2008 Third Congress of the World

Union of Wound Healing Societies,

Toronto, Canada

Fundam
entals
of
MMPs-
their
role in
wound
healing
Professor
David
Leaper
Department
of Wound
Healing
Cardiff
University
M
M
P

i
n
h
i
b
i
t
i
o
n

t
h
e
 r
a
p
y
:
understanding the
next trend in active
wound healing
W
UWH
S
Toron
to 4-
8
June
2008
2008 Third Congress of the World Union
of Wound Healing Societies, Toronto,

Canada types
 of
wound
healin
g (acute
and chronic)
1 primary healing
(first intention) no
defect
2 delayed primary

healing defect
3 secondary

healing
(secondary
intention) defect
4 chronic wounds

not healed, 6
weeks optimal
therapy

Wo
un
d
C
ar
e

D
one
By :
Mo
 nira
h
Albl
ous
hi
1Objectives•To
know Anatomy and
Physiology of related to
wound Care .
2•To know the wound
classifications.
3•To know the wound
healing process .
4•identify Types of wound
drainage.
5•identify Factors
affecting wound healing.
•Identify the common
6

complications of wound.

Functions of the
skinprotection
Thermoregulation Fluid and
Electrolyte Balance vitamin D
synthesis sensation
Psychosocial
Classification of wounds Intentional
Unintentional open Closed penetrating superficial
clean clean/contaminated contaminated infected
full-thickness partial-thickness abrasion contusion
incision laceration puncture
Phases of wound healing
1.Defensive(inflammatory) phase begins
immediately after injury 1.Hemostasis
1.vasoconstriction 2. Aggregation of platelets
3.invasion of fibrin 4.Contraction of the fibrin clot
2.inflammation 1.secretion of multiple products
2.vasodilation of local blood vessels 3.increased
permeability of capillaries 4.Chemotaxis attraction
of white blood cell 3.Encouragement of actions to
avoid further injury 4.walling off injured tissues
and lymphaticsfrom remaining tissues
Phases of wound
healing2.proliferativephase 1.begins 3 or 4
days after injury 2.macrophages stimulate the
migration of fibroblasts to the wound 3.The
collagen and proteogylcansynthesized by
fibroblasts forms a scaffold 4.Macrophages also
stimulate the formation of "buds5.proliferation of
epithelial cells across the wound 3.maturation
phase 1.begins after 21 days after injury
2.firbroblasts continue to synthesize collagen and
proteoglycan the collagen and proteogylcanfibers,
laid haphazardly
Types of wound drainage
serous exudate consists chiefly
of serum derived from blood and
serous membranes of the
bodysanguineous consists of serum
and red blood cellspurulent consists
of serum and pus (leukocytes,
liquefied living and dead bacteria,
dead tissue debris(
Factors affecting wound healing
1.Impaired Circulation & OxygenationAdvanced
age Anemia Peripheral vasculardisorders
Diabetes Mellitus Smoking Obesity Chronic Lung
Disease 2Malnourishment Protein vitamin
Kvitamin A B complex vitamins Vitamin C zinc
copper & iron 3.Medications Radiation Aspirin
Antineoplastics
WarfarinCorticoidsteriods4.Contamination and
Infection
Wound Healing
ComplicationsHemorrhage Infection
Dehiscence Evisceration Fistula