AUDIOLOGY FIGURES FOR NASOPHARYNX CARCINOMA PATIENTS FROM WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR BEFORE AND AFTER TREATMENT

WITH CISPLATIN
Eka Savitri, Eryadi Djamzuli, Nur Qamariah
Ear Nose Throat Departement, Medical Faculty, Hasanuddin University, Makassar

ABSTRACT
Background: Cisplatin is an effective chemotherapy agent which is currently used as standard treatment for most malignancies, including nasopharinx carcinoma (NPC). However, clinical application is limited because of serious and irreversible toxicity including ototoxicity. Objectives: To measure the audiologic patterns of nasopharinx carcinoma patients before and after a regime of Cisplatin therapy. Methods: Ten patients from Wahidin Sudirohusodo hospital diagnosed with NPC that were treated by using Cispatin regiments for 5 cycles were involved in the study. Pure tone audiometric (PTA) and Oto Acoustic Emission (OAE) were measured before and after chemotherapy. Results: Seventy percent of the patients treated with the Cisplatin regime had decreased hearing ability at high frequenceis (4000, 6000 and 8000 Hz) while the remaining 30% were normal. OAE results showed that 40% of the patients had bilateral sensoryneural hearing loss, 10% had bilateral sensoryneural hearing loss and 50% were normal after chemotherapy. Conclusions: There was a decrease in both the PTA & OAE figures of nasopharynx patients after Cisplatine therapy. Keywords : Audiology, nasopharynx, cancer, Cisplatin

GAMBARAN AUDIOLOGI PENDERITA KARSINOMA NASOFARING YANG DITERAPI CISPLATIN DI RUMAH SAKIT WAHIDIN SUDIROHUSODO MAKASSAR

DENGAN

Latar belakang: Cisplatin merupakan kemoterapi yang cukup efektif untuk terapi berbagai keganasan, termasuk karsinoma nasofaring (KNF), namun penggunaannya secara klinis dibatasi karena dapat menyebabkan gangguan pendengaran sensorineural permanen. Tujuan: untuk mengetahui gambaran audiologik pasien KNF Metode: pemeriksaan Pure Tone Audiometry (PTA) dan Oto Acoustic Emission (OAE) dilakukan pada penderita KNF sebelum dan sesudah terapi Cisplatin. Subyek penelitian adalah semua pasien KNF yang diterapi dengan regimen Cisplatin, yang datang berobat ke Rumah Sakit Wahidin Sudirohusodo. Hasil: gambaran PTA menunjukkan dari 10 orang pasien KNF yang mendapatkan regimen Cisplatin, 70% penderita mengalami penurunan ambang pendengaran pada frekwensi tinggi (4000, 6000, 8000 Hz). Gambaran OAE menunjukkan 40% penderita tuli sensorineural bilateral dan 10% penderita tuli sensorineural unilateral. Simpulan: terdapat perubahan gambaran PTA dan OAE sebelum dan sesudah pemberian Cisplatin pada pasien KNF di Makassar Kata kunci: Audiologi, nasofaring, kanker, Cisplatin