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Pharmacrystal NIPER JEE NOTES : 2011 (Question & Discussion)
1. Drug having high affinity but low capacity for serum albumin A) Sulfonamides . B) Phyenytoin C) Tolbutamide D) Warfarine 2. In tablet dissolution characteristic is tested to determine A) Drug interaction B) Drug absorption and physiologic availability C) Drug disintegration and bioavailability D) Drug dissociation and absorption 3. H.L.B. value of gelatin in A 2.1 B 9.8 C 16.7 D 40.7 4.In a balanced chemical equation A Coefficients are equal B Atoms are conserved C Molecules are equal D Energy is always produced

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5.In pH titration method, 0.25 N solution hydroxide solution is used to titrate the complex (glycinecupric) solution. What is the reason? A Complex is formed only under alkaline conditions B Complex does not form completely under acidic conditions C Concentration of ligand bound to metal ion can be obtained D Neutralization of amino acid and glycine is essential 6. 1.how many companies are listed in BSE and NSE 2.ASSESTS include 3.Insulin discoverd by Ans : 1.) around 5000 companies i guess ... 2.) Current assets include cash, accounts receivable, inventory, marketable securities, prepaid expenses and other liquid assets that can be readily converted to cash......3.) Dr. Fredrick Banting. 7. use of amoxicllin +clavulanic acid who is the president of PCI and IPA Ans : president of PCI : Prof. M.Suresh ,president of IPA: Dr. Dipak Chetia Supriya Jonnalagadda amoxicillin + clavulanate potassium (augmentin)...used for sinus infectins, uti, ear infections, pneumonia and skin infections. 8. rohypnol contains and its use ANS : date rape drug 9. wat is disposition in biopharma? a)ADME b)DME 2

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c)ME d)only E ANS : b check biopharm book by brahmankar 1st and distribution chapter the question is related to biopharma..n always disposition is only DME.. 10. Drug use in lie detector??? 11. Which is first antisuicidal drug approve by us fda? ANS: clozapine!! clozapine (clozaril) efficiency was compared with that of olanzapine (zyprexa) and found to be around 7 times efficacious in decreasing suicidal tencency..so it was approved by us fda as the antisuicidal drug!! 12. blood bank license is issued inthe form num:--------license to operate blood bank is granted by__________ ANS : 28c give second ans... Means its the central licence approving authority.. Following M/s. Fergusons Report (which brought out various deficiencies with regard to quality control of blood and blood products etc. in the year 1990 and based on concern expressed in different fora and in Parliament, the D&C Rules were again amended (Rules 68A, Part XB and Part XIIB of Schedule F) in the year 1992-93 and Drugs Controller General (India) was vested with the power of Central Licence Approving Authority (CLAA) to approve the licence of notified drugs viz. Blood and Blood Products, I.V. Fluids and Vaccines and Sera. Definitions.- (1) In this Part and in the Forms contained in Schedule A and in Part XII B and Part XIIC of schedule F, unless there is anything repugnant in the subject or context,(a) apheresis means for the process by which blood d...See More

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(h) leucapheresis means the process by which the blood drawn from a donor, after leucocyte concentrates have been separated, is re-transfused simultaneously into the said donor; (i) plasmapheresis means the process by which the 13. wat is infusaid?wat is catapress??? ANS : InfusAID-provides oncology practices with state-of-the-art ambulatory infusion equipment and superior service. This allows offices to increase revenue by billing for the pump initiation and/or refill while decreasing the amount of time, energy, and costs wasted on all of the details that the service providers continuously take care of if u google it u'll find the homepage of the InfusAID service providers..wher u can find the rest of information CATAPRES-it is the marketed name of clonidine hydrochloride USP.it is used as an hypotensive agent. catapress:it is a tdds,indusaid:vapour presurre aided pump its also available as tablets clonidine is an centrally acting alpha2 partial agonist with high affinity and intrinsic activity at alpha 2a receptors,alpha 2a receptors are autoreceptors,associated with hemodynamic effects,so by potentiating the action of these receptors clonidine prevents the central discharge of noradrenaline,there by decreasing the symphathetic activity..and treating hypertension clonidine is an imidazoline derivative IN BRAIN NOW PRESENCE OF IMIDAZOLINE RECEPTORS ARE IDENTIFIED WHICH ARE DIFFERENT FROM ALPHA RECEPTORS..THE PROPOSED MOA IS:clonidine and other structurally related compounds activate imidazoline receptors which trigger the medullary alpha 2a receptors to decrease sympathetic outflow bcos of central action clonidine poses more side effects than other hypotensive drugs:sedation,mental depression,sleep disturbances,dryness of mouth,nose and ears,impotence..also when doses are missed it causes sudden high rise in bp..also tolerance.. hence now it is not frst choice of drug,usually used in combo witn diuretics and betablockers.. probably it is formulated in TDDS to facilitate slow release of drug,long duration of action and decrease the advent of adverse effects.. 14.

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Latest Drug Information Updates:

Edurant:Generic Name: rilpivirine Date of Approval: May 20, 2011 Company: Tibotec Pharmaceuticals Victrelis Generic Name: boceprevir Date of Approval: May 13, 2011 Company: Merck Tradjenta Generic Name: linagliptin Date of Approval: May 2, 2011 Company: Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company Zytiga Generic Name: abiraterone acetate Date of Approval: April 28, 2011 Company: Centocor Ortho Biotech In Duexis Generic Name: ibuprofen and famotidine Date of Approval: April 23, 2011 Company: Horizon Pharma USA, Inc. Sylatron Generic Name: peginterferon alfa-2b Date of Approval: March 29, 2011 5

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Company: Merck 15. aptitude qns for niper: augmentin is product of:GLAXOSMITH KLINE RILPIVIRINE:developed by tibotech is a second generation non nucleoside reverse transcriptase inhibitor,approved by us fda this may Dcold total,ring guard,itchguard,boroplus,moov,stopache,dermicool,zatak,livon,borosoft:PRODUCTS OF PARAS PHARMA GATIFLOXACIN and TEGASERODE:banned in INDIA in 2010 RANBAXY taken over by japanese DAIICHI SANKYO for the generic drugs AURBINDO pharma got USFDA approval for DIVALPROEX SODIUM DELAYED RELEASE TABLETS ANS: its clavulanic acid+amoxicillin..clavulanic acid is as suicide inhibitor and helps in preventing the development of resistance to amoxicillin by betalactamase produced by species like staph aureus Clavulanic acid is produced by the fermentation of Streptomyces clavuligerus. It is a -lactam structurally related to the penicillins and possesses the ability to inactivate a wide variety of lactamases by blocking the active sites of th...See More 16. boceprevir is ahepatitis c virus NS3/4A proteaseinhibitor indicated for the treatement of chronic hepatitis c 17. ALISKIREN:fst clas of drugs called direct renin inhibitor,its current licensed indication is primary hypertension 18. which neurotransmitter is most likely to function in hierarchial systems: a)dopamine b)glutamate c)epinephrine d)5-ht B :catecholamines,opiod peptides and serotonin act as neurotransmitters in non-specific or diffuse neuronal sysytems. glutamate is the primary excitatory neurotransmitter in hierachial neuronal systems.

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its only 5-ht ANS B 19. wat is antifreeze glycoprotein and it contains how many aminoacids??? ANS Revathi Chapa it contains around 150 aminoacid units. 20. Which of the following sulfonylureas least to cause hypoglycemic shock? A :Tolbutamide B :Glibenclamide C :Chlorpropamide D :Glipizid ANS: B tolbutamide is safer drug,least likely to cause hypoglycemia,glibenclamide yields active products on metabolism so can cause hypoglycemic shock,chlorpropamide is longer acting,can lead to HS,glipizide can also cause hypoglycemia due to longer duration of action..so answer must be A!! wats d ryt answer?

21. I REQUEST EVERYONE TO GO THROUGH OFFICIAL PAGE OF US FDA..EVRYTHING IS VERY CLEARLY GIVEN IN IT,ALL REGULATIONS,DRUG APPROVALS...ATLEAST SPARE 30 MIN DAILY FOR IT..M SURE IT WUD BE VERY USEFUL!! 22. Optically active system is A) Spiro B) Biphenyl C) Allene D) None ANS :B 23. IMPORTANT POINT REGARDING CONFORMATIONAL ISOMERS: when we talk about conformers,we generally talk about the most stable conformer(ex:staggered in ethane) and least stable conformer(eclipsed) and the one with intermediate stability (skew state). But most of us think that these are the only possible conformers..but no.. 7

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conformers are obtained by free rotation of C-C single bond,so for every infinetissimal change in angle of rotation,we get one conformer..so infinite conformers are possible for every given structure wat we are primarily concerned is with the stability of a given conformation,we generally speak about highly stable and least stable conformers.. Stability is totally depend on energy, and we are not concern about its because has very high energy we can not even measure its transformation, still if you want to mark there transfer may be possible at deep freez temperature..... 24. The therapeutic biological products now under CDER's review include: Monoclonal antibodies for in-vivo use Cytokines, growth factors, enzymes, immunomodulators; and thrombolytics Proteins intended for therapeutic use that are extracted from animals or microorganisms, including recombinant versions of these products (except clotting factors) Other non-vaccine therapeutic immunotherapies 25. I REQUEST EVERYONE TO GO THROUGH OFFICIAL PAGE OF US FDA..EVRYTHING IS VERY CLEARLY GIVEN IN IT,ALL REGULATIONS,DRUG APPROVALS...ATLEAST SPARE 30 MIN DAILY FOR IT..M SURE IT WUD BE VERY USEFUL!! Divya Sri Priyanka hey type us fda in google home page,u will find official website 26. Optically active system is A) Spiro B) Biphenyl C) Allene D) None 27. IMPORTANT POINT REGARDING CONFORMATIONAL ISOMERS: when we talk about conformers,we generally talk about the most stable conformer(ex:staggered in ethane) and least stable conformer(eclipsed) and the one with intermediate stability (skew state). But most of us think that these are the only possible conformers..but no.. 8

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28. The therapeutic biological products now under CDER's review include: Monoclonal antibodies for in-vivo use Cytokines, growth factors, enzymes, immunomodulators; and thrombolytics Proteins intended for therapeutic use that are extracted from animals or microorganisms, including recombinant versions of these products (except clotting factors) Other non-vaccine therapeutic immunotherapies 29. wat is myomectomy??? removal of uterine fibroids... uterus is preserved in myomectomy..!

30. use of USTEKINUMAB? IT IS mab directed against IL-12 AND 1L-23, fro treatment of psoroasis infliximab,adalimumab: rheumatoid arthritis,Crohn's diseases, Ulcerative Colitis etanercept:rheumatoid arthritis,basiliximab,daclizumab:Acute rejection of kidney transplants,omalizumab:moderate-to-severe allergic asthma,gemtuzumab:relapsed acute myeloid leukaemia,alemtuzumab[:B cell leukemia,rituximab:non-Hodgkin's lymp...See More all mabs are really confusing......by the way mab means queen in english......vocabulary qns are also included in niper... used to treat severe plaque psoriasis. belimumab:b lymphocyte stimulator...specific inhibitor for the treatment of systemic lupus erythomatus 31. genistein and coumestrol:naturally ocurring plant oestrogens but they have non steroidal structures.... 9

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32 wat is snells law?? snells law is also called as snell-descartes law and law of refraction it gives relation between the angles of incidence and refraction, when referring to light or other waves passing through a boundary between two different isotropic media, such as water and glass. Snell's law states that the ratio of the sines of the angles of incidence and refraction is equivalent to the ratio of phase velocities in the two media, or equivalent to the opposite ratio of the indices of refraction: 33. SMON syndrome is related to a)metronidazole b)diloxanide c)quiniodochlor d)tetracyclin

ANS :C subacute myelo-optico neuropathy syndrome: Diiodohydroxyquin (Diodoquin) and Lodochlorhydroxyquinoline (Enteroquinol)These drugs are useful in the treatment of asymptomatic cyst passers. They act against the amoebae in the intestines but are not effective against acute amoebic dysen...See More 34. link for latest pharma updates..my frnd gave me this link, m passing on this...very useful for niper...please do check out... Biotech Industry, Biotech News, Biotechnology Articles FierceBiotech www.fiercebiotech.com Biotech Industry, Biotech News, Biotechnology Articles FierceBiotech www.fiercebiotech.com 10

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Read the latest biotechnology articles on biotech industry leaders, emerging biotech companies, FDA decisions, VC deals, and other biotech industry news. Biotech Industry, Biotech News, Biotechnology Articles FierceBiotech www.fiercebiotech.com Read the latest biotechnology articles on biotech industry leaders, emerging biotech companies, FDA decisions, VC deals, and other biotech industry news. 35. GRAS:related to a)safety b)stability c)reactivity d)none of the above ANS :its safety GRAS-IT IS ACRONYM FOR GENERALLY REGARDED AS SAFE

36. pharmacy education in INDIA started in 1937 by PROF.M.L.SCHROFF at BANARAS HINDU UNIVERSITY as bsc degree 37. TYPES OF OPTICALLY ACTIVE COMPOUNDS: 1) compounds with stereogenic carbon atom 2)compounds with other quadrivalent stereogenic atoms:Si,Ge, Sn,and N (in quaternary salts or Noxides) 3)compounds with tervalent stereogenic atoms: Atoms with pyramidal bonding

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might be expected to give rise to optical activity if the atom is connected to three different groups, since the unshared pair of electrons is analogous to a fourth group, necessarily different from the others. 4)suitably substituted adamantanes: Adamantanes bearing four different substituents at the bridgehead positions are chiral and optically active. 5)restricted rotation giving rise to perpenndicular disymmetric plane: biphenyls containing four large groups in orthopositions 6) chirality due to a helical shape: hexahelicene,trans-cyclooctene,heptalene 7)optical activity caused by restricted rotation of other types:subsituted paracyclophanes,metallic complexes of suitable geometry

38. little info abt HUMAN GENOME PROJECT for niper aptitude qns: Project goals were to identify all the approximately 20,000-25,000 genes in human DNA, determine the sequences of the 3 billion chemical base pairs that make up human DNA, store this information in databases, improve tools for data analysis, transfer related technologies to the private sector, and address the ethical, legal, and social issues (ELSI) that may arise from the project

Completed in 2003, the Human Genome Project (HGP) was a 13-year project coordinated by the U.S. Department of Energy and the National Institutes of Health The Department of Energy's Human Genome Program research was directed by Ari Patrinos, head of the Office of Biological and Environmental Research. Francis Collins directed the National Institutes of Health, National Human Genome Research Institute efforts. 16 hours ago Like Subscribe Tejas Patadia and Divya Sri Priyanka like this. Shilpa Laggyshetty worlds fst private company which decoded human genome:gentech 12

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39. IMPORTANT UNSATURATED FATTY ACIDS OF PHYSIOLOGIC AND NUTRITIONAL SIGNIFICANCE: MONOENOIC ACID(one double bond):palmitoleic acid-16:1,9 means 16 carbon atoms,one double bond at 9th position,omega 7 fattyacid oleic acid-18:1,9,omega 9 fatty acid-cis-9-octadecenoic acid elaidic acid-18:1,9,omega 9 fatty acid-trans-9-octadecenoic acid DIENOIC ACIDS: linoleic acid-18:2;9,12 ; omega6 fatty acid-all-cis-9,12-octadecadienoic acid (HERE NUMBER 9,12 INDICATE POSITION OF DOUBLE BOND) TRIENOIC ACIDS: gamma linolenic acid-18:3;6,9,12; omega 6 fatty acid, alpha linolenic acid-18:3;9,12,15 ; omega 3 fatty acid TETRAENOIC ACID: arachidonic acid-20:4; 5,8,11,14 ; omega 6 fatty acid PENTAENOIC ACID: timnodonic acid: 20:5; 5,8,11,14,17; omega 3 fatty acid HEXAENOIC ACID: cervonic acid-22:6; 4,7,10,13,16,19- omega 3 fatty acid 40. OMEGA NOMENCLATURE IS USED FOR UNSATURATED FATTY ACIDS(BASED ON GREEK LETTERS WHERE OMEGA IS THE LAST LETTER,36th letter) example: C-C-C-C-C=C-C-C-C-C-C-C-C-COOH here the extreme left carbon will get omega 1 number,(UNLIKE THE TRADITIONAL NOMENCLATURE WHERE -COOH CARBON GETS NUMBER 1) and so...the doubly bonded carbon gets omega 5 so,myristoleic acid a monounsaturated fatty acid is an omega-5 fatty acid.. so if u knw the no of carbon atoms in a fatty acid and position of double bonds u can assign omega nomenclature,no need of mugging up!! 41. Which one of the following is best associated with Lumefantrine? a. Antimycobacterial b. Antifungal 13

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c. Antimalarial d. Antiamoebic ANS :C 42. Which fatty is biosynthesized by human body? a)Stearic acid b)Oleic acid c)Linoleic acid d)Linolenic acid ANS : a linoleic and linolenic acids are essential fatty acids,need to be supplemented thru diet. palmitic and oleic acids can be synthesized in our body by introducing a double bond at delta 9 position of a saturated fatty acid coz oleic acid is an unsaturated fatty acid biosynthesised and stearic acid is a saturated FA which is also biosynthesised 43. Microemulsion behave like A)newtonian fluid B)pseudoplastic fluid C)dilatant fluid D)plastic fluid ANS : A Microemulsions are thermodynamically stable,optically transparent, isotropic dispersions of aqueous and hydrocarbon liquids stabilized by an interfacial film of surfactant molecules. Microemulsions are monodispersed spherical droplets (diameter < 100 nm) of water in oil or oil in water, depending on the nature of the surfactant.

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according to varying shear rates,microemulsions exhibit either newtonian or non newtonian behaviour..best option might be newtonian out of all.. 44. The group of antibiotics which possess additional anti-inflammatory and immunomodulatory activities is a. Tetracyclines b. Polypeptide antibiotics c. Fluoroquinolones d. Macrolides ANS : macrolides exhibit antiinflammatory and immunomodulatory effects but now many antibiotics are attributed with those activities:telithromycin belonging to ketolide group has shown to exert immunomodulatory properties tetracyclines inhibit collagenase activity,matrix metalloproteinases (MMPs), as the activity of these enzymes is zinc-dependent and the antibiotic is able to chelate zinc from their active site. doxycycline inhibits leukocyte function in vitro via divalent cation binding and may reduce leukocyte adhesion. The immunomodulatory and neuroprotective effects of tetracyclines especially minocycline in neurological diseases are considered to be due in part to the suppression of microglia activation. Suppression of T-cell activity by rifampicin has long been noticed in both patients suffering from tuberculosis and healthy controls. 15

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link for further information on immunomodulatory activity of antibiotics:www.benthamscience.com

45. Oculogyric crisis is known to be produced by all of the following drugs except a. Trifluoperazine b. Atropine c. Perchlorperazine d. Perphenazine ANS : Drugs that can trigger an oculogyric crisis include neuroleptics (such as olanzapine), amantadine, benzodiazepines, carbamazepine, chloroquine, cisplatin, diazoxide, influenza vaccine,levodopa,lithium, metoclopramide, domperidone, nifedipin...See More b 46. Which of following is endothermic? a. Adsorption b. crystallization c. vaporization d. all ANS : D only vaporization............adsorption makes bond and releases energy, crystallzation makes bond and releases energy while energy is needed to vaporize something so needs energy so only it is endothermic.............always use concepts to solve any question.....it will benefit u only. 47. dna without introns is?

A. B dna b. Z dna c. C dna d. Mitochondrial dna 16

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a C dna is synthesized from MATURE mRNA template by reverse transcriptase enzyme and DNA polymerase enzyme..hence it is not interrupted by any noncoding sequences i.e introns. It is used widely in gene cloning strategies and as gene probes Z DNA is the left-handed double helical structure in which the double helix winds to the left in a zig-zag pattern, B DNA is the right handed double helical structure. for further details about structural differences between A,B and Z DNa one can refer back to biotech books or wikipedia,guess this is enuf!! 48. All of the following are topically used sulphonamides except a. Sulphacetamide b. Sulphadiazine c. Silver sulphadiazine d. Mafenide ANS B. Sulphadiazine 49. All of the following are topically used sulphonamides except a. Sulphacetamide b. Sulphadiazine c. Silver sulphadiazine d. Mafenide 50. Calamine lotion exhibit which type of rehological behaviour (flow ) ?

newtonian no newtonian is for simple liquids. Plastic flow 17

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51. NIPER very imp - what does paragraph 4 in ANDA certification mean? is ANDA is abbrevated new drug application??? paragraph 1 is for drugs for which no patenta are existing paragraph 2 is for drugs which had patent but gt expired paragraph 3- patent is valid for a given drug,n the generic drug which has cleared anda and is not marketed until the patent of the branded drug is expired paragraph 4- patent is valid for a drug,if a competetor wants to introduce his product he can introduce it by INVALIDATING THE EXISTING PRODUCT OR BY NON-INFRINGEMENT paragraph 4 gives the competetor an 180 DAY EXCLUSIVITY, that is one can sell his product FOR 6 MONTHS ALONG WITH THE INNOVATOR 52. asked trade mark is renewed after every.....yrs? a.5 b.3 c.7 d.6

Further 1000 Question For register Member only

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