non of the above :the amount of water in adult male is about -126 a-25% b-60% c-80% d-10% e-17% ?Which of the following are causes of oedema -127 a- hydrostatic pressure b- oncotic pressure c- capillary permeability d- a and b e- a , b and c Patients prescribed non reversible monoamine -128 oxidase inhibitor should be advised not to consume food containing tyramine because this :combination causes a-postural hypotension b-hallucinations c-anaphylactic shock d-muscle weakness and tremor e-acute adrenergic crisis including sever hypertention

Effect:

Concurrent use of MAO inhibitors (e.g. phenelzine) and

anorexiants (e.g. amphetamine) leads to increased amounts of norepinephrine, which increases sympathetic activity. Potential reactions include chest pain, cardiac arrhythmias, hypertensive crisis (headache, hyperpyrexia, and hypertension), seizures, cerebral hemorrhage, and death.

Tyramine-containing foods: aged cheese, aged or spoiled meats,

beer, red wine, yeast

 .....
?Concerning COX 2 inhibitors , which is NOT true -129
a-they have lower risk gastric adverse reactions b-good evidence about their effectiveness c-cardiac toxicity is a recent concern of this class d-they usually administrated twice daily e-combination with non selective agents give more effective action

In the treatment of osteoporosis which of the -130 ?following is NOT true

a-alendronate should be taken 60 min. before breakfast b-Ca and vit. D are essential c-hormone replacement therapy should be considered d-outcome should be assessed with periodic bone density e-raloxifeno is selective oestrogen modulator

Which of the following is the first choice in acute -131 ?gout a-allopurinol b-indomethacin c-colchicine d-probencid e-sulfinylpyrazone

Which of the following is NOT a risk factor for -132 ?osteoparalysis a-minimal exercise b-low calcium intake c-male gender d-family history e-minimal exposure to sunlight : Early symptoms of aspirin poisoning are -133 a-lethergy & fatigue b-skin rash & headache c-throbbing headache & dizziness d-fluid retention hypotension e-ringing in the ears & blurred vision

Which of the following is NOT true about -134 infiximab

a-IL-1 blocker

b-used for treatment of severe rheumatoid arthritis c-may increase risk of infections d-administered as IV infusion e-postadministration reactions include fever & chills