Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada

Universitas Airlangga untuk digunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Lea MS Soebagijo Adi S., dr., Sp.PD, K-EMD Sri Murtiwi, dr.,Sp.PD, K-EMD Prof. Dr. Agung Pranoto, dr.,MSc.Sp.PD-KEMD Dr. Ari Sutjahjo, dr.,Sp.PD-KEMD Sony Wibisono, dr. Sp.PD.K-EMD FINAIM

CORRELATION BETWEEN INSULIN RESISTANCE AND SMALL DENSE LDL INPATIENTS WITH T2DM (Cross sectional descriptive Study In Surabaya)
Abstrak :

CORRELATION BETWEEN INSULIN RESISTANCE AND SMALL DENSE LDL INPATIENTS WITH T2DM (Cross sectional descriptive Study In Surabaya)

Askandar Tjakroprawiro, Lea MS, Soebagijo Adi, Sri Murtiwi, Agung Pranoto, Hendromartono, Ari Sutjahjo, Sony Wibisono Diabetes and Nutrition Centre Department of Internal Medicine Dr, Soetomo Hospital Airlangga University School of Medicine, Surabaya

OBJECTIVE LDL (low density lipoprotein) is the major carrier of cholesterol in human plasma, and as such is intimately involved in the process atherosclerosis, All LDL is not created equal, There are different types of LDL. Small dense LDL is more atherogenic or more toxic to the endothelium. It is more likely to enter the vessel wall, become oxidized and trigger atherosclerosis process. Causes of small dense LDL are multiple. There is a genetic predisposition to have small dense LDL. An atherogenic lifestyle involving minimal activity, Insulin resistance is the last major cause of small dense LDL, The aim of this study is to determine correlation between small dense LDL and resistance insulin. RESEARCH DESIGN AND METHOD_ We conducted a cross sectional study in 50 type 2 DM patients aged 21 70 years. The type 2 DM was diagnosed according to PERKENI 2002 . Small dense LDL particles are measured by ratio of LDL cholesterol with Apo B, if the ratio of LDL cholesterol with Apo B is less than 1.2 revealed small dense LDL abnormality, Homeostasis model assessment of resistance insulin (HOMAR) was vsed to quantify of insulin resistance. HOMA R measurement is calculated by using formula as follow Matheus (1985), Falutz (2002), Tjokroprawiro (2005). HOMA R abnormality is more than 4. HOMAR = Fasting Insulin (_Ulml) x FPG (mmol/1) (N < 4)

Page 1

Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada Universitas Airlangga untuk digunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Lea MS Soebagijo Adi S., dr., Sp.PD, K-EMD Sri Murtiwi, dr.,Sp.PD, K-EMD Prof. Dr. Agung Pranoto, dr.,MSc.Sp.PD-KEMD Dr. Ari Sutjahjo, dr.,Sp.PD-KEMD Sony Wibisono, dr. Sp.PD.K-EMD FINAIM

Page 2

Dokumen Artikel Penelitian ini milik penulis/peneliti yang diserahkan sebagian (judul dan Abstrak) hak ciptanya kepada Universitas Airlangga untuk digunakan referensi dalam penulisan artikel ilmiah.

Tim Peneliti : Lea MS Soebagijo Adi S., dr., Sp.PD, K-EMD Sri Murtiwi, dr.,Sp.PD, K-EMD Prof. Dr. Agung Pranoto, dr.,MSc.Sp.PD-KEMD Dr. Ari Sutjahjo, dr.,Sp.PD-KEMD Sony Wibisono, dr. Sp.PD.K-EMD FINAIM

22.5 RESULTS Data were analyzed for 50 subjects with type 2 DIVI with a mean age of 53,12 year, a mean BMI of 27.60 kg/m, a mean waist circumference for male of 96.07 m and for female of 113.7 cm, a mean triglycerida of 177.48 mg/dI, a mean LDL cholesterol of 126.62 mg/dI, a mean HDL cholesterol for male of 45.22 and for female f 45.36 mg/dI, cholesterol total of 200.9 mg/dI, a mean HOMA R of 4.57, a mean mail dense LDL of 1.134. A total of 34 patients (68%) have abnormality of small dense LDL. There was significant correlation between resistance insulin and small dense LDL r = 0.281, p = 0.04). CONCLUSION The resistance insulin was significantly correlated to the small dense LDL level in patient with type 2 DM. Keyword : LDL ,T2DM

Page 3