REGISTRATION OF SUBJECT FOR DISSERTATION A PROTOCOL FOR THE PROJECT WORK ENTITLED

STUDIES IN THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF COMPOUNDS OF MEDICINAL IMPORTANCE:1, 3, 4- OXADIAZOLES

By, JISHA PREMS M.Pharm, Part- I Department of Pharmaceutical Chemistry N.G.S.M. Institute of Pharmaceutical Sciences Paneer, Deralakatte Mangalore 574160

RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE KARNATAKA.

ANNEXURE II PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION

1.

NAME OF THE JISHA PREMS CANDIDATE N.G.S.M INSTITUTE OF PHARMACEUTICAL SCIENCES, AND ADDRESS PANEER, DERALAKATTE, MANGALORE 574160. NAME OF THE N.G.S.M. INSTITUTE OF PHARMACEUTICAL SCIENCES, INSTITUTION COURSE OF STUDY AND SUBJECT DATE OF PANEER, DERALAKATTE, MANGALORE 574160. M.PHARM [PHARMACEUTICAL CHEMISTRY] JUNE 2008

2. 3.

4. 5.

ADMISSION TITLE OF THE TOPIC: STUDIES IN THE SYNTHESIS AND BIOLOGICAL ACTIVITIES OF COMPOUNDS OF MEDICINAL IMPORTANCE:-1,3,4-OXADIAZOLES

6.

Brief resume of the intended work : 6.1 Need for the study: Among the wide variety of heterocycles that have been explored for developing pharmaceutically important molecules, 1, 3, 4-oxadiazole derivatives have played a vital role in the medicinal chemistry. It was observed from the literature that certain five membered heterocyclic compounds possess interesting biological and pharmacological activities. Oxadiazoles are five membered heterocyclic compounds with two nitrogen atoms and one oxygen atom. They are synthesized by ring condensation and rearrangements. Depending on the position of hetero atoms they are named as 1,2,3:- ;1,2,4:- ;1,2,5:- and 1,3,4-oxadiazoles. All of them were reported to possess one or the other biological activities. In general N and O heterocycles were reported to possess wide variety of biological activities .The incorporation of various heterocyclic moieties with 1,3,4oxadiazoles was proved to show enhanced activities. 1, 3, 4- oxadiazoles possess various biological and pharmacological activities viz; antimicrobial1, anti-inflammatory2, ulcerogenic2, lipid peroxidation2, antifungal3, anticancer 4,antitubercular5 etc. In the present work, 2-furoic acid has taken as the starting material. Furan derivatives, by virtue of their structures and functional groups, are used in the preparation of many physiologically active intermediates employed in medicines and

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agrochemicals .Further furan and its substituted compounds[furan-2-aldehyde, furoic 3 acid] have showed varied pharmacological activities.

SCHEME

COOH O

con. H2SO4
C2H5OH

COOC2 H5 O

NH2NH2

CONHNH 2 O

R-CHO

R-COCH3

H CONHN=CH-R O O CONHN=C CH3

AC2O

AC2O

COCH 3 H

COCH3 H

O O

O H O

CH 3

1,3,4-oxadiazoles

1,3,4-oxadiazoles