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Drug Study

Generic Name/ Brand Name Generic Name: Hydrocortisone Sodium succinate Brand Name: Soku-cortef Classification: Corticosteroid, short-acting Dosage: 100mg Route: IV Frequency: every 6 hours Action of the Drug Suppress inflammation of the normal immune response. Replace endogenous cortisol in deficiency states. Also have potent mineralcorticoid (sodiumretaining) activity. Indication Replacement therapy in adrenal cortical insufficiency Hypercalcemia: associated with cancer Short term inflammatory disorders Contraindication Infections, especially TB, fungal infections, amoebiasis, hepatitis B. liver disease, liver cirrhosis, active or latent peptic ulcer Side effects/ Adverse effects Vertigo Headache Hypotension Shock Thin Fragile skin Petechiae Amenorrhea Muscle weakness Nursing Considerations 1. Give daily before 9am to mimic normal peak diurnal corticosteroid levels and minimize HPA suppression. 2. Space multiple dose evenly throughout the day. 3. Use minimal dose for minimal duration to minimize adverse effects 4. Use alternate dry maintenance therapy with short acting corticosteroids whenever possible.

Generic Name/ Brand Name Generic Name: Acetylcysteine Brand Name: Fluimucil Classification: Mucolytic Agent

Action of the Drug is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose.

Indication Mucolytic Adjuvant therapy for abnormal, viscid, or inspissated mucus secretion in acute and chronic bronchpulmonary disease (pneumonia,asthma,TB)

Contraindication Contraindicated with hypersensitivity to acetylcysteine; use caution and discontinue if bronchospasm occurs.

Side effects/ Adverse effects Nausea Rhinorrhea Bronchospasm especially in asthmatics Stomatitis urticaria

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Nursing considerations Dilute with normal saline solution or sterile water for injection Administer the following drugs separately because they are incompatible with acetylcysteine: tetracyclines, hydrogen peroxide, trypsin Use water to remove residual drug solution on the patients face after administration by face mask. Inform patient that nebulization may produce an initial disagreeable odor, bit will soon disapper

Generic Name/ Brand Name Generic Name: Cefuroxime sodium Brand Name: Cettin Classification: Antibiotic/ Anti infective Route: IV Dose: 1.5 g

Action of the Drug Second-generation cephalosporin that inihibits cell wall synthesis, promoting osmotic instability; usually bactericidal.

Indication Pre-prophylaxis/ penoperative prevention

Contraindication Contraindicated in patient hypersensitive to drug or other cephalosporin Use cautiously in patient with hypersensitivity to penicillin because of possibility of cross-sensitivity with other beta lactam antibiotics.

Side effects/ Adverse effects Nausea Vomiting Diarrhea Elevated temperature Urticarial

Nursing Considerations Obtain specimen for culture and sensitivity test before giving first dose. Ask patient or relatives if there is sensitivity in penicillin or other cephalosporin drugs.