Natural Remedies Pvt Ltd., Curcuma longa Ext.

Curcuma longa Linn. Dry Extract.

English name: Turmeric

Family: Zingiberaceae

Part used: Rhizomes

Traditional uses 1: The rhizomes are bitter, acrid, thermogenic carminative emollient,
anodyne, anti- inflammatory, vulnerary, depurative, antiseptic, appetiser, stomachic,
anthelmintic, laxative, diuretic, expectorant, haematinic, alterative, alexiteric,
stimulant, febrifuge and tonic. It is useful in vitiated conditions of kapha and pitta,
inflammations, ulcers, wounds, skin diseases, allergic conditions, anorexia, dyspepsia,
constipation, cough, anaemia, dropsy, gonorrhea, amenorrhoea, jaundice and general
debility.

Phytochemistry2: The major bioactive constituent of Curcuma longa are a group of diferuloylmethanes known as
“curcuminoids”, which contains mainly curcumin along with desmethoxycurcumin and bisdesmethoxycurcumin. The
rhizome also contains volatile oil consisting mainly of bisabolane derivatives; polysaccharides viz. ukonan A, B, C
and D common : phytosterols and fatty ac ids.

Pharmacology: Curcuma longa has been evaluated for various pharmacological activities. Curcuma longa has been
found to be potent, anti-inflammatory3- 5, anti rheumatic, antiarthritic 5 and wound healing activity6. Curcuma
longa is also been reported for gastroprotective 7, antispasmodic 8, anticoagulant 9, antifertility1 0, hypolipidemic 11,
antibacterial12, antifungal 13 and antitumour1 4 activity.

Marker constituent(s): Curcumin.

O O

H3CO OCH 3

HO OH

Molecular Formula = C21 H20 O6 Formula Weight = 368.380

Curcumin

Main use(s): Anti-inflammatory, antioxidant, food colorant.

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 Natural Remedies Pvt Ltd., Curcuma longa Ext.

References:

1. Warrier PK, Nambiar VPK, Raman Kutty C. (1997) Indian Medicinal Plants a compendium of 500 species, Orient
Longman Publications, Madras, India. 2 : 259-261
2. Anonymous (1998) Indian Herbal Pharmacopoeia Joint Publication of Indian Drug Manufacturer’s Association,
Mumbai and Regional Research Laboratory, Jammu-Tawi. 1: 64-72.
3. Ammon HPT, Safayhi H, Mack T, Sabieraj J. (1993) J. Ethnopharmacol. 38: 113-119.
4. Srimal RC, Dhawan BN. (1973) J.Pharm.Pharmac. 25: 447-452.
5. Chandra D, Gupta SS. (1972) Indian. J. Med. Res. 60(1) : 138-142.
6. Gujral ML, Chowdhury NK, Saxena PN. (1953) Ind. Med. Assoc. 22: 273.
7. Prasad DN, Gupta B, Srivastava RK, Satyavati GV. (1976) Indian J. Physiol. Pharmacol. 20: 92.
8. Rao TS, Basu N, Siddiqui HH. (1982) Indian J. Med. Res. 75: 574-578.
9. Srivastava R, Dikshit M, Srimal RC, Dhawan BN. (1985) Thromb. Res. 40: 413-417.
10. Garg SK, Mathur VS., Chaudhury RR. (1978) Indian J. Exptl. Biol, 16: 1077-1079.
11. Rao AJ, Kotagi SG. (1984) IRCS Med.Sci. 12: 500-501.
12. Lutomski J, Ked zia B, Debska W. (1974) Plant Med. 26: 9 -19.
13. Mishra SK, Sahu KC. (1977) Indian. J. Pharmacol. 9: 269-272.
14. Hunag MT, Smart RC, Wong Ch Q, Conney AH. (1988) Cancer Res. 48: 5941-5946.

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 Natural Remedies Pvt Ltd., Curcuma longa Ext.

Analytical specifications 95 % Curcumino ids .

No. Tests Limits Protocol

1. Description Yellow to orange yellow powder soluble in alcohol and almost
insoluble in water
2. Physico-chemical analysis
Moisture (%w/w) < 1.0
As per USP 24<561> Vegetable Drugs Pg.1885
Volatile Oil (%w/v) < 2.0
Residue on Ignition (%w/w) < 1.0
3. Particle Size As per USP 24 <616> 1913-1914 Method – I
Bulk Density (g/cc) 0.2 – 0.6
Material passing through 30# BS/35 ASTM (%w/w) > 99.0 As per USP 24 <786> Particle Size distribution.
4. H e a v y m e t a l a n a l y si
si s
Lead < 10 ppm AAS / ICP –ES
Cadmium < 1 ppm
Arsenic < 2ppm
5. Microbiological analysis
As per FIP Guidelines
Total Viable Aerobic Count < 104 cfu g-1
Total Enterobacteriaceae < 102 org g- 1
Total Fungal Count < 102 fs g-1
As per WHO/PHARMA/92.559/Rev.1 Pg.49-52
6. Test for Specific Pathogen
As per FIP Guidelines
E.coli (1g) Absent
Salmonella typhi (10g) Absent
S.aureus (1g) Absent
7. Mycotoxin analysis As per USP 24 Test for Aflatoxins Pg.1888
Aflatoxins (B1 + B 2 + G1 + G2) <5ppb
8. Residual solvent analysis
As per ICH Guidelines As per USP 24 <467>
Methanol <3000 ppm
9. Pesticide residue analysis
As per USP & BP Limits
To comply with
Organochlorine Pesticides As per AOAC / USP 24
USP
Organophosphorus Pesticides
Synthetic pyrethroids
10. Phytochemical analysis
Colour value > 15000 By Spectrophotometry
Total curcuminoids (%w/w) ≥ 95.0
Curcumin --
Demethoxy Curcumin -- By HPLC
Bis demethoxy Curcumin --

Note:

1. Residual solvent analysis and residual pesticide analysis are performed

only on request
.

F o r e n q u i r i e s c o n t a c t : M/s Natural Remedies Pvt Ltd., Bangalore – 561 229. (Tel.) : +91-80-7832265, 7833092, 7834872.
(Fax) : +91 -80-7834369, E-mail: indherbs@vsnl.com, Internet: www.indianherbs.com.

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