Page 1 of 40 UNIVERSITY OF DELHI _______ SCHEME OF EXAMINATION AND COURSES OF READING FOR B.Sc.

(Honours) CHEMISTRY EXAMINATION I Semester Examination November 2010 II Semester Examination April 2011 III Semester Examination November 2011 IV Semester Examination April 2012 V Semester Examination November 2012 VI Semester Examination April 2013 Syllabus applicable for the students seeking admission to the B.Sc. (Honours) Chemistry Course in the academic year 2010-11Page 2 of 40 COURSES OF STUDY FOR B.Sc. (Hons.) CHEMISTRY FOR THE SESSION 20102011 SCHEME OF EXAMINATION SEMESTER I Paper No. Title Duration (Hrs.) Maximum Marks 101 Inorganic Chemistry- I 3 100 201 Organic Chemistry I 400 English 501 Mathematics I

PRACTICALS Note: Students should be given intensive training in the understanding and applications of concepts. They should also be trained for solving a variety of problems rather than in reproduction of factual information from books and lecture notes. Problem solving questions related to numerical, structural, synthetic, mechanistic and conceptual type should be given due emphasis in the examination. Students should be encouraged to develop initiative and self-reliance through home/library/internet assignments. Only SI units and IUPAC conventions should be followed throughout the course. Students are permitted to use non-programmable calculators during theory and practical examinations, but these may not be shared during examinations. The University will provide log tables during examinations. Name reactions in Organic Chemistry are to be dealt with as relevant to the context. Discussions of organic reactions should deal with their reaction mechanisms. Semi-micro level procedures should be used in the laboratory experiments. Use of carcinogenic and highly toxic chemicals is to be avoided as far as possible. All theory papers will have 5 periods per week, including 1 period for assignments, discussion, presentations, etc. The practical classes will be of three hours duration. SEMESTER II Paper No. Title Duration (Hrs.) Maximum Marks 301 Physical Chemistry I 3 100 601 Molecular Biology I 700 Applications of Computers in Chemistry

801 Physics I Practical Page 3 of 40 SEMESTER III Paper No. Title Duration (Hrs.) Maximum Marks 102 Inorganic Chemistry II 3 100 202 Organic Chemistry II 302 Physical Chemistry II 802 Physics II Practical SEMESTER IV Paper No. Title Duration (Hrs.) Maximum Marks 103 Inorganic Chemistry III 3 100 203 Organic Chemistry III 303 Physical Chemistry III 502 Mathematics II Practical SEMESTER V Paper No. Title Duration (Hrs.) Maximum Marks 104 Inorganic Chemistry IV 3 100 204 Organic Chemistry IV 304 Physical Chemistry IV 602 Molecular Biology II Practical SEMESTER VI Paper No. Title Duration (Hrs.) Maximum Marks

105 Inorganic Chemistry V 3 100 205 Organic Chemistry V 305 Physical Chemistry V 900 Analytical Methods of Analysis Practical Total Number of Papers : 24 Major subjects : 16 Minor Subjects : 06 Interdisciplinary Subjects : 02 Page 4 of 40 Semester System at the undergraduate level Course of Study: B. Sc. (Hons.) Chemistry SEMESTER I Paper 101 - Inorganic Chemistry - I (Atomic Structure)

Atomic Structure: Bohrs theory, its limitations and atomic spectrum of hydrogen atom. Wave mechanics: de Broglie matter wave, Heisenbergs uncertainty principle and its significance, Schrdingers wave equation, significance of and 2 Quantum numbers and their significance. Normal and orthogonal wave functions. Sign of wave functions. Radial and angular wave functions. Radial and angular distribution curves. Shapes of s, p, d and f orbitals. Contour boundary and probability diagrams. Paulis exclusion principle, Hunds rule of maximum multiplicity, Aufbaus principle and its limitations, Variation of orbital energy with atomic number.

Periodicity of Elements: s, p, d, f block elements, the long from of periodic table. Detailed discussion of the following properties of the elements, with reference to s & pblock. (a) Effective nuclear charge, shielding or screening effect, Slater rules, variation of effective nuclear charge in periodic table. (b) Atomic radii (van der Waals) (c) Ionic and crystal radii. (d) Covalent radii (octahedral and tetrahedral ) (e) Ionization enthalpy, Successive ionization enthalpies and factors affecting ionization energy. Applications of ionization enthalpy. (f) Electron gain enthalpy, trends of electron gain enthalpy. (g) Electronegativity, Paulings/ Mullikens/ Allred Rachows/ and MullikenJaffes electronegativity scales. Variation of electronegativity with bond order, partial charge, hybridization, group electronegativity. Sandersons electron density ratio. Recommended Texts: 1. Lee, J.D. Concise Inorganic Chemistry, ELBS, 1991. 2. Douglas, B.E. and Mc Daniel, D.H. Oxford. 3. Atkins, P.W. & Paula, J. de Atkins Physical Chemistry, Oxford Press, 2006. 4. Day, M.C. and Selbin, J. Theoretical Inorganic Chemistry, ACS Publications 1962. Page 5 of 40 Paper 201 Organic Chemistry - I (Basics of Organic Chemistry & Stereochemistry) Unit-I: Basics of Organic Chemistry Importance of organic chemistry and organic systems to human beings and society and current issues.

Organic Compounds: Natural sources, Classification, and Nomenclature. Hybridization: Shape of molecules, Influence of hybridization on bond properties. Electronic Displacements: Inductive, Inductomeric, Electromeric, Resonance and Mesomeric effects, and Hyperconjugation; their applications; Dipole moment. Organic acids and bases; their relative strength. Homolytic and Heterolytic fission with suitable examples. Curly arrow rules, formal charges Electrophiles and Nucleophiles; Nucleophlicity and basicity. Reactive Intermediates: Carbocations, Carbanions, Free radicals, Carbenes, Nitrenes Types, shape and their relative stability. Types of Organic Reactions and their Mechanism: Addition, Elimination, Substitution and Rearrangement reactions. Unit II: Stereochemistry Fischer Projection, Newmann and Sawhorse Projection Formulae and their interconversion Geometrical Isomerism: cistrans Isomerism, syn-anti and E/Z notations with C.I.P rules. Optical Isomerism: Optical Activity, Specific Rotation, Chirality/Asymmetry, Enantiomers, molecules with two or more chiral-centres, Distereoisomers, Epimers, Meso structures, Racemic mixture and Resolution. Relative configuration: D/L and R/S designations. Unit III: Chemistry of Aliphatic Hydrocarbons

A. Carbon-Carbon sigma bonds

Chemistry of Alkanes: Formation of alkanes with special emphasis on Corey House synthesis; Wurtz Reaction, Wurtz- Fittig Reactions, Reaction of alkanes: Free radical substitutions - Halogenation - relative reactivity and selectivity. B. Carbon-Carbon pi bonds Formation of Alkenes and Alkynes by Elimination: Mechanism of E1, E2, E1cb reactions. Saytzeff and Hofmann Eliminations. Reactions of Alkenes: Electrophilic and Free radical additions, their mechanisms (Markownikoff/ Anti Markownikoff addition), mechanism of oxymercurationdemercuration, hydroboration-oxidation, ozonolysis, reduction (catalytic and chemical), syn and anti hydroxylation (oxidation). Page 6 of 40 Reactions of Alkynes: Acidity, Electrophilic and Nucleophilic additions. Hydration to form carbonyl compounds, Alkylation of terminal alkynes. Conjugated Alkenes/Alkynes: 1, 2- and 1, 4- addition reactions, Diels-Alder Reaction. Allylic and Benzylic bromination and mechanism, e.g. propene, 1-butene, toluene, ethyl benzene. C. Cycloalkanes and Conformational Analysis Types of Cycloalkanes and their relative stability; Bayer Strain Theory. Conformation Analysis of Alkanes: Relative stability: Energy diagrams of Cyclohexane: Chair, Boat and Twist Boat forms; Relative stability with energy diagrams. Unit IV: Aromatic Hydrocarbons Aromaticity: Hckels rule, aromatic character of arenes, cyclic carbocations/carbanions and heterocyclic compounds with suitable examples. Antiaromaticity and nonaromaticity. Structure and Stability of Benzene.

Electrophilic Aromatic Substitution: halogenation, nitration, sulphonation and FriedelCrafts alkylation/acylation with their mechanism. Stability of Wheland Intermediates (sigma complex). Activation/deactivation of the aromatic ring and Directing Effects of the groups. Bibliography: 1. Robert Thornton Morrison and Robert Neilson Boyd, Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 2. I. L. Finar, Organic Chemistry (Volume 1), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 3. I. L. Finar, Organic Chemistry (Volume 2: Stereochemistry and the Chemistry of Natural Products), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 4. E. L. Eliel, S. H. Wilen, Stereochemistry of Organic Compounds; Wiley: London, 1994. Paper 400: English A textbook-cum-workbook consisting of a selection of essays and poems of special interest to students of science and a workbook with exercises on vocabulary (word roots, prefixes, infixes and suffixes antonyms, etc.), grammar and usage, comprehension (inference-drawing, coherence, etc.) and composition exercises. Page 7 of 40 Paper 501: Mathematics I Fundamentals. Mathematical functions, polynomial expressions, logarithms, the exponential function, units of a measurement, interconversion of units, constants and variables, equation of a straight line, plotting graphs. Uncertainty in experimental techniques: Displaying uncertainties, measurements in chemistry, decimal places, significant figures, combining quantities. Uncertainty in

measurement: types of uncertainties, combining uncertainties. Statistical treatment of uncertainties. Mean, standard deviation, relative error. Data reduction and the propagation of errors. Graphical and numerical data reduction. Numerical curve fitting: the method of least squares (regression). Algebraic operations on real scalar variables (e.g. manipulation of van der Waals equation in different forms). Roots of quadratic equations analytically and iteratively (e.g. pH of a weak acid). Numerical methods of finding roots (Newton-Raphson, binary bisection, e.g. pH of a weak acid not ignoring the ionization of water, volume of a van der Waals gas, equilibrium constant expressions). Mathematical series: Power series, Maclaurin, Taylor series, convergence (e.g. pressure virial equation of state, colligative properties). Pythagoras theorem in three dimensions. Trigonometric functions, identities. Differential calculus: The tangent line and the derivative of a function, numerical differentiation (e.g., change in pressure for small change in volume of a van der Waals gas, potentiometric titrations), differentials, higher order derivatives, discontinuities, stationary points, maximum-minimum problems, inflexion points, limiting values of functions: LHpitals rule, combining limits. Integral calculus: The process of integration, odd and even functions, indefinite integrals, standard integrals, methods of integration (e.g. integrated rate law for second order reaction), numerical integration (Trapezoidal and Simpsons rule, e.g. entropy/enthalpy change from heat capacity data), probability distributions (gas kinetic theory) and mean values. Calculus of the trigonometric functions. Calculus with several independent variables: functions of several independent variables, change of variables, relations between partial derivatives (e.g. change in pressure for small changes in volume and temperature), total differentials, chain rules for partial

differentiation, Eulers theorem, exact and inexact differentials (thermodynamics), line integrals. Recommended texts: McQuarrie, D. A. Mathematics for Physical Chemistry University Science Books (2008). Mortimer, R. Mathematics for Physical Chemistry. 3 rd Ed. Elsevier (2005). Steiner, E. The Chemical Maths Book Oxford University Press (1996). Yates, P. Chemical calculations. 2 nd Ed. CRC Press (2007). Page 8 of 40 SEMESTER- I PRACTICAL INORGANIC LABORATORY - I (A) Titrimetric Analysis (i) Calibration and use of apparatus (i) Preparation of solutions of different Molarity/Normality of titrants (b) Acid- Base Titrations (i) Estimation of carbonate and hydroxide present together in mixture. (ii) Estimation of carbonate and bicarbonate present together in a mixture. (ii) Estimation of free alkali present in different soaps/detergents (c) Oxidation- Reduction Titrimetry (i) Estimation of Fe(II) and oxalic acid using standardized KMnO4 solution.

(ii) Estimation of oxalic acid and sodium oxalate in the give mixture. (iii) Estimation of Fe (II) with K2 Cr2 O7 using internal (diphenylamine, anthranilic acid) and external indicator. Reference text: 1. Vogel, A.I. A text book of quantitative Inorganic Analysis, ELBS. ORGANIC LABORATORY - I Calibration of thermometer. Purification of organic compounds by crystallization: (i) benzoic acid from hot water (ii) naphthalene from alcohol. . Determination of melting point and mixed melting point. Determination of boiling point and purification of aniline by distillation. Determiantion of boiling point by inverse capillary method. Chromatographic separation of the following mixtures and Rf value calculation of the components: (i) Amino acids (ii) Sugars by Paper chromatography ortho- and para- nitrophenols by Thin layer chromatography. Page 9 of 40 SEMESTER II Paper 301: Physical Chemistry - I MOLECULAR INTERACTIONS AND STATES OF MATTER Classification of Matter Gaseous state

Kinetic molecular model of a gas: postulates and derivation of the kinetic gas equation; collision frequency; collision diameter; mean free path and viscosity of gases, including their temperature and pressure dependence, relation between mean free path and coefficient of viscosity, calculation of from ; variation of viscosity with temperature and pressure. Barometric distribution and its use in evaluating molecular velocities (average, root mean square and most probable) and average kinetic energy, law of equipartition of energy, degrees of freedom and molecular basis of heat capacities. Behaviour of real gases: Deviations from ideal gas behaviour, compressibility factor, Z, and its variation with pressure for different gases. Causes of deviation from ideal behaviour. van der Waals equation of state, its derivation and application in explaining real gas behaviour, mention of other equations of state (Berthelot, Dietrici); virial equation of state; van der Waals equation expressed in virial form and calculation of Boyle temperature. Isotherms of real gases and their comparison with van der Waals isotherms, continuity of states, critical state, relation between critical constants and van der Waals constants, law of corresponding states. Liquid state Qualitative treatment of the structure of the liquid state; Radial distribution function; physical properties of liquids; vapour pressure, surface tension and coefficient of viscosity, and their determination. Effect of addition of various solutes on surface tension and viscosity. Explanation of cleansing action of detergents. Temperature variation of viscosity of liquids and comparison with that of gases. Qualitative discussion of structure of water. Solid state

Nature of the solid state, law of constancy of interfacial angles, law of rational indices, Miller indices, elementary ideas of symmetry, symmetry elements and symmetry operations, qualitative idea of point and space groups, seven crystal systems and fourteen Bravais lattices; X-ray diffraction, Braggs law, a simple account of rotating crystal Page 10 of 40 method and powder pattern method. Analysis of powder diffraction patterns of NaCl, CsCl and KCl. Defects in crystals. Glasses and liquid crystals. Ionic equilibria Strong, moderate and weak electrolytes, degree of ionization, factors affecting degree of ionization, ionization constant and ionic product of water. Ionization of weak acids and bases, pH scale, common ion effect; dissociation constants of mono-, di- and tri-protic acids (exact treatment). Salt hydrolysis-calculation of hydrolysis constant, degree of hydrolysis and pH for different salts. Buffer solutions; derivation of Henderson equation and its applications; buffer capacity, buffer range, buffer action and applications of buffers in analytical chemistry and biochemical processes in the human body. Solubility and solubility product of sparingly soluble salts applications of solubility product principle. Qualitative treatment of acid base titration curves (calculation of pH at various stages). Theory of acid base indicators; selection of indicators and their limitations. Multistage equilibria in polyelectrolyte systems; hydrolysis and hydrolysis constants. Recommended texts: Atkins, P. W. & Paula, J. de Atkins Physical Chemistry 8 th Ed., Oxford University Press (2006).

Ball, D. W. Physical Chemistry Thomson Press, India (2007). Castellan, G. W. Physical Chemistry 4 th Ed. Narosa (2004). Mortimer, R. G. Physical Chemistry 3 rd Ed. Elsevier: NOIDA, UP (2009). Page 11 of 40 Paper 601 : Molecular Biology - I Theory Unit 1. Nucleic Acids convey Genetic Information (Ch 2 Watson)

DNA as the carrier of genetic information, DNA Double helix, Genetic code, The Central Dogma, Direction of Protein Synthesis, Genomics. Unit 2. The Structures of DNA and RNA / Genetic Material (Ch 6 Watson; Ch 18 Becker) DNA Structure: Miescher to Watson and Crick- historic perspective, DNA structure, Salient features of double helix, Types of DNA, genome size, Types of genetic material, denaturation and renaturation, cot curves. DNA topology - linking number, topoisomerases; Organization of DNAProkaryotes, Viruses, Eukaryotes. RNA Structure Organelle DNA -- mitochondria and chloroplast DNA. Unit 3. Genome Structure, Chromatin and the Nucleosome (Ch 7 Watson; Ch 18 Becker) Genome Sequence and Chromosome Diversity, Chromosome Duplication and Segregation, The Nucleosome Chromatin structure- Euchromatin,

Heterochromatin- Constitutive and Facultative heterochromatin. Regulation of Chromatin Structure and Nucleosome Assembly. Unit 4. The Replication of DNA (Prokaryotes and Eukaryotes) (Ch 8 Watson, Ch 19 Becker) Fidelity of replication, general principles - bidirectional replication, Semiconservative, Semi discontinuous,RNA priming, Various models of DNA replication including rolling circle, D-loop (mitochondrial), (theta) mode of replication, replication of linear ds-DNA, replicating the 5end of linear chromosome. DNA synthesis at telomeres. Enzyme involved in DNA replication DNA polymerases, DNA ligase, Primase, Telomerase and other accessory proteins Unit 5. The Mutability and Repair of DNA (Ch 9 Watson) Replication Errors and their repair, DNA Damage. PRACTICAL 1. Preparation of Polytene chromosome from Chironomous larva/Drosophila larva 2. Demonstration of mammalian sex chromatin. Page 12 of 40 3. Preparations of temporary mount and study the different stages of Mitosis (Onion root tip). 4. Demonstration of PCR technique 5. Demonstration of Southern Blotting. 6. Demonstration of Northern Blotting. 7. Demonstration of Western Blotting. Recommended texts: 1. Karp, G. (2010). Cell and Molecular Biology: Concepts and Experiments. VI Edition. John Wiley & Sons. Inc.

2. De Robertis, E.D.P. and De Robertis, E.M.F. (2006). Cell and Molecular Biology. VIII Edition. Lippincott Williams and Wilkins, Philadelphia. 3. Becker, W.M., Kleinsmith, L.J., Hardin. J. and Bertoni, G. P. (2009). The World of the Cell. VII Edition. Pearson Benjamin Cummings Publishing, San Francisco. 4. Watson, J. D., Baker T.A., Bell, S. P., Gann, A., Levine, M., and Losick, R., (2008) Molecular Biology of the Gene (VI Edition.). Cold Spring Harbour Lab. Press, Pearson Pub. Paper 700: Applications of Computers in Chemistry Theory Computer basics: PC hardware, operating systems, data storage and backup, networks, information technology. Basic operations using windows. Computer programming: Constants, variables, bits, bytes, binary and ASCII formats, arithmetic expressions, hierarchy of operations, inbuilt functions. Elements of the BASIC language. BASIC keywords and commands. Logical and relative operators. Strings and graphics. Compiled versus interpreted languages. Debugging. Simple programs using these concepts. Matrix addition and multiplication. Statistical analysis. Practicals Word processing: Incorporating chemical structures into word processing documents, presentation graphics, on-line publication (www/html), multimedia animations, etc. Handling numeric data: spreadsheet software (Excel), simple calculations, statistical analysis, plotting graphs using a spreadsheet (radial distribution curves for hydrogenic orbitals, gas kinetic theory, spectral data), graphical solution of equations, solving equations numerically (e.g. pH of a weak acid ignoring/ not ignoring the ionization of water, volume of a van der Waals gas, equilibrium constant expressions). Numeric modelling, numerical curve fitting, numerical differentiation (e.g. handling data

from potentiometric titrations), integration (e.g. entropy/enthalpy change from heat capacity data). Numerical solution of differential equations (e.g. kinetics). Page 13 of 40 BASIC programs for numerical differentiation and integration, finding roots (quadratic formula, iterative, Newton-Raphson method), numerical solution of differential equations. Computational chemistry: Visualization of 3D structures, calculation of molecular structures and properties (e.g., conformational energies of butane, rotation of 1,3butadiene, distribution of isomers, energies of orbitals and total energy as a function of bond angle for H2O, Diels-Alder reaction). Chemical information on the web. Chemical abstracts. Structures and properties. Note: 1.Software: Microsoft Office, ChemOffice. 2. References: Internet, documentation of software. These are representative projects. The students must be encouraged to explore other projects and prepare a presentation based on their project. Internal assessment may be based on the project. Recommended texts: Noggle, J. H. Physical chemistry on a microcomputer. Little Brown & Co. (1985). Venit, S.M. Programming in Basic: Problem solving with structure and style. Jaico Publishing House: Delhi (1996) Paper 801 : Physics I Mathematical Physics: Scalar and vector products, polar and axial vectors, triple and quadruple products. Vector calculus: Scalar and vector fields, differentiation of a vector, gradient, divergence, curl and operations and their meaning, idea of line, surface and volume integrals, Gauss and Stokes theorem.

Classical Mechanics: Particle dynamics: Newtons laws of motion, conservation of linear momentum, centre of mass, conservative forces, work energy theorem, particle collision. Rotational kinematics and dynamics: Rotational motion, forces and pseudo forces, torque and angular momentum, kinetic energy of rotation, rigid body rotation dynamics, moment of inertia, conservation of angular momentum, comparison of linear and angular momentum, motion of a top. Oscillations: Linearity and superposition principle, free oscillation with one and two degrees of freedom, simple pendulum, combination of two simple harmonic motions. Lissajous figures, free and damped vibrations, forced vibrations and resonance, Q factor, wave equation, travelling and standing waves, superposition of waves, phase and group velocity. Wave optics: Interference, division of amplitudes, Youngs double split, Fresnels biprism, interference in thin films and wedged shaped films. Fresnel diffraction: Diffraction at a single slit and a circular aperture, diffraction at a double split, plane transmission grating, resolving power of a telescope and a microscope, resolving and dispersive power of a plane diffraction grating. Polarization: Polarization by reflection and refraction, Brewsters law, double refraction, nicol prism, quarter and half-wave plates, Production and analysis of circularly and elliptically polarized light.Page 14 of 40 SEMESTER II PRACTICAL Physical Chemistry Laboratory I (I) Surface tension measurements (use of organic solvents excluded). a) Determine the surface tension by (i) drop number (ii) drop weight method.

b) Study the variation of surface tension of detergent solutions with concentration (II) Viscosity measurement using Ostwalds viscometer (use of organic solvents excluded). (a) Study the effect of the addition of solutes such as (i) polymer (ii) ethanol (iii) sodium chloride on the viscosity of water at room temperature. (b) Study the effect of variation of viscosity of an aqueous solution with the concentration of solute. (III) pH measurements a) Measurement of pH of different solutions using pH-meter. b) Preparation of buffer solutions (i) Sodium acetate-acetic acid (ii) Ammonium chloride-ammonium hydroxide Measurement of the pH of buffer solutions and comparison of the values with theoretical values. c) pH metric titrations of (i) strong acid and strong base (ii) weak acid and strong base Any other experiment carried out in the class. SEMESTER III PAPER- 102: Inorganic Chemistry -II (Chemical Bonding and molecular structure) Chemical Bonding: (h) lonic bond: General characteristic, types of ions, size effects, radius ration rule and their limitations. Packing of ions in crystals. Born-Lande equation with derivation and importance of Kapustinskii expression for lattice

energy. Madelung constant, Born-Haber cycle and its application, Solvation energy. (ii) Covalent bond : Lewis structure, Valence Bond theory (Heitler-London approach). Energetics of hybridization, equivalent and non-equivalent hybrid orbitals. Bents rule, Resonance and resonance energy, Molecular orbital theory. Molecular orbital diagrams of diatomic and simple polyatomic molecules N2, O2, C2, B2, F2, CO, No, and their ions; HCI, BeF2, CO2, (idea of s-p mixing and orbital interaction to be given). Formal charge, Valence shell electron pair repulsion theory (VSEPR), Page 15 of 40 shapes of simple molecules and ions containing lone pairs and bond pairs of electrons, multiple bonding ( and bond approach), bent bond approach and bond lengths. Covalent character in ionic compounds, polarizing power and polarizability. Fajans rules and consequences of polarization. Lonic character in covalent compounds: Bond moment and dipole moment. Percentage ionic character from dipole moment and electronegativity difference. (iii)Methallic Bond: Qualitative idea of valence bond and band theories. Semiconductors and insultors, defects in solids. (iv)Weak Chemical forces: van der Waals forces, ion-dipole forces, dipoledipole interactions, induced dipole interactions, Instantaneous dipoleinduced dipole interactions. Repulsive forces, Hydrogen bonding (theories of hydrogen bonding, valence bond treatment) Effects of chemical force, melting and boiling points, solubility energetics of dissolution process. (v) Acids and Bases : Brnsted- Lowry concept of acid-base reaction, solvated proton, relative strength of acids, types of acid-base reactions, levelling solvents, Lewis acid-base concept, Classification of Lewis acids, Hard and

Soft Acids and Bases (H.S.A.B) Application of H.S.A.B principle. Bibliography: 1. Huheey, J.E. Inorganic Chemistry, Prentice Hall 1993 2. Dougleas, B.E. and Mc Daniel, D.H., Concepts & Models 3. Inorganic Chemistry, Oxford, 1970 4. Lee, J.D. concise Inorganic Chemistry, ELBS 5. Shriver & Atkins, Inorganic Chemistry, Oxford Press Paper 202: Organic Chemistry - II (Chemistry of Halogenated hydrocarbons)

Unit I: Chemistry of Halogenated hydrocarbons Alkyl halides: Methods of Preparation including Finkelstein and Hunsdicker reaction, Nucleophilic Substitution Reactions SN1, SN2 and SNi Mechanisms with stereochemical aspects and effect of solvent. Nucleophilic substitution versus Elimination; Haloform reaction with mechanistic details. Aryl Halides: Preparation from diazonium Salts. Nucleophilic Aromatic Substitution; SNAr, Benzyne Intermediate Relative reactivity of Alkyl, Allyl/Benzyl, Vinyl and Aryl Halides towards nucleophilic substitution reactions. Organometallic Compounds of Mg and Li Use in Synthesis of Organic Compounds. Page 16 of 40 Unit II: Chemistry of C-O Bond Alcohols: Preparation, Properties and relative reactivity of 1

0 ,2 0 ,3 0 alcohols. BouvaeltBlanc Reduction and Baeyer Villiger Oxidation; Preparation and properties of glycols: Oxidation by periodic acid and Lead tetraacetate, Pinacol- Pinacolone Rearrangement; Phenols : Preparation and properties; Acidity - Comparison with Alcohols; Ring Substitution Reactions, Reimer Tiemann and Kolbes Schmidt Reactions, Fries and Claisen Rearrangements with mechanism; Ethers and Epoxides: Preparation and reactions with acids. Unit III: Carbonyl Compounds Aldehydes and Ketones (aliphatic and aromatic): Structure, Preparation and Reactions; Nucleophilic addition-Relative reactivity of Aldehydes and Ketones; Nucleophilic addition-Elimination reactions with ammonia derivatives with mechanism; Mechanism of Aldol and Benzoin Condensation, Claisan-Schmidt, Perkin, Cannizzaro and Wittig Reaction, Beckmann and Benzil-Benzilic Acid Rearrangements; -substitution, oxidation and reduction (Clemmensen, Wolff-Kishner and MPV reduction); Addition Reactions of Unsaturated Carbonyl Compounds: Michael addition. Unit IV: Carboxylic Acids and their Derivatives (aliphatic and aromatic)

Preparation and properties of monocarboxylic acids: acidity and effect of substituent, Hell-Volhard-Zelinski and Schmidt Reactions. Typical reactions and uses of dicarboxylic acids, hydroxy acids and unsaturated acids: succinic/phthalic, lactic, malic, tartaric, citric, maleic and fumaric acids; Preparation and reactions of acid chlorides, anhydrides, esters and amides: Comparative study of nucleophilic sustitution at acyl group - Mechanism of acidic and alkaline hydrolysis of Esters, Claisen Ester Condensation, Dieckmann and Reformatsky Reaction, Hofmann - bromamide degradation and Curtius Rearrangement; Preparation and typical reactions of urea and urethanes; Active Methylene Compounds: Keto-enol tautomerism. Preparation and Synthetic Applications of diethyl malonate and ethyl acetoacetate: Knoevenagel Condensation. Unit V: Sulphur containing compounds Preparation and reactions of thiols, thioethers and sulphonic acids. Bibliography: 1. Robert Thornton Morrison and Robert Neilson Boyd, Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). Page 17 of 40 2. I. L. Finar, Organic Chemistry (Volume 1), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). Paper 302: Physical Chemistry - II Chemical Thermodynamics

Chemical thermodynamics Intensive and extensive variables; state and path functions; isolated, closed and open

systems; zeroth law of thermodynamics. First law: Concept of heat, q, work, w, internal energy U and statement of first law; enthalpy, H, relation between heat capacities, calculations of q, w, U and H for reversible, irreversible and free expansion of gases (ideal and van der Waals) under isothermal and adiabatic conditions. Thermochemistry: Heats of reactions: standard states; enthalpy of formation of molecules and ions and enthalpy of combustion and its applications; calculation of bond energy, bond dissociation energy and resonance energy from thermochemical data, effect of temperature (Kirchoffs equations) and pressure on enthalpy of reactions. Adiabatic flame temperature, explosion temperature. Second Law: Concept of entropy; thermodynamic scale of temperature, statement of the second law of thermodynamics; molecular and statistical interpretation of entropy. Calculation of entropy change for reversible and irreversible processes. Third Law: Statement of third law, concept of residual entropy, calculation of absolute entropy of molecules. Free Energy Functions: Gibbs and Helmholtz energy; variation of S, G, A with T, V, P; Free energy change and spontaneity. Relation between Joule-Thomson coefficient and other thermodynamic parameters; inversion temperature; Gibbs-Helmholtz equation; Maxwell relations; thermodynamic equation of state. Systems of variable composition Partial molar quantities, dependence of thermodynamic parameters on composition; Gibbs-Duhem equation, chemical potential of ideal mixtures, change in thermodynamic functions in mixing of ideal gases. Chemical equilibrium Criteria of thermodynamic equilibrium, degree of advancement of reaction, chemical

equilibria in ideal gases, concept of fugacity. Thermodynamic derivation of relation between Gibbs free energy of reaction and reaction quotient. Coupling of exoergic and endoergic reactions. Equilibrium constants and their quantitative dependence on temperature, pressure and concentration. Free energy of mixing and spontaneity; thermodynamic derivation of relations between the various equilibrium constants Kp, Kc and Kx. Le Chatelier principle (quantitative treatment); equilibrium between ideal gases and a pure condensed phase. Solutions and colligative properties Dilute solutions; lowering of vapour pressure, Raoults and Henrys Laws and their applications. Excess thermodynamic functions. Thermodynamic derivation using chemical potential to derive relations between the four colligative properties [(i) relative lowering of vapour pressure, (ii) elevation of boiling Page 18 of 40 point, (iii) Depression of freezing point, (iv) osmotic pressure] and amount of solute. Applications in calculating molar masses of normal, dissociated and associated solutes in solution. Recommended texts: Atkins, P. W. & Paula, J. de Atkins Physical Chemistry 8 th Ed., Oxford University Press (2006). Castellan, G. W. Physical Chemistry 4 th Ed. Narosa (2004). Engel, T. & Reid, P. Thermodynamics, Statistical Thermodynamics, & Kinetics Pearson Education, Inc: New Delhi (2007). McQuarrie, D. A. & Simon, J. D. Molecular Thermodynamics Viva Books Pvt. Ltd.: New Delhi

(2004). Paper 802 : Physics II Electrostatics: Electric field, potential due to a charge distribution and due to a dipole, electrical potential energy, flux, Gausss law, electric field in a dielectric, polarization, energy stored in an electric field. Magnetism: Magnetic field due to a current-carrying conductor, Biot Savart law, magnetic force on a current, Lorentz force, electromagnetic induction, Lenzs law, magnetic properties of matter, para- dia- and ferromagnetism, spinning of a magnetic dipole in an external magnetic field. Fundamental laws of electromagnetism: Modification of Amperes law, equation of continuity and displacement current, Maxwells equations, wave equation and its plane wave solution, nature of electromagnetic waves, tranversality and polarization, propaganation of electromagnetic plane waves in dielectric media. Electronics: Half-wave, full-wave and bridge rectifiers, ripple factor, rectification efficiency, filters (series in inductor, shunt capacitator, LC and sections), voltage regulations, load regulation, Zener diode as voltage regulator. Characteristic curves of bipolar transistors, static and dynamic load line, biasing (fixed and self) of transistor circuit, thermal instability of bias, the black box idea of CE, CB and CC transistor circuits as two-port network, small signal active output, hybrid model of a CE transistor circuit, analysis of a small signal amplifier: its voltage and current gains, negative and positive feedback. Barkhausens criterion for self-sustaining oscillations, LC and phase shift oscillators. Digital electronics: Number systems (binary, BCD, octal and hexadecimal), 1s and 2s complements. Logic gates, AND, OR, NAND, NOR, XOR and NXOR. Boolean algebra (Boolean laws and simple expressions), binary adders, half adder, half subtractor, full

adder and full subtractor. Page 19 of 40 SEMESTER III PRACTICAL Inorganic Laboratory II (a) Iodo / Iodimetric Titrations (i) Estimation of Cu (II) and K2Cr2 O7 Using sodium thiosulphate solution (Iodimetrically). (ii) Estimation of (i) arsenite and (ii) antimony in tartar-emetic iodimetrically (iii) Estimation of available chlorine in bleaching powder iodomertically. (b) Inorganic preparations (i) Cuprous Chloride, Cu2Cl2 (ii) Preparation of Manganese (III) phosphate, MnPO4.H2O (iii) Preparation of Aluminium Potassium sulphate KAl (SO4)2.12H2O (Potash alum) or Chrome alum. Reference text: 1. Vogel, A.I. A text book of quantitative Inorganic Analysis, ELBS. 1978. Organic Laboratory II Organic Preparations Acetylation of Aniline to Acetanilide. Benzoylation of Glycine to Hippuric acid. Nitration of Nitrobenzene to meta-dinitrobenzene. Reduction of meta-dinitrobenzene to meta-nitroaniline. Oxidation of Benzaldehyde to Benzoic acid.

Hydrolysis of benzamide to benzoic acid. Diazotization and coupling to prepare Methyl Orange/ Methyl Red. Derivatives of carbonyl group: Preparation of 2, 4- DNP and semicarbazone of aldehydes/ ketones. Preparation of S-benzylisothiouronium chloride from benzyl chloride. Preparation of benzilic acid from benzil by green method. Physical Laboratory II (I) Thermochemistry (a) Determination of heat capacity of a calorimeter for different volumes using Page 20 of 40 change of enthalpy data of a known system (method of back calculation of heat capacity of calorimeter from known enthalpy of solution or enthalpy of neutralization). (b) Determination of heat capacity of the calorimeter and enthalpy of neutralization of hydrochloric acid with sodium hydroxide. (c) Calculation of the enthalpy of ionization of ethanoic acid. (d) Determination of heat capacity of the calorimeter and integral enthalpy (endothermic and exothermic) solution of salts. (e) Determination of basicity/proticity of a polyprotic acid by the thermochemical method in terms of the changes of temperatures observed in the graph of temperature versus time for different additions of a base. Also calculate the enthalpy of neutralization of the first step. (f) Determination of enthalpy of hydration of copper sulphate. (g) Study of the solubility of benzoic acid in water and determination of H. (II) Indexing of given powder diffraction pattern of a cubic crystalline system. Any other experiments carried out in the class. Page 21 of 40

SEMESTER IV Paper- 103: Inorganic Chemistry III (Chemistry of s & p block elements) Chemistry of s and p block elements: Inert pair effect, Relative stability of different oxidation states, diagonal relationship and anomalous behaviour of first member of each group. Allotropy and catenation. Complex formation tendency of s & p block elements. Hydrides and their classification ionic, covalent and interstitial. Basic beryllium acetate and nitrate.

A Study of the following compounds with emphasis on structure, bonding, preparation, properties and uses. Boric Acid and borates, boron nitrides, borohydrides (diborane) carboranes and graphitic compounds, silanes, Oxides and oxoacids of nitrogen, Phosphorus and chlorine. Peroxo acids of sulphur, interhalogen compounds, polyhalide ions, pseudohalogens and basis properties of halogens. Theoretical principles involved in volumetric analysis done in the lab. Noble gases : Occurrence & uses, rationalization of inertness of noble gases and its failings; Clathrates, preparation and properties of XeF2 and XeF4 and XeF6 Nature of bonding in noble gas compounds (Valance bond treatment and MO treatment for XeF2 Molecular shapes of noble gas compounds (VSEPR theory). Inorganic Polymers: Types of inorganic polymers, comparison with organic polymers, synthesis, structural aspects and applications of silicones and siloxanes. Phosphonitrilic halides, condensed phosphates, Borazines, phosphazenes silicates and polysulphates. Bibliography: 1. Greenwood, N.N. and Earnshwa, Chemistry of the Elements, Butterworth-Heinemann.

1997. 2. Lee, J.D. Concise Inorganic Chemistry, ELBS. 3. Canham, G.R. and Uverton, T., Descriptive Inorgnaic Chemistry, Freeman & Co. 4. Cotton, F.A. and Wilkinson, G, Advanced Inorganic Chemistry, Wiley, VCH, 1999. Page 22 of 40 Paper 203: Organic Chemistry - III (Nitrogen Containing Functional Groups) Unit I: Nitrogen Containing Functional Groups (aliphatic and aromatic) Nitro and Nitroso Compounds, Nitriles and Isonitriles: Preparation and Important reactions; Amines: Effect of substituent and solvent on Basicity; Preparation and properties: Gabriel phthalimide synthesis and Hoffmann bromamide degradation, Carbylamine reaction, Mannich Reaction, Hoffmanns Exhaustive Methylation, Hofmann-Elimination Reaction; Distinction between 1 0 ,2 0 and 3 0 amines with Hinsberg reagent and Nitrous acid; Diazonium Salts: Preparation and their Synthetic applications. Unit II: Amino acids and Proteins

Amino acids and their Classification. - Amino Acids - Synthesis, Ionic properties and Reactions. Zwitterions, pKa values, Isoelectric Point and Electrophoresis; Study of peptides: determination of their primary structures-end group analysis, methods of Peptide Synthesis - Solid-phase Synthesis Descriptive Study of Proteins: their Classification and biological importance; Primary, secondary structures of proteins - -helix and -pleated sheet structures and tertiary structures of proteins; Denaturation. Unit III: Polynuclear Hydrocarbons Naphthalene, Phenanthrene and Anthracene: Structure, Preparation (including Haworths Synthesis) and Reactions; Structure elucidation and Important derivatives of Naphthalene and Anthracene; Polynuclear Hydrocarbons; Mutagenicity and Carcinogenicity. Unit IV: Heterocyclic Compounds Classification and Nomenclature, Structure, Aromaticity in 5-numbered and 6-membered rings containing one heteroatom Synthesis, Reactions and mechanism of substitution reactions of: Furan, Pyrrole (Paal-Knorr synthesis, Knorr pyrrole synthesis, Hantzsch synthesis) Thiophene, Pyridine (Hantzsch synthesis), Pyrimidine, Indole (Fischer indole synthesis, Madelung synthesis, Reissert synthesis), Quinoline (Skraup synthesis, Friedlanders synthesis, Conrad-Limpach synthesis, Knorr quinoline synthesis, DoebnerMiller synthesis, Pfitzinger reaction) and Isoquinoline (Bischler-Napieralski reaction, Pictet-Spengler reaction, Pomeranz-Fritsch reaction); Derivatives of Furan: Furfural and Furoic acid. Page 23 of 40 Unit V:

Alkaloids Natural occurrence, General structural features, Isolation and their Physiological Action Hoffmanns Exhaustive Methylation, Emdes Modification, Structural Elucidation and Synthesis of Hygrine and Nicotine. Medicinal importance of Nicotine, Hygrine, Quinine, Morphine, Cocaine, and Reserpine. Bibliography: 1. Robert Thornton Morrison and Robert Neilson Boyd, Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 2. I. L. Finar, Organic Chemistry (Volume 1), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 3. I. L. Finar, Organic Chemistry (Volume 2: Stereochemistry and the Chemistry of Natural Products), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). Paper 303: Physical III Phase equilibria Concept of phases, components and degrees of freedom, derivation of Gibbs Phase Rule for non-reactive and reactive systems; Clausius-Clapeyron equation and its applications to solid-liquid, liquid-vapour and solid-vapour equilibria, phase diagram for one component systems, with applications. Phase diagrams for systems of solid-liquid equilibria involving eutectic, congruent and incongruent melting points, solid solutions. Three component systems, water-chloroform-acetic acid system, triangular plots. Binary solutions: Gibbs-Duhem-Margules equation, its derivation and applications to fractional distillation of binary miscible liquids (ideal and nonideal), azeotropes, lever rule, partial miscibility of liquids, CST, miscible pairs, steam distillation. Nernst distribution law: its derivation and applications.

Electrochemistry Quantitative aspects of Faradays laws of electrolysis, rules of oxidation/reduction of ions based on half-cell potentials, applications of electrolysis in metallurgy and industry. Chemical cells, reversible and irreversible cells with examples. Electromotive force of a cell and its measurement, Nernst equation; Standard electrode (reduction) potential and its application to different kinds of half-cells. Application of EMF measurements in determining (i) free energy, enthalpy and entropy of a cell reaction, (ii) equilibrium constants, and (iii) pH values, using hydrogen, quinone-hydroquinone, glass and SbO/Sb2O3 electrodes. Concentration cells with and without transference, liquid junction potential; determination of activity coefficients and transference numbers. Qualitative discussion of potentiometric titrations (acid-base, redox, precipitation). Recommended texts: Atkins, P. W. & Paula, J. de Atkins Physical Chemistry 8 th Ed., Oxford University Press (2006). Ball, D. W. Physical Chemistry Thomson Press, India (2007). Castellan, G. W. Physical Chemistry 4 th Ed. Narosa (2004). Page 24 of 40 Mortimer, R. G. Physical Chemistry 3 rd Ed. Elsevier: NOIDA, UP (2009). Paper 502 : Mathematics II Differential equations: differential equations with separable variables, series solution, numerical solutions of differential equations. Newton laws of motion. The linear

harmonic oscillator: Linear differential equations with constant coefficients. Partial differential equations: separation of variables. The wave equation. Schrdingers equation. Multiple integrals. Changing variables. Vector derivative operators. Multiple integrals involving other coordinate systems (spherical polar). Maximum and minimum values of functions of several variables. Stationary points, imaginary and complex numbers, complex plane, Eulers formula and polar form of complex numbers, complex conjugates, modulus of a complex number. Operators: operator algebra, linear operators, eigenfunctions and eigenvalues, commutators of operators, Hermitian operators. Vectors and coordinate systems: Unit vectors (application in solid state), addition and subtraction of vectors, multiplication of vectors. Vector calculus. Vectors and coordinate systems in three dimensions (Cartesian, spherical polar and their interconversion). Determinants. Matrix algebra, Simultaneous equations: method of substitution and elimination, consistency and independence. Homogeneous linear equations. Simultaneous equations with more than two unknowns (e.g. spectrophotometry), Cramers rule, matrix inversion, orthogonal and unitary matrices, matrix eigenvalues and eigenvectors, diagonalization of a matrix. Recommended texts: McQuarrie, D. A. Mathematics for Physical Chemistry University Science Books (2008). Mortimer, R. Mathematics for Physical Chemistry. 3 rd Ed. Elsevier (2005). Steiner, E. The Chemical Maths Book Oxford University Press (1996). Yates, P. Chemical calculations. 2

nd Ed. CRC Press (2007).Page 25 of 40 SEMESTER IV PRACTICAL Inorganic Laboratory III (a) Complexometric Titrations: (i) Complexometric estimation of (i) Mg 2+ (ii) Zn 2+ using EDTA (ii) Estimation of total hardnesss of water samples (iii) Estimation of Ca 2+ in solution by (substitution method) Erio-T as indicator. (iv) Estimation of Ca/Mg in drugs and in Biological samples. (b) Argentometry Estimation of Cl (i) By Mohrs method, (ii) By Vohlards method, (iii) By Fajans method. (c) Paper Chromatographic separation of (I) Ni (II) ad Co(II), Cu(II) ad Cd (II) Organic Laboratory III Detection of Extra elements (N, S, Cl, Br and I) in organic compounds. Identification of functional groups in organic compounds.

Determination of strength of phenol and aniline by bromate - bromide method. Preparation of derivatives of phenols picrates and acetates Carboxylic acids Amides and Sbenzylisothiouronium Hydrolysis of esters Oximes of carbonyl compounds Picrates of hydrocarbons. Physical Laboratory III (I) Study the equilibrium of at least one of the following reactions by the distribution method: (i) I 2 (aq) + I -I 3 (aq) (ii) Cu 2+ (aq) + nNH3 Cu(NH3 ( n 2+

(II) Perform the following potentiometric titrations (at least two): (i) Strong acid with strong base (ii) weak acid with strong base and (iii)

dibasic acid with strong base (III) Potentiometric titration of Mohr's salt with potassium dichromate. (IV) Determination of critical solution temperature and composition of the phenolwater system and to study the effect of impurities on it. (V) Phase equilibria: Construction of the phase diagram of (i) simple eutectic and (ii) congruently melting systems, using cooling curves and ignition tube methods. Any other experiment carried out in the class. Page 26 of 40 SEMESTER V Paper 104: Inorganic Chemistry IV (Transition Elements and Coordination Chemistry) Transition elements: General group trends with special reference to electronic configuration, colour, variable valency, magnetic and catalytic properties, ability to form complexes. Stability of various oxidation states and e.m.f. (Latimer & Bsworth diagrams). Difference between the first, second and third transition series. Chemistry of Ti, V, Cr Mn, Fe and Co in various oxidation states (excluding their metallurgy) Lanthanoids and antinoids: electronic configuration, oxidation states, colour, spectral and magnetic properties, lanthanore contraction, separation of lanthanores (ion-exchange method only). Coordination Chemistry Bonding theories: Werners theory, valence bond theory (inner and outer orbital complexes), electroneutrality principle and back bonding. Crystal field theory, measurement of (10 Dq (o), CFSE in weak and strong fields, pairing energies, factors effecting the magnitude of 10 Dq (o, t). Octahedral vs. tetrahedral coordination, tetragonal distortions from octahedral geometry Jahn-Teller theorem, square planar

coordination. Ligand field and MO Theories (Elementary idea only). Isomerism in coordination compounds. IUPAC nomenclature of coordination compounds Stereochemistry of complexes with 4 and 6 coordination numbers. Chelate effect, polynuclear complexes. Reaction kinetics and mechanism: The trans effect, theories of trans effect, mechanism of trans effect, kinetics of substitution reactions in square planar complexes. Thermodynamic and kinetic stability including factors affecting them. Labile and inert complexes. Electron transfer reactions, Inner sphere, outer sphere, without breaking M-L bond. Bibliography: 1. Purecell, K.F. and Kotz, J.C., W.B. Saunders compandy, 1977. 2. Basolo, F, and Pearson, R.C., Mechanism of Inorganic Chemistry, John Wiley & Sons, NY, 1967. 3. Greenwood, N.N. and Earnshaw A, Chemistry of Elements, Butterworth-Heinemann. Page 27 of 40 Paper 204: Organic Chemistry - IV (Bio-molecules) Unit I: Carbohydrates Occurrence, Classification and their biological importance Monosaccharides: constitution and absolute configuration of Glucose and Fructose, Mutarotation, determination of Ring size of Glucose and Fructose, Haworth projections and conformational structures; Interconversion of Aldoses and Ketoses; Structure of Ribose and 2-deoxyribose; Disaccharides - Structures of Maltose, Lactose and Sucrose (excluding structure determination and synthesis);

Polysaccharides elementary treatment of Starch, Cellulose and Glycogen. Unit II: Nucleic Acids Components of nucleic acids, Nucleosides and Nucleotides; Structure, Synthesis and Reactions of: Adenine, Guanine, Cytosine, Uracil and Thymine; Polynucleotides: Structure of DNA (Watson - Crick Model) and RNA. Genetic Code; Biological roles of DNA and RNA: Replication, Transcription and Translation. Introduction to Gene Therapy. Unit III: Enzymes Nomenclature, Characteristics features (mention of ribozymes), Classification; Active site, Specificity, Mechanism of Enzyme Action, Stereospecificity of Enzymes; Fischer and Koshland models; Coenzymes and Cofactors; Competitive and Noncompetitive Inhibition, Enzyme Inhibitors; Alcoholic Fermentation, Glycolysis, Kreb Cycle. Introduction to Biocatalysis: Importance in Green Chemistry and Chemical Industry Unit IV: Pharmaceutical Compounds : Structure and Importance Introduction to natural and synthetic medicinal compounds: Azadirectin (neem), Curcumin (haldi) Vitamin C Their Medicinal values; Drug Action; Classification, Structure and Therapeutic uses of Antipyretics: Paracetamol (with

synthesis), Analgesics: Ibuprofen (with green synthesis), Antimalarials: Chloroquine (with synthesis), Antacids: Ranitidine, Antibacterials: Povidone - Iodine Solutions, Antihistamins: Benadryl. An elementary treatment of Antibiotics and detailed study of Chloramphenicol. Page 28 of 40 Unit V: Terpenes Occurrence, Classification, Isoprene Rule; Elucidation of stucture and synthesis of Citral, Neral and - terpineol. Bibliography: 1. Robert Thornton Morrison and Robert Neilson Boyd, Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 2. I. L. Finar, Organic Chemistry (Volume 1), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 3. I. L. Finar, Organic Chemistry (Volume 2: Stereochemistry and the Chemistry of Natural Products), Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 4. David L. Nelson, Michael M. Cox, Lehninger Principles of Biochemistry, Fourth Edition, W. H. Freeman. 5. Jeremy M. Berg, John L. Tymoczko and Lubert Stryer, Biochemistry, Sixth Edition, W. H. Freeman. Paper 304: Physical Chemistry IV (Electrolysis and Conductance) Conductance Arrhenius theory of electrolytic dissociation. Conductivity, equivalent and molar conductivity and their variation with dilution for weak and strong electrolytes. Molar conductivity at infinite dilution. Kohlrausch law of independent migration of ions. Debye-Hckel-Onsager equation, Wien effect, Debye-Falkenhagen effect, Waldens

rules. Ionic velocities, mobilities and their determinations, transference numbers and their relation to ionic mobilities, determination of transference numbers using Hittorf and Moving Boundary methods. Applications of conductance measurement: (i) degree of dissociation of weak electrolytes, (ii) ionic product of water (iii) solubility and solubility product of sparingly soluble salts, (iv) conductometric titrations, and (v) hydrolysis constants of salts. Chemical Kinetics Order and molecularity of a reaction, rate laws in terms of the advancement of a reaction, differential and integrated form of rate expressions up to second order reactions, experimental methods of the determination of rate laws, kinetics of complex reactions (integrated rate expressions up to first order only): (i) Opposing reactions (ii) parallel reactions and (iii) consecutive reactions and their differential rate equations (steady-state approximation in reaction mechanisms) (iv) chain reactions. Temperature dependence of reaction rates; Arrhenius equation; activation energy. Collision theory of reaction rates, Lindemann mechanism, qualitative treatment of the theory of absolute reaction rates. Surface chemistry: Physical adsorption, chemisorption, adsorption isotherms. nature of adsorbed state. Page 29 of 40 Catalysis: Types of catalyst, specificity and selectivity, mechanisms of catalyzed reactions at solid surfaces; effect of particle size and efficiency of nanoparticles as catalysts. Enzyme catalysis, Michaelis-Menten mechanism, acid-base catalysis. Photochemistry Characteristics of electromagnetic radiation, Lambert-Beers law and its limitations, physical significance of absorption coefficients. Laws, of photochemistry, quantum yield,

actinometry, examples of low and high quantum yields, photochemical equilibrium and the differential rate of photochemical reactions, photosensitised reactions, quenching. Role of photochemical reactions in biochemical processes, photostationary states, chemiluminescence. Recommended texts: Atkins, P. W. & Paula, J. de Atkins Physical Chemistry 8 th Ed., Oxford University Press (2006). Ball, D. W. Physical Chemistry Thomson Press, India (2007). Castellan, G. W. Physical Chemistry 4 th Ed. Narosa (2004). Laidler, K. J. Chemical Kinetics Pearson Education: New Delhi (2004). Paper 602: Molecular Biology - II THEORY Unit 1. Mechanism of Transcription (Ch 12 Watson; Ch 21 Becker)

RNA Polymerase and the transcription cycle Transcription in Prokaryotes Transcription in Eukaryotes Unit 2. RNA Splicing (Ch 13 Watson)

Introns amd their removal, spliceosome machinery, splicing pathways, alternative splicing, exon shuffling, RNA editing, and mRNA transport. Unit 3. Translation (Prokaryotes and Eukaryotes) (Ch 14 Watson; Ch 22 Becker, Ch 21 DeRobertis) Assembly line of polypeptide synthesis - ribosome structure and assembly, mRNA,

various steps in protein synthesis. Charging of tRNA, aminoacyl tRNA synthetases. Proteins involved in initiation, elongation and termination of polypeptides. Fidelity of translation. Inhibitors of protein synthesis. Regulation of translation Translation-dependent regulation of mRNA and Protein Stability. Unit 4. Transcription Regulation in Prokaryotes (Ch 16 Watson)

Principles of transcriptional regulation, regulation at initiation, Bacteriophage lambda as example. Page 30 of 40 Unit 5. Transcription Regulation in Eukaryotes (Ch 17 Watson)

Conserved mechanism of regulation, Eukaryotic activators, Signal integration, combinatorial control, transcriptional repressors, signal transduction and control of transcriptional regulator, Gene Silencing Unit 6. Regulatory RNAs (Ch 18 Watson)

Riboswitches, RNA interference, miRNA, RNAi, Regulatory RNA and X-inactivation PRACTICALS 1. Identification and study of cancer cells- Slides/Photomicrographs. 2. Preparation of culture medium (LB) for E.coli. 3. Culture of E.coli (LB agar plate/liquid culture). 4. Preparation of E.coli culture growth curve. 5. Culture of E.coli containing plasmid (pUC 18/19) in LB medium with/without antibiotic pressure and interpretation of results. 6. Isolation and quantitative estimation of plasmid DNA (from E.coli) using spectrophotometer. Recommended texts: 1. Karp, G. (2010). Cell and Molecular Biology: Concepts and Experiments. VI Edition.

John Wiley & Sons. Inc. 2. De Robertis, E.D.P. and De Robertis, E.M.F. (2006). Cell and Molecular Biology. VIII Edition. Lippincott Williams and Wilkins, Philadelphia. 3. Becker, W.M., Kleinsmith, L.J., Hardin. J. and Bertoni, G. P. (2009). The World of the Cell. VII Edition. Pearson Benjamin Cummings Publishing, San Francisco. 4. Watson, J. D., Baker T.A., Bell, S. P., Gann, A., Levine, M., and Losick, R., (2008) Molecular Biology of the Gene (VI Edition.). Cold Spring Harbour Lab. Press, Pearson Pub. Page 31 of 40 SEMESTER- V PRACTICAL Inorganic Laboratory IV (a) Quantitative Analysis : The following quantitative estimations are to be carried out. (i) Estimation of nickel (II) using Dimethylglyoxime as the pr eciptant. (ii) Estimation of copper as CuSCN (iii) Estimation of iron as Fe2O3by precipitating iron as Fe (OH)3 through (i) Heterogenous and (ii) Homogenous media. (iv) Estimation of Al (III) by precipitating with oxine and weighings Al (oxine)3 (aluminium oxiate). (b) Inorganic Preparations (i) Tetraammine copper (II) sulphate, [Cu(NH3)4] So4 H2O (ii) Potassium trisoxalatochromate (III), K3[Cr(C2O4)3] (iii) Cis and trans K [Cr(C2O4)2 (H2O2] Potassium dioxalatodiaquachromate (III) (iv) Pentaammne carbonato Cobalt (III) ion

(c) Estimation of Ferrous ion spectrophotometry by using 1,10 phenanthroline Reference Text 1. Vogel, A.I. A text book of Quantitative Analysis, ELBS. Organic Laboratory IV Systematic identification of organic compounds: Physical analysis data Detection of extra elements Chemical analysis data Derivatization Complete identification A variety of compounds with varied functionalities must be covered. Physical Laboratory IV (I) To study changes in conductance in the following systems (i) strong acid-strong base (ii) weak acid-strong base and (iii) mixture of strong acid and weak acid-strong base (II) Study the kinetics of the following reactions. 1. Initial rate method: Iodide-persulphate reaction Page 32 of 40 2. Integrated rate method: (a) Acid hydrolysis of methyl acetate with hydrochloric acid, volumetrically or conductometrically. (b) Iodide-persulphate reaction (c) Saponification of ethyl acetate. Any other experiment carried out in the class. Page 33 of 40

SEMESTER VI Paper 105: Inorganic Chemistry - V (Theoretical principles, Organometallic & Bio-inorganic Chemistry) Theoretical principles and chemistry involved in qualitative analysis of mixture of cations and anions including interfering and insolubles. Organometallic Compounds: Definition and classification of organometallic compounds, EAN rule (18e and 16e) Metal carbonyls: preparation, properties, structure and bonding of mononuclear carbonyls. - acceptor behaviour of carbon monoxide, synergic effect (Mo diagram of CO be refer for synergic effect refer to I R frequencies) Carbonylate anions, ferrocene and its reactions. Bioinorganic Chemistry : Metal ions present in biological systems : classification of elements according to their action in biological system. Geochemical effect on the distribution of metals. Sodium / K-pump. Biochemistry of Mg and Ca Metalloenzyme oxaloacetate decarboxylase and carboxypeptidase. Excess and deficiency of some trace metals. Toxicity of metal ions (Hg, Pb and As) reasons for toxicity, Use of chelating agents in medicine. Iron and its application in bio-systems, Storage and transfers of iron. Bibliography: 1. Purcell, K.F & Kotz, J.C. W.B. Saunders Co, 1977. 2. Huheey, J.E., Inorganic Chemistry, Prentice Hall, 1993. 3. Lippard, S.J. and Berg, J.M. Principles of Bioiongranc Panima Publishing Company. 4. Cotton, F.A. and Urilkinren G, Advanced Inorganic Chemistry. Wiley, -UCH, 1999. Paper 205: Organic Chemistry - V

Unit I: Organic spectroscopy General Principles, IR Spectroscopy: Fundamental and Non-fundamental molecular vibrations; IR absorption positions of O, N and S containing functional groups; Effect of H- bonding on IR absorptions; Fingerprint region and its significance; application in functional group analysis. UV Spectroscopy: Types of electronic transitions, max, Chromophores and Auxochromes, Bathochromic and Page 34 of 40 Hypsochromic Shifts, Intensity of Absorption; Application of Woodward Rules for calculation of max for the following systems: , unsaturated aldehydes, ketones, carboxylic acids and esters; Conjugated dienes: alicyclic, homoannular and heteroannular; Extended conjugated systems (aldehydes, ketones and dienes); Cis and trans isomers. NMR Spectroscopy: Basic principles of Proton Magnetic Resonance, Chemical Shift and factors influencing it; Spin Spin Coupling and Coupling constant; Anisotropic Effects in Alkene, alkyne, Cycloalkane, Carbonyl compounds and benzene; Study of AX, AX2, AX3, A2X3 and AMX Patterns of NMR spectra. Applications of IR, NMR and UV in Structural Identification of Simple Organic Molecules. Unit II: Lipids Classification of Oils and Fats and their Vegetable origin, Structure of common fatty

acids present. Structure, Properties and Biological Importance of triglycerides and phosphoglycerides; Change of flavour of oils, Reversion and Rancidity; Saponification Value and Iodine Number. Role of Triglycerides in Cholesterol deposition in arteries; Liposomes and their biological functions and underlying applications. Unit III: Dyes Classification, Mordant and Wet Dyes; Color and Constitution, Chemistry of Dying; Synthesis and applications of: Azo dyes Methyl Orange and Congo Red ( mechanism of Diazo Coupling ); Triphenyl Methane Dyes - Malachite Green, Rosaniline and Crystal Violet; Phthalein Dyes Phenolphthalein and Fluorescein; Natural Dyes Structure Elucidation and synthesis of Alizarin and Indigotin; Edible Dyes with Examples. Unit IV: Polymers Introduction and Classification including di-block, tri-block and amphiphilic polymers; Number average molecular weight, Weight average molecular weight, Degree of Polymerization, Polydispersity Index. Polymerisation Reactions - Addition and Condensation - Mechanism of cationic, anionic and free radical addition polymerization; Metallocene-based Ziegler-Natta polymerisation of alkenes; Preparation and applications of plastics thermosetting (Phenol-formaldehyde,

Polyurethanes) and thermosoftening (PVC, Polythene); Polymer Additives; Page 35 of 40 Fabrics natural and synthetic (acrylic, polyamido, polyester); Rubbers Natural and Synthetic: Buna-S, Chloroprene and Neoprene; Vulcanization; Introduction to Liquid Crystal Polymers; Biodegradable and Conducting Polymers with examples. Bibliography: 1. William Kemp, Organic Spectroscopy, Palgrave. 2. P S Kalsi, Textbook of Organic Chemistry (1st Ed.), New Age International (P) Ltd. Pub. 3. Robert Thornton Morrison and Robert Neilson Boyd, Organic Chemistry, Dorling Kindersley (India) Pvt. Ltd. (Pearson Education). 4. Fred W. Billmeyer, Textbook of Polymer Science, John Wiley & Sons, Inc. 5. V. R. Gowariker, N. V. Viswanathan, Jayadev Sreedhar, Polymer Science, New Age International (P) Ltd. Pub. Paper 305: Physical Chemistry - V (Quantum Mechanics) Quantum Chemistry Postulates of quantum mechanics, quantum mechanical operators, Schrdinger equation and its application to free particle and particle-in-a-box (rigorous treatment), quantization of energy levels, zero-point energy and Heisenberg Uncertainty principle; wavefunctions, probability distribution functions, nodal properties, Extension to two and three dimensional boxes, separation of variables, degeneracy. Qualitative treatment of simple harmonic oscillator model of vibrational motion: Setting up of Schrdinger equation and discussion of solution, wavefunctions. Vibrational energy

of diatomic molecules and zero-point energy. Rigid rotator model of rotation of diatomic molecule. Schrdinger equation, transformation to spherical polar coordinates and separation of variables. Angular momentum commutation rules, quantization of square of total angular momentum and zcomponent. Qualitative treatment of hydrogen atom and hydrogen-like ions: setting up of Schrdinger equation in spherical polar coordinates, radial part, quantization of energy, radial distribution functions of 1s, 2s, 2p, 3s, 3p and 3d orbitals. Average and most probable distances of electron from nucleus. Setting up of Schrdinger equation for many-electron atoms. Indistinguishability of electrons and Pauli exclusion principle. Need for approximation methods. Statement of variation theorem. and application to simple systems. Chemical bonding: Covalent bonding, valence bond and molecular orbital approaches, LCAO-MO treatment of H2 + and H2 molecules, valence bond treatment of H2 molecule, and comparison of LCAO-MO and VB treatments of H2. Localised and non-localised molecular orbitals of homonuclear, heteronuclear diatomic and triatomic (BeH2, H2O) molecules. Qualitative MO theory and its application to AH2 type molecules. Simple Hckel Molecular Orbital (HMO) theory and its application to simple polyenes (ethylene, butadiene). Page 36 of 40 Molecular spectroscopy Interaction of electromagnetic radiation with molecules and various types of spectra; Born-Oppenheimer approximation. Rotation spectroscopy: Selection rules, intensities of spectral lines, determination of bond length of diatomic and linear triatomic molecules, isotopic substitution.

Vibrational spectroscopy: Classical equation of vibration, computation of force constant, amplitude of diatomic molecular vibrations, anharmonicity, Morse potential, dissociation energies, fundamental frequencies, overtones, hot bands, degrees of freedom for polyatomic molecules, modes of vibration, concept of group frequencies. Vibrationrotation spectroscopy: diatomic vibrating rotator, P, Q, R branches. Raman spectroscopy: Qualitative treatment of Rotational Raman effect; Effect of nuclear spin, Vibrational Raman spectra, Stokes and anti-Stokes lines; their intensity difference, rule of mutual exclusion. Electronic spectroscopy: Franck-Condon principle, electronic transitions, singlet and triplet states, fluorescence and phosphorescence, dissociation and predissociation, calculation of electronic transitions of polyenes using free electron model. Ideas of auxochromes, chromophores, bathochromic, hyperchromic and hypochromic shifts. Nuclear Magnetic Resonance (NMR) spectroscopy: Principles of NMR spectroscopy, Larmor precession, chemical shift and low resolution spectra, different scales, spin-spin coupling and high resolution spectra, interpretation of PMR spectra of A-X type organic molecules. Electron Spin Resonance (ESR) spectroscopy: Its principle, hyperfine structure, ESR of simple radicals. Recommended texts: Atkins, P. W. & Paula, J. de Atkins Physical Chemistry 8 th Ed., Oxford University Press (2006). Banwell, C. N. & McCash, E. M. Fundamentals of Molecular Spectroscopy 4 th Ed. Tata McGraw-Hill: New Delhi (2006).

House, J. E. Fundamentals of Quantum Chemistry 2 nd Ed. Elsevier: USA (2004). Lowe, J. P. & Peterson, K. Quantum Chemistry Academic Press (2005). Paper 900: Analytical Methods of Analysis Qualitative and Quantitative aspects of analysis: Sampling, evaluation of analytical data, errors, accuracy and precision, methods of their expression, normal law of distribution if indeterminate errors, statistical test of data; F, Q, and T test, rejection of data, and confidence intervals. Optical methods of analysis: Origin of spectra, interaction of radiation with matter, fundamental laws of spectroscopy & selection rules, validity of Beer-Lamberts law.

UV-Visible Spectrometry: Basic principles of instrumentation (choice of source, monochromator & detector) for single and double beam instrument; Page 37 of 40 Basic principle of quantitative analysis: estimation of metal ions from aqueous solution, geometrical isomers, keto-enol tautomers. Determination of composition of metal complexes using Jobs method of continuous variation and Mole ratio method.

Infrared Spectrometry: Basic principles of instrumentation (choice of source, monochromator & detector) for single and double beam instrument; sampling techniques. Structural illustration through interpretation of data, Effect and importance of isotope substitution. Flame Atomic Absorption and Emission Spectrometry: Basic principles of instrumentation (choice of source, monochromator, detector, Choice of flame and Burner

designs. Techniques of atomization and sample introduction; Method of background correction, sources of chemical interferences and their method of removal. Techniques for the quantitative estimation of trace level of metal ions from water samples. Thermal method of analysis: Theory of thermogravimetry (TG), basic principle of instrumentation. Techniques for quantitative estimation of Ca and Mg from their mixture. Electro analytical methods: Classification of electro analytical methods, basic principle of pH metric, potentiometric and conductometric titrations. Techniques used for the determination of equivalence point. Techniques used for the determination of pKa values. Separation Techniques: Solvent extraction: Classification and principle and efficiency of the technique. Mechanism of extraction: extraction by solvation and chelation. Technique of extraction: batch, continuous and counter current extractions. Qualitative and quantitative aspects of solvent extraction: extraction of metal ions from aqueous solution, extraction of organic species from the aqueous and non aqueous media. Chromatography: Classification and principle and efficiency of the technique. Mechanism of separation: adsorption, partition & ion exchange. Development of chromatograms: frontal, elution and displacement methods. Qualitative and quantitative aspects of chromatographic methods of analysis: IC, GLC, GPC, TLC and HPLC. Stereo isomeric separation and analysis: Measurement of optical rotation, calculation of Enantiomeric excess (ee)/ diastereomeric excess (de) ratios and determination of Enantiomeric composition using NMR, Chiral solvents and chiral shift reagents Chiral chromatographic techniques using chiral columns (GC and HPLC).

Role of computer in instrumental methods of analysis Bibliography: 1. Vogel, Arthur I: A Test book of Quantitative Inorganic Analysis (Rev. by GH Jeffery and others) 5 th Ed. Page 38 of 40 The English Language Book Society of Longman 2. Willard, Hobert H. et. al : Instrumental Methods of Analysis, 7 th Ed. Wardsworth Publishing company, Belmont, California, USA, 1988. 3. Christian, Gary D; Analytical Chemistry, 6 th Ed. New York- John Willy, 2004. 4. Harris, Daniel C: Exploring Chemical Analysis, 2 nd Ed. New York, W.H. Freeman, 2001. 5. Khopkar, S.M. Basic concept of Analytical Chemistry New Age, International Publisher, 2009. 6. SKoog, D.A. Holler F.J. and Nieman, T.A. Principles, of Instrumental Analysis, Thomson Asia Pvt. Ltd. Signapore. 7. Mikes, O. Chalmes, R.A. Laboratory Hand Book of Chromatographic & Allied Methods, Elles Harwood Ltd. London. 8. Ditts, R.V. Analytical Chemistry Methods of separation.

SEMESTER VI PRACTICAL Inorganic Laboratory - V Qualitative analysis: Using H2S /PTC/ Thioacetamide or any other reagent. Identification of cations and simple anions in a mixture of salts containing not more than six ions (Three cations and three anions) interfering anions using semimicro scheme of analysis. If combination of cations or anions is given in the mixture, insoluble should be avoided. Spot tests should be carried out for final identifications wherever feasible. Cation : Pb 2+ , Bi 3+ Cu 2+ , Cd 2+ , As 3+ , Sb 3+ , Sn 2+ or Sn 4+ , Fe

2+ OR Fe 3+ , Al 3+ , Cr 3+ ,Co 2+ , Ni 2+ , Zn 2+ , Mn 2+ , Ba 2+ , Sr 2+ , Ca 2+ , Mg 2+ , NH4

+ ,K + Anion : CO3 2, SO3 2, CO 2 3, SO 23, S 2, NO 2, CH3 COO , NO 3, Cl , Br ,I -

, SO4 2, PO4 3, BO3 3,F , C2O 24 Organic Laboratory V Determination of saponification value of an oil (caster, coconut or linseed oil). Determination of Iodine number of an oil/fat. Preparation of ibuprofen by green method. Preparation of malachite green dye. Estimation of glucose Estimation of glycine Estimation of urea Identification of functional groups using ultraviolet spectroscopy. Interpretation of NMR spectra of simple organic compounds; Note: UV and NMR spectra is to be provided. Physical Laboratory V Colourimetry

 Verification of Lambert-Beer's Law Determination of pK (indicator) for phenolphthalein or methyl red Page 39 of 40 Study the formation of a complex between ferric and thiocyanate (or salicylate) ions. Study the kinetics of interaction of crystal violet with sodium hydroxide colourimetrically. Analysis of the given vibration-rotation spectrum of HCl(g) Record the UV spectrum of p-nitrophenol (in 1:4 ethanol:water mixture). Repeat after adding a small crystal of NaOH. Comment on the difference, if any. Record the U.V. spectrum of a given compound (acetone) in cyclohexane (a) Plot transmittance versus wavelength. (b) Plot absorbance versus wavelength. (c) Calculate the energy involved in the electronic transition in different units, i.e. cm -1 , kJ/mol, kcal/mol & eV. Any other experiment carried out in the class. Analytical Methods of Analysis Separation Techniques 1. Chromatography (a) Separation of mixtures

(i) Paper chromatographic separation of Fe 3+ , Al 3+ , and Cr

3+ (ii) Separate and identify the monosaccharides present in the given mixture (glucose & fructose) by paper chromatography. Report the Rf values. (b) Separate a mixture of Sudan yelliro and sudan Red by TLC technique and

identify them on the basis of their Rf values. (c) Chromatographic separation of the active ingredients of Plant, flower and juices by TLC 2. Solvent Extraction (i) To separate a mixture of Ni 2+ & Fe 3+ by complexing with DMG and extracting the Ni 2+ DMG complex in chloroform, and determine its concentration with spectrophotomatry. (ii) Solvent extraction of zisconium with amberliti LA-1, separation from a mixture of irons and gallium. 3. Determine the pH of given aerated drinks fruit juices, shampoos and soaps. 4. Determination of Na Ca, Li in cola drinks and fruit juices using fame photometric techniques. 5. Analysis of soil (i) Determination of pH of soil.

(ii) Total soluble salt (iii) Estimation of calcium, magnesium, phosphate, nitrate Page 40 of 40 6 Ion exchange: (i) Determination of exchange capacity of cation exchange resin and anion exchange resins. (ii) Separation metalions from their binary mixture. (iii) Separation of amino acids from organic acids by ion exchange chromatography. 6. Determination of pka, values of indicator using spectrophotometery. 7. Structural characterization of compounds by Infra-Red spectroscopy. 8. Determination of dissolved oxygen in water. 9. Determination of chemical oxygen demand (COD). 10. Determination of Biological oxygen demand (BOD).